OPC 4392 hydrochloride

Cat. No.: HY-106781A Purity: 98.99%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

OPC 4392 hydrochloride is an agonist for presynaptic dopamine receptor and an antagonist for postsynaptic D2 receptor. OPC 4392 reverses the Reserpine (HY-N0480)-induced dopamine accumulation, inhibits Apomorphine (HY-12723)-induced stereotypic and climbing behaviors in mouse models.

For research use only. We do not sell to patients.

OPC 4392 hydrochloride Chemical Structure

CAS No. : 1329509-60-5

Size	Price	Stock	Quantity
1 mg	USD 160	In-stock	Estimated Time of Arrival: December 31
5 mg	USD 400	In-stock	Estimated Time of Arrival: December 31
10 mg		Get quote
50 mg		Get quote

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This product is a controlled substance and not for sale in your territory.

Customer Review

Based on 1 publication(s) in Google Scholar

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Dopamine Receptor D₁ Receptor D₂ Receptor D₃ Receptor D₄ Receptor D₅ Receptor

Biological Activity
Purity & Documentation
References
Customer Review

Description

Molecular Weight

427.97

Formula

C₂₄H₃₀ClN₃O₂

CAS No.

1329509-60-5

Appearance

Solid

Color

White to off-white

SMILES

O=C1C=CC2=C(N1)C=C(OCCCN3CCN(CC3)C4=CC=CC(C)=C4C)C=C2.Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility

In Vitro:

DMSO : 50 mg/mL (116.83 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.3366 mL	11.6831 mL	23.3661 mL
5 mM	0.4673 mL	2.3366 mL	4.6732 mL
10 mM	0.2337 mL	1.1683 mL	2.3366 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo:

For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: Lactic acid buffer (50 mM, pH 4.0)
Solubility: 4.3 mg/mL (10.05 mM); Clear solution; Need ultrasonic
Protocol 2

Add each solvent one by one: Lactated Ringers solution
Solubility: 4.3 mg/mL (10.05 mM); Clear solution; Need ultrasonic

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 98.99%

Select Batch:

Data Sheet (269 KB) SDS (252 KB)

COA (246 KB)

Handling Instructions (2659 KB)

References

[1]. Yasuda Y, et al., 7-[3-(4-[2,3-Dimethylphenyl]piperazinyl)propoxy]-2(1H)-quinolinone (OPC-4392), a presynaptic dopamine autoreceptor agonist and postsynaptic D2 receptor antagonist. Life Sci. 1988;42(20):1941-54. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	2.3366 mL	11.6831 mL	23.3661 mL	58.4153 mL
	5 mM	0.4673 mL	2.3366 mL	4.6732 mL	11.6831 mL
	10 mM	0.2337 mL	1.1683 mL	2.3366 mL	5.8415 mL
	15 mM	0.1558 mL	0.7789 mL	1.5577 mL	3.8944 mL
	20 mM	0.1168 mL	0.5842 mL	1.1683 mL	2.9208 mL
	25 mM	0.0935 mL	0.4673 mL	0.9346 mL	2.3366 mL
	30 mM	0.0779 mL	0.3894 mL	0.7789 mL	1.9472 mL
	40 mM	0.0584 mL	0.2921 mL	0.5842 mL	1.4604 mL
	50 mM	0.0467 mL	0.2337 mL	0.4673 mL	1.1683 mL
	60 mM	0.0389 mL	0.1947 mL	0.3894 mL	0.9736 mL
	80 mM	0.0292 mL	0.1460 mL	0.2921 mL	0.7302 mL
	100 mM	0.0234 mL	0.1168 mL	0.2337 mL	0.5842 mL