2. Apoptosis NF-κB Metabolic Enzyme/Protease Immunology/Inflammation Cell Cycle/DNA Damage
  3. Apoptosis Reactive Oxygen Species Polo-like Kinase (PLK)
  4. Scytonemin

Scytonemin is a hydrophobic alkaloid pigment that can be isolated from the outer sheath of cyanobacteria. Scytonemin has protective function against short-wave solar ultraviolet (UV) radiation, which can reduce the generation of reactive oxygen species (ROS) and the formation of DNA damage. Scytonemin also has anti-inflammatory and anti-proliferative activities, produces concentration-dependent inhibition (IC50=2.0 μM) of polo-like kinase 1 (PLK1)-mediated cdc25C phosphorylation, and plays an important role in regulating the G2/M transition in the cell cycle. It can be used in the research of cancer, acute inflammation and sunscreen cosmetics.

For research use only. We do not sell to patients.

Scytonemin Chemical Structure

Scytonemin Chemical Structure

CAS No. : 152075-98-4

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Based on 1 publication(s) in Google Scholar

Scytonemin Related Antibodies

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Description

Scytonemin is a hydrophobic alkaloid pigment that can be isolated from the outer sheath of cyanobacteria. Scytonemin has protective function against short-wave solar ultraviolet (UV) radiation, which can reduce the generation of reactive oxygen species (ROS) and the formation of DNA damage. Scytonemin also has anti-inflammatory and anti-proliferative activities, produces concentration-dependent inhibition (IC50=2.0 μM) of polo-like kinase 1 (PLK1)-mediated cdc25C phosphorylation, and plays an important role in regulating the G2/M transition in the cell cycle. It can be used in the research of cancer, acute inflammation and sunscreen cosmetics[1][2][3][4][5].

In Vitro

Scytonemin (3 μM; 24 h) inhibits the proliferation of human T-cell leukemia Jurkat cells (IC50= 7.8 μM) and induces apoptosis[4].
Scytonemin (100 nM-30 μM) has an inhibitory effect on PDGF-induced RSF and ECGF-induced HUVEC proliferation (IC50=1.5 μM; IC50=5.4 μM) [4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Scytonemin Related Antibodies

Cell Viability Assay[4]

Cell Line: human T-cell leukemia Jurkat cells
Concentration: 3 μM
Incubation Time: 24 h
Result: Induced 24% of cells to undergo apoptosis.
In Vivo

Scytonemin has a highly effective inhibitory effect (ED50=10 mg/kg) on Phorbol 12-myristate 13-acetate (HY-18739) induced ear inflammation in mice when administered parenterally[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

544.56

Formula

C36H20N2O4
CAS No.
Appearance

Solid

Color

Brown to black

SMILES

O=C(/C1=C\C2=CC=C(O)C=C2)C(C(C(/C3=C\C4=CC=C(O)C=C4)=O)=C5C3=NC6=C5C=CC=C6)=C7C1=NC8=C7C=CC=C8
Structure Classification
Initial Source

Cyanobacteria
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 5 mg/mL (9.18 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.8363 mL 9.1817 mL 18.3634 mL
5 mM 0.3673 mL 1.8363 mL 3.6727 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 99.53%

COA (259 KB) HNMR (295 KB) RP-HPLC (206 KB) LCMS (306 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.8363 mL 9.1817 mL 18.3634 mL 45.9086 mL
5 mM 0.3673 mL 1.8363 mL 3.6727 mL 9.1817 mL
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Scytonemin Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Scytonemin152075-98-4ApoptosisReactive Oxygen SpeciesPolo-like Kinase (PLK)Inhibitorinhibitorinhibit

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