Search Result

Results for "

14-3-3

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Akt (1) Angiotensin-converting Enzyme (ACE) (3) Apoptosis (4) Autophagy (1) Bacterial (3) Biochemical Assay Reagents (2) Caspase (1) Drug Derivative (1) Endogenous Metabolite (1) Estrogen Receptor/ERR (4) Fluorescent Dye (1) Hippo (MST) (1) HIV (1) Insulin Receptor (1) Isotope-Labeled Compounds (1) MicroRNA (8) Molecular Glues (5) NF-κB (1) PARP (1) PDGFR (2) PROTACs (1) Raf (2) Reference Standards (1) Small Interfering RNA (siRNA) (2) Toll-like Receptor (TLR) (3) VEGFR (1) YAP (1)
By Research Areas:	Cancer (16) Cardiovascular Disease (3) Infection (4) Inflammation/Immunology (8) Metabolic Disease (2) Neurological Disease (2)
Oligonucleotides:	miRNA mimics (2) miRNA agomirs (2) miRNA antagomirs (2) MicroRNAs (8) Mouse Pre-designed siRNA Sets (1) miRNA inhibitors (2) Human Pre-designed siRNA Sets (1) siRNAs (2)

Inhibitors & Agonists

Screening Libraries

Fluorescent Dye

Biochemical Assay Reagents

Peptides

Natural
Products

Recombinant Proteins

Isotope-Labeled Compounds

Antibodies

Oligonucleotides

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-146302

14-3-3η Protein inhibitor 1 2 Publications Verification	Apoptosis	Cancer
14-3-3η Protein inhibitor 1 (Compound C11) is a *14-3-3η* protein inhibitor with a K_D of 35 µM. 14-3-3η Protein inhibitor 1 shows inhibitory activities against several typical human liver cancer cell lines. 14-3-3η Protein inhibitor 1 induces cell apoptosis and G1-S cell cycle arrest with good metabolic stability .

HY-B1433

Perindoprilat S 9780	Angiotensin-converting Enzyme (ACE)	Cardiovascular Disease
Perindoprilat (S 9780) is an angiotensin-converting enzyme (ACE) inhibitor with the IC₅₀ value ranging from 1.5 to 3.2 nM. Perindoprilat can be used in hypertension research .

HY-161611

14-3-3-IN-1	YAP	Others
14-3-3-IN-1 (Compound 2) is an inhibitor for 14-3-3 proteins in Arabidopsis thaliana, with an IC₅₀ of 1.21 μM. 14-3-3-IN-1 exhibits different inhibitory activities against different 14-3-3 isomers. 14-3-3-IN-1 promotes the closure of stomata on leaves .

HY-175872

14-3-3σ/ERα stabilizer-2	Estrogen Receptor/ERR Molecular Glues	Others
14-3-3σ/ERα stabilizer-2 (Compound 41) is a covalent 14-3-3σ/ERα stabilizer with a K_d of 10.1 nM. 14-3-3σ/ERα stabilizer-2 significantly decreases the dissociation rate of ERα, stabilizing the binary ERα/14-3-3σ interaction. 14-3-3σ/ERα stabilizer-2 can be used for molecular glues research .

HY-156125

14-3-3σ/ERα stabilizer-1	Estrogen Receptor/ERR	Others
14-3-3σ/ERα stabilizer-1 (Compound 181) is a covalent *14-3-3σ*/ERα stabilizer. 14-3-3σ/ERα stabilizer-1 can be used for research of molecular glues .

HY-B1433S

Perindoprilat-d3 disodium S 9780-d₃ disodium	Angiotensin-converting Enzyme (ACE) Isotope-Labeled Compounds	Cardiovascular Disease
Perindoprilat-d₃ disodium is deuterated labeled Perindoprilat (HY-B1433). Perindoprilat (S 9780) is an angiotensin-converting enzyme (ACE) inhibitor with the IC₅₀ value ranging from 1.5 to 3.2 nM. Perindoprilat can be used in hypertension research .

HY-D1433

FITC-C6-LEHD-FMK	Fluorescent Dye	Cancer
FITC-C6-LEHD-FMK, a fluorescently labeled caspase-9 inhibitor, can be used for detection of active caspase-9 in mammalian cells undergoing apoptosis. FITC-C6-LEHD-FMK provides a convenient means for sensitive detection of activated caspase-9 in living cells. Z-LEHD-FMK is a specific caspase-9 inhibitor .

HY-NP143

Nerve Growth Factor 2.5S,murine submaxillary gland	Biochemical Assay Reagents	Neurological Disease
Nerve Growth Factor 2.5S, murine submaxillary gland is a neurotrophic polypeptide required for normal growth and development of sympathetic and embryonic sensory neurons and certain cholinergic neurons in the central nervous system. Nerve Growth Factor 2.5S, murine submaxillary gland has only β-subunit , and shows nerve growth-promoting activity .

HY-P1433

[Pro3]-GIP (Rat)	Insulin Receptor	Metabolic Disease
[Pro3]-GIP (Rat) is a selective GIP receptor partial agonist with a K_i of 13 nM. [Pro3]-GIP (Rat) can be used in diabetes research .

HY-N1433R

Phytolaccagenin (Standard)	Reference Standards Bacterial	Infection Inflammation/Immunology
Phytolaccagenin (Standard) is the analytical standard of Phytolaccagenin. This product is intended for research and analytical applications. Phytolaccagenin, a triterpenoid saponin, is the active component of Radix Phytolaccae. Phytolcaccagenin has antifungal activity, anti-inflammatory activity and lower toxicity

HY-B1433R

Perindoprilat (Standard)	Angiotensin-converting Enzyme (ACE)	Cardiovascular Disease
Perindoprilat (Standard) is the analytical standard of Perindoprilat. This product is intended for research and analytical applications. Perindoprilat (S 9780) is an angiotensin-converting enzyme (ACE) inhibitor with the IC50 value ranging from 1.5 to 3.2 nM. Perindoprilat can be used in hypertension research .

HY-N1433

Phytolaccagenin	Bacterial	Infection Inflammation/Immunology
Phytolaccagenin, a triterpenoid saponin, is the active component of Radix Phytolaccae. Phytolcaccagenin has antifungal activity, anti-inflammatory activity and lower toxicity

HY-169905

*GR–14-3-3* stabilizer-1**	Molecular Glues	Others
GR-14-3-3 stabilizer-1 (compound 10) is a molecular glue stabilizer that can be used to prepare molecular glues targeting glucocorticoids (GR) and block the interaction between GR and 14-3-3 .

HY-170593

*ChREBPα/14-3-3* regulator-1**	Molecular Glues	Metabolic Disease
ChREBPα/14-3-3 regulator-1 (Compound 43) is a selective molecular gel that can stabilize the interaction of carbohydrate response element binding protein (ChREBP) with *14-3-3* proteins (EC₅₀: 3.8 μM). ChREBPα/14-3-3 regulator-1 effectively protects β cells from glucolipotoxicity and maintains cell function, and can be used in the study of type 2 diabetes .

HY-W1005067

EN171	Molecular Glues Hippo (MST) Estrogen Receptor/ERR	Others
EN171 is a covalent ligand that covalently targets both C38 and C96 on *14-3-3* to enhance *14-3-3* interactions with ERα, YAP and TAZ, leading to impaired estrogen receptor and Hippo pathway transcriptional activity. EN171 can not only be used as a molecular glue to enhance native protein interactions but can also be used as a covalent *14-3-3* recruiter in heterobifunctional molecules to sequester nuclear neo-substrates such as BRD4 and BLC6 into the cytosol .

HY-119757

Tyrphostin AG1433 SU1433; AG1433	PDGFR VEGFR	Cancer
Tyrphostin AG1433 (SU1433) is a tyrosine kinases inhibitor. AG1433 is also a selective PDGFRβ and VEGFR-2 (Flk-1/KDR) inhibitor with IC₅₀s of 5.0 μM and 9.3 μM, respectively. Tyrphostin AG1433 prevents blood vessel formation .

HY-119757A

Tyrphostin AG1433 hydrochloride SU1433 hydrochloride; AG1433 hydrochloride	PDGFR	Inflammation/Immunology
Tyrphostin AG 1433 is a specific and potent inhibitor of PDGFR-β and of KDR/Flk-1. Tyrphostin AG 1433 acts as an angiogenesis inhibitor .

HY-169081

QS-57	PROTACs Molecular Glues	Others
QS-57 is a PROTAC targeting BRD4. QS-57 can be used as a 14-3-3 molecular glue. (Red: EN171 (HY-W1005067), black: (2-Aminoethyl) carbamic acid (HY-W398806), Blue: JQ-1 (carboxylic acid) (HY-78695)) .

HY-P1039

R18 PHCVPRDLSWLDLEANMCLP	Raf	Cancer
R18 is a peptide antagonists of *14-3-3, with a K_D of 70-90 nM. R18 efficiently blocks the binding of 14-3-3* to the kinase Raf-1, a physiological ligand of 14-3-3, and effectively abolished the protective role of 14-3-3 against phosphatase-induced inactivation of Raf-1 .

HY-P1039A

R18 TFA PHCVPRDLSWLDLEANMCLP TFA	Raf	Cancer
R18 TFA is a peptide antagonists of *14-3-3, with a K_D of 70-90 nM. R18 efficiently blocks the binding of 14-3-3* to the kinase Raf-1, a physiological ligand of 14-3-3, and effectively abolished the protective role of 14-3-3 against phosphatase-induced inactivation of Raf-1 .

HY-162838

TCF199	Estrogen Receptor/ERR	Others
TCF199 is an allosteric stabilizer that stabilizes the 14-3-3/TAZ peptide interaction, binding to the 14-3-3ζ/E R α peptide and 14-3-3ζ/Chibby peptide. TCF199 has a Kd value of 122 μM for its interaction with 14-3-3/TAZ .

HY-122815

Fusicoccin Fusicoccin A	Apoptosis	Cancer
Fusicoccin (Fusicoccin A), a fungal pytotoxin, is a stabilizer of specific *14-3-3* protein-protein interactions. Fusicoccin sabilizes H ⁺-ATPase/14-3-3 cmplex in pants, maintaining the enzyme in activated state. Fusicoccin also stabilizes 14-3-3 protein interactions with binding partners containing a C-terminal 14-3-3 recognition motif (a mode 3 motif), such as ERα, GPIbα, TASK3, CTFR, and p53. Fusicoccin induces apoptosis in cancer cells and has anticancer activity .

HY-P1380A

Difopein TFA	Apoptosis	Cancer
Difopein TFA, a specific and competitive inhibitor of 14-3-3 protein (a highly conserved eukaryotic regulatory molecule), blocking the ability of 14-3-3 to bind to target proteins and inhibits 14-3-3/Ligand interactions. Difopein TFA is not cell permeable. Difopein TFA leads to induction of apoptosis and enhances the ability of Cisplatin (HY-17394) to kill cells .

HY-N13798

ADHPE	NF-κB Biochemical Assay Reagents	Inflammation/Immunology
ADHPE is a stabilizer of 14-3-3σ and p65 protein complex. ADHPE inhibits NF-κB (p65) signaling pathway and reduces the inflammatory response. ADHPE can be used for pediatric pneumonia-related acute lung injury and acute respiratory distress syndrome study .

HY-101985

BV02 1 Publications Verification	Bacterial PARP Caspase Apoptosis Autophagy Akt	Infection Neurological Disease Inflammation/Immunology
BV02 is a *14-3-3* inhibitor and an antibacterial agent. BV02 enhances the cleavage of PARP and caspase-3. BV02 induces Apoptosis, Autophagy, and enhances Akt activation. BV02 has anti-B. melitensis infection and epilepsy-promoting effects. BV02 can also be used in colitis research.

HY-171977

UTKO1	Drug Derivative	Cancer
UTKO1 (Compound 2) is a derivate of Moverastin.UTKO1 has optical activity and significant inhibitory activity against tumor cell migration by abrogating the binding of *14-3-3ζ/Tiam1*. UTKO1 can be used for cancers like esophageal cancer and epidermoid carcinoma research .

HY-RS15944

YWHAQ Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
YWHAQ Human Pre-designed siRNA Set A contains three designed siRNAs for YWHAQ gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

YWHAQ Human Pre-designed siRNA Set A YWHAQ Human Pre-designed siRNA Set A

HY-R04234

*rno-miR-143-3p mimic*	MicroRNA	Cancer
rno-miR-143-3p mimics are small, chemically synthesized double-stranded RNAs that mimic endogenous miRNAs and enable miRNA functional analysis by up-regulation of miRNA activity.

rno-miR-143-3p mimic rno-miR-143-3p mimic

HY-R00278

*hsa-miR-143-3p mimic*	MicroRNA	Cancer
hsa-miR-143-3p mimics are small, chemically synthesized double-stranded RNAs that mimic endogenous miRNAs and enable miRNA functional analysis by up-regulation of miRNA activity.

hsa-miR-143-3p mimic hsa-miR-143-3p mimic

HY-RS16629

Sfn Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Sfn Mouse Pre-designed siRNA Set A contains three designed siRNAs for Sfn gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Sfn Mouse Pre-designed siRNA Set A Sfn Mouse Pre-designed siRNA Set A

HY-P2797A

Chitinase, Streptomyces griseus AMCase, Streptomyces griseus	Endogenous Metabolite	Others
Chitinase, Streptomyces griseus is a chitinase mainly found in Bacillus species and uses colloidal chitin as a substrate. The Km and Vmax of Chitinase are 4.28 mg/mL and 14.29 μg/(Min·mL) respectively. The final enzymatic hydrolysis product is N-acetylglucosamine, and the monomer and dimer contents are 14.33% and 85.67% respectively .

HY-RI04234

*rno-miR-143-3p inhibitor*	MicroRNA	Cancer
rno-miR-143-3p inhibitors are chemically-modified oligonucleotides that hybridize with mature miRNAs. The miRNA inhibitors have full-length nucleotide 2'-methoxy modification. The miRNA inhibitors strongly compete with mature miRNAs to prevent the complementary pairing of miRNAs and their target genes, thereby inhibiting miRNAs from functioning.

rno-miR-143-3p inhibitor rno-miR-143-3p inhibitor

HY-RI00278

*hsa-miR-143-3p inhibitor*	MicroRNA	Cancer
hsa-miR-143-3p inhibitors are chemically-modified oligonucleotides that hybridize with mature miRNAs. The miRNA inhibitors have full-length nucleotide 2'-methoxy modification. The miRNA inhibitors strongly compete with mature miRNAs to prevent the complementary pairing of miRNAs and their target genes, thereby inhibiting miRNAs from functioning.

hsa-miR-143-3p inhibitor hsa-miR-143-3p inhibitor

HY-148042

HIV-1 inhibitor-47	HIV	Infection
HIV-1 inhibitor-47 is an inhibitor of HIV-1, and inhibits vif-dependent degradation of human APOBEC3G, with an IC₅₀ value of 14.33 μM. HIV-1 inhibitor-47 also involves in derivatives of 1-(2-pyrimidinyl)piperazine synthesis, with potential antianxiety, antidepressant, and antipsychotic effect .

