2. Antibody-drug Conjugate/ADC Related Cell Cycle/DNA Damage
  3. Drug-Linker Conjugates for ADC Topoisomerase
  4. MC-GGFG-Exatecan

MC-GGFG-Exatecan  (Synonyms: MC-GGFG-DX8951)

Cat. No.: HY-114233 Purity: 99.71%
COA Handling Instructions

Molarity Calculator

MC-GGFG-Exatecan (MC-GGFG-DX8951) is a agent-linker conjugate for ADC. MC-GGFG-Exatecan is a DX8951 (a DNA topoisomerase I inhibitor) derivative with protease cleavable MC-GGFG linker. MC-GGFG-Exatecan shows antitumor activity and can be used to prepare DX8951 antibody conjugate (ADC).

For research use only. We do not sell to patients.

MC-GGFG-Exatecan Chemical Structure

MC-GGFG-Exatecan Chemical Structure

CAS No. : 1600418-29-8

Size Price Stock Quantity
5 mg USD 340 In-stock
10 mg USD 540 In-stock
25 mg USD 1100 In-stock
50 mg USD 1750 In-stock
100 mg USD 2800 In-stock
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500 mg   Get quote  

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This product is a controlled substance and not for sale in your territory.

Customer Review

Based on 3 publication(s) in Google Scholar

MC-GGFG-Exatecan Related Antibodies

Top Publications Citing Use of Products

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Topoisomerase Topo I Topo II

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

MC-GGFG-Exatecan (MC-GGFG-DX8951) is a agent-linker conjugate for ADC. MC-GGFG-Exatecan is a DX8951 (a DNA topoisomerase I inhibitor) derivative with protease cleavable MC-GGFG linker. MC-GGFG-Exatecan shows antitumor activity and can be used to prepare DX8951 antibody conjugate (ADC)[1].

IC50 & Target

Camptothecins

 

In Vitro

In MC-GGFG-Exatecan, GGFG is selectively cleaved by lysosomal enzymes (presumably cathepsins)[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

MC-GGFG-Exatecan Related Antibodies
In Vivo

In MC-GGFG-Exatecan, GGFG is known to release drugs into tumor tissue without releasing them into peripheral circulation[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

946.97

Formula

C49H51FN8O11
CAS No.
Appearance

Solid

Color

Light yellow to yellow

SMILES

O=C1OCC2=C(C=C(C3=NC4=CC(F)=C(C)C(CC[C@@H]5NC(CNC([C@@H](NC(CNC(CNC(CCCCCN6C(C=CC6=O)=O)=O)=O)=O)CC7=CC=CC=C7)=O)=O)=C4C5=C3C8)N8C2=O)[C@@]1(O)CC
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 50 mg/mL (52.80 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.0560 mL 5.2800 mL 10.5600 mL
5 mM 0.2112 mL 1.0560 mL 2.1120 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 99.71%

COA (253 KB) HNMR (205 KB) LCMS (119 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.0560 mL 5.2800 mL 10.5600 mL 26.4000 mL
5 mM 0.2112 mL 1.0560 mL 2.1120 mL 5.2800 mL
10 mM 0.1056 mL 0.5280 mL 1.0560 mL 2.6400 mL
15 mM 0.0704 mL 0.3520 mL 0.7040 mL 1.7600 mL
20 mM 0.0528 mL 0.2640 mL 0.5280 mL 1.3200 mL
25 mM 0.0422 mL 0.2112 mL 0.4224 mL 1.0560 mL
30 mM 0.0352 mL 0.1760 mL 0.3520 mL 0.8800 mL
40 mM 0.0264 mL 0.1320 mL 0.2640 mL 0.6600 mL
50 mM 0.0211 mL 0.1056 mL 0.2112 mL 0.5280 mL
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MC-GGFG-Exatecan Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

MC-GGFG-Exatecan1600418-29-8MC-GGFG-DX8951Drug-Linker Conjugates for ADCTopoisomeraseDX8951MC-GGFG linkerantitumor activityInhibitorinhibitorinhibit

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