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Results for "

Ammonia

" in MedChemExpress (MCE) Product Catalog:

36

Inhibitors & Agonists

1

Screening Libraries

8

Fluorescent Dye

3

Biochemical Assay Reagents

1

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3

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Products

3

Recombinant Proteins

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-B0543

    Thiosinamine; N-Allylthiourea

    Reactive Oxygen Species Cancer
    Allylthiourea can selectively inhibit the oxidation of ammonia. Allylthiourea is commonly used to inhibit nitrification by targeting ammonia monooxygenase and chelating copper in the active site to suppress its activity. Allylthiourea also exhibits anticancer activity, showing cytotoxicity against the MCF-7 cell line with an IC50 of 5.22 mM. Allylthiourea can be utilized in research related to micropollutant biodegradability and cancer studies .
    Allylthiourea
  • HY-E70003

    Biochemical Assay Reagents Endocrinology
    Glutamate dehydrogenase is an enzyme in both prokaryotes and eukaryotic mitochondria. Glutamate dehydrogenase can be used for the enzymatic determination of ammonia, alpha-ketoglutaric acid, L-glutamate and urease .
    Glutamate dehydrogenase
  • HY-169004

    TGF-beta/Smad Interleukin Related Neurological Disease Inflammation/Immunology
    CBT-295 is an orally active autotaxin (ATX) inhibitor. CBT-295 exhibits a significant reduction in inflammatory cytokines like TGF-β, TNF-α and IL-6 levels, also reduced bile duct proliferation marker CK-19 and lowered liver fibrosis. The reversal of liver fibrosis with CBT-295 led to a reduction in blood and brain ammonia levels. CBT-295 also reduced neuroinflammation induced by ammonia. CBT-295 is promising for research of liver cirrhosis and associated encephalopathy .
    CBT-295
  • HY-P2951

    Others Others
    Phenylalanine ammonia-lyase is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
    Phenylalanine ammonia-lyase
  • HY-N11886

    Drug Metabolite Others
    5-NH2-Baicalein is an aminated metabolite of Baicalein (HY-N0196). 5-NH2-Baicalein can be used for research of ammonia and ammonia-associated chronic diseases .
    5-NH2-Baicalein
  • HY-E70002

    Biochemical Assay Reagents Others
    Deamino-NADPH is a 2'-phosphorylated coenzyme. Deamino-NADPH can be used in ammonia determination .
    Deamino-NADPH
  • HY-114929

    Glutaminase Neurological Disease
    THDP17 is an orally active glutaminase inhibitor. THDP17 decreases ammonia production through glutaminase inhibition .
    THDP17
  • HY-107792

    Bacterial Infection
    Benurestat is an orally active urease inhibitor. Benurestat can be used for infected ureolysis research .
    Benurestat
  • HY-P2876

    Bacterial Infection
    Tryptophanase, a bacterial enzyme, catalyzes degradation of tryptophan to indole, pyruvate and ammonia .
    Tryptophanase
  • HY-E70410

    NAD+ Synthetase; Nicotinamide adenine dinucleotide synthetase

    Endogenous Metabolite Neurological Disease Metabolic Disease Cancer
    NAD synthetase is responsible for the final step in the synthesis of nicotinamide adenine dinucleotide (NAD). The Km values for NAD, ATP, and ammonia of NAD synthetase from Escherichia coli are 200 μM, 11 μM, and 0.65 μM, respectively, while the Km values for NAD, ATP, and ammonia of NAD synthetase from yeast are 170 μM, 190 μM, and 64 μM, respectively. NAD synthetase can be used for enzymatic assays to determine ATP, ammonia, urea, or creatinine, and is also suitable for enzymatic cycling methods. Additionally, NAD synthetase holds potential for research into metabolic diseases, cancer, aging, and neurodegenerative diseases .
    NAD Synthetase
  • HY-134230

    L-α-aminooxy-β-phenylpropionic acid; AOPP

    Others Metabolic Disease
    L-2-Aminooxy-3-phenylpropanoic acid is a potent inhibitor of L-phenylalanine ammonia-lyase .
    L-2-Aminooxy-3-phenylpropanoic acid
  • HY-134230A

