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5-HT1A receptor antagonist

" in MedChemExpress (MCE) Product Catalog:

By Targets:	5-HT Receptor (126) Adrenergic Receptor (26) Apoptosis (1) Bacterial (4) Biochemical Assay Reagents (1) Calcium Channel (1) Dopamine Receptor (57) Histamine Receptor (3) iGluR (1) Isotope-Labeled Compounds (7) Parasite (1) Phosphodiesterase (PDE) (1) Reactive Oxygen Species (2) Serotonin Transporter (8) Sigma Receptor (1) Wnt (1)
By Research Areas:	Cancer (14) Cardiovascular Disease (5) Endocrinology (17) Inflammation/Immunology (4) Metabolic Disease (4) Neurological Disease (116)

137

Inhibitors & Agonists

Natural
Products

Isotope-Labeled Compounds

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-12709

ARC 239	Adrenergic Receptor 5-HT Receptor	Neurological Disease
ARC 239 is an α2B/C-adrenergic receptor antagonist with pK_i of 7.06 and 6.95 for rat kidney α2B and human α2C, respectively. ARC 239 also inhibits **5-HT1A receptor with a K_i** of 63.1 nM .

HY-B0500

Alverine citrate 1 Publications Verification NSC 35459	5-HT Receptor	Metabolic Disease
Alverine citrate is a *5-HT_1A* receptor antagonist, with an IC₅₀ of 101 nM.

HY-B0716

Urapidil	5-HT Receptor Adrenergic Receptor	Neurological Disease Endocrinology
Urapidil is an α1 adrenoreceptor antagonist and a **5-HT_1A receptor** agonist.

HY-116076

S-15535	5-HT Receptor	Neurological Disease
S-15535 is a highly selective *5-HT_1A* receptor ligand. S-15535 is an antagonist of postsynaptic *5-HT_1A* receptors and an agonist of presynaptic *5-HT_1A* receptors. S-15535 can be used in research on psychiatric disorders, such as anti-anxiety .

HY-120939

S14063	5-HT Receptor	Neurological Disease
S14063 is a potent **5-HT1A receptor** antagonist. S14063 is devoid of β-adrenoceptor blocking properties .

HY-144764

5-HT1A antagonist 1	5-HT Receptor	Neurological Disease
5-HT1A antagonist 1 (compound 6f) is a potent and selective antagonist of **5-HT_1A receptor, with a K_i** of 35 nM. 5-HT1A antagonist 1 can be used for the research of CNS diseases .

HY-100925

Binospirone hydrochloride	Others	Others
Binospirone hydrochloride serves as an antagonist of the 5-HT1A receptor.

HY-B0500A

Alverine	5-HT Receptor	Metabolic Disease
Alverine citrate is a *5-HT_1A* receptor antagonist, with an IC₅₀ of 101 nM.

HY-B0500B

Alverine hydrochloride	5-HT Receptor	Metabolic Disease
Alverine hydrochloride citrate is a *5-HT_1A* receptor antagonist, with an IC₅₀ of 101 nM.

HY-116309

SDZ 216-525	5-HT Receptor	Neurological Disease
SDZ 216-525 is a selective silent antagonist of *5-HT_1A* receptor .

HY-117575A

WAY-100135 dihydrochloride	5-HT Receptor	Neurological Disease
WAY-100135 dihydrochloride is a selective antagonist at presynaptic and postsynaptic *5-HT_1A* receptor, with an IC₅₀ of 34 nM at the rat hippocampal 5-HT_1A receptor. WAY-100135 dihydrochloride has potential antipsychotic properties .

HY-19818A

NAN-190 hydrobromide	5-HT Receptor	Neurological Disease
NAN-190 hydrobromide is a serotonin receptor 5-HT antagonist. NAN-190 is a selective antagonist of *5-HT_1A* .

HY-120738

p-MPPI hydrochloride 1 Publications Verification	5-HT Receptor	Neurological Disease
p-MPPI hydrochloride is a selective **5-HT1A receptor** antagonist with high affinity for 5-HT1A receptors. p-MPPI hydrochloride can crosses the blood-brain barrier, and has clear antidepressant and anxiolytic-like effects .