HY-159671B

3D-Monophosphoryl Lipid (14) ammonium 3D-MPL (14) ammonium	Toll-like Receptor (TLR)	Inflammation/Immunology
3D-Monophosphoryl Lipid (14) (3D-MPL (14)) ammonium is a TLR agonist that can be used as a vaccine adjuvant to enhance the immunogenicity of vaccines .

HY-159671

3D-Monophosphoryl Lipid (14) 3D-MPL (14)	Toll-like Receptor (TLR)	Inflammation/Immunology
3D-Monophosphoryl Lipid (14) (3D-Monophosphoryl Lipid (14)) is a TLR4 agonist that can be used as a vaccine adjuvant to enhance the immunogenicity of vaccines .

HY-159671A

3D-Monophosphoryl Lipid (14) triethylamine 3D-MPL (14) triethylamine	Toll-like Receptor (TLR)	Inflammation/Immunology
3D-Monophosphoryl Lipid (14) (3D-Monophosphoryl Lipid (14)) triethylamine is a TLR4 agonist that can be used as a vaccine adjuvant to enhance the immunogenicity of vaccines .

HY-R00278A

*hsa-miR-143-3p agomir*	MicroRNA	Cancer
hsa-miR-143-3p agomirs are chemically-modified double-strand miRNA mimics with modified mature miRNA strand: 2 phosphorothioates at the 5' end, 4 phosphorothioates at the 3' end, 3' end cholesterol group, and full-length nucleotide 2'-methoxy modification. They are designed to mimic endogenous miRNAs and recommended for miRNA functional studies. Compared with miRNA mimics, they exhibits enhanced cellular uptake, stability and regulatory activity in vivo.

hsa-miR-143-3p agomir hsa-miR-143-3p agomir

HY-R04234A

*rno-miR-143-3p agomir*	MicroRNA	Cancer
rno-miR-143-3p agomirs are chemically-modified double-strand miRNA mimics with modified mature miRNA strand: 2 phosphorothioates at the 5' end, 4 phosphorothioates at the 3' end, 3' end cholesterol group, and full-length nucleotide 2'-methoxy modification. They are designed to mimic endogenous miRNAs and recommended for miRNA functional studies. Compared with miRNA mimics, they exhibits enhanced cellular uptake, stability and regulatory activity in vivo.

rno-miR-143-3p agomir rno-miR-143-3p agomir

HY-RI00278A

*hsa-miR-143-3p antagomir*	MicroRNA	Cancer
hsa-miR-143-3p antagomirs are chemically-modified oligonucleotides that hybridize with mature miRNAs. The miRNA antagomirs have 2 phosphorothioates at the 5' end, 4 phosphorothioates at the 3' end, 1 cholesterol group at the 3' end, and full-length nucleotide 2'-methoxy modification. The miRNA antagomirs strongly compete with mature miRNAs to prevent the complementary pairing of miRNAs and their target genes, thereby inhibiting miRNAs from functioning. Stability of miRNA antagomirs appears to be significantly higher than miRNA inhibitors, they exhibits enhanced cellular uptake, stability and regulatory activity in vivo.

hsa-miR-143-3p antagomir hsa-miR-143-3p antagomir

HY-RI04234A

*rno-miR-143-3p antagomir*	MicroRNA	Cancer
rno-miR-143-3p antagomirs are chemically-modified oligonucleotides that hybridize with mature miRNAs. The miRNA antagomirs have 2 phosphorothioates at the 5' end, 4 phosphorothioates at the 3' end, 1 cholesterol group at the 3' end, and full-length nucleotide 2'-methoxy modification. The miRNA antagomirs strongly compete with mature miRNAs to prevent the complementary pairing of miRNAs and their target genes, thereby inhibiting miRNAs from functioning. Stability of miRNA antagomirs appears to be significantly higher than miRNA inhibitors, they exhibits enhanced cellular uptake, stability and regulatory activity in vivo.

rno-miR-143-3p antagomir rno-miR-143-3p antagomir

Cat. No.	Product Name

HY-L143

Marine-Sourced Natural Product Library	61 compounds
Oceans cover more than 70% of the Earth’s surface and host a huge species diversity. Marine organisms are considered the most recent source of bioactive natural products after terrestrial plants and nonmarine microorganisms. Marine biological sources are taxonomically diverse and include sponges, tunicates, corals, mollusks, fungi, and sediment-derived bacteria. Marine organisms can produce a plethora of small molecules with novel chemical structures and potent biological properties, being a rich source for the discovery of pharmacologically active compounds, already with several marine-derived agents approved as drugs. Ziconotide, a peptide originally discovered in a tropical cone snail, was the first marine-derived compound to be approved in the United States in December 2004 for the treatment of pain. Then, in October 2007, Trabectedin became the first marine anticancer drug to be approved in the European Union. MCE offers a unique collection of 61 marine-sourced natural products which can be used for drug discovery for high throughput screening (HTS) and high content screening (HCS). MCE marine-sourced natural product library is an important source for drug discovery and development.

Marine-Sourced Natural Product Library

61 compounds

Oceans cover more than 70% of the Earth’s surface and host a huge species diversity. Marine organisms are considered the most recent source of bioactive natural products after terrestrial plants and nonmarine microorganisms. Marine biological sources are taxonomically diverse and include sponges, tunicates, corals, mollusks, fungi, and sediment-derived bacteria.

