2. Anti-infection Apoptosis Cell Cycle/DNA Damage Metabolic Enzyme/Protease
  3. Bacterial Antibiotic Orthopoxvirus Apoptosis DNA/RNA Synthesis HSP
  4. Novobiocin sodium

Novobiocin sodium  (Synonyms: Albamycin sodium; Cathomycin sodium)

Cat. No.: HY-B0425A Purity: 99.12%
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Novobiocin (Albamycin) sodium is a potent and orally active antibiotic. Novobiocin sodium also is a DNA gyrase inhibitor and a heat shock protein 90 (Hsp90) antagonist. Novobiocin sodium has the potential for the research of highly beta-lactam-resistant pneumococcal infections. Novobiocin sodium shows anti-orthopoxvirus activity.

For research use only. We do not sell to patients.

Novobiocin sodium Chemical Structure

Novobiocin sodium Chemical Structure

CAS No. : 1476-53-5

Size Price Stock Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 USD 119 In-stock
Solution
10 mM * 1 mL in DMSO USD 119 In-stock
Solid
100 mg USD 108 In-stock
500 mg USD 240 In-stock
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Customer Review

Based on 9 publication(s) in Google Scholar

Other Forms of Novobiocin sodium:

Novobiocin sodium Related Antibodies

Top Publications Citing Use of Products

    Novobiocin sodium purchased from MedChemExpress. Usage Cited in: Blood. 2018 Jul 19;132(3):307-320.  [Abstract]

    K562, KCL22 and HL60 are treated with the indicated (cytotoxic) concentration of Amidopyrine (AX), Novobiocin (NB) and AUY922 for 48h and later protein lysates are subjected to immunoblot analysis.

    View All Antibiotic Isoform Specific Products:

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    View All HSP Isoform Specific Products:

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    HSP40 HSP70 HSP90 HSP105 HSF1 HSP HSPA5

    • Biological Activity

    • Purity & Documentation

    • References

    • Customer Review

    Description

    Novobiocin (Albamycin) sodium is a potent and orally active antibiotic. Novobiocin sodium also is a DNA gyrase inhibitor and a heat shock protein 90 (Hsp90) antagonist. Novobiocin sodium has the potential for the research of highly beta-lactam-resistant pneumococcal infections. Novobiocin sodium shows anti-orthopoxvirus activity[1][2][3][4].

    IC50 & Target[1]

    β-lactam

     

    HSP90

     

    In Vitro

    Novobiocin sodium (1 mM) competitively inhibits ATP binding to gyrase B to interfere with nucleotide binding and interferes with the association of the co-chaperones Hsc70 and p23 with Hsp90[1].
    Novobiocin sodium (200 μM; 24 h) inhibits the rate of repair of both cis-DDP and BCNU induced DNA interstrand cross-links and with a corresponding decrease in the clonogenic survival of the human glioblastoma multiforme cells[2].
    Novobiocin sodium (0.3 mM; 48 hours) induces a caspase-3/7 enzyme–dependent apoptosis assays with an induction of approximately three- to fivefold of apoptotic cells in K562, HL60, Mutz-2[5].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Novobiocin sodium Related Antibodies

    Western Blot Analysis[2]

    Cell Line: K562, HL60, Mutz-2 cells
    Concentration: 0.3 mM
    Incubation Time: 48 hours
    Result: Decreased caspase-3/7 activity in K562, HL60, Mutz-2 cells.
    In Vivo

    Novobiocin sodium (25, 50, 100, 200 mg/kg; s.c.; 4 times at 1, 5, 24 and 48 h after infection) shows anti-infection activity in mice infected with amoxicillin-resistant Streptococcus pneumoniae[3].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Animal Model: 30 g adult female Swiss mice (sepsis induced by the penicillin-susceptible strain (AR33118))[3]
    Dosage: 25, 50, 100, 200 mg/kg
    Administration: S.c.; given at 1, 5, 24 and 48 h after infection
    Result: Showed anti-infection activity in mice infected with amoxicillin-resistant S. pneumoniae.
    Clinical Trial
    Molecular Weight