HY-101322A

MM 77 dihydrochloride	5-HT Receptor	Neurological Disease
MM 77 dihydrochloride is a potent postsynaptic antagonist of the **5-HT_1A receptor**. MM 77 dihydrochloride exhibits anxiolytic-like activity .

HY-12701

U-99194 U-99194A free base; PNU-99194A; JPC-211	Dopamine Receptor	Neurological Disease
U-99194 is a potent and selective D3 receptor antagonist .

HY-12701A

U-99194 maleate U-99194A; PNU-99194A maleate; JPC-211 maleate	Dopamine Receptor	Neurological Disease
U-99194 maleate is a potent and selective Dopamine3 Receptor (D3 receptor) antagonist. U-99194 maleate also enhances prolactin secretion and striatal dopamine synthesis .

HY-19417A

Wf-516	Serotonin Transporter 5-HT Receptor	Neurological Disease
Wf-516 is an inhibitor of 5-HT reuptake, and an antagonist of *5-HT1A* and 5-HT2A receptors, with K_i of 5 nM and 40 nM for 5-HT1A receptor and 5-HT2A receptor in humans, respectively, and has potent antidepressant activity.

HY-19417

Wf-516 hydrochloride	Serotonin Transporter 5-HT Receptor	Neurological Disease
Wf-516 hydrochloride is an inhibitor of 5-HT reuptake, and an antagonist of *5-HT1A* and 5-HT2A receptors, with K_i of 5 nM and 40 nM for 5-HT1A receptor and 5-HT2A receptor in humans, respectively.Wf-516 hydrochloride has potent antidepressant activity.

HY-117646

FG-5893	5-HT Receptor	Neurological Disease
FG-5893 is a **5-HT1A receptor** agonist and a 5-HT2 receptor antagonist. FG-5893 has anxiolytic effect .

HY-10349

WAY-100635 5+ Cited Publications	5-HT Receptor Dopamine Receptor	Neurological Disease
WAY-100635 is a potent and selective 5-HT_1A Receptor antagonist with a pIC₅₀ of 8.87, an apparent pA₂ of 9.71. WAY-100635 is a potent and selective 5-hydroxytryptamine 1A (5-HT1A) receptor antagonist with an IC₅₀ value of 0.91 nM and K_i value of 0.39 nM. WAY-100635 has pIC₅₀ values for *5-HT1A* and α1-adrenergic receptors of 8.9 and 6.6, respectively. WAY-100635 is also a potent dopamine D₄ receptor agonist .

HY-B0716S1

Urapidil-d3	5-HT Receptor Adrenergic Receptor	Neurological Disease Endocrinology
Urapidil-d₃ is the deuterium labeled Urapidil. Urapidil is an α1 adrenoreceptor antagonist and a 5-HT1A receptor agonist.

HY-118775

LEK 8804	Others	Others
LEK 8804 is a compound with 5-HT1A receptor agonist and 5-HT2 receptor antagonist properties, and has the activity of modulating related receptor-mediated behavioral responses. LEK 8804 can induce spontaneous tail-flick response in rats in a dose-dependent manner, showing complete 5-HT1A agonist activity, and can inhibit 5-HTP-induced head twitch response in mice, probably through antagonism of 5-HT2 receptors rather than agonism of 5-HT1A receptors.

HY-B0982

Pindolol 2 Publications Verification LB-46	5-HT Receptor Adrenergic Receptor	Neurological Disease Endocrinology
Pindolol (LB-46) is a nonselective β-blocker with partial beta-adrenergic receptor agonist activity, also functions as a 5-HT1A receptor weak partial antagonist (Ki=33nM).

HY-B0716R

Urapidil (Standard)	5-HT Receptor Adrenergic Receptor	Neurological Disease Endocrinology
Urapidil (Standard) is the analytical standard of Urapidil. This product is intended for research and analytical applications. Urapidil is an α1 adrenoreceptor antagonist and a **5-HT_1A receptor** agonist.

HY-B0500R

Alverine citrate (Standard)	5-HT Receptor	Metabolic Disease
Alverine (citrate) (Standard) is the analytical standard of Alverine (citrate). This product is intended for research and analytical applications. Alverine citrate is a 5-HT1A receptor antagonist, with an IC50 of 101 nM.

HY-119389

RGH-1756	Dopamine Receptor 5-HT Receptor	Neurological Disease
RGH-1756 is an atypical antipsychotic that has a strong and selective antagonist activity on human D₃ and less pronounced activity on human D_2L and **5HT_1A receptors** .

