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Results for "

σ1 receptor antagonist

" in MedChemExpress (MCE) Product Catalog:

50

Inhibitors & Agonists

4

Natural
Products

3

Isotope-Labeled Compounds

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-10815
    σ1 Receptor antagonist-1
    1 Publications Verification

    		 Sigma Receptor Apoptosis Neurological Disease Cancer
    σ1 Receptor antagonist-1 is a highly potent and selective sigma 1 receptor antagonist (pKi=10.28). σ1 Receptor antagonist-1 inhibits cell growth, arrests cell cycle at G0/G1 phase and induces apoptosis of MCF-7/ADR cells [1].
    σ1 Receptor antagonist-1
  • HY-125819
    Sigma-1 receptor antagonist 2

    		Sigma Receptor Neurological Disease
    Sigma-1 receptor antagonist 2 is a potent and selective sigma 1 receptor (σ1 R) antagonist with Kis of 3.88 and 1288 nM for σ1 and σ2 receptor, respectively [1].
    Sigma-1 receptor antagonist 2
  • HY-125820
    Sigma-1 receptor antagonist 3

    		Sigma Receptor Potassium Channel Neurological Disease
    Sigma-1 receptor antagonist 3 (compound135) is a potent and selective Sigma-1 (σ1) receptor antagonist with a Ki of 1.14 nM. Sigma-1 receptor antagonist 3 inhibits Human Ether-a-go-go-Related Gene (hERG) with an IC50 of 1.54 μM. Sigma-1 receptor antagonist 3 has the potential for the neuropathic pain [1].
    Sigma-1 receptor antagonist 3
  • HY-135608
    BD-1008

    		Sigma Receptor Neurological Disease
    BD-1008 is a selective sigma 1 (σ1) receptor antagonist with a Ki of 2 nM. BD-1008 exhibits 4-fold selectivity over the sigma-2 receptor (Ki of 8 nM). BD-1008 can be used for the study of neurological diseases [1] .
    BD-1008
  • HY-100966
    BD-1008 dihydrobromide

    		Sigma Receptor Neurological Disease
    BD-1008 dihydrobromide is a selective sigma 1 (σ1) receptor antagonist with a Ki of 2 nM. BD-1008 dihydrobromide exhibits 4-fold selectivity over the sigma-2 receptor (Ki of 8 nM). BD-1008 dihydrobromide can be used for the study of neurological diseases [1] .
    BD-1008 dihydrobromide
  • HY-125821
    Sigma-1 receptor antagonist 1

    		Sigma Receptor Neurological Disease
    Sigma‑1 receptor antagonist 1 (compound 137) is a potent and selective sigma-1 receptor (σ1R) antagonist, with a high binding affinity to σ1R receptor (Ki = 1.06 nM). Sigma‑1 receptor antagonist 1 exhibits antineuropathic pain activity and acts as a promising agent for the treatment of neuropathic pain [1].
    Sigma-1 receptor antagonist 1
  • HY-108513
    σ1 Receptor antagonist 4

    		Sigma Receptor Neurological Disease
    σ1 Receptor antagonist 4 (compound TC1) is a selective sigma1 (σ1) receptor antagonist with a Ki of 10 nM. σ1 Receptor antagonist 4 is weakly active at σ2 receptor (Ki of 370 nM) and has no activity at dopamine (DAT), serotonin (SERT), and norepinephrine (NET) transporters [1].
    σ1 Receptor antagonist 4
  • HY-147560
    σ1 Receptor/μ Opioid receptor modulator 1

    		Sigma Receptor Opioid Receptor Neurological Disease
    σ1 Receptor/μ Opioid receptor modulator 1 (Compound 44) is a potent σ1 receptor antagonist and μ opioid receptor agonist with Kis of 1.86 nM and 2.1 nM, respectively.σ1 Receptor/μ Opioid receptor modulator 1 exhibits potent analgesic activity. σ1 Receptor/μ Opioid receptor modulator 1 can be used for the research of neuropathic pain [1].
    σ1 Receptor/μ Opioid receptor modulator 1
  • HY-100966S
    BD-1008-d5 dihydrobromide

    		Isotope-Labeled Compounds Sigma Receptor Neurological Disease
    BD-1008-d5 dihydrobromide is the deuterium labeled BD-1008 dihydrobromide (HY-100966) [1]. BD-1008 dihydrobromide is a selective sigma 1 (σ1) receptor antagonist with a Ki of 2 nM. BD-1008 dihydrobromide exhibits 4-fold selectivity over the sigma-2 receptor (Ki of 8 nM). BD-1008 dihydrobromide can be used for the study of neurological diseases .
    BD-1008-d5 dihydrobromide
  • HY-162759
    Sigma-1 receptor antagonist 6

    		Sigma Receptor Neurological Disease
    Sigma-1 receptor antagonist 6 (Compound 12) is an antagonist of the Sigma-1 receptor (σ1R). Sigma-1 receptor antagonist 6 exerts a robust antiallodynic effect by antagonizing σ1R. Sigma-1 receptor antagonist 6 can be used in neuropathic pain animal models to alleviate mechanical allodynia induced by paclitaxel (HY-B0015) [1].
    Sigma-1 receptor antagonist 6
  • HY-149335
    Sigma-1 receptor antagonist 5

    		Sigma Receptor Histamine Receptor Neurological Disease
    Sigma-1 receptor antagonist 5 (compound 12)，a 4-pyridylpiperidine derivative with analgesic activity，is an antagonist of sigma receptor (Ki=4.5 nM (σ1R)，10 nM (σ2R)) and histamine H3 (hH3R，Ki=7.7 nM，IC50=215 nM). Sigma-1 receptor antagonist 5 suppresses Capsaicin-induced nociception with antinociceptive activity and shows potent efficacy in nociceptive and neuropathic pain models [1].
    Sigma-1 receptor antagonist 5
  • HY-149274
    Sigma-1 receptor antagonist 4

    		Sigma Receptor Neurological Disease
    Sigma-1 receptor antagonist 4 (Compound 32) is a potent σ1R antagonist that significantly enhances the analgesic effect of morphine and rescues morphine-induced analgesic tolerance, with potential to prevent morphine tolerance [1].
    Sigma-1 receptor antagonist 4
  • HY-163065
    σ1 Receptor/μ Opioid receptor modulator 2

    		Opioid Receptor Sigma Receptor Neurological Disease
    σ1 Receptor/μ Opioid receptor modulator 2 (compound 4x) is a dual μOR agonist/σ1R antagonist, and displays picomolar μOR agonism activity (EC50: 0.6 ± 0.2 nM) and good σ1R inhibitory activity (Ki: 363.7 ± 5.6 nM). σ1 Receptor/μ Opioid receptor modulator 2 exhibits robust analgesic effects in various pain models [1].
    σ1 Receptor/μ Opioid receptor modulator 2
  • HY-134004
    Pentoxyverine

    Carbetapentane

    		 Sigma Receptor mAChR Neurological Disease Inflammation/Immunology
    Pentoxyverine (Carbetapentane) is an orally active sigma-1 receptor agonist, with Kis of 41 nM, 894 nM and 75 nM for σ1, σ2 and guinea-pig brain membran σ1, respectively. Pentoxyverine is a muscarinic antagonist. Pentoxyverine is a potent antitussive, anticonvulsant, and spasmolytic agent. Pentoxyverine can be used for inhibiting bronchial interceptor, weakening of cough reflex, bronchial smooth muscle relaxation and reduction of airway resistance [1] .
    Pentoxyverine
  • HY-B1055
    Pentoxyverine citrate