    L-α-aminooxy-β-phenylpropionic acid hydrobromide; AOPP hydrobromide

    Others Metabolic Disease
    L-2-Aminooxy-3-phenylpropanoic acid hydrobromide is a potent inhibitor of L-phenylalanine ammonia-lyase .
    L-2-Aminooxy-3-phenylpropanoic acid hydrobromide
  • HY-P2767

    Bacterial Others
    Urease, Jack bean is derived from jack bean and Catalyzes hydrolysis of urea to carbon dioxide and ammonia. Urease, Jack bean is useful in the determination of urea in body fluids.
    Urease, Jack bean
  • HY-B0543R

    Reactive Oxygen Species Cancer
    Allylthiourea (Standard) is the analytical standard of Allylthiourea. This product is intended for research and analytical applications. Allylthiourea can selectively inhibit the oxidation of ammonia. Allylthiourea is commonly used to inhibit nitrification by targeting ammonia monooxygenase and chelating copper in the active site to suppress its activity. Allylthiourea also exhibits anticancer activity, showing cytotoxicity against the MCF-7 cell line with an IC50 of 5.22 mM. Allylthiourea can be utilized in research related to micropollutant biodegradability and cancer studies [4].
    Allylthiourea (Standard)
  • HY-B2087

    HPN-100

    Sigma Receptor Cardiovascular Disease
    Glycerol phenylbutyrate is a sigma-2 (σ2) receptor ligand, with a pKi of 8.02. Glycerol phenylbutyrate (GPB) is a new generation ammonia scavenger agent .
    Glycerol phenylbutyrate
  • HY-P2987

    Endogenous Metabolite Metabolic Disease
    L-Amino acid oxidase is a homodimeric proteins containing flavin adenine dinucleotide. L-Amino acid oxidase can catalyze the stereospecific oxidative deamination of L-amino acids to α-keto acids and ammonia .
    L-Amino acid oxidase
  • HY-P2736

    Endogenous Metabolite Metabolic Disease
    Amidases, a member of nitrilase superfamily, catalyzes the hydrolysis of an amide, leading to the formation of carboxylic acid and ammonia. Amidases contain a conserved stretch of approximately 130 amino acids known as the AS sequence, and play a role in important metabolic processes .
    Amidase
  • HY-W134309

    Biochemical Assay Reagents Others
    Nickel(II) carbonate (hydroxide tetrahydrate) is insoluble in water but soluble in ammonia water and dilute acids. Nickel(II) carbonate (hydroxide tetrahydrate) is a kind of biological materials or organic compounds that are widely used in life science research .
    Nickel(II) carbonate hydroxide tetrahydrate
  • HY-D2105

    Fluorescent Dye Others
    TAMRA-PEG3-NHS is a dye derivative of TAMRA (HY-135640) containing 3 PEG units. TAMRA-PEG3-NHS contains NHS groups that react with ammonia to form ester bonds.
    TAMRA-PEG3-NHS
  • HY-D2106

    Fluorescent Dye Others
    TAMRA-PEG4-NHS is a dye derivative of TAMRA (HY-135640) containing 4 PEG units. TAMRA-PEG4-NHS contains NHS groups that react with ammonia to form ester bonds.
    TAMRA-PEG4-NHS
  • HY-D2107

    Fluorescent Dye Others
    TAMRA-PEG8-NHS is a dye derivative of TAMRA (HY-135640) containing 8 PEG units. TAMRA-PEG8-NHS contains NHS groups that react with ammonia to form ester bonds.
    TAMRA-PEG8-NHS
  • HY-D2108

    Fluorescent Dye Others
    TAMRA-PEG3-COOH is a dye derivative of TAMRA (HY-135640) containing 3 PEG units. TAMRA-PEG3-COOH contains carboxyl groups, which can condense ammonia to form covalent bonds.
    TAMRA-PEG3-COOH
  • HY-D2109

    Fluorescent Dye Others
    TAMRA-PEG4-COOH is a dye derivative of TAMRA (HY-135640) containing 4 PEG units. TAMRA-PEG4-COOH contains carboxyl groups, which can condense ammonia to form covalent bonds.
    TAMRA-PEG4-COOH
  • HY-D2110

