2. GPCR/G Protein Neuronal Signaling
  3. Dopamine Receptor
  4. OPC 4392 hydrochloride

OPC 4392 hydrochloride is an agonist for presynaptic dopamine receptor and an antagonist for postsynaptic D2 receptor. OPC 4392 reverses the Reserpine (HY-N0480)-induced dopamine accumulation, inhibits Apomorphine (HY-12723)-induced stereotypic and climbing behaviors in mouse models.

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OPC 4392 hydrochloride Chemical Structure

OPC 4392 hydrochloride Chemical Structure

CAS No. : 1329509-60-5

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1 mg USD 160 In-stock
5 mg USD 400 In-stock
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Based on 1 publication(s) in Google Scholar

OPC 4392 hydrochloride Related Antibodies

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  • Biological Activity

  • Purity & Documentation

  • References

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Description

OPC 4392 hydrochloride is an agonist for presynaptic dopamine receptor and an antagonist for postsynaptic D2 receptor. OPC 4392 reverses the Reserpine (HY-N0480)-induced dopamine accumulation, inhibits Apomorphine (HY-12723)-induced stereotypic and climbing behaviors in mouse models[1].

Molecular Weight

427.97

Formula

C24H30ClN3O2
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C1C=CC2=C(N1)C=C(OCCCN3CCN(CC3)C4=CC=CC(C)=C4C)C=C2.Cl
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : 50 mg/mL (116.83 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.3366 mL 11.6831 mL 23.3661 mL
5 mM 0.4673 mL 2.3366 mL 4.6732 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo:

For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  Lactic acid buffer (50 mM, pH 4.0)

    Solubility: 4.3 mg/mL (10.05 mM); Clear solution; Need ultrasonic

  • Protocol 2

    Add each solvent one by one:  Lactated Ringers solution

    Solubility: 4.3 mg/mL (10.05 mM); Clear solution; Need ultrasonic

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 98.99%

COA (246 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.3366 mL 11.6831 mL 23.3661 mL 58.4153 mL
5 mM 0.4673 mL 2.3366 mL 4.6732 mL 11.6831 mL
10 mM 0.2337 mL 1.1683 mL 2.3366 mL 5.8415 mL
15 mM 0.1558 mL 0.7789 mL 1.5577 mL 3.8944 mL
20 mM 0.1168 mL 0.5842 mL 1.1683 mL 2.9208 mL
25 mM 0.0935 mL 0.4673 mL 0.9346 mL 2.3366 mL
30 mM 0.0779 mL 0.3894 mL 0.7789 mL 1.9472 mL
40 mM 0.0584 mL 0.2921 mL 0.5842 mL 1.4604 mL
50 mM 0.0467 mL 0.2337 mL 0.4673 mL 1.1683 mL
60 mM 0.0389 mL 0.1947 mL 0.3894 mL 0.9736 mL
80 mM 0.0292 mL 0.1460 mL 0.2921 mL 0.7302 mL
100 mM 0.0234 mL 0.1168 mL 0.2337 mL 0.5842 mL
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OPC 4392 hydrochloride Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

OPC 43921329509-60-5OPC4392OPC-4392Dopamine ReceptorSchizophreniadepressive disorderInhibitorinhibitorinhibit

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