Marine organisms can produce a plethora of small molecules with novel chemical structures and potent biological properties, being a rich source for the discovery of pharmacologically active compounds, already with several marine-derived agents approved as drugs. Ziconotide, a peptide originally discovered in a tropical cone snail, was the first marine-derived compound to be approved in the United States in December 2004 for the treatment of pain. Then, in October 2007, Trabectedin became the first marine anticancer drug to be approved in the European Union.

MCE offers a unique collection of 61 marine-sourced natural products which can be used for drug discovery for high throughput screening (HTS) and high content screening (HCS). MCE marine-sourced natural product library is an important source for drug discovery and development.

Cat. No.	Product Name	Type

HY-D1433

FITC-C6-LEHD-FMK	Fluorescent Dyes/Probes
FITC-C6-LEHD-FMK, a fluorescently labeled caspase-9 inhibitor, can be used for detection of active caspase-9 in mammalian cells undergoing apoptosis. FITC-C6-LEHD-FMK provides a convenient means for sensitive detection of activated caspase-9 in living cells. Z-LEHD-FMK is a specific caspase-9 inhibitor .

Cat. No.	Product Name	Type

HY-NP143

Nerve Growth Factor 2.5S,murine submaxillary gland	Native Proteins
Nerve Growth Factor 2.5S, murine submaxillary gland is a neurotrophic polypeptide required for normal growth and development of sympathetic and embryonic sensory neurons and certain cholinergic neurons in the central nervous system. Nerve Growth Factor 2.5S, murine submaxillary gland has only β-subunit , and shows nerve growth-promoting activity .

HY-159671

3D-Monophosphoryl Lipid (14) 3D-MPL (14)	Drug Delivery
3D-Monophosphoryl Lipid (14) (3D-Monophosphoryl Lipid (14)) is a TLR4 agonist that can be used as a vaccine adjuvant to enhance the immunogenicity of vaccines .

Cat. No.	Product Name	Target	Research Area

HY-P1039A

R18 TFA PHCVPRDLSWLDLEANMCLP TFA	Raf	Cancer
R18 TFA is a peptide antagonists of *14-3-3, with a K_D of 70-90 nM. R18 efficiently blocks the binding of 14-3-3* to the kinase Raf-1, a physiological ligand of 14-3-3, and effectively abolished the protective role of 14-3-3 against phosphatase-induced inactivation of Raf-1 .

HY-P1380A

Difopein TFA	Apoptosis	Cancer
Difopein TFA, a specific and competitive inhibitor of 14-3-3 protein (a highly conserved eukaryotic regulatory molecule), blocking the ability of 14-3-3 to bind to target proteins and inhibits 14-3-3/Ligand interactions. Difopein TFA is not cell permeable. Difopein TFA leads to induction of apoptosis and enhances the ability of Cisplatin (HY-17394) to kill cells .

HY-P1433

[Pro3]-GIP (Rat)	Insulin Receptor	Metabolic Disease
[Pro3]-GIP (Rat) is a selective GIP receptor partial agonist with a K_i of 13 nM. [Pro3]-GIP (Rat) can be used in diabetes research .

HY-P1039

R18 PHCVPRDLSWLDLEANMCLP	Raf	Cancer
R18 is a peptide antagonists of *14-3-3, with a K_D of 70-90 nM. R18 efficiently blocks the binding of 14-3-3* to the kinase Raf-1, a physiological ligand of 14-3-3, and effectively abolished the protective role of 14-3-3 against phosphatase-induced inactivation of Raf-1 .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N1433

Phytolaccagenin	Triterpenes Classification of Application Fields Terpenoids Source classification Phytolacca acinosa Roxb. Plants Inflammation/Immunology Disease Research Fields Phytolaccaceae	Bacterial
Phytolaccagenin, a triterpenoid saponin, is the active component of Radix Phytolaccae. Phytolcaccagenin has antifungal activity, anti-inflammatory activity and lower toxicity

HY-122815

Fusicoccin Fusicoccin A	Microorganisms Classification of Application Fields Terpenoids Source classification Diterpenoids Disease Research Fields Cancer	Apoptosis
Fusicoccin (Fusicoccin A), a fungal pytotoxin, is a stabilizer of specific *14-3-3* protein-protein interactions. Fusicoccin sabilizes H ⁺-ATPase/14-3-3 cmplex in pants, maintaining the enzyme in activated state. Fusicoccin also stabilizes 14-3-3 protein interactions with binding partners containing a C-terminal 14-3-3 recognition motif (a mode 3 motif), such as ERα, GPIbα, TASK3, CTFR, and p53. Fusicoccin induces apoptosis in cancer cells and has anticancer activity .

HY-N1433R

Phytolaccagenin (Standard)	Triterpenes Terpenoids Source classification Phytolacca acinosa Roxb. Plants Phytolaccaceae	Reference Standards Bacterial
Phytolaccagenin (Standard) is the analytical standard of Phytolaccagenin. This product is intended for research and analytical applications. Phytolaccagenin, a triterpenoid saponin, is the active component of Radix Phytolaccae. Phytolcaccagenin has antifungal activity, anti-inflammatory activity and lower toxicity

HY-N13798

ADHPE	Zingiber officinale Roscoe Source classification Phenols Polyphenols Plants Zingiberaceae	NF-κB Biochemical Assay Reagents
ADHPE is a stabilizer of 14-3-3σ and p65 protein complex. ADHPE inhibits NF-κB (p65) signaling pathway and reduces the inflammatory response. ADHPE can be used for pediatric pneumonia-related acute lung injury and acute respiratory distress syndrome study .