    Fluorescent Dye Others
    TAMRA-PEG8-COOH is a dye derivative of TAMRA (HY-135640) containing 8 PEG units. TAMRA-PEG8-COOH contains carboxyl groups, which can condense ammonia to form covalent bonds.
    TAMRA-PEG8-COOH
  • HY-D2166

    Fluorescent Dye Others
    AF 594 NHS ester is a derivative of the red fluorescent dye AF 594 with high fluorescence quantum yield and high photostability (Ex=594 nm, Em=615 nm). AF 594 NHS ester can form an ester bond by reacting the NHS group with ammonia, with maximum excitation wavelength of 594 nm .
    AF 594 NHS ester
  • HY-B2087R

    Sigma Receptor Cardiovascular Disease
    Glycerol phenylbutyrate (Standard) is the analytical standard of Glycerol phenylbutyrate. This product is intended for research and analytical applications. Glycerol phenylbutyrate is a sigma-2 (σ2) receptor ligand, with a pKi of 8.02. Glycerol phenylbutyrate (GPB) is a new generation ammonia scavenger agent .
    Glycerol phenylbutyrate (Standard)
  • HY-A0282

    Others Metabolic Disease Inflammation/Immunology
    L-Ornithine L-aspartate is a stable salt of two natural nonessential L-amino acids with oral activity: ornithine and aspartic acid. L-Ornithine L-aspartate lowers blood ammonia concentration and to eliminate symptoms of hepatic encephalopathy associated with liver cirrhosis. L-Ornithine L-aspartate also improves mitochondrial functions .
    L-Ornithine L-aspartate
  • HY-P2965

    Others Cancer
    L-Lysine α-oxidase is a potent anticancer agent. L-Lysine α-oxidase also a L-amino acid oxidase, deaminates L-lysine with the yield of H2O2, ammonia, and α-keto-ε-aminocaproate. L-Lysine α-oxidase shows cytotoxicity and anticancer activity .
    L-Lysine α-oxidase
  • HY-B1571

    Fluorescent Dye Others
    Bromophenol blue is an acid phthalein dye, and it is used as a tracking dye for electrophoresis. Bromophenol blue is also used as a pH indicator, with a transition range of pH 3 to 4.6. Bromophenol blue is used as a sensor for the determination of several compounds including ammonia, drugs, proteins and amino acids. The binding of Bromophenol blue to proteins is accompanied by the appearance of a strong absorbance at 610 nm .
    Bromophenol blue
  • HY-B1529A
    Citric acid triammonium
    Maximum Cited Publications
    26 Publications Verification

    Triammonium citrate

    Endogenous Metabolite Apoptosis Biochemical Assay Reagents Others Cancer
    Citric acid triammonium (Triammonium citrate) is formed by Citric acid (HY-N1428) reacting with ammonia in a molar ratio of 1:3. Citric acid triammonium can be used as the carbon source to prepare carbon quantum dots (CDs). Citric acid triammonium with higher nitrogen components might promote the nitrogen-based functional groups in CDs, leading to a more efficient emission-color tunability .
    Citric acid triammonium
  • HY-B1142
    Lipoamide
    5+ Cited Publications

    (±)-α-Lipoamide; DL-Lipoamide; DL-6,8-Thioctamide

    NO Synthase Others
    Lipoamide ((±)-α-Lipoamide) is a monocarboxylic acid derivative of a neutral amide, formed by the condensation of the carboxyl group of lipoic acid and ammonia. Lipoamide protects against oxidative stress-mediated neuronal cell damage and also acts as a coenzyme to transfer acetyl groups and hydrogen during pyruvate deacylation. Lipoamide also stimulates mitochondrial biogenesis in adipocytes through the endothelial NO synthase-cGMP-protein kinase G signaling pathway .
    Lipoamide
  • HY-129982

    Apical Sodium-Dependent Bile Acid Transporter Metabolic Disease
    SC-435 is an orally effective apical sodium codependent bile acid transporter (ASBT) inhibitor. SC-435 effectively removes neurotoxic bile acids and ammonia from the blood by inhibiting intestinal ASBT, thereby alleviating liver and brain damage caused by liver failure. SC-435 can alter hepatic cholesterol metabolism and lower plasma low-density lipoprotein-cholesterol concentrations .
    SC-435
  • HY-N1836

    3-Hydroxy-3-acetonyloxindole

    TMV Infection
    3-Acetonyl-3-hydroxyoxindole (AHO) is a potent systemic acquired resistance (SAR) inducer in plants. 3-Acetonyl-3-hydroxyoxindole induces resistance in tobacco plants against infection with tobacco mosaic virus (TMV) and the fungal pathogen Erysiphe cichoracearum. 3-Acetonyl-3-hydroxyoxindole increases the level of pathogenesis-related gene 1 (PR-1) expression, salicylic acid (SA) accumulation and phenylalanine ammonia-lyase activity .
    3-Acetonyl-3-hydroxyoxindole
  • HY-B1692
    L-Methionine-DL-sulfoximine
    1 Publications Verification

    MSX; MSO

    Glutaminase Neurological Disease
    L-Methionine-DL-sulfoximine (MSX; MSO), a highly specific and irreversible inhibitor of Glutamine synthetase (GS), is also a potent convulsant which metabolically and morphologically primarily affects astroglia. L-Methionine-DL-sulfoximine has been employed to inhibit the Gln-dependent ammonia-stimulated neuronal toxicity in vitro, potentiating Gln deficit-dependent depression. L-Methionine-DL-sulfoximine tremendously increases the rate of release of fixed nitrogen in cyanobacteria. L-Methionine-DL-sulfoximine is a promising candidate for research in biofertilizers and convulsive seizures (CS) .
    L-Methionine-DL-sulfoximine
  • HY-135078

    NSC 270912

    Others Others
    2,5-Deoxyfructosazine is a pyrazine derivative that can be found in cured tobacco and is used as a flavoring agent in the food and tobacco industry. Pyrazines, including 2,5-deoxyfructosazine, can be produced either by pyrolytic decomposition of natural compounds or by the reaction of sugars with alcoholic ammonia. 2,5-Deoxyfructosazine is also formed by the breakdown of D-glucosamine at neutral pH. Like glucosamine, 2,5-deoxyfructosazine has DNA strand breakage activity and strongly inhibits IL-2 production by Jurkat cells stimulated with phytohemagglutinin (IC50=~1.25 mM).
    2,5-Deoxyfructosazine
  • HY-121659

    Others Cancer
    DCFBC is a prostate-specific membrane antigen (PSMA) inhibitor for small animal positron emission tomography (PET) imaging. [18F]DCFBC was prepared by reacting fluorine-18 labeled phenyl bromide with the precursor (S)-2-[3-[(R)-1-carboxy-2-thiolethyl]urea]-glutaric acid in ammonia-saturated methanol at 60°C for 10 min and then purified by C-18 reversed-phase HPLC. [18F]DCFBC was injected via the tail vein in severe combined immunodeficient mice for in vitro biodistribution or imaging. For in vitro biodistribution studies, mice were sacrificed at 5, 15, 30, 60, and 120 min after injection, and tumors, blood, and major organs were collected, weighed, and radioactivity was counted. Imaging was performed using a GE eXploreVista small animal PET scanner, collecting 12 consecutive 10-min frames. Results showed that the radiochemical yield of [18F]DCFBC averaged 16±6% (n=8) from 4-[18F]fluorophenyl bromide. Specific radioactivity ranged from 13 to 133 GBq/Amol (350-3600 Curie/mmol) with an average of 52 GBq/Amol (1392 Curie/mmol; n=6). Biodistribution and imaging studies showed high uptake of [18F]DCFBC in PIP tumors and almost no uptake in FLU tumors. High radiopharmaceutical uptake was also seen in the kidney and bladder; however, radioactivity washout from these organs was faster than from the PIP tumors. Maximum PIP tumor uptake was reached at 60 min post-injection at 8.16±2.55% injected dose/g and decreased to 4.69±0.89 at 120 min post-injection. The PIP tumor-to-muscle ratio was 20 at 120 min post-injection. Based on mouse biodistribution, the dose-limiting organ was the kidney (estimated human absorbed dose: 0.05 mGy/MBq; 0.2 rad/mCi). Conclusions: [18F]DCFBC localizes specifically to PSMA+ expressing tumors in mice and is suitable for small animal PET imaging. This novel radiopharmaceutical is an attractive candidate for further study in PET imaging of prostate cancer.
    DCFBC

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