HY-N0096

Rotundine (-)-Tetrahydropalmatine; L-Tetrahydropalmatine	5-HT Receptor Dopamine Receptor	Neurological Disease
Rotundine is an antagonist of dopamine D1, D2 and D3 receptors with IC₅₀s of 166 nM, 1.4 μM and 3.3 μM, respectively. Rotundine is also an antagonist of *5-HT_1A* with an IC₅₀ of 370 nM.

HY-B0716S2

Urapidil-d4	Isotope-Labeled Compounds Adrenergic Receptor 5-HT Receptor	Endocrinology
Urapidil-d₄ is the deuterium labeled Urapidil[1]. Urapidil is an α1 adrenoreceptor antagonist and a 5-HT1A receptor agonist[2].

HY-B1115A

Buspirone 1 Publications Verification	5-HT Receptor Dopamine Receptor Reactive Oxygen Species	Neurological Disease Cancer
Buspirone is an orally active **5-HT1A receptor** agonist, and a dopamine D2 autoreceptorsant antagonist. Buspirone is an anxiolytic agent, and can be used for the generalized anxiety disorder research .

HY-19686

Ipsapirone TVX Q 7821 free base	5-HT Receptor	Neurological Disease
Ipsapirone (TVX Q 7821) is an anxiolytic compound and a *5-HT_1A* receptor partial agonist. Ipsapirone (TVX Q 7821) also exhibits *5-HT_1A* receptor antagonistic effect, and only at high doses it can also produce an inhibitory effect on 5-HT₂ and the α₁-adrenergic function .

HY-19686A

Ipsapirone hydrochloride TVX Q 7821	5-HT Receptor	Neurological Disease
Ipsapirone hydrochloride (TVX Q 7821) is an anxiolytic compound and a *5-HT_1A* receptor partial agonist. Ipsapirone hydrochloride (TVX Q 7821) also exhibits *5-HT_1A* receptor antagonistic effect, and only at high doses it can also produce an inhibitory effect on 5-HT₂ and the α₁-adrenergic function .

HY-10349A

WAY-100635 maleate 5+ Cited Publications	5-HT Receptor Dopamine Receptor	Neurological Disease
WAY-100635 maleate is a potent and selective 5-hydroxytryptamine 1A (5-HT1A) receptor antagonist with an IC₅₀ value of 0.91 nM and K_i value of 0.39 nM. WAY-100635 maleate has pIC₅₀ values for *5-HT1A* and α1-adrenergic receptors of 8.9 and 6.6, respectively. WAY-100635 maleate is also a potent dopamine D₄ receptor agonist .

HY-121053A

Adatanserin hydrochloride WY-50324 hydrochloride; SEB-324 hydrochloride	5-HT Receptor	Neurological Disease
Adatanserin hydrochloride is a high affinity, selective and partial agonist for the *5-HT_1A* receptor with a K_i of 1 nM. Adatanserin hydrochloride is a moderate affinity 5-HT₂ receptor antagonist with a K_i of 73 nM. Adatanserin hydrochloride shows significant anxiolytic and antidepressant activity in an animal conflict model .

HY-B1517B

Alprenolol benzoate	5-HT Receptor	Cardiovascular Disease Cancer
Alprenolol benzoate is an orally active non-selective β-adrenoceptor antagonist and an antagonist of *5-HT1A* and 5-HT1B receptors. Alprenolol benzoate is used as an anti-hypertensive, anti-anginal and anti-arrhythmic agent .

HY-19742A

Lecozotan hydrochloride SRA-333 hydrochloride	5-HT Receptor	Neurological Disease
Lecozotan (SRA-333) hydrochloride is an orally active and selective antagonist of *5-HT_1A* with a K_i of 4.5 nM for cloned human 5-HT_1A receptor. Lecozotan hydrochloride enhances the stimulated release of glutamate and acetylcholine in the hippocampus and possesses cognitive-enhancing properties. Lecozotan hydrochloride has the potential for mild-to-moderate Alzheimer's disease (AD) research .

