2. Apoptosis
  3. MDM-2/p53
  4. NSC-207895

NSC-207895 (XI-006), a DNA damaging agent, is an anticancer agent and p53 activator.

For research use only. We do not sell to patients.

NSC-207895 Chemical Structure

NSC-207895 Chemical Structure

CAS No. : 58131-57-0

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Customer Review

Based on 2 publication(s) in Google Scholar

NSC-207895 Related Antibodies

Top Publications Citing Use of Products

1 Publications Citing Use of MCE NSC-207895

WB

    NSC-207895 purchased from MedChemExpress. Usage Cited in: Arthritis Res Ther. 2023 Apr 4;25(1):54.  [Abstract]

    NSC-207895 (0.5 μM; 6 h) inhibits miR-325-3p mimic-induced decreased expression of P16, P21 and P53 in chondrocyte cells.

    • Biological Activity

    • Purity & Documentation

    • References

    • Customer Review

    Description

    NSC-207895 (XI-006), a DNA damaging agent, is an anticancer agent and p53 activator[1][2][3].

    In Vitro

    NSC-207895 (0.5 μM, 30 min), a MDM2 inhibitor, upregulates p53 protein levels[2].
    NSC-207895, MDMX inhibitor, downregulates the expression of MDMX in AML cells at the mRNA and protein levels[3].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    NSC-207895 Related Antibodies

    Western Blot Analysis[2]

    Cell Line: RAW 264.7 cells.
    Concentration: 0.5 μM.
    Incubation Time: 30 min (stimulated with LPS (100 ng/ml) for 6 h).
    Result: Upregulated p53 protein levels.
    Molecular Weight

    279.25

    Formula

    C11H13N5O4
    CAS No.
    Appearance

    Solid

    Color

    Brown to reddish brown

    SMILES

    O=[N+](C1=CC=C(N2CCN(C)CC2)C3=[N+]([O-])ON=C31)[O-]
    Shipping

    Room temperature in continental US; may vary elsewhere.
    Storage

    4°C, protect from light

    *In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

    Solvent & Solubility
    In Vitro: 

    DMSO : 31.25 mg/mL (111.91 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 3.5810 mL 17.9051 mL 35.8102 mL
    5 mM 0.7162 mL 3.5810 mL 7.1620 mL
    View the Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

    • Molarity Calculator

    • Dilution Calculator

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

    Mass
    =
    Concentration
    ×
    Volume
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    Molecular Weight *

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    This equation is commonly abbreviated as: C1V1 = C2V2

    Concentration (start)

    C1

    ×
    Volume (start)

    V1

    =
    Concentration (final)

    C2

    ×
    Volume (final)

    V2

    In Vivo:

    Select the appropriate dissolution method based on your experimental animal and administration route.

    For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
    To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
    The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

    • Protocol 1

      Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% Saline

      Solubility: ≥ 2.08 mg/mL (7.45 mM); Clear solution

      This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown).

      Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

      Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
    • Protocol 2

      Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in Saline)

      Solubility: 2.08 mg/mL (7.45 mM); Suspended solution; Need ultrasonic

      This protocol yields a suspended solution of 2.08 mg/mL. Suspended solution can be used for oral and intraperitoneal injection.

      Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

      Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
    In Vivo Dissolution Calculator
    Please enter the basic information of animal experiments:

    Dosage

    mg/kg

    Animal weight
    (per animal)

    g

    Dosing volume
    (per animal)

    μL

    Number of animals

    Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
    Please enter your animal formula composition:
    %
    DMSO +
    % 
    +
    %
    Tween-80 +
    %
    Saline
    Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
    The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
    Calculation results:
    Working solution concentration: mg/mL
    Method for preparing stock solution: mg drug dissolved in μL  DMSO (Stock solution concentration: mg/mL).

    *In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

    The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).
    Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.
     If the continuous dosing period exceeds half a month, please choose this protocol carefully.
    Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
    Purity & Documentation
    References

    Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

    Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
    DMSO 1 mM 3.5810 mL 17.9051 mL 35.8102 mL 89.5255 mL
    5 mM 0.7162 mL 3.5810 mL 7.1620 mL 17.9051 mL
    10 mM 0.3581 mL 1.7905 mL 3.5810 mL 8.9526 mL
    15 mM 0.2387 mL 1.1937 mL 2.3873 mL 5.9684 mL
    20 mM 0.1791 mL 0.8953 mL 1.7905 mL 4.4763 mL
    25 mM 0.1432 mL 0.7162 mL 1.4324 mL 3.5810 mL
    30 mM 0.1194 mL 0.5968 mL 1.1937 mL 2.9842 mL
    40 mM 0.0895 mL 0.4476 mL 0.8953 mL 2.2381 mL
    50 mM 0.0716 mL 0.3581 mL 0.7162 mL 1.7905 mL
    60 mM 0.0597 mL 0.2984 mL 0.5968 mL 1.4921 mL
    80 mM 0.0448 mL 0.2238 mL 0.4476 mL 1.1191 mL
    100 mM 0.0358 mL 0.1791 mL 0.3581 mL 0.8953 mL
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    NSC-207895 Related Classifications

    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    NSC-20789558131-57-0XI-006NSC207895NSC 207895XI006XI 006MDM-2/p53p53MDM2MDMXLPSInhibitorinhibitorinhibit

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