Metamizol (Synonyms: Methamizole)

Cat. No.: HY-148147: Data Sheet Handling Instructions Technical Support

Metamizol (Methamizole) is an anti-thyroid agent, which blocks thyroid hormone production from the thyroid gland. Metamizol can cause hepatotoxicity.

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Metamizol Chemical Structure

CAS No. : 50567-35-6

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Other In-stock Forms of Metamizol:

Metamizole sodium hydrate

Other Forms of Metamizol:

Metamizole sodium hydrate In-stock
Metamizole sodium Get quote

1 Publications Citing Use of MCE Metamizol

•Animal Model Exp Med. 2024 Jan 15. [Abstract]

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Description

Metamizol (Methamizole) is an anti-thyroid agent, which blocks thyroid hormone production from the thyroid gland. Metamizol can cause hepatotoxicity^[1].

In Vivo

Metamizo (Methamizole; 100 mg/kg; i.p.; once; male Swiss albino mice) causes hepatotoxicity as revealed by an increase in serum alanine aminotransferase (ALT) activity^[1].
Metamizo (100 mg/kg; i.p.; once; male Swiss albino mice) causes a decrease in hepatic glutathione (GSH) contents^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Male Swiss albino mice (6 weeks old, 25-40 g)^[1]
Dosage:	100 mg/kg
Administration:	Intraperitoneal injection; once
Result:	Increased serum ALT level at 5 hours and the maximum serum ALT levels occurred at 5 hours.

Animal Model:	Male Swiss albino mice (6 weeks old, 25-40 g)^[1]
Dosage:	100 mg/kg
Administration:	Intraperitoneal injection; once
Result:	Induced reduction in hepatic glutathione (GSH) content in mice.

Clinical Trial

NCT Number	Sponsor	Condition	Start Date	Phase
NCT03244540	Medical University of Lublin	Cesarean Section\|Pain, Postoperative\|Pain, Neuropathic	September 4, 2017	Phase 4
NCT02804126	Micha? Borys\|Medical University of Lublin	Cesarean Section\|Pain Management\|Neuropathic Pain	June 2016	Phase 4
NCT02184273	Boehringer Ingelheim	Pain	March 2002	Phase 4
NCT03255330	Masaryk University	Chronic Pain Due to Trauma\|Spinal Cord Injuries	October 2017	Phase 3
NCT03389243	Medical University of Silesia\|Silesian University of Medicine	Vitreoretinal Surgeries\|Postoperative Nausea and Vomiting\|Postoperative Pain	January 15, 2018	Not Applicable
NCT02973581	Medical University of Silesia\|Silesian University of Medicine	Vitreoretinal Surgeries\|Postoperative Nausea and Vomiting\|Postoperative Pain	February 2016	Not Applicable
NCT02971540	Medical University of Silesia\|Silesian University of Medicine	Lumbar Disc Disease	February 2016	Not Applicable
NCT03203070	Hospital General Universitario Elche	Pain, Postoperative	March 1, 2017	Phase 3
NCT02183220	Boehringer Ingelheim	Migraine Disorders	October 1998	Phase 3

Molecular Weight

311.36

Formula

C₁₃H₁₇N₃O₄S

CAS No.

50567-35-6

SMILES

O=C1C(N(CS(=O)(O)=O)C)=C(C)N(C)N1C2=CC=CC=C2

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Data Sheet (272 KB) Handling Instructions (2659 KB)

References

[1]. Heidari R, et, al. Effects of Enzyme Induction and/or Glutathione Depletion on Methimazole-Induced Hepatotoxicity in Mice and the Protective Role of N-Acetylcysteine. Adv Pharm Bull. 2014;4(1):21-8. [Content Brief]

Metamizol Related Classifications

Cardiovascular Disease Cancer

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Keywords:

Metamizol50567-35-6MethamizoleThyroid Hormone ReceptorTHRanti-thyroidthyroid hormonethyroid glandhepatotoxicityInhibitorinhibitorinhibit

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