HY-117575

WAY-100135	Others	Neurological Disease
WAY-100135 is a serotonergic compound belonging to the phenylpiperazine family, utilized in scientific research for its role as a strong antagonist of the 5-HT1A receptor and a partial agonist of the 5-HT1D receptor, with minimal activity at the 5-HT1B receptor.

HY-103415

Nemonapride YM-09151-2; Emonapride	Dopamine Receptor 5-HT Receptor	Neurological Disease
Nemonapride is a highly potent dopamine D₂ receptor antagonist with a K_i of 0.06 nM. Nemonapride also activates **5-HT_1A receptor with an IC₅₀** of 34 nM. Nemonapride is an antipsychotic that readily passes through the blood brain barrier and exhibits potent neuroleptic effects in animals .

HY-B1517

Alprenolol 5+ Cited Publications (RS)-Alprenolol; dl-Alprenolol	5-HT Receptor	Cancer
Alprenolol ((RS)-Alprenolol; dl-Alprenolol) is an orally active non-selective β-adrenoceptor antagonist and an antagonist of *5-HT1A* and 5-HT1B receptors. Alprenolol is used as an anti-hypertensive, anti-anginal and anti-arrhythmic agent .

HY-B1517A

Alprenolol hydrochloride 5+ Cited Publications (RS)-Alprenolol hydrochloride; dl-Alprenolol hydrochloride	5-HT Receptor	Cancer
Alprenolol ((RS)-Alprenolol; dl-Alprenolol) hydrochloride is an orally active non-selective β-adrenoceptor antagonist and an antagonist of *5-HT1A* and 5-HT1B receptors. Alprenolol hydrochloride is used as an anti-hypertensive, anti-anginal and anti-arrhythmic agent .

HY-117799

LY-426965	5-HT Receptor	Endocrinology
LY426965 is a potent arylpiperazine compound known for its role as a full antagonist of the serotonin 1A receptor, lacking partial agonist activity. It is identified as a selective 5-HT1A antagonist, showing promise in preclinical studies for treating conditions associated with serotonin dysregulation, such as smoking cessation and depression-related disorders .

HY-A0007

Rotigotine Hydrochloride 1 Publications Verification N-0923 Hydrochloride	Dopamine Receptor Adrenergic Receptor 5-HT Receptor	Neurological Disease
Rotigotine Hydrochloride (N-0923 Hydrochloride) is a full agonist of dopamine receptor, a partial agonist of the **5-HT1A receptor*, and an antagonist* of the α2B-adrenergic receptor, with K_i of 0.71?nM, 4-15?nM, and 83?nM for the dopamine D3 receptor and D2, D5, D4 receptors, and dopamine D1 receptor.

HY-15394A

(Rac)-Rotigotine N-0437	Adrenergic Receptor 5-HT Receptor Dopamine Receptor	Neurological Disease Endocrinology
(Rac)-Rotigotine (N-0437) is a racemate of Rotigotine. Rotigotine is a full agonist of dopamine receptor, a partial agonist of the **5-HT1A receptor*, and an antagonist* of the α2B-adrenergic receptor, with K_is of 0.71 nM, 4-15 nM, and 83 nM for the dopamine D3 receptor and D2, D5, D4 receptors, and dopamine D1 receptor.

HY-121053

Adatanserin WY-50324; SEB-324	5-HT Receptor	Neurological Disease
Adatanserin (WY-50324) is a high affinity, selective and partial agonist for the *5-HT_1A* receptor with a K_i of 1 nM. Adatanserin is a moderate affinity 5-HT₂ receptor antagonist with a K_i of 73 nM. Adatanserin shows significant anxiolytic and antidepressant activity in an animal conflict model .

HY-108509

BMY-14802 hydrochloride BMY-14802-1; BMS 181100 hydrochloride	Sigma Receptor 5-HT Receptor Adrenergic Receptor	Neurological Disease
BMY-14802 hydrochloride (BMY-14802-1) is a selective and orally active sigma receptor antagonist with an IC₅₀ of 112 nM. BMY-14802 hydrochloride is also a *5-HT1A* and adrenergic α1 receptors agonist. BMY-14802 hydrochloride has antipsychotic effects .

HY-B0982R

Pindolol (Standard) LB-46 (Standard)	5-HT Receptor Adrenergic Receptor	Neurological Disease Endocrinology
Pindolol (Standard) is the analytical standard of Pindolol. This product is intended for research and analytical applications. Pindolol (LB-46) is a nonselective β-blocker with partial beta-adrenergic receptor agonist activity, also functions as a 5-HT1A receptor weak partial antagonist (Ki=33nM).

