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2-Deoxyuridine

" in MedChemExpress (MCE) Product Catalog:

48

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2

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1

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4

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9

Isotope-Labeled Compounds

4

Click Chemistry

16

Oligonucleotides

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-D0186
    2'-Deoxyuridine
    1 Publications Verification

    		 Endogenous Metabolite Thymidylate Synthase Infection
    2’-deoxyuridine is a brain-penetrant pyrimidines nucleotide that is associated with nervous system diseases. 2'-Deoxyuridine could increase chromosome breakage and results in a decreased thymidylate synthetase activity. 2'-Deoxyuridine is a precursor in the synthesis of Edoxudine (HY-B1011) and also an analogue of 5-ethynyl-2'-deoxyuridine, EdU (HY-118411). 2’-deoxyuridine reduces microglial activation and improve oxidative stress damage by modulating glycolytic metabolism on the Aβ25-35-induced brain injury, which is promising for research of Alzheimer’s disease (AD) [2] .
    2'-Deoxyuridine
  • HY-W011142
    2'-Deoxyuridine 5'-monophosphate disodium

    		Endogenous Metabolite Metabolic Disease
    2'-Deoxyuridine 5'-monophosphate disodium is reductively methylated to dTMP (2'-deoxythymidine 5'-monophosphate) by bisubstrate enzyme thymidylate synthase (TS). dTMP is a nucleotide required for DNA synthesis .
    2'-Deoxyuridine 5'-monophosphate disodium
  • HY-154329
    2-Deoxyuridine

    		Nucleoside Antimetabolite/Analog Cancer
    2-Deoxyuridine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc .
    2-Deoxyuridine
  • HY-D0186R
    2'-Deoxyuridine (Standard)

    		Endogenous Metabolite Thymidylate Synthase Infection
    2'-Deoxyuridine (Standard) is the analytical standard of 2'-Deoxyuridine. This product is intended for research and analytical applications. 2’-deoxyuridine is a brain-penetrant pyrimidines nucleotide that is associated with nervous system diseases. 2'-Deoxyuridine could increase chromosome breakage and results in a decreased thymidylate synthetase activity. 2'-Deoxyuridine is a precursor in the synthesis of Edoxudine (HY-B1011) and also an analogue of 5-ethynyl-2'-deoxyuridine, EdU (HY-118411). 2’-deoxyuridine reduces microglial activation and improve oxidative stress damage by modulating glycolytic metabolism on the Aβ25-35-induced brain injury, which is promising for research of Alzheimer’s disease (AD) [2] . In Vitro:The interaction between the 2-deoxyuridine and the column increases the duration of retention of 2-deoxyuridine [2].
    Gradient elution with sodium acetate buffer-ACN eluent on two ZIC-HILIC homemade columns separates 2-deoxyuridine in under 9 min [2].
    In Vivo:2'-Deoxyuridine (34.42 ng/mL, gavage, 15 min) passes the blood-brain barrier (BBB) to enter the hippocampus of mice brain .
    2'-Deoxyuridine (20 mg/kg, gavage, daily for 4 weeks) improves cognition and memory loss and attenuates the damage to the hippocampus in Aβ25-35-induced mice model .
    2'-Deoxyuridine (Standard)
  • HY-D0186S5
    2'-Deoxyuridine-d

    		Isotope-Labeled Compounds Endogenous Metabolite Infection
    2'-Deoxyuridine-d is the deuterium labeled 2'-Deoxyuridine. 2'-Deoxyuridine could increase chromosome breakage and results in a decreased thymidylate synthetase activity. A known use of 2'-Deoxyuridine is as a precursor in the synthesis of Edoxud[1]<
    2'-Deoxyuridine-d
  • HY-D0186S4
    2'-Deoxyuridine-d2