    Carbetapentane citrate

    		 Sigma Receptor mAChR Neurological Disease Inflammation/Immunology
    Pentoxyverine (Carbetapentane) citrate is an orally active sigma-1 receptor agonist, with Kis of 41 nM, 894 nM and 75 nM for σ1, σ2 and guinea-pig brain membrane σ1, respectively. Pentoxyverine citrate is a muscarinic antagonist. Pentoxyverine citrate is a potent antitussive, anticonvulsant, and spasmolytic agent. Pentoxyverine citrate can be used for inhibiting bronchial interceptor, weakening of cough reflex, bronchial smooth muscle relaxation and reduction of airway resistance [1] .
    Pentoxyverine citrate
  • HY-134189
    EST73502

    		Opioid Receptor Sigma Receptor Neurological Disease
    EST73502 is a selective, orally active and blood-brain barrier (BBB) penetrant dual μ-opioid receptor (MOR) agonist and σ1 receptor (σ1R) antagonist, with Kis of 64 nM and 118 nM for MOR and σ1R, respectively. EST73502 has antinociceptive activity [1].
    EST73502
  • HY-134189A
    EST73502 monohydrochloride

    		Sigma Receptor Opioid Receptor Neurological Disease
    EST73502 monohydrochloride is a selective, orally active and blood-brain barrier (BBB) penetrant dual μ-opioid receptor (MOR) agonist and σ1 receptor (σ1R) antagonist, with Kis of 64 nM and 118 nM for MOR and σ1R, respectively. EST73502 monohydrochloride has antinociceptive activity [1].
    EST73502 monohydrochloride
  • HY-134004R
    Pentoxyverine (Standard)

    Carbetapentane (Standard)

    		 Reference Standards Sigma Receptor mAChR Neurological Disease Inflammation/Immunology
    Pentoxyverine (Standard) is the analytical standard of Pentoxyverine. This product is intended for research and analytical applications. Pentoxyverine (Carbetapentane) is an orally active sigma-1 receptor agonist, with Kis of 41 nM, 894 nM and 75 nM for σ1, σ2 and guinea-pig brain membran σ1, respectively. Pentoxyverine is a muscarinic antagonist. Pentoxyverine is a potent antitussive, anticonvulsant, and spasmolytic agent. Pentoxyverine can be used for inhibiting bronchial interceptor, weakening of cough reflex, bronchial smooth muscle relaxation and reduction of airway resistance [1] .
    Pentoxyverine (Standard)
  • HY-14222
    UMB24

    		Sigma Receptor Neurological Disease
    UMB24 is a potent antagonist of σ2 receptor, with Ki values of 170 nM anf 322 nM for σ2 receptor and σ1 receptor, respectively. UMB24 attenuats cocaine-induced convulsions and locomotor activity, but not lethality [1].
    UMB24
  • HY-B1055R
    Pentoxyverine citrate (Standard)

    Carbetapentane citrate (Standard)

    		 Reference Standards Sigma Receptor mAChR Neurological Disease Inflammation/Immunology
    Pentoxyverine (citrate) (Standard) is the analytical standard of Pentoxyverine (citrate). This product is intended for research and analytical applications. Pentoxyverine (Carbetapentane) citrate is an orally active sigma-1 receptor agonist, with Kis of 41 nM, 894 nM and 75 nM for σ1, σ2 and guinea-pig brain membrane σ1, respectively. Pentoxyverine citrate is a muscarinic antagonist. Pentoxyverine citrate is a potent antitussive, anticonvulsant, and spasmolytic agent. Pentoxyverine citrate can be used for inhibiting bronchial interceptor, weakening of cough reflex, bronchial smooth muscle relaxation and reduction of airway resistance [1] [4].
    Pentoxyverine citrate (Standard)
  • HY-101376
    (+)-N-Allylnormetazocine hydrochloride

    (+)-SKF 10047 hydrochloride; (+)-N-Allyl-N-normetazocine hydrochloride

    		 Opioid Receptor Neurological Disease
    (+)-N-Allylnormetazocine ((+)-SKF 10047) hydrochloride is a benzomorphan opioid with psychotomi metic effects. (+)-N-Allylnormetazocine hydrochloride is an opioid receptor antagonist with Ki values of 300 nM and 27 μM for σ1 and σ2 opioid receptors, respectively. (+)-N-Allylnormetazocine hydrochloride can be used for the research of neurological disease [1] .
    (+)-N-Allylnormetazocine hydrochloride
  • HY-18099
    S1RA
    2 Publications Verification

