2. Metabolic Enzyme/Protease
  3. Endogenous Metabolite
  4. NADPH

NADPH is an essential electron donor in organisms, providing reducing power for anabolic reactions and redox balance, with potential applications in electrosynthesis. The cellular NADPH homeostasis is associated with tumorigenesis. As a key factor in the cellular antioxidant system, NADPH can mediate cell death through its effects on oxidative stress. This approach, based on NADPH-regulated metabolism, holds promise for research in the field of cancer therapy.

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NADPH Chemical Structure

NADPH Chemical Structure

CAS No. : 53-57-6

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Based on 10 publication(s) in Google Scholar

Other Forms of NADPH:

NADPH Related Antibodies

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Description

NADPH is an essential electron donor in organisms, providing reducing power for anabolic reactions and redox balance, with potential applications in electrosynthesis. The cellular NADPH homeostasis is associated with tumorigenesis. As a key factor in the cellular antioxidant system, NADPH can mediate cell death through its effects on oxidative stress. This approach, based on NADPH-regulated metabolism, holds promise for research in the field of cancer therapy[1][2][3].

IC50 & Target

Human Endogenous Metabolite

 

Molecular Weight

745.42

Formula

C21H30N7O17P3
CAS No.
Appearance

Solid

Color

White to light yellow

SMILES

O=P(O)(O)O[C@H]1[C@H](N2C3=NC=NC(N)=C3N=C2)O[C@@H]([C@H]1O)COP(OP(OC[C@H]4O[C@@H](N5C=C(CC=C5)C(N)=O)[C@@H]([C@@H]4O)O)(O)=O)(O)=O
Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility
In Vitro: 

H2O : 116.67 mg/mL (156.52 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.3415 mL 6.7076 mL 13.4153 mL
5 mM 0.2683 mL 1.3415 mL 2.6831 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

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Volume (start)

V1

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Concentration (final)

C2

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Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation

Purity: 99.49%

SDS (251 KB)

COA (263 KB) HNMR (302 KB) CNMR (348 KB) LCMS (94 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 1.3415 mL 6.7076 mL 13.4153 mL 33.5381 mL
5 mM 0.2683 mL 1.3415 mL 2.6831 mL 6.7076 mL
10 mM 0.1342 mL 0.6708 mL 1.3415 mL 3.3538 mL
15 mM 0.0894 mL 0.4472 mL 0.8944 mL 2.2359 mL
20 mM 0.0671 mL 0.3354 mL 0.6708 mL 1.6769 mL
25 mM 0.0537 mL 0.2683 mL 0.5366 mL 1.3415 mL
30 mM 0.0447 mL 0.2236 mL 0.4472 mL 1.1179 mL
40 mM 0.0335 mL 0.1677 mL 0.3354 mL 0.8385 mL
50 mM 0.0268 mL 0.1342 mL 0.2683 mL 0.6708 mL
60 mM 0.0224 mL 0.1118 mL 0.2236 mL 0.5590 mL
80 mM 0.0168 mL 0.0838 mL 0.1677 mL 0.4192 mL
100 mM 0.0134 mL 0.0671 mL 0.1342 mL 0.3354 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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NADPH Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

NADPH53-57-6Endogenous Metabolitereducing agentelectrosynthesisInhibitorinhibitorinhibit

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