HY-117799A

LY-426965 hydrochloride	5-HT Receptor	Endocrinology
LY-426965 hydrochloride is a potent arylpiperazine compound known for its role as a full antagonist of the serotonin 1A receptor, lacking partial agonist activity. It is identified as a selective 5-HT1A antagonist, showing promise in preclinical studies for treating conditions associated with serotonin dysregulation, such as smoking cessation and depression-related disorders .

HY-B0731

Perospirone hydrochloride SM-9018	5-HT Receptor Dopamine Receptor	Neurological Disease
Perospirone hydrochloride (SM-9018) is an orally active antagonist of 5-HT_2A receptor (K_i of 0.6 nM) and dopamine D₂ receptor (K_i of 1.4 nM). Perospirone hydrochloride is also a partial agonist of *5-HT_1A* receptor (K_i of 2.9 nM). Perospirone hydrochloride is an atypical antipsychotic agent and has the potential for schizophrenic disease research .

HY-106617A

Etoperidone hydrochloride	5-HT Receptor Adrenergic Receptor	Neurological Disease
Etoperidone hydrochloride, an antidepressant agent, is an orally active serotonin and nor-adrenaline re-uptake antagonist. Etoperidone hydrochloride shows K_d values of 36 nM, 38 nM, 85 nM, and 570 nM for 5-HT2 receptor, α1-adrenergic receptor, 5-HT1A receptor, and α2-adrenergic receptor, respectively .

HY-W795507

Cyanopindolol	Adrenergic Receptor 5-HT Receptor	Neurological Disease
Cyanopindolol is an β3-adrenoceptor antagonist. Cyanopindolol is a potent and selective antagonist at the presynaptic serotonin autoreceptor in the rat brain cortex. Cyanopindolol has binding affinity for *5-HT1A* and 5-HT1B receptor (K_i: 2.1 and 3 nM respectively) .

HY-A0095S

Flibanserin-d4 BIMT-17-d₄; BIMT-17BS-d₄	5-HT Receptor	Neurological Disease
Flibanserin-d₄ is a deuterium labeled Flibanserin (BIMT-17). Flibanserin is a full agonist of the serotonin 5-HT1A receptor (Ki=1 nM) and an antagonist of 5-HT2A (49 nM)[1].

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N0096

Rotundine (-)-Tetrahydropalmatine; L-Tetrahydropalmatine	Alkaloids Structural Classification Corydalis yanhusuo W. T. Wang Source classification Plants Isoquinoline Alkaloids Papaveraceae	5-HT Receptor Dopamine Receptor
Rotundine is an antagonist of dopamine D1, D2 and D3 receptors with IC₅₀s of 166 nM, 1.4 μM and 3.3 μM, respectively. Rotundine is also an antagonist of *5-HT_1A* with an IC₅₀ of 370 nM.

HY-N0049

Nuciferine 4 Publications Verification	Structural Classification Alkaloids Aporphine Alkaloids other families Source classification Plants Isoquinoline Alkaloids	Parasite 5-HT Receptor Dopamine Receptor
Nuciferine is an antagonist at 5-HT_2A (IC₅₀=478 nM), 5-HT_2C (IC₅₀=131 nM), and 5-HT_2B (IC₅₀=1 μM), an inverse agonist at 5-HT₇ (IC₅₀=150 nM), a partial agonist at D₂ (EC₅₀=64 nM), D₅ (EC₅₀=2.6 μM) and 5-HT₆ (EC₅₀=700 nM), an agonist at *5-HT_1A* (EC₅₀=3.2 μM) and D₄ (EC₅₀=2 μM) receptor.

HY-N0049R

Nuciferine (Standard)	Structural Classification Alkaloids other families Source classification Plants	5-HT Receptor Dopamine Receptor
Nuciferine (Standard) is the analytical standard of Nuciferine. This product is intended for research and analytical applications. Nuciferine is an antagonist at 5-HT_2A (IC₅₀=478 nM), 5-HT_2C (IC₅₀=131 nM), and 5-HT_2B (IC₅₀=1 μM), an inverse agonist at 5-HT₇ (IC₅₀=150 nM), a partial agonist at D₂ (EC₅₀=64 nM), D₅ (EC₅₀=2.6 μM) and 5-HT₆ (EC₅₀=700 nM), an agonist at *5-HT_1A* (EC₅₀=3.2 μM) and D₄ (EC₅₀=2 μM) receptor.