    E-52862

    		 Sigma Receptor 5-HT Receptor Neurological Disease
    S1RA (E-52862) is a highly selective σ1 receptor (σ1R) antagonist with Kis of 17 nM and 23.5 nM for human σ1R and guinea pig σ1R, respectively. S1RA has Moderate antagonistic activity for human 5-HT2B receptor (Ki= 328 nM). S1RA has antinociceptive effects in neuropathic pain models. S1RA prevents mechanical and cold hypersensitivity in Oxaliplatin (HY-17371)-treated mice [1] .
    S1RA
  • HY-B0765
    Dehydroepiandrosterone sulfate sodium
    5 Publications Verification

    DHEA sulfate sodium; Prasterone sulfate sodium

    		 GABA Receptor Sigma Receptor iGluR PPAR NF-κB Neurological Disease Metabolic Disease Inflammation/Immunology
    Dehydroepiandrosterone sulfate (DHEA sulfate; Prasterone sulfate) sodium salt is a neurosteroid and the main secretion product of the adrenal gland. Dehydroepiandrosterone sulfate sodium salt has both non-competitive antagonist activity of GABAA receptor and agonist activity of σ1 receptor. Dehydroepiandrosterone sulfate sodium salt can partially penetrate the blood-brain barrier, inhibit GABAA receptor-mediated chloride influx, enhance NMDA receptor activity through σ1 receptors, exert anti-inflammatory, anti-glucocorticoid and antidepressant effects, and increase convulsive sensitivity. Dehydroepiandrosterone sulfate sodium salt participates in neuroprotection, neurite growth regulation and catecholamine secretion regulation, and can be used in the study of depression, post-traumatic stress disorder (PTSD), Alzheimer's disease, etc. Dehydroepiandrosterone sulfate sodium salt may also be a biomarker for cardiovascular disease mortality, and its concentration is independently and negatively correlated with mortality [1] .
    Dehydroepiandrosterone sulfate sodium
  • HY-113416
    Dehydroepiandrosterone sulfate
    5 Publications Verification

    DHEA sulfate; Prasterone sulfate

    		 GABA Receptor Sigma Receptor iGluR PPAR NF-κB Neurological Disease Metabolic Disease Inflammation/Immunology
    Dehydroepiandrosterone sulfate (DHEA sulfate; Prasterone sulfate) is a neurosteroid and the main secretion product of the adrenal gland. Dehydroepiandrosterone sulfate has both non-competitive antagonist activity of GABAA receptor and agonist activity of σ1 receptor. Dehydroepiandrosterone sulfate can partially penetrate the blood-brain barrier, inhibit GABAA receptor-mediated chloride influx, enhance NMDA receptor activity through σ1 receptors, exert anti-inflammatory, anti-glucocorticoid and antidepressant effects, and increase convulsive sensitivity. Dehydroepiandrosterone sulfate participates in neuroprotection, neurite growth regulation and catecholamine secretion regulation, and can be used in the study of depression, post-traumatic stress disorder (PTSD), Alzheimer's disease, etc. Dehydroepiandrosterone sulfate may also be a biomarker for cardiovascular disease mortality, and its concentration is independently and negatively correlated with mortality [1] .
    Dehydroepiandrosterone sulfate
  • HY-107708
    threo-Ifenprodil hemitartrate

    		iGluR Sigma Receptor Potassium Channel Neurological Disease
    threo Ifenprodil hemitartrate is a σ receptor agonist, with Kis of 59.1 and 2 nM for σ1 and σ2 receptors, respectively. threo Ifenprodil hemitartrate is also a NR2B subunit-selective NMDA receptor antagonist (IC50=0.22 μM). threo Ifenprodil hemitartrate is a hERG potassium channel inhibitor, with an IC 50 of 88 nM, showing antiarrhythmic activity [1] .
    threo-Ifenprodil hemitartrate
  • HY-131914B
    EST64454 maleate

