PPA24

Name: PPA24
Brand: MedChemExpress
SKU: HY-163828
Rating: 4.5 (1 reviews)

Cat. No.: HY-163828 Purity: 98.09%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

PPA24 (commound 19a) is a PP2A activator. PPA24 can induce apoptosis and oxidative stress and reduce c-Myc expression levels. PPA24 can be used in anti-cancer research.

For research use only. We do not sell to patients.

PPA24 Chemical Structure

CAS No. : 3035032-77-7

Size	Price	Stock	Quantity
Free Sample (0.1 - 0.5 mg)		Apply Now
5 mg	USD 200	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 325	In-stock	Estimated Time of Arrival: December 31
25 mg	USD 685	In-stock	Estimated Time of Arrival: December 31
50 mg	USD 1100	In-stock	Estimated Time of Arrival: December 31
100 mg	USD 1750	In-stock	Estimated Time of Arrival: December 31
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500 mg		Get quote

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Based on 1 publication(s) in Google Scholar

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Description

PPA24 (commound 19a) is a PP2A activator. PPA24 can induce apoptosis and oxidative stress and reduce c-Myc expression levels. PPA24 can be used in anti-cancer research^[1].

IC₅₀ & Target

PP2A

Molecular Weight

508.91

Formula

C₂₂H₂₇BrClN₅S

CAS No.

3035032-77-7

Appearance

Solid

Color

White to off-white

SMILES

ClC1=CC=C2C(N(C3=CC=CC=C3S2)CCCC[N+]4(C[N@@](C5)C6)C[N@@]6C[N@@]5C4)=C1.[Br-]

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (196.50 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.9650 mL	9.8249 mL	19.6498 mL
5 mM	0.3930 mL	1.9650 mL	3.9300 mL
10 mM	0.1965 mL	0.9825 mL	1.9650 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.5 mg/mL (4.91 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Protocol 2

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 2.5 mg/mL (4.91 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
Protocol 3

Add each solvent one by one: 10% DMSO 90% Corn Oil
Solubility: ≥ 2.5 mg/mL (4.91 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

DMSO +

Tween-80 +

Saline

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Calculation results:

Working solution concentration: mg/mL

Method for preparing stock solution: mg drug dissolved in μL DMSO (Stock solution concentration: mg/mL).

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).

Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.

If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.

Purity & Documentation

Purity: 98.09%

Select Batch:

Data Sheet (272 KB) SDS (251 KB)

COA (250 KB) HNMR (142 KB) RP-HPLC (244 KB) LCMS (106 KB)

Handling Instructions (2659 KB)

References

[1]. Johnson H, et al. Identification of a Novel Protein Phosphatase 2A Activator, PPA24, as a Potential Therapeutic for FOLFOX-Resistant Colorectal Cancer. J Med Chem. 2024 Jul 14. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	1.9650 mL	9.8249 mL	19.6498 mL	49.1246 mL
	5 mM	0.3930 mL	1.9650 mL	3.9300 mL	9.8249 mL
	10 mM	0.1965 mL	0.9825 mL	1.9650 mL	4.9125 mL
	15 mM	0.1310 mL	0.6550 mL	1.3100 mL	3.2750 mL
	20 mM	0.0982 mL	0.4912 mL	0.9825 mL	2.4562 mL
	25 mM	0.0786 mL	0.3930 mL	0.7860 mL	1.9650 mL
	30 mM	0.0655 mL	0.3275 mL	0.6550 mL	1.6375 mL
	40 mM	0.0491 mL	0.2456 mL	0.4912 mL	1.2281 mL
	50 mM	0.0393 mL	0.1965 mL	0.3930 mL	0.9825 mL
	60 mM	0.0327 mL	0.1637 mL	0.3275 mL	0.8187 mL
	80 mM	0.0246 mL	0.1228 mL	0.2456 mL	0.6141 mL
	100 mM	0.0196 mL	0.0982 mL	0.1965 mL	0.4912 mL

PPA24 Related Classifications

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PPA243035032-77-7PPA 24PPA-24ApoptosisPhosphataseNSC49Lcolorectal cancer (CRC),molecular modelingfragment-based designInhibitorinhibitorinhibit

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PPA24

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PPA24 Related Antibodies

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Complete Stock Solution Preparation Table

PPA24 Related Classifications

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