Cat. No.	Product Name	Chemical Structure

HY-B0716S1

Urapidil-d3
Urapidil-d₃ is the deuterium labeled Urapidil. Urapidil is an α1 adrenoreceptor antagonist and a 5-HT1A receptor agonist.

HY-15780S

Brexpiprazole-d8
Brexpiprazole-d₈ is a deuterium labeled Brexpiprazole (OPC-34712). Brexpiprazole, an atypical antipsychotic agent, is a partial agonist of human 5-HT1A and dopamine receptor (Ki=0.12 nM and 0.3 nM, respectively). Brexpiprazole is also a 5-HT2A receptor antagonist (Ki=0.47 nM)[1][2].

HY-A0095S1

Flibanserin-d4-1

Flibanserin-d₄-1 is deuterium labeled Flibanserin. Flibanserin (BIMT-17) is a full agonist of the serotonin 5-HT1A receptor (Ki=1 nM) and an antagonist of 5-HT2A (49 nM). Flibanserin binds to dopamine D4 receptors (4-24 nM), and has negligible affinity for a variety of other neurotransmitter receptors and ion channels. Flibanserin is efficacious in treating hypoactive sexual desire disorder (HSDD)[1][2].

HY-15780S1

Brexpiprazole-d8-1

Brexpiprazole-d₈-1 is the deuterium labeled Brexpiprazole[1]. Brexpiprazole (OPC-34712), an atypical orally active antipsychotic agent, is a partial agonist of human 5-HT1A and dopamine D2L receptor with Kis of 0.12 nM and 0.3 nM, respectively. Brexpiprazole is also a 5-HT2A receptor antagonist with a Ki of 0.47 nM. Brexpiprazole also shows potent antagonist activity at human noradrenergic α1B (Ki=0.17 nM) and α2C receptors (Ki=0.59 nM)[2][3].

HY-B0716S2

Urapidil-d4
Urapidil-d₄ is the deuterium labeled Urapidil[1]. Urapidil is an α1 adrenoreceptor antagonist and a 5-HT1A receptor agonist[2].

HY-A0095S

Flibanserin-d4
Flibanserin-d₄ is a deuterium labeled Flibanserin (BIMT-17). Flibanserin is a full agonist of the serotonin 5-HT1A receptor (Ki=1 nM) and an antagonist of 5-HT2A (49 nM)[1].

HY-B0982S

Pindolol-d7
Pindolol-d₇ (LB-46-d7) is the deuterium labeled Pindolol. Pindolol (LB-46) is a nonselective β-blocker with partial beta-adrenergic receptor agonist activity, also functions as a 5-HT1A receptor weak partial antagonist (Ki=33 nM)[1][2].

HY-B1213S

Trimipramine-d3 maleate
Trimipramine-d₃ (maleate) is the deuterium labeled Trimipramine maleate. Trimipramine maleate is a 5-HT receptor antagonist, with pKis of 6.39, 8.10, 4.66 for 5-HT1C, 5-HT2 and 5-HT1A, respectively[1][2].

HY-B0032AS

Lurasidone-d8
Lurasidone-d₈ is deuterium labeled Lurasidone. Lurasidone (SM-13496) is an antagonist of both dopamine D2 and 5-HT7 with IC50s of 1.68 and 0.495 nM, respectively. Lurasidone (SM-13496) is also a partial agonist of 5-HT1A receptor with an IC50 of 6.75 nM.

HY-B0031S2

Quetiapine-d8 fumarate

Quetiapine-d₈ (fumarate) is the deuterium labeled Quetiapine. Quetiapine is a 5-HT receptors agonist with a pEC50 of 4.77 for human 5-HT1A receptor. Quetiapine is a dopamine receptor antagonist with a pIC50 of 6.33 for human D2 receptor. Quetiapine has moderate to high affinity for the human D2, HT1A, 5-HT2A, 5-HT2C receptor with pKis of 7.25, 5.74, 7.54, 5.55. Antidepressant and anxiolytic effects[1][2].