    		Sigma Receptor Inflammation/Immunology
    EST64454 maleate is a highly soluble σ1 receptor antagonist, demonstrating potent antinociceptive properties for pain treatment. EST64454 maleate exhibits excellent metabolic stability across various species and possesses an adequate pharmacokinetic profile in rodents. EST64454 maleate has been identified as a promising clinical candidate due to its favorable aqueous solubility and high permeability in Caco-2 cells.
    EST64454 maleate
  • HY-113416AS
    Dehydroepiandrosterone sulfate-d6 sodium dihydrate

    DHEA sulfate-d6 sodium dihydrate; Prasterone sulfate-d6 sodium dihydrate

    		 Isotope-Labeled Compounds GABA Receptor Sigma Receptor iGluR PPAR NF-κB Neurological Disease Metabolic Disease Inflammation/Immunology
    Dehydroepiandrosterone sulfate sodium dihydrate-d6 sodium dihydrate is the deuterium labeled Dehydroepiandrosterone sulfate sodium dihydrate. Dehydroepiandrosterone sulfate (DHEA sulfate; Prasterone sulfate) sodium dihydrate is a neurosteroid and the main secretion product of the adrenal gland. Dehydroepiandrosterone sulfate sodium dihydrate has both non-competitive antagonist activity of GABAA receptor and agonist activity of σ1 receptor. Dehydroepiandrosterone sulfate sodium dihydrate can partially penetrate the blood-brain barrier, inhibit GABAA receptor-mediated chloride influx, enhance NMDA receptor activity through σ1 receptors, exert anti-inflammatory, anti-glucocorticoid and antidepressant effects, and increase convulsive sensitivity. Dehydroepiandrosterone sulfate sodium dihydrate participates in neuroprotection, neurite growth regulation and catecholamine secretion regulation, and can be used in the study of depression, post-traumatic stress disorder (PTSD), Alzheimer's disease, etc. Dehydroepiandrosterone sulfate sodium dihydrate may also be a biomarker for cardiovascular disease mortality, and its concentration is independently and negatively correlated with mortality [1] .
    Dehydroepiandrosterone sulfate-d6 sodium dihydrate
  • HY-113416R
    Dehydroepiandrosterone sulfate (Standard)

    DHEA sulfate (Standard); Prasterone sulfate (Standard)

    		 Reference Standards GABA Receptor Sigma Receptor iGluR PPAR NF-κB Neurological Disease Metabolic Disease Inflammation/Immunology
    Dehydroepiandrosterone sulfate (DHEA sulfate; Prasterone sulfate) (Standard) is the analytical standard of Dehydroepiandrosterone sulfate (HY-113416). This product is intended for research and analytical applications. Dehydroepiandrosterone sulfate (DHEA sulfate; Prasterone sulfate) is a neurosteroid and the main secretion product of the adrenal gland. Dehydroepiandrosterone sulfate has both non-competitive antagonist activity of GABAA receptor and agonist activity of σ1 receptor. Dehydroepiandrosterone sulfate can partially penetrate the blood-brain barrier, inhibit GABAA receptor-mediated chloride influx, enhance NMDA receptor activity through σ1 receptors, exert anti-inflammatory, anti-glucocorticoid and antidepressant effects, and increase convulsive sensitivity. Dehydroepiandrosterone sulfate participates in neuroprotection, neurite growth regulation and catecholamine secretion regulation, and can be used in the study of depression, post-traumatic stress disorder (PTSD), Alzheimer's disease, etc. Dehydroepiandrosterone sulfate may also be a biomarker for cardiovascular disease mortality, and its concentration is independently and negatively correlated with mortality [1] .
    Dehydroepiandrosterone sulfate (Standard)
  • HY-141921S
    Dehydroepiandrosterone sulfate sodium-d6

    DHEA sulfate sodium-d6; Prasterone sulfate sodium-d6

    		 Isotope-Labeled Compounds GABA Receptor Sigma Receptor iGluR PPAR NF-κB Neurological Disease Metabolic Disease Inflammation/Immunology
    Dehydroepiandrosterone sulfate sodium salt-d6 (DHEA sulfate sodium salt-d6; Prasterone sulfate sodium salt-d6) is the deuterium labeled Dehydroepiandrosterone sulfate sodium salt (HY-B0765). Dehydroepiandrosterone sulfate (DHEA sulfate; Prasterone sulfate) sodium salt is a neurosteroid and the main secretion product of the adrenal gland. Dehydroepiandrosterone sulfate sodium salt has both non-competitive antagonist activity of GABAA receptor and agonist activity of σ1 receptor. Dehydroepiandrosterone sulfate sodium salt can partially penetrate the blood-brain barrier, inhibit GABAA receptor-mediated chloride influx, enhance NMDA receptor activity through σ1 receptors, exert anti-inflammatory, anti-glucocorticoid and antidepressant effects, and increase convulsive sensitivity. Dehydroepiandrosterone sulfate sodium salt participates in neuroprotection, neurite growth regulation and catecholamine secretion regulation, and can be used in the study of depression, post-traumatic stress disorder (PTSD), Alzheimer's disease, etc. Dehydroepiandrosterone sulfate sodium salt may also be a biomarker for cardiovascular disease mortality, and its concentration is independently and negatively correlated with mortality [1] .
    Dehydroepiandrosterone sulfate sodium-d6
  • HY-B0765R
    Dehydroepiandrosterone sulfate sodium (Standard)

    DHEA sulfate sodium (Standard); Prasterone sulfate sodium (Standard)

    		 Reference Standards GABA Receptor Sigma Receptor iGluR PPAR NF-κB Neurological Disease Metabolic Disease Inflammation/Immunology
    Dehydroepiandrosterone sulfate (DHEA sulfate; Prasterone sulfate) sodium salt (Standard) is the analytical standard of Dehydroepiandrosterone sulfate sodium salt (HY-B0765). This product is intended for research and analytical applications. Dehydroepiandrosterone sulfate (DHEA sulfate; Prasterone sulfate) is a neurosteroid and the main secretion product of the adrenal gland. Dehydroepiandrosterone sulfate has both non-competitive antagonist activity of GABAA receptor and agonist activity of σ1 receptor. Dehydroepiandrosterone sulfate can partially penetrate the blood-brain barrier, inhibit GABAA receptor-mediated chloride influx, enhance NMDA receptor activity through σ1 receptors, exert anti-inflammatory, anti-glucocorticoid and antidepressant effects, and increase convulsive sensitivity. Dehydroepiandrosterone sulfate participates in neuroprotection, neurite growth regulation and catecholamine secretion regulation, and can be used in the study of depression, post-traumatic stress disorder (PTSD), Alzheimer's disease, etc. Dehydroepiandrosterone sulfate may also be a biomarker for cardiovascular disease mortality, and its concentration is independently and negatively correlated with mortality [1] .
    Dehydroepiandrosterone sulfate sodium (Standard)
  • HY-108511A
    PB28

    		Sigma Receptor Apoptosis SARS-CoV Infection Cancer
    PB28 is a cyclohexylpiperazine derivative and a high affinity and selective sigma 2 (σ2) receptor agonist with a Ki of 0.68 nM. PB28 is also a σ1 antagonist with a Ki of 0.38 nM. PB28 is less affinity for other receptors. PB28 inhibits electrically evoked twitch in guinea pig bladder and ileum with EC50 values of 2.62 μM and 3.96 μM, respectively. PB28 can modulate SARS-CoV-2-human protein-protein interaction. PB28 induces caspase-independent apoptosis and has antitumor activity [1] .
    PB28
  • HY-108511
    PB28 dihydrochloride

