PRLX-93936 dihydrochloride

Cat. No.: HY-119264A Purity: 99.83%: FAQs
Data Sheet SDS COA Handling Instructions Technical Support

PRLX-93936 dihydrochloride (Compound 16) is a HIF-1α inhibitor with anticancer activity. PRLX-93936 can inhibit the activated Ras pathway and can be used in the study of relapsed or refractory multiple myeloma.

For research use only. We do not sell to patients.

PRLX-93936 dihydrochloride Chemical Structure

CAS No. : 1094210-96-4

Size	Stock	Quantity
1 mg	In-stock	Estimated Time of Arrival: December 31
5 mg	In-stock	Estimated Time of Arrival: December 31
10 mg	In-stock	Estimated Time of Arrival: December 31
50 mg	Get quote
100 mg	Get quote

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Other Forms of PRLX-93936 dihydrochloride:

PRLX-93936 Get quote

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•Related Screening Libraries:

•Related Small Molecules:

•Related Proteins:

View All HIF/HIF Prolyl-Hydroxylase Isoform Specific Products:

View All Isoforms

HIF-1α HIF

View All Ras Isoform Specific Products:

View All Isoforms

K-Ras H-Ras N-Ras Ras

Biological Activity
Purity & Documentation
References
Customer Review

Description

Molecular Weight

437.36

Formula

C₂₁H₂₆Cl₂N₄O₂

CAS No.

1094210-96-4

Appearance

Solid

Color

White to off-white

SMILES

O=C1N(C(CN2CCNCC2)=NC3=C1C=CC=C3)C4=CC=CC=C4OCC.Cl.Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility

In Vitro:

DMSO : 125 mg/mL (285.81 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.2864 mL	11.4322 mL	22.8645 mL
5 mM	0.4573 mL	2.2864 mL	4.5729 mL
10 mM	0.2286 mL	1.1432 mL	2.2864 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

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Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 99.83%

Select Batch:

Data Sheet (272 KB) SDS (393 KB)

COA (253 KB) HNMR (266 KB) LCMS (93 KB)

Handling Instructions (2659 KB)

References

[1]. Huang W, et al. Synthesis and evaluation of quinazolin-4-ones as hypoxia-inducible factor-1α inhibitors. Bioorg Med Chem Lett. 2011 Sep 15;21(18):5239-43. [Content Brief]

[2]. Voorhees P M, et al. An open-label, dose escalation, multi-center phase 1 study of PRLX 93936, an agent synthetically active against the activated ras pathway, in the treatment of relapsed or relapsed and refractory multiple myeloma[J]. Blood, 2014, 124(21): 2140.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	2.2864 mL	11.4322 mL	22.8645 mL	57.1612 mL
	5 mM	0.4573 mL	2.2864 mL	4.5729 mL	11.4322 mL
	10 mM	0.2286 mL	1.1432 mL	2.2864 mL	5.7161 mL
	15 mM	0.1524 mL	0.7621 mL	1.5243 mL	3.8107 mL
	20 mM	0.1143 mL	0.5716 mL	1.1432 mL	2.8581 mL
	25 mM	0.0915 mL	0.4573 mL	0.9146 mL	2.2864 mL
	30 mM	0.0762 mL	0.3811 mL	0.7621 mL	1.9054 mL
	40 mM	0.0572 mL	0.2858 mL	0.5716 mL	1.4290 mL
	50 mM	0.0457 mL	0.2286 mL	0.4573 mL	1.1432 mL
	60 mM	0.0381 mL	0.1905 mL	0.3811 mL	0.9527 mL
	80 mM	0.0286 mL	0.1429 mL	0.2858 mL	0.7145 mL
	100 mM	0.0229 mL	0.1143 mL	0.2286 mL	0.5716 mL