    		Isotope-Labeled Compounds Endogenous Metabolite Infection
    2'-Deoxyuridine-d2 is the deuterium labeled 2'-Deoxyuridine. 2'-Deoxyuridine could increase chromosome breakage and results in a decreased thymidylate synthetase activity. A known use of 2'-Deoxyuridine is as a precursor in the synthesis of Edoxud[1]
    2'-Deoxyuridine-d2
  • HY-D0186S1
    2'-Deoxyuridine-2′-13C

    		Isotope-Labeled Compounds Endogenous Metabolite Infection
    2'-Deoxyuridine-2′- 13C is the 13C labeled 2'-Deoxyuridine. 2'-Deoxyuridine could increase chromosome breakage and results in a decreased thymidylate synthetase activity. A known use of 2'-Deoxyuridine is as a precursor in the synthesis of Edoxud[1]
    2'-Deoxyuridine-2′-13C
  • HY-D0186S
    2'-Deoxyuridine-1′-13C

    		Isotope-Labeled Compounds Endogenous Metabolite Infection
    2'-Deoxyuridine-1′- 13C is the 13C labeled 2'-Deoxyuridine. 2'-Deoxyuridine could increase chromosome breakage and results in a decreased thymidylate synthetase activity. A known use of 2'-Deoxyuridine is as a precursor in the synthesis of Edoxud[1]
    2'-Deoxyuridine-1′-13C
  • HY-D0186S2
    2'-Deoxyuridine-3′-13C

    		Isotope-Labeled Compounds Endogenous Metabolite Infection
    2'-Deoxyuridine-3′- 13C is the 13C labeled 2'-Deoxyuridine. 2'-Deoxyuridine could increase chromosome breakage and results in a decreased thymidylate synthetase activity. A known use of 2'-Deoxyuridine is as a precursor in the synthesis of Edoxud[1]
    2'-Deoxyuridine-3′-13C
  • HY-D0186S3
    2'-Deoxyuridine-5′-13C

    		Isotope-Labeled Compounds Endogenous Metabolite Infection
    2'-Deoxyuridine-5′- 13C is the 13C labeled 2'-Deoxyuridine. 2'-Deoxyuridine could increase chromosome breakage and results in a decreased thymidylate synthetase activity. A known use of 2'-Deoxyuridine is as a precursor in the synthesis of Edoxud[1]
    2'-Deoxyuridine-5′-13C
  • HY-D0186S8
    2'-Deoxyuridine-d2-1

    		Endogenous Metabolite Infection
    2'-Deoxyuridine-d2-1 is the deuterium labeled 2'-Deoxyuridine[1]. 2'-Deoxyuridine could increase chromosome breakage and results in a decreased thymidylate synthetase activity. A known use of 2'-Deoxyuridine is as a precursor in the synthesis of Edoxudine[2].
    2'-Deoxyuridine-d2-1
  • HY-D0186S7
    2'-Deoxyuridine-13C,15N2

    		Endogenous Metabolite Infection
    2'-Deoxyuridine- 13C, 15N2 is the 13C and 15N labeled 2'-Deoxyuridine[1]. 2'-Deoxyuridine could increase chromosome breakage and results in a decreased thymidylate synthetase activity. A known use of 2'-Deoxyuridine is as a precursor in the synthesis of Edoxudine[2].
    2'-Deoxyuridine-13C,15N2
  • HY-129983
    5-Hydroxymethyl-2'-deoxyuridine

    		HSV Infection Cancer
    5-Hydroxymethyl-2'-deoxyuridine is a nucleoside analog. 5-Hydroxymethyl-2'-deoxyuridine inhibits the replication of multiple human leukemia cell lines with IC50 values of 1.7-5.8 μM. 5-Hydroxymethyl-2'-deoxyuridine prolongs the survival of mice carrying L1210 leukemia. 5-Hydroxymethyl-2'-deoxyuridine can be used for the research of cell replication and leukemia [2] .
    5-Hydroxymethyl-2'-deoxyuridine
  • HY-W424779R
    5-Carboxy-2′-deoxyuridine (Standard)

    		Drug Metabolite Infection
    5-Carboxy-2′-deoxyuridine (Standard) is the analytical standard of 5-Carboxy-2′-deoxyuridine. This product is intended for research and analytical applications. 5-Carboxy-2′-deoxyuridine is a metabolite of Trifluridine . 5-Carboxy-2′-deoxyuridine is a methyl oxidation product of Thymidine that can be formed by menadione-mediated photosensitization of Thymidine [2].
    5-Carboxy-2′-deoxyuridine (Standard)
  • HY-W424779
    5-Carboxy-2′-deoxyuridine

    		Drug Metabolite Infection
    5-Carboxy-2′-deoxyuridine is a metabolite of Trifluridine . 5-Carboxy-2′-deoxyuridine is a methyl oxidation product of Thymidine that can be formed by menadione-mediated photosensitization of Thymidine [2].
    5-Carboxy-2′-deoxyuridine
  • HY-W341499
    5-Formyl-2'-deoxyuridine

    		Endogenous Metabolite Others
    5-Formyl-2'-deoxyuridine is a product formed when the 5-methyl group of thymine in DNA undergoes oxidation due to exposure to gamma radiation or certain chemical agents. Serving as a biomarker of oxidative DNA damage, 5-formyl-2'-deoxyuridine is employed in investigations of DNA damage and repair mechanisms. Additionally, 5-Formyl-2'-deoxyuridine can be used in studies involving chemically crosslinking with peptides derived from the RecA protein .
    5-Formyl-2'-deoxyuridine
  • HY-118411
    5-Ethynyl-2'-deoxyuridine
    10+ Cited Publications

    		 PROTAC Linkers Cancer
    5-Ethynyl-2'-deoxyuridine (EdU), a thymidine analogue, is incorporated into cellular DNA during DNA replication and the subsequent reaction of EdU with a fluorescent azide in a “Click” reaction. EdU staining is a fast, sensitive and reproducible method to study cell proliferation . 5-Ethynyl-2'-deoxyuridine is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs [2]. 5-Ethynyl-2'-deoxyuridine is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
    5-Ethynyl-2'-deoxyuridine
  • HY-130801
    5-Hydroxy-2'-deoxyuridine

    5-OHdU

    		 Endogenous Metabolite Metabolic Disease
    5-Hydroxy-2'-deoxyuridine (5-OHdU) is a major stable oxidation product of 2'-Deoxycytidine. 5-Hydroxy-2'-deoxyuridine can be incorporated into DNA in vitro by DNA polymerase .
    5-Hydroxy-2'-deoxyuridine
  • HY-135957
    2'-Azido-2'-deoxyuridine

    N3dUrd

    		 DNA/RNA Synthesis Cancer
    2'-Azido-2'-deoxyuridine (N3dUrd) is a ribonucleotide reductase inhibitor. 2'-Azido-2'-deoxyuridine has anti-cancer activity . 2'-Azido-2'-deoxyuridine is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    2'-Azido-2'-deoxyuridine
  • HY-W190976
    5-Vinyl-2'-deoxyuridine

    5-VINYL-DURD

    		 DNA/RNA Synthesis Apoptosis Cancer
    5-Vinyl-2'-deoxyuridine (5-VINYL-DURD), a thymidine analogue, is incorporated into cellular DNA during DNA replication. 5-Vinyl-2'-deoxyuridine is a click chemistry reagent, it contains an Alkyne group and induces DNA damage leads to apoptosis in human cultured cells .
    5-Vinyl-2'-deoxyuridine
  • HY-W154172
    2′-Chloro-2′-deoxyuridine

    		Nucleoside Antimetabolite/Analog Cancer
    2′-Chloro-2′-deoxyuridine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc .
    2′-Chloro-2′-deoxyuridine
  • HY-154120
    6-Aza-2'-deoxyuridine