    		Sigma Receptor Apoptosis SARS-CoV Infection Cancer
    PB28 dihydrochloride, a cyclohexylpiperazine derivative, is a high affinity and selective sigma 2 (σ2) receptor agonist with a Ki of 0.68 nM. PB28 dihydrochloride is also a σ1 antagonist with a Ki of 0.38 nM. PB28 dihydrochloride is less affinity for other receptors. PB28 dihydrochloride inhibits electrically evoked twitch in guinea pig bladder and ileum with EC50 values of 2.62 μM and 3.96 μM, respectively. PB28 dihydrochloride can modulate SARS-CoV-2-human protein-protein interaction. PB28 dihydrochloride induces caspase-independent apoptosis and has antitumor activity [1] .
    PB28 dihydrochloride
  • HY-100985
    IPAG

    		Sigma Receptor Cancer
    IPAG is a potent sigma-1 receptor antagonist with a pKi of 4.3 [1]. IPAG induces apoptosis .
    IPAG
  • HY-124462
    Trifluperidol hydrochloride

    R 2498

    		 Sigma Receptor Neurological Disease
    Trifluperidol hydrochloride is a Sigma-1 receptor antagonist with a Ki value of 3.3 nM. Trifluperidol hydrochloride is used in the study of psychosis [1].
    Trifluperidol hydrochloride
  • HY-18101A
    BD1063 dhydrochloride
    3 Publications Verification

    		 Sigma Receptor Metabolic Disease
    BD1063 dhydrochloride is a potent and selective sigma 1 receptor antagonist.
    BD1063 dhydrochloride
  • HY-131914A
    EST64454 hydrochloride

    		Sigma Receptor Neurological Disease
    EST64454 hydrochloride is a selective and orally active sigma-1 receptor antagonist with a Ki of 22 nM. EST64454 hydrochloride has the potential for the research of the pain [1].
    EST64454 hydrochloride
  • HY-A0172
    Captodiame

    Captodiamine

    		 5-HT Receptor Dopamine Receptor Sigma Receptor Neurological Disease
    Captodiame (Captodiamine) is a 5-HT2c receptor antagonist and sigma-1 and D3 dopamine receptor agonist. Captodiame shows antidepressant effect [1].
    Captodiame
  • HY-155614
    KSK68

    		Sigma Receptor Histamine Receptor Neurological Disease
    KSK68 is a high-affinity dual sigma-1 and histamine H3 receptor antagonist, with Kis of 7.7, 3.6, 22.4 nM for H3 receptor, sigma-1, sigma-2 receptor respectively. KSK68 has negligible affinity at the other histamine receptor subtypes. KSK68 can be used for research of nociceptive and neuropathic pain [1].
    KSK68
  • HY-131914
    EST64454

    		Sigma Receptor
    EST64454 (compound 9k) is a selective, orally active sigma-1 receptor antagonist with Ki 22 nM. EST64454 can be used to study pain [1].
    EST64454
  • HY-153091
    BMY 14802

    		Adrenergic Receptor 5-HT Receptor Sigma Receptor Neurological Disease
    BMY 14802 is a sigma-1 receptor (σ1R) antagonist, as well as an agonist at serotonin (5-HT) 1A and adrenergic alpha-1 receptors. BMY 14802 inhibits abnormal involuntary movement (AIM) in rat Parkinson's disease (PD) model, with down-regulating the expression of AIM [1] .
    BMY 14802
  • HY-155616
    KSK94

    		Sigma Receptor Histamine Receptor Neurological Disease
    KSK94 is a high-affinity histamine H3 receptor antagonist, with Kis of 7.9, 2958, 75.2 nM for H3 receptor, sigma-1, sigma-2 receptor respectively. KSK94 can be used for research of nociceptive and neuropathic pain [1].
    KSK94
  • HY-18099A
    S1RA hydrochloride
    2 Publications Verification

    E-52862 hydrochloride

    		 Sigma Receptor 5-HT Receptor Neurological Disease
    S1RA (E-52862) hydrochloride is an orally active and selective sigma-1 receptor (σ1R) antagonist with a Ki value of 17 nM. S1RA hydrochloride shows good selectivity against σ2R (Ki >1000 nM). S1RA hydrochloride is a human 5-HT2B receptor antagonist with an IC50 value of 4.7 μM. S1RA hydrochloride inhibits neuropathic pain and activity-induced spinal sensitization [1] .
    S1RA hydrochloride
  • HY-155615
    KSK67

