2. Cell Cycle/DNA Damage Epigenetics
  3. HDAC
  4. KPZ560

KPZ560 is a potent inhibitor of HDAC1 and HDAC2, with IC50s of 12 nM and 68 nM, respectively. KPZ560 can increase in the spine density of granule neuron dendrites of mice and inhibitor cell growth of breast cancer cell line MCF.

For research use only. We do not sell to patients.

KPZ560 Chemical Structure

KPZ560 Chemical Structure

CAS No. : 2397562-43-3

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5 mg USD 325 Get quote 5 - 7 weeks 5 - 7 weeks 4 - 6 weeks
10 mg USD 520 Get quote 5 - 7 weeks 5 - 7 weeks 4 - 6 weeks
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50 mg USD 1750 Get quote 5 - 7 weeks 5 - 7 weeks 4 - 6 weeks
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Based on 1 publication(s) in Google Scholar

KPZ560 Related Antibodies

Top Publications Citing Use of Products

View All HDAC Isoform Specific Products:

View All Isoforms
HDAC HDAC1 HDAC2 HDAC3 HDAC4 HDAC5 HDAC6 HDAC7 HDAC8 HDAC9 HDAC10 HDAC11 HD1 HD2

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Description

KPZ560 is a potent inhibitor of HDAC1 and HDAC2, with IC50s of 12 nM and 68 nM, respectively. KPZ560 can increase in the spine density of granule neuron dendrites of mice and inhibitor cell growth of breast cancer cell line MCF[1].

IC50 & Target

HDAC1

12 nM (IC50)

HDAC2

68 nM (IC50)

Molecular Weight

515.61

Formula

C26H21N5O3S2
CAS No.
SMILES

NC1=C(C=C(C=C1)C2=CC=CS2)NC(C3=CC=C(C=C3)C4=CN(N=N4)CS(C5=CC=CC=C5)(=O)=O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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KPZ560 Related Classifications

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

KPZ5602397562-43-3KPZ 560KPZ-560HDACHistone deacetylasesHDAC1/2 InhibitorCancerNeurodegenerative DisordersInhibitorinhibitorinhibit

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