    		Nucleoside Antimetabolite/Analog Cancer
    6-Aza-2'-deoxyuridine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc .
    6-Aza-2'-deoxyuridine
  • HY-112669
    5-Chloro-2'-deoxyuridine
    1 Publications Verification

    5-ChloroDeoxyuridine; CldU

    		 Nucleoside Antimetabolite/Analog Neurological Disease
    5-Chloro-2'-deoxyuridine, a thymine analog, is to study the potential of hypochlorous acid damage to DNA and DNA precursors.
    5-Chloro-2'-deoxyuridine
  • HY-154253
    5-Azidomethyl-2'-deoxyuridine

    5-AmdU; α-Azidothymidine

    		 Nucleoside Antimetabolite/Analog Cancer
    5-Azidomethyl-2'-deoxyuridine (5-AmdU) is a purine nucleoside analog. 5-Azidomethyl-2'-deoxyuridine demonstrates effective radiosensitization in EMT6 tumor cells. . 5-Azidomethyl-2'-deoxyuridine is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    5-Azidomethyl-2'-deoxyuridine
  • HY-154533
    3’-O-Acetyl-2’-deoxyuridine

    		Nucleoside Antimetabolite/Analog Cancer
    3’-O-Acetyl-2’-deoxyuridine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc .
    3’-O-Acetyl-2’-deoxyuridine
  • HY-154239
    5’-O-Triphenylmethyl-2’-deoxyuridine

    		Nucleoside Antimetabolite/Analog Cancer
    5’-O-Triphenylmethyl-2’-deoxyuridine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc .
    5’-O-Triphenylmethyl-2’-deoxyuridine
  • HY-154026
    5-Amino-2'-deoxyuridine monohydrochloride

    		Nucleoside Antimetabolite/Analog Cancer
    5-Amino-2'-deoxyuridine (monohydrochloride) is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc .
    5-Amino-2'-deoxyuridine monohydrochloride
  • HY-48873
    5'-O-DMT-5-Ethynyl-2'-deoxyuridine 3'-CE phosphoramidite

    		DNA/RNA Synthesis Others
    5'-O-DMT-5-Ethynyl-2'-deoxyuridine 3'-CE phosphoramidite is a phosphorite monomer that can be used in the synthesis of oligonucleotides.
    5'-O-DMT-5-Ethynyl-2'-deoxyuridine 3'-CE phosphoramidite
  • HY-W097792
    5'-O-(4,4'-Dimethoxytrityl)-2'-deoxyuridine

    5'-O-DMT-dU

    		 DNA/RNA Synthesis Others
    5'-O-(4,4'-Dimethoxytrityl)-2'-deoxyuridine (5'-O-DMT-dU) is a competitive inhibitor of E. coli dUTP nucleotidohydrolase (dUTPase), with the Ki higher than 1000 μM. 5'-O-(4,4'-Dimethoxytrityl)-2'-deoxyuridine can be used in machine-assisted DNA synthesis by synthesizing nucleosidic phosphoramidite blocks [2].
    5'-O-(4,4'-Dimethoxytrityl)-2'-deoxyuridine
  • HY-W553730
    2’-Deoxy-2’-iodouridine; 2’-Iodo-2’-deoxyuridine

    		Nucleoside Antimetabolite/Analog Cancer
    2’-Deoxy-2’-iodouridine; 2’-Iodo-2’-deoxyuridine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc .
    2’-Deoxy-2’-iodouridine; 2’-Iodo-2’-deoxyuridine
  • HY-W141338
    2′-Bromo-2′-deoxyuridine

    2'-Bromo-2'-deoxy-D-uridine

    		 Nucleoside Antimetabolite/Analog Cancer
    2′-Bromo-2′-deoxyuridine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc .
    2′-Bromo-2′-deoxyuridine
  • HY-W251781
    4-Thio-2’-deoxyuridine