    634.61

    Formula

    C31H35N2NaO11
    CAS No.
    Appearance

    Solid

    Color

    White to off-white

    SMILES

    CC1=C(OC2=O)C(C(O)=C2NC(C3=CC(C/C=C(C)/C)=C(O[Na])C=C3)=O)=CC=C1O[C@H](OC(C)(C)[C@H](OC)[C@H]4OC(N)=O)[C@@H]4O
    Structure Classification
    Initial Source

    Streptomyces niveus
    Shipping

    Room temperature in continental US; may vary elsewhere.
    Storage

    4°C, sealed storage, away from moisture

    *In solvent : -80°C, 1 year; -20°C, 6 months (sealed storage, away from moisture)

    Solvent & Solubility
    In Vitro: 

    H2O : 50 mg/mL (78.79 mM; Need ultrasonic)

    DMSO : ≥ 30 mg/mL (47.27 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

    *"≥" means soluble, but saturation unknown.

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 1.5758 mL 7.8789 mL 15.7577 mL
    5 mM 0.3152 mL 1.5758 mL 3.1515 mL
    View the Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 1 year; -20°C, 6 months (sealed storage, away from moisture). When stored at -80°C, please use it within 1 year. When stored at -20°C, please use it within 6 months.

    * Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

    • Molarity Calculator

    • Dilution Calculator

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    This equation is commonly abbreviated as: C1V1 = C2V2

    Concentration (start)

    C1

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    Volume (start)

    V1

    =
    Concentration (final)

    C2

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    In Vivo:

    For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
    The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

    • Protocol 1

      Add each solvent one by one:  PBS

      Solubility: 100 mg/mL (157.58 mM); Clear solution; Need ultrasonic and warming and heat to 60°C

    In Vivo Dissolution Calculator
    Please enter the basic information of animal experiments:

    Dosage

    mg/kg

    Animal weight
    (per animal)

    g

    Dosing volume
    (per animal)

    μL

    Number of animals

    Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
    Calculation results:
    Working solution concentration: mg/mL
    This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
    The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
    Purity & Documentation

    Purity: 99.12%

    SDS (393 KB)

    COA (249 KB) HNMR (202 KB) LCMS (120 KB)

    Handling Instructions (2659 KB)
    References

    Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 1 year; -20°C, 6 months (sealed storage, away from moisture). When stored at -80°C, please use it within 1 year. When stored at -20°C, please use it within 6 months.

    Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
    DMSO / H2O 1 mM 1.5758 mL 7.8789 mL 15.7577 mL 39.3943 mL
    5 mM 0.3152 mL 1.5758 mL 3.1515 mL 7.8789 mL
    10 mM 0.1576 mL 0.7879 mL 1.5758 mL 3.9394 mL
    15 mM 0.1051 mL 0.5253 mL 1.0505 mL 2.6263 mL
    20 mM 0.0788 mL 0.3939 mL 0.7879 mL 1.9697 mL
    25 mM 0.0630 mL 0.3152 mL 0.6303 mL 1.5758 mL
    30 mM 0.0525 mL 0.2626 mL 0.5253 mL 1.3131 mL
    40 mM 0.0394 mL 0.1970 mL 0.3939 mL 0.9849 mL
    H2O 50 mM 0.0315 mL 0.1576 mL 0.3152 mL 0.7879 mL
    60 mM 0.0263 mL 0.1313 mL 0.2626 mL 0.6566 mL

    * Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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    Novobiocin sodium Related Classifications

    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    Novobiocin1476-53-5AlbamycinCathomycinBacterialAntibioticOrthopoxvirusApoptosisDNA/RNA SynthesisHSPHeat shock proteinsK562HL60Mutz-2cellsanti-orthopoxvirusorally activeanti-infectionpneumococcalDNA interstrand cross-linksInhibitorinhibitorinhibit

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