Species:	Human (13) Mouse (6) Cynomolgus (1)
Tag:	His (10) SUMO (1) Tag Free (5) Myc (1) GST (5)
Source:	Sf9 insect cells (3) P. pastoris (2) E. coli (15)

Cat. No.	Compare	Product Name	Species	Source

HY-P75548A

	14-3-3 theta Protein, Human (His) 14-3-3 protein theta	Human	E. coli
	14-3-3 theta proteins are adapters in multiple signaling pathways that recognize phosphoserine or phosphothreonine motifs and modulate chaperone activity upon binding. It negatively regulates PDPK1 kinase activity, forms homodimers, and interacts with CDK16, phosphorylated RGS7, SSH1, phosphorylated CDKN1B, GAB2, phosphorylated PDPK1, and phosphorylated DAPK2. 14-3-3 theta Protein, Human (His) is the recombinant human-derived 14-3-3 theta protein, expressed by E. coli , with N-6His labeled tag.

HY-P74438

	14-3-3 sigma Protein, Mouse 14-3-3 protein sigma; HME1; SFN; Stratifin; Mkrn3	Mouse	E. coli
	14-3-3 sigma proteins are adapter proteins in various signaling pathways that bind to phosphoserine or phosphothreonine motifs to regulate chaperone activity. When bound to KRT17, it stimulates the regulation of protein synthesis and cell growth through the Akt/mTOR pathway. 14-3-3 sigma Protein, Mouse is the recombinant mouse-derived 14-3-3 sigma protein, expressed by E. coli , with tag free.

HY-P75549

	14-3-3 epsilon Protein, Mouse (His) 14-3-3 protein epsilon, N-GST; YWHAE; 14-3-3E	Mouse	E. coli
	14-3-3 epsilon proteins are adapter proteins in various signaling pathways that bind to phosphoserine or phosphothreonine motifs to regulate chaperone activity.It positively regulates HSF1 nuclear export to the cytoplasm, forming homo- and heterodimers with YWHAZ.14-3-3 epsilon Protein, Mouse (His) is the recombinant mouse-derived 14-3-3 epsilon protein, expressed by E.coli , with N-6*His labeled tag.

HY-P71682

	14-3-3 eta Protein, Human (GST) 14-3-3 protein eta; Brain protein 14-3-3; eta isoform; HGNC:12853; Protein AS1; YWHA 1; YWHA1; Ywhah	Human	E. coli
	YWHAH proteins are adapter proteins in multiple signaling pathways that recognize phosphoserine or phosphothreonine motifs and regulate chaperone activity upon binding. It negatively regulates PDPK1 kinase activity and interacts with nuclear hormone receptors (AR, ESR1, ESR2, MC2R, NR3C1, NRIP1, PPARBP, THRA) and cofactors. 14-3-3 eta Protein, Human (GST) is the recombinant human-derived YWHAH protein, expressed by E. coli , with N-GST labeled tag.

HY-P74440

	14-3-3 beta Protein, Human KCIP-1; 14-3-3 protein beta/alpha; GW128; Protein 1054; YWHAB	Human	E. coli
	14-3-3 beta proteins serve as adapter proteins that regulate multiple signaling pathways by recognizing phosphoserine or phosphothreonine motifs and regulating chaperone activity. It acts as a negative regulator during osteogenesis, inhibiting nuclear translocation of SRPK2 and preventing neuronal apoptosis. 14-3-3 beta Protein, Human is the recombinant human-derived 14-3-3 beta protein, expressed by E. coli , with tag free.

HY-P75550

	14-3-3 beta Protein, Cynomolgus KCIP-1; 14-3-3 protein beta/alpha; GW128; Protein 1054; YWHAB	Cynomolgus	E. coli
	14-3-3 beta proteins act as adapters, binding to phosphoserine or phosphothreonine motifs in different signaling pathways, regulating chaperone activity. It negatively regulates osteogenesis by blocking the nuclear translocation of phosphorylated SRPK2 and counteracting the pro-apoptotic effect of SRPK2 through cyclin D1 expression. 14-3-3 beta Protein, Cynomolgus is the recombinant cynomolgus-derived 14-3-3 beta protein, expressed by E. coli , with tag free.

HY-P703012

	14-3-3 theta Protein, Mouse (sf9, His) 14-3-3 protein theta; 14-3-3 protein tau; Ywhaq	Mouse	Sf9 insect cells
	14-3-3 theta Protein, Mouse (sf9, His) is the recombinant mouse-derived 14-3-3 theta protein, expressed by Sf9 insect cells, with His tag.