    2′-Deoxy-4-thiouridine; 4-ThioDeoxyuridine

    		 Nucleoside Antimetabolite/Analog Cancer
    4-Thio-2’-deoxyuridine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc .
    4-Thio-2’-deoxyuridine
  • HY-154423
    2′-Azido-5′-O-[bis(4-methoxyphenyl)phenylmethyl]-2′-deoxyuridine

    		Nucleoside Antimetabolite/Analog Cancer
    2′-Azido-5′-O-[bis(4-methoxyphenyl)phenylmethyl]-2′-deoxyuridine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc . 2′-Azido-5′-O-[bis(4-methoxyphenyl)phenylmethyl]-2′-deoxyuridine is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    2′-Azido-5′-O-[bis(4-methoxyphenyl)phenylmethyl]-2′-deoxyuridine
  • HY-B0307A
    Idoxuridine hydrate

    5-Iodo-2′-Deoxyuridine hydrate; 5-IUdR hydrate; IdUrd hydrate

    		 Phosphatase Infection Cancer
    Idoxuridine (5-Iodo-2′-deoxyuridine, 5-IUdR, IdUrd) hydrate is an iodinated thymidine analogue that competitively inhibits phosphorylases. Idoxuridine can inhibit viral activity, particularly viral eye infections, including herpes simplex keratitis, by inhibiting DNA polymerase and affecting viral replication. Idoxuridine against feline herpesvirus has the IC50 value of 4.3 μM .
    Idoxuridine hydrate
  • HY-154160
    5-(2-Hydroxyethyl)-2’,3’-di-O-toluoyl-2’-deoxyuridine

    		Nucleoside Antimetabolite/Analog Cancer
    5-(2-Hydroxyethyl)-2’,3’-di-O-toluoyl-2’-deoxyuridine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc .
    5-(2-Hydroxyethyl)-2’,3’-di-O-toluoyl-2’-deoxyuridine
  • HY-B0307
    Idoxuridine
    5 Publications Verification

    5-Iodo-2′-Deoxyuridine; 5-IUdR; IdUrd

    		 Phosphatase Orthopoxvirus Infection Cancer
    Idoxuridine (5-Iodo-2′-deoxyuridine, 5-IUdR, IdUrd) is an iodinated thymidine analogue that competitively inhibits phosphorylases. Idoxuridine can inhibit viral activity, particularly viral eye infections, including herpes simplex keratitis, by inhibiting DNA polymerase and affecting viral replication. Idoxuridine against feline herpesvirus has the IC50 value of 4.3 μM . Idoxuridine shows anti-orthopoxvirus activity.
    Idoxuridine
  • HY-154424
    2′-Amino-5′-O-[bis(4-methoxyphenyl)phenylmethyl]-2′-deoxyuridine

    		Nucleoside Antimetabolite/Analog Cancer
    2′-Amino-5′-O-[bis(4-methoxyphenyl)phenylmethyl]-2′-deoxyuridine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc .
    2′-Amino-5′-O-[bis(4-methoxyphenyl)phenylmethyl]-2′-deoxyuridine
  • HY-W397503
    5’-O-DMTr-5-iodo-2’-deoxyuridine

    2'-Deoxy-5'-O-DMT-5-iodouridine

    		 Nucleoside Antimetabolite/Analog Cancer
    5’-O-DMTr-5-iodo-2’-deoxyuridine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc .
    5’-O-DMTr-5-iodo-2’-deoxyuridine
  • HY-138253S
    2′,2′-Difluorodeoxyuridine-13C,15N2

    dFdU-13C,15N2; 2',2'-Difluoro-2'-Deoxyuridine-13C,15N2

    		 Isotope-Labeled Compounds Others
    2′,2′-Difluorodeoxyuridine- 13C, 15N2 (dFdU- 13C, 15N2; 2',2'-Difluoro-2'-deoxyuridine- 13C, 15N2) is a 13C- and 15N-labeled compound.
    2′,2′-Difluorodeoxyuridine-13C,15N2
  • HY-154211
    5'-O-DMTr-dU-methyl phosphonamidite

