2. Metabolic Enzyme/Protease
  3. Endogenous Metabolite
  4. N-​Carbamoyl-​DL-​aspartic acid

N-​Carbamoyl-​DL-​aspartic acid  (Synonyms: Ureidosuccinic Acid)

Cat. No.: HY-128425 Purity: 98.86%
COA Handling Instructions

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N-​Carbamoyl-​DL-​aspartic acid (Ureidosuccinic acid) is a precursor of nucleic acid pyrimidines.

For research use only. We do not sell to patients.

N-​Carbamoyl-​DL-​aspartic acid Chemical Structure

N-​Carbamoyl-​DL-​aspartic acid Chemical Structure

CAS No. : 923-37-5

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10 mM * 1 mL in DMSO
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10 mM * 1 mL in DMSO USD 50 In-stock
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5 g USD 200 In-stock
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Based on 1 publication(s) in Google Scholar

Other Forms of N-​Carbamoyl-​DL-​aspartic acid:

N-​Carbamoyl-​DL-​aspartic acid Related Antibodies

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  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

N-​Carbamoyl-​DL-​aspartic acid (Ureidosuccinic acid) is a precursor of nucleic acid pyrimidines[1].

Molecular Weight

176.13

Formula

C5H8N2O5
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C(O)CC(C(O)=O)NC(N)=O
Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 2 years
-20°C 1 year
Solvent & Solubility
In Vitro: 

DMSO : 83.33 mg/mL (473.12 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 5.6776 mL 28.3881 mL 56.7762 mL
5 mM 1.1355 mL 5.6776 mL 11.3552 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% Saline

    Solubility: ≥ 2.08 mg/mL (11.81 mM); Clear solution

    This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown).

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

    Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
  • Protocol 2

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in Saline)

    Solubility: ≥ 2.08 mg/mL (11.81 mM); Clear solution

    This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown).

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

    Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
%
DMSO +
% 
+
%
Tween-80 +
%
Saline
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Calculation results:
Working solution concentration: mg/mL
Method for preparing stock solution: mg drug dissolved in μL  DMSO (Stock solution concentration: mg/mL).
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).
Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.
 If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Purity & Documentation

Purity: 98.86%

COA (247 KB) HNMR (275 KB) LCMS (259 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 5.6776 mL 28.3881 mL 56.7762 mL 141.9406 mL
5 mM 1.1355 mL 5.6776 mL 11.3552 mL 28.3881 mL
10 mM 0.5678 mL 2.8388 mL 5.6776 mL 14.1941 mL
15 mM 0.3785 mL 1.8925 mL 3.7851 mL 9.4627 mL
20 mM 0.2839 mL 1.4194 mL 2.8388 mL 7.0970 mL
25 mM 0.2271 mL 1.1355 mL 2.2710 mL 5.6776 mL
30 mM 0.1893 mL 0.9463 mL 1.8925 mL 4.7314 mL
40 mM 0.1419 mL 0.7097 mL 1.4194 mL 3.5485 mL
50 mM 0.1136 mL 0.5678 mL 1.1355 mL 2.8388 mL
60 mM 0.0946 mL 0.4731 mL 0.9463 mL 2.3657 mL
80 mM 0.0710 mL 0.3549 mL 0.7097 mL 1.7743 mL
100 mM 0.0568 mL 0.2839 mL 0.5678 mL 1.4194 mL
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N-​Carbamoyl-​DL-​aspartic acid Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

N-​Carbamoyl-​DL-​aspartic acid923-37-5Ureidosuccinic AcidEndogenous MetaboliteInhibitorinhibitorinhibit

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