2. Immunology/Inflammation Stem Cell/Wnt PI3K/Akt/mTOR Cell Cycle/DNA Damage
  3. Aryl Hydrocarbon Receptor GSK-3 CDK
  4. MeBIO

MeBIO is a potent AhR (aryl hydrocarbon receptor) agonist, with IC50 of 44 μM (GSK-3) and 55 μM (CDK1/cyclin B), respectively.

For research use only. We do not sell to patients.

MeBIO Chemical Structure

MeBIO Chemical Structure

CAS No. : 667463-95-8

Size Price Stock Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 In-stock
Solution
10 mM * 1 mL in DMSO In-stock
Solid
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10 mg In-stock
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Customer Review

Based on 1 publication(s) in Google Scholar

MeBIO Related Antibodies

Top Publications Citing Use of Products

View All GSK-3 Isoform Specific Products:

View All Isoforms
GSK-3 GSK-3α GSK-3β

View All CDK Isoform Specific Products:

View All Isoforms
CDK1 CDK2 CDK3 CDK4 CDK5 CDK6 CDK7 CDK8 CDK9 CDK11 CDK12 CDK13 CDK14 CDK16 CDK19 CDC CLK Pho85

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

MeBIO is a potent AhR (aryl hydrocarbon receptor) agonist, with IC50 of 44 μM (GSK-3) and 55 μM (CDK1/cyclin B), respectively[1].

IC50 & Target

GSK-3

44 μM (IC50)

Cdk1/cyclin B

55 μM (IC50)

Cdk5/p25

>100 μM (IC50)

In Vitro

MeBIO (25 μM, 90 min) causes redistribution of AhR to the nucleus in wild-type Hepa-1 and ARNT mutant cells[2].
MeBIO (10 μM, 24 h) induces the aggregation of 5L cells in the G1 phase and increases the upregulation of p27 KIP1 expression in 5L cells[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

MeBIO Related Antibodies

Western Blot Analysis[2]

Cell Line: 5 L cells and BP8 cells
Concentration: 10 μM
Incubation Time: 24 h
Result: Increased the expression of p27 KIP1 in 5L cells but not in BP8 cells
Molecular Weight

370.20

Formula

C17H12BrN3O2
CAS No.
Appearance

Solid

Color

Brown to reddish brown

SMILES

O=C1N(C)C2=C(C=CC(Br)=C2)/C1=C3NC4=C(C=CC=C4)C/3=N\O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 14.71 mg/mL (39.74 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.7012 mL 13.5062 mL 27.0124 mL
5 mM 0.5402 mL 2.7012 mL 5.4025 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
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Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

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Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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g

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(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.7012 mL 13.5062 mL 27.0124 mL 67.5311 mL
5 mM 0.5402 mL 2.7012 mL 5.4025 mL 13.5062 mL
10 mM 0.2701 mL 1.3506 mL 2.7012 mL 6.7531 mL
15 mM 0.1801 mL 0.9004 mL 1.8008 mL 4.5021 mL
20 mM 0.1351 mL 0.6753 mL 1.3506 mL 3.3766 mL
25 mM 0.1080 mL 0.5402 mL 1.0805 mL 2.7012 mL
30 mM 0.0900 mL 0.4502 mL 0.9004 mL 2.2510 mL
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MeBIO Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

MeBIO667463-95-8Aryl Hydrocarbon ReceptorGSK-3CDKAhRGlycogen synthase kinase-3Glycogen synthase kinase 3Cyclin dependent kinaseAgonistAryl Hydrocarbon Receptor (AhR)Inhibitorinhibitorinhibit

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