    		DNA/RNA Synthesis Others
    5’-O-DMTr-dU-methyl phosphonamidite; 5’-O-DMTr-2’-deoxyuridine-3’-O-(P-methyl-N,N-diisopropylamino)phosphonamidite is a phosphoramidite that can be used in the synthesis of oligonucleotides.
    5'-O-DMTr-dU-methyl phosphonamidite
  • HY-W017068A
    dUTP sodium

    2'-Deoxyuridine-5'-triphosphate sodium salt

    		 Biochemical Assay Reagents Others
    dUTP sodium is used for PCR.
    dUTP sodium
  • HY-W017068
    dUTP trisodium

    2'-Deoxyuridine-5'-triphosphate trisodium salt

    		 DNA/RNA Synthesis Others
    dUTP trisodium is used for PCR.
    dUTP trisodium
  • HY-15910
    5-BrdU
    Maximum Cited Publications
    56 Publications Verification

    BrdU; 5-Bromo-2'-Deoxyuridine; BUdR

    		 Nucleoside Antimetabolite/Analog DNA/RNA Synthesis Cancer
    5-BrdU (BrdU) is a nucleoside analog that competes with thymidine for incorporation into DNA. 5-BrdU is commonly used in the detection of proliferating cells.
    5-BrdU
  • HY-D1023
    5-BrdUTP sodium salt

    5-Bromo-2'-Deoxyuridine 5'-triphosphate sodium salt

    		 DNA/RNA Synthesis Others
    5-BrdUTP sodium salt is a TdT substrate which can be used to label the DNA double-strand breaks.
    5-BrdUTP sodium salt
  • HY-138253
    2′,2′-Difluorodeoxyuridine

    dFdU; 2',2'-Difluoro-2'-Deoxyuridine

    		 Drug Metabolite Cancer
    2′,2′-Difluorodeoxyuridine (dFdU) is the main metabolite of Gemcitabine (HY-17026). 2′,2′-Difluorodeoxyuridine causes a concentration- and schedule- dependent radiosensitising effect in vitro .
    2′,2′-Difluorodeoxyuridine
  • HY-B0307R
    Idoxuridine (Standard)

    		Phosphatase Orthopoxvirus Infection Cancer
    Idoxuridine (Standard) is the analytical standard of Idoxuridine. This product is intended for research and analytical applications. Idoxuridine (5-Iodo-2′-deoxyuridine, 5-IUdR, IdUrd) is an iodinated thymidine analogue that competitively inhibits phosphorylases. Idoxuridine can inhibit viral activity, particularly viral eye infections, including herpes simplex keratitis, by inhibiting DNA polymerase and affecting viral replication. Idoxuridine against feline herpesvirus has the IC50 value of 4.3 μM . Idoxuridine shows anti-orthopoxvirus activity.
    Idoxuridine (Standard)
  • HY-W014109
    (E)-5-(2-Bromovinyl)pyrimidine-2,4(1H,3H)-dione

    (E)-5-(2-Bromovinyl)uracil; BVU

    		 Others Infection
    (E)-5-(2-Bromovinyl)uracil (BVU) is a pyrimidine base and an inactive metabolite of the antiviral agents sorivudine and (E)-5-(2-bromovinyl)-2'-deoxyuridine (BVDU) that may be regenerated to BVDU in vivo. BVU irreversibly inactivates dihydropyrimidine dehydrogenase (DPD) in an NADPH-dependent manner. It enhances the efficacy of the chemotherapeutic agent and DPD substrate 5-fluorouracil (HY-90006) in a P388 murine leukemia model when administered at a dose of 200 μmol/kg, increasing survival time.
    (E)-5-(2-Bromovinyl)pyrimidine-2,4(1H,3H)-dione
  • HY-P5443
    Pyrrhocoricin

    		Bacterial Others
    Pyrrhocoricin is a biological active peptide. (Antimicrobial activity against Gram-negative bacteria)
    Pyrrhocoricin

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