HY-P75548

	14-3-3 theta Protein, Human (GST) 14-3-3 protein theta; 14-3-3 protein tau; Protein HS1; YWHAQ	Human	E. coli
	14-3-3 theta proteins are adapters in multiple signaling pathways that recognize phosphoserine or phosphothreonine motifs and modulate chaperone activity upon binding. It negatively regulates PDPK1 kinase activity, forms homodimers, and interacts with CDK16, phosphorylated RGS7, SSH1, phosphorylated CDKN1B, GAB2, phosphorylated PDPK1, and phosphorylated DAPK2. 14-3-3 theta Protein, Human (GST) is the recombinant human-derived 14-3-3 theta protein, expressed by E. coli , with N-GST labeled tag.

HY-P702997

	14-3-3 zeta Protein, Human 14-3-3 zeta; YWHAZ; KCIP-1; MGC111427; MGC126532; MGC138156	Human	E. coli
	14-3-3 zeta Protein, Human is the recombinant human-derived 14-3-3 zeta, expressed by E. coli, with tag free labeled tag.

HY-P702996

	14-3-3 zeta Protein, Human (sf9, His) 14-3-3 zeta; YWHAZ; KCIP-1; MGC111427; MGC126532; MGC138156	Human	Sf9 insect cells
	14-3-3 zeta Protein, Human (sf9, His) is the recombinant human-derived 14-3-3 zeta, expressed by Sf9 insect cells, with His labeled tag.

HY-P74439

	14-3-3 beta Protein, Human (GST) KCIP-1; 14-3-3 protein beta/alpha; GW128; Protein 1054; YWHAB	Human	E. coli
	14-3-3 beta proteins serve as adapter proteins that regulate multiple signaling pathways by recognizing phosphoserine or phosphothreonine motifs and regulating chaperone activity. It acts as a negative regulator during osteogenesis, inhibiting nuclear translocation of SRPK2 and preventing neuronal apoptosis. 14-3-3 beta Protein, Human (GST) is the recombinant human-derived 14-3-3 beta protein, expressed by E. coli , with N-GST labeled tag.

HY-P700304

	14-3-3 beta Protein, Human (His) KCIP-1; 14-3-3 protein beta/alpha; GW128; Protein 1054; YWHAB	Human	E. coli
	14-3-3 beta proteins serve as adapter proteins that regulate multiple signaling pathways by recognizing phosphoserine or phosphothreonine motifs and regulating chaperone activity. It acts as a negative regulator during osteogenesis, inhibiting nuclear translocation of SRPK2 and preventing neuronal apoptosis. 14-3-3 beta Protein, Human (His) is the recombinant human-derived 14-3-3 beta protein, expressed by E. coli , with N-6*His labeled tag.

HY-P703013

	14-3-3 zeta Protein, Mouse (sf9, His) 14-3-3 protein zeta/delta; Protein kinase C inhibitor protein 1 (KCIP-1); SEZ-2; Ywhaz	Mouse	Sf9 insect cells
	14-3-3 zeta Protein, Mouse (sf9, His) is the recombinant mouse-derived 14-3-3 zeta, expressed by Sf9 insect cells, with His labeled tag.

HY-P7445

	14-3-3 epsilon Protein, Human (GST) rHu14-3-3 protein epsilon, N-GST; YWHAE	Human	E. coli
	14-3-3 epsilon Protein, Human (GST) is a mediator that guides chondrocytes toward an inflammatory phenotype with GST tag.

HY-P702995

	14-3-3 zeta Protein, Human (GST) Proto-oncogene vav; VAV1; VAV	Human	E. coli
	14-3-3 zeta Protein, Human (GST) is the recombinant human-derived 14-3-3 zeta, expressed by E. coli, with GST labeled tag.

HY-P71339

	Stratifin Protein, Human 1 Publications Verification 14-3-3 Protein Sigma; Epithelial Cell Marker Protein 1; Stratifin; SFN; HME1	Human	E. coli
	Stratifin (14-3-3 sigma), encoded by SFN, functions as a multifaceted adapter protein that binds to partners through phosphoserine or phosphothreonine motifs and participates in a variety of cellular processes. It regulates epithelial cell growth and protein synthesis through keratin 17 (KRT17), and may affect MDM2 autoubiquitination and activate p53. Stratifin Protein, Human is the recombinant mouse-derived Stratifin protein, expressed by E. coli , with tag free.

HY-P700308

	Stratifin Protein, Human (N-His, C-Myc) 14-3-3 Protein Sigma; Epithelial Cell Marker Protein 1; Stratifin; SFN; HME1	Human	E. coli
	Stratifin (14-3-3 sigma), encoded by SFN, functions as a multifaceted adapter protein that binds to partners through phosphoserine or phosphothreonine motifs and participates in a variety of cellular processes. It regulates epithelial cell growth and protein synthesis through keratin 17 (KRT17), and may affect MDM2 autoubiquitination and activate p53. Stratifin Protein, Human (N-His, C-Myc) is the recombinant human-derived Stratifin protein, expressed by E. coli , with N-10*His, C-Myc labeled tag.

HY-P71850

	KCIP-1 Protein, Mouse (P.pastoris, His) Ywhab; 14-3-3 protein beta/alpha; Protein kinase C inhibitor protein 1; KCIP-1	Mouse	P. pastoris
	KCIP-1 protein serves as the linker of TNFRSF1A/TNFR1 and mediates its interaction with FADD. Overexpression induces TNF-induced responses: apoptosis and NF-κ-B activation. KCIP-1 Protein, Mouse (P.pastoris, His) is the recombinant mouse-derived KCIP-1 protein, expressed by P. pastoris , with N-6*His labeled tag.

