2. Cell Cycle/DNA Damage Epigenetics Neuronal Signaling
  3. HDAC Monoamine Oxidase Histone Demethylase
  4. LSD1/HDAC6-IN-2

LSD1/HDAC6-IN-2 (JBI-802) is an orally active LSD1/HDAC6/MAO-A inhibitor, with IC50 values of 5 nM, 11 nM, and 5 nM, respectively. LSD1/HDAC6-IN-2 can inhibit the growth of multiple myeloma cells MM.1S, MM.1R, and RPMI-8226. LSD1/HDAC6-IN-2 can be used for research on diseases such as acute myeloid leukemia and lymphoma.

For research use only. We do not sell to patients.

LSD1/HDAC6-IN-2 Chemical Structure

LSD1/HDAC6-IN-2 Chemical Structure

CAS No. : 2982787-50-6

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1 mg USD 160 In-stock
5 mg USD 400 In-stock
10 mg USD 622 In-stock
25 mg USD 1244 In-stock
50 mg USD 1866 In-stock
100 mg USD 2800 In-stock
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Customer Review

Based on 1 publication(s) in Google Scholar

LSD1/HDAC6-IN-2 Related Antibodies

Top Publications Citing Use of Products

View All HDAC Isoform Specific Products:

View All Isoforms
HDAC HDAC1 HDAC2 HDAC3 HDAC4 HDAC5 HDAC6 HDAC7 HDAC8 HDAC9 HDAC10 HDAC11 HD1 HD2

View All Monoamine Oxidase Isoform Specific Products:

View All Isoforms
MAO-A MAO-B

View All Histone Demethylase Isoform Specific Products:

View All Isoforms
KDM1/LSD1 KDM2 KDM3 KDM4 KDM5 KDM6

  • Biological Activity

  • Purity & Documentation

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Description

LSD1/HDAC6-IN-2 (JBI-802) is an orally active LSD1/HDAC6/MAO-A inhibitor, with IC50 values of 5 nM, 11 nM, and 5 nM, respectively. LSD1/HDAC6-IN-2 can inhibit the growth of multiple myeloma cells MM.1S, MM.1R, and RPMI-8226. LSD1/HDAC6-IN-2 can be used for research on diseases such as acute myeloid leukemia and lymphoma[1][2].
IC50 & Target

HDAC6

11 nM (IC50)

MAO-A

5 nM (IC50)

MAO-B

6600 nM (IC50)

LSD1

5 nM (IC50)

In Vitro

LSD1/HDAC6-IN-2 (JBI-802) exhibits growth inhibitory activity against multiple myeloma cells MM.1S, MM.1R, and RPMI-8226, with EC50values of 2 nM, 6 nM, and 280 nM, respectively[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

LSD1/HDAC6-IN-2 Related Antibodies
In Vivo

LSD1/HDAC6-IN-2 (JBI-802) (25 mg/kg; once daily; 12 days; p.o.) exhibits anti-tumor activity in multiple myeloma mice[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Multiple myeloma cells MM.1S xenograft mice model[1].
Dosage: 25 mg/kg
Administration: Oral gavage (p.o.); once daily; 12 days
Result: Had an oral bioavailability of 44% and exhibited strong anti-cancer effects on the MM.1S xenograft model, surpassing HDAC6 inhibitor ACY-1215 (HY-16026) and LSD1 inhibitor GSK-2879552 (HY-18632).
Molecular Weight

443.34

Formula

C21H23BrN4O2
CAS No.
Appearance

Solid

Color

Off-white to light yellow

SMILES

ONC(C(C=C1)=CC=C1CN(N=C2)C=C2CN[C@H]3[C@H](C4=CC=CC=C4)C3)=O.[H]Br
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : ≥ 100 mg/mL (225.56 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.2556 mL 11.2780 mL 22.5561 mL
5 mM 0.4511 mL 2.2556 mL 4.5112 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.2556 mL 11.2780 mL 22.5561 mL 56.3901 mL
5 mM 0.4511 mL 2.2556 mL 4.5112 mL 11.2780 mL
10 mM 0.2256 mL 1.1278 mL 2.2556 mL 5.6390 mL
15 mM 0.1504 mL 0.7519 mL 1.5037 mL 3.7593 mL
20 mM 0.1128 mL 0.5639 mL 1.1278 mL 2.8195 mL
25 mM 0.0902 mL 0.4511 mL 0.9022 mL 2.2556 mL
30 mM 0.0752 mL 0.3759 mL 0.7519 mL 1.8797 mL
40 mM 0.0564 mL 0.2820 mL 0.5639 mL 1.4098 mL
50 mM 0.0451 mL 0.2256 mL 0.4511 mL 1.1278 mL
60 mM 0.0376 mL 0.1880 mL 0.3759 mL 0.9398 mL
80 mM 0.0282 mL 0.1410 mL 0.2820 mL 0.7049 mL
100 mM 0.0226 mL 0.1128 mL 0.2256 mL 0.5639 mL
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LSD1/HDAC6-IN-2 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

LSD1/HDAC6-IN-22982787-50-6HDACMonoamine OxidaseHistone DemethylaseHistone deacetylasesMAOorally activeLSD1HDAC6MM.1SMM.1RRPMI-8226multiple myelomaInhibitorinhibitorinhibit

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