    		Sigma Receptor Histamine Receptor Neurological Disease
    KSK67 is a high-affinity dual sigma-2 and histamine H3 receptor antagonist, with Kis of 3.2, 1531, 101 nM for H3 receptor, sigma-1, sigma-2 receptor respectively. KSK67 can be used for research of nociceptive and neuropathic pain [1].
    KSK67
  • HY-101484A
    NE-100 hydrochloride

    		Sigma Receptor ATF6 Neurological Disease
    NE-100 hydrochloride is an orally active and selective sigma-1 receptor antagonist with an IC50 of 4.16 nM. NE-100 hydrochloride can improve cognitive impairment and has neuroprotective and antipsychotic activities. NE-100 hydrochloride can be used for research on nervous system diseases [1] .
    NE-100 hydrochloride
  • HY-101043
    4-PPBP maleate

    		Sigma Receptor iGluR Neurological Disease
    4-PPBP maleate is a potent σ 1 receptor ligand and agonist. 4-PPBP maleate is a non-competitive, selective NR1a/2B NMDA receptors (expressed in Xenopus oocytes) antagonist. 4-PPBP maleate provides neuroprotection [1] .
    4-PPBP maleate
  • HY-10684
    Pridopidine

    ACR16; ASP2314; FR310826

    		 Dopamine Receptor Neurological Disease
    Pridopidine, a dopamine (DA) stabilizer, acts as a low affinity dopamine D2 receptor (D2R) antagonist. Pridopidine exerts high affinity towards sigma 1 receptor (S1R) with Ki between 70 and 80 nM, which is ~100× higher than its affinity toward D2R.
    Pridopidine
  • HY-101484AR
    NE-100 hydrochloride (Standard)

    		Reference Standards Sigma Receptor ATF6 Neurological Disease
    NE-100 hydrochloride (Standard) is the analytical standard of NE-100 hydrochloride (HY-101484A). This product is intended for research and analytical applications. NE-100 hydrochloride is an orally active and selective sigma-1 receptor antagonist with an IC50 of 4.16 nM. NE-100 hydrochloride can improve cognitive impairment and has neuroprotective and antipsychotic activities. NE-100 hydrochloride can be used for research on nervous system diseases [1] .
    NE-100 hydrochloride (Standard)
  • HY-111210
    Pridopidine hydrochloride

    ACR16 hydrochloride; ASP2314 hydrochloride; FR310826 hydrochloride

    		 Dopamine Receptor Neurological Disease
    Pridopidine (ACR16) hydrochloride, a dopamine (DA) stabilizer, acts as a low affinity dopamine D2 receptor (D2R) antagonist. Pridopidine exerts high affinity towards sigma 1 receptor (S1R) with Ki between 70 and 80 nM, which is ~100-fold higher than its affinity toward D2R.
    Pridopidine hydrochloride
  • HY-161873
    PW507

    		Sigma Receptor Neurological Disease
    PW507 is a potent, brain-penetrant and selective sigma 1 receptor (S1R) antagonist with a Ki of 7.5 nM for human S1R. PW507 displays a low binding affinity to S2R and hERG. PW507 can be used for the study of painful diabetic neuropathy (PDN) [1].
    PW507
  • HY-10684R
    Pridopidine (Standard)

    		Dopamine Receptor Neurological Disease
    Pridopidine (Standard) is the analytical standard of Pridopidine. This product is intended for research and analytical applications. Pridopidine, a dopamine (DA) stabilizer, acts as a low affinity dopamine D2 receptor (D2R) antagonist. Pridopidine exerts high affinity towards sigma 1 receptor (S1R) with Ki between 70 and 80 nM, which is ~100× higher than its affinity toward D2R.
    Pridopidine (Standard)

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