HY-P71850Y

	KCIP-1 Protein, Mouse (P.pastoris, His, solution) Ywhab; 14-3-3 protein beta/alpha; Protein kinase C inhibitor protein 1; KCIP-1	Mouse	P. pastoris
	KCIP-1 protein serves as the linker of TNFRSF1A/TNFR1 and mediates its interaction with FADD. Overexpression induces TNF-induced responses: apoptosis and NF-κ-B activation. KCIP-1 Protein, Mouse (P.pastoris, His, solution) is the recombinant mouse-derived KCIP-1 protein, expressed by P. pastoris , with N-6*His labeled tag.

HY-P72226

	HJURP Protein, Human (His-SUMO) HJURP; FAKTS; FLEG1; URLC9; Holliday junction recognition protein; 14-3-3-associated AKT substrate; Fetal liver-expressing gene 1 protein; Up-regulated in lung cancer 9	Human	E. coli
	The HJURP protein is a centromeric factor that plays a critical role in centromeric integration and maintenance of CENPA. As a chaperone, it ensures the integration of newly synthesized CENPA into nucleosomes at replicating centromeres. HJURP Protein, Human (His-SUMO) is the recombinant human-derived HJURP protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag.

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HY-B1433S

Perindoprilat-d3 disodium
Perindoprilat-d₃ disodium is deuterated labeled Perindoprilat (HY-B1433). Perindoprilat (S 9780) is an angiotensin-converting enzyme (ACE) inhibitor with the IC₅₀ value ranging from 1.5 to 3.2 nM. Perindoprilat can be used in hypertension research .

Cat. No.	Compare	Product Name	Application	Reactivity

HY-P82210

	14-3-3 theta Antibody (YA1955) YWHAQ; 14-3-3 protein theta; 14-3-3 protein T-cell; 14-3-3 protein tau; Protein HS1	WB	Human, Mouse, Rat
	14-3-3 theta Antibody (YA1955) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to 14-3-3 theta.

HY-P82909

	14-3-3 sigma Antibody (YA2654) SFN; HME1; 14-3-3 protein sigma; Epithelial cell marker protein 1; Stratifin	WB, IHC-P	Human, Rat
	14-3-3 sigma Antibody (YA2654) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to 14-3-3 sigma.

HY-P82884

	14-3-3 epsilon Antibody (YA2629) 14-3-3 epsilon; 14-3-3E; 143E; KCIP-1; MDCR; Protein kinase C inhibitor protein-1; YWHAE	WB, IHC-P, ICC/IF, FC	Human, Mouse, Rat
	14-3-3 epsilon Antibody (YA2629) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to 14-3-3 epsilon.

HY-P80525

	14-3-3 eta Antibody (YA838) 14-3-3 protein eta; 1433F_HUMAN; Brain protein 14-3-3; eta isoform; HGNC:12853; Protein AS1; Tyrosine 3/tryptophan 5 monooxygenase activation protein eta polypeptide; YWHA 1; YWHA1; Ywhah.	WB	Human, Mouse, Rat
	14-3-3 eta Antibody (YA838) is a Mouse-derived and non-conjugated IgG monoclonal antibody, targeting to 14-3-3 eta.

HY-P84258

	14-3-3 beta Antibody (YA3955) HS1; GW128; YWHAA; KCIP-1; HEL-S-1	WB, IHC-P, ICC/IF, FC, ELISA	Human, Mouse, Rat
	14-3-3 beta Antibody (YA3955) is a Mouse-derived and non-conjugated IgG2b monoclonal antibody, targeting to 14-3-3 beta.

HY-P81688

	TARBP2 Antibody (YA1433) LOQS; Prbp; tarbp2; TRBP; TRBP1; TRBP2	WB, IHC-P, ICC/IF, IP, FC	Human, Mouse, Rat
	TARBP2 Antibody (YA1433) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to TARBP2.

HY-P84223

	14-3-3 theta Antibody (YA3920) 1C5; HS1; 14-3-3	WB, ELISA	Human, Mouse, Rat, Monkey
	14-3-3 theta Antibody (YA3920) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to 14-3-3 theta.

HY-P85780

	14-3-3 eta Antibody (YA5472) 14-3-3 protein eta; Protein AS1;	WB, IHC-P	Human, Mouse, Rat
	14-3-3 eta Antibody (YA5472) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to 14-3-3 eta.

HY-P82923

	14-3-3 gamma Antibody (YA2668) YWHAG; 14-3-3 protein gamma; Protein kinase C inhibitor protein 1; KCIP-1	WB	Human, Mouse, Rat
	14-3-3 gamma Antibody (YA2668) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to 14-3-3 gamma.

HY-P82204

	14-3-3 beta Antibody (YA1949) YWHAB; 14-3-3 protein beta/alpha; Protein 1054; Protein kinase C inhibitor protein 1; KCIP-1	WB	Human, Rat
	14-3-3 beta Antibody (YA1949) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to 14-3-3 beta.