2. PI3K/Akt/mTOR
  3. PI3K
  4. PI3Kα-IN-11

PI3Kα-IN-11 is a potent PI3Kα inhibitor with anticancer activity.

For research use only. We do not sell to patients.

PI3Kα-IN-11 Chemical Structure

PI3Kα-IN-11 Chemical Structure

CAS No. : 300803-79-6

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10 mg USD 380 In-stock
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Based on 1 publication(s) in Google Scholar

PI3Kα-IN-11 Related Antibodies

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  • Biological Activity

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Description

PI3Kα-IN-11 is a potent PI3Kα inhibitor with anticancer activity[1].

IC50 & Target[1]

PI3Kα

 

Cellular Effect
Cell Line Type Value Description References
HCT-116 IC50
0.73 μM
Compound: 13, NSC 675972
Growth inhibition of human HCT116 cells overexpressing PI3Kalpha H1047R mutant after 48 hrs by MTT assay
Growth inhibition of human HCT116 cells overexpressing PI3Kalpha H1047R mutant after 48 hrs by MTT assay
[PMID: 22212721]
HCT-116 IC50
1.1 μM
Compound: 13, NSC 675972
Growth inhibition of human HCT116 cells overexpressing PI3Kalpha after 48 hrs by MTT assay
Growth inhibition of human HCT116 cells overexpressing PI3Kalpha after 48 hrs by MTT assay
[PMID: 22212721]
HCT-116 IC50
1.8 μM
Compound: 13, NSC 675972
Growth inhibition of human HCT116 cells after 48 hrs by MTT assay
Growth inhibition of human HCT116 cells after 48 hrs by MTT assay
[PMID: 22212721]
In Vitro

The IC50 of HCT116-WT and HCT116-MUT (H1047R) cell lines were 1.1 and 0.73 μM, respectively.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

PI3Kα-IN-11 Related Antibodies
Molecular Weight

294.30

Formula

C17H14N2O3
CAS No.
Appearance

Solid

Color

White to light yellow

SMILES

O=C1NC2=C(C(O)=C1C(NCC3=CC=CC=C3)=O)C=CC=C2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 10 mg/mL (33.98 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.3979 mL 16.9895 mL 33.9789 mL
5 mM 0.6796 mL 3.3979 mL 6.7958 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
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Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.3979 mL 16.9895 mL 33.9789 mL 84.9473 mL
5 mM 0.6796 mL 3.3979 mL 6.7958 mL 16.9895 mL
10 mM 0.3398 mL 1.6989 mL 3.3979 mL 8.4947 mL
15 mM 0.2265 mL 1.1326 mL 2.2653 mL 5.6632 mL
20 mM 0.1699 mL 0.8495 mL 1.6989 mL 4.2474 mL
25 mM 0.1359 mL 0.6796 mL 1.3592 mL 3.3979 mL
30 mM 0.1133 mL 0.5663 mL 1.1326 mL 2.8316 mL
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PI3Kα-IN-11 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PI3Kα-IN-11300803-79-6PI3KPhosphoinositide 3-kinaseHCT116-WTHCT116-MUTcancerInhibitorinhibitorinhibit

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