HY-B0031S3

Quetiapine-d8 hemifumarate

Quetiapine-d₈ (hemifumarate) is the deuterium labeled Quetiapine hemifumarate. Quetiapine hemifumarate is a 5-HT receptors agonist with a pEC50 of 4.77 for human 5-HT1A receptor. Quetiapine hemifumarate is a dopamine receptor antagonist with a pIC50 of 6.33 for human D2 receptor. Quetiapine hemifumarate has moderate to high affinity for the human D2, HT1A, 5-HT2A, 5-HT2C receptor with pKis of 7.25, 5.74, 7.54, 5.55. Antidepressant and anxiolytic effects[1].

HY-B0031S4

Quetiapine hemifumarate-d8

Quetiapine (hemifumarate)-d₈ is the deuterium labeled Quetiapine hemifumarate[1]. Quetiapine hemifumarate is a 5-HT receptors agonist with a pEC50 of 4.77 for human 5-HT1A receptor. Quetiapine hemifumarate is a dopamine receptor antagonist with a pIC50 of 6.33 for human D2 receptor. Quetiapine hemifumarate has moderate to high affinity for the human D2, HT1A, 5-HT2A, 5-HT2C receptor with pKis of 7.25, 5.74, 7.54, 5.55. Antidepressant and anxiolytic effects[2].

HY-B0031S5

Quetiapine-d4-1 fumarate

Quetiapine-d₄-1 fumarate is deuterated labeled Quetiapine (hemifumarate) (HY-B0031). Quetiapine hemifumarate is a 5-HT receptors agonist with a pEC₅₀ of 4.77 for human 5-HT1A receptor. Quetiapine hemifumarate is a dopamine receptor antagonist with a pIC₅₀ of 6.33 for human D2 receptor. Quetiapine hemifumarate has moderate to high affinity for the human D2, HT1A, 5-HT2A, 5-HT2C receptor with pK_is of 7.25, 5.74, 7.54, 5.55. Antidepressant and anxiolytic effects .

HY-133152S

Brexpiprazole S-oxide-d8

Brexpiprazole S-oxide-d₈ is a deuterium labeled Brexpiprazole S-oxide. Brexpiprazole S-oxide is a main metabolite of Brexpiprazole and is metabolized by cytochrome P450 3A4 (CYP3A4). Brexpiprazole is an atypical antipsychotic agent and a partial agonist of human 5-HT1A and dopamine receptor with Kis of 0.12 nM and 0.3 nM, respectively. Brexpiprazole is also a 5-HT2A receptor antagonist with a Ki of 0.47 nM[1][2][3].

HY-15414AS

Vortioxetine-d8 hydrobromide
Vortioxetine-d₈ (Lu AA 21004-d₈) hydrobromide is the deuterated form of Vortioxetine. Vortioxetine (Lu AA 21004) is an antagonist of 5-HT_3A and 5-HT₇ receptors (K_i: 3.7 nM, 19 nM) and an inhibitor of 5-hydroxytryptamine transporter (SERT) (K_i: 1.6 nM), as well as a 5-HT_1A agonist and a partial 5-HT_1B agonist (K_i: 15 nM, 33 nM) .

HY-15414S

Vortioxetine-d8
Vortioxetine-d₈ (Lu AA 21004-d₈) is a deuterated version of Vortioxetine. Vortioxetine (Lu AA 21004) is an antagonist of 5-HT_3A and 5-HT₇ receptors (K_i: 3.7 nM, 19 nM) and an inhibitor of 5-hydroxytryptamine transporter (SERT) (K_i: 1.6 nM), as well as a 5-HT_1A agonist and a partial 5-HT_1B agonist (K_i: 15 nM, 33 nM) .

HY-15414S1

Vortioxetine-d6
Vortioxetine-d6 (Lu AA 21004-d6) is the deuterium labeled Vortioxetine (HY-B1490A). Vortioxetine (Lu AA 21004) is an antagonist of 5-HT_3A and 5-HT₇ receptors (K_i: 3.7 nM, 19 nM) and an inhibitor of serotonin transporter (SERT) (K_i: 1.6 nM), as well as a **5-HT_1A agonist and a partial agonist of 5-HT_1B (K_i: 15 nM, 33 nM) .**

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