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Results for "

BiP

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Amino Acid Derivatives (3) Amylases (1) Apoptosis (3) Autophagy (1) Bcl-2 Family (1) DNA/RNA Synthesis (1) Glycosidase (1) GSK-3 (1) HSP (6) IRE1 (1) Ras (1) Sigma Receptor (1)
By Research Areas:	Cancer (6) Inflammation/Immunology (1) Metabolic Disease (1) Neurological Disease (4)

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Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-P5965

BiP substrate	HSP	Others
BiP substrate is a peptide substrate of BiP that can be used to measure the BiP ATPase activity .

HY-110188

BiP inducer X 5 Publications Verification	Apoptosis	Neurological Disease
BiP inducer X, a selective inducer of immunoglobulin heavy chain binding protein (BiP)/GRP78, is an effective ER (endoplasmic reticulum) stress inhibitor. BiP inducer X preferentially induces BiP with slight inductions of GRP94, calreticulin, and C/EBP homologous protein. BiP inducer X protects neurons from ER stress .

HY-111055

BIP-135	GSK-3	Neurological Disease
BIP-135 is a potent and selective ATP-competitive GSK-3 inhibitor, with IC₅₀s of 16 nM and 21 nM for GSK-3α and GSK-3β, respectively. BIP 135 exhibits neuroprotective effect .

HY-P0081

Bax inhibitor peptide V5 10+ Cited Publications BiP-V5; BAX Inhibiting Peptide V5	Bcl-2 Family Apoptosis	Cancer
Bax inhibitor peptide V5 (BIP-V5) is a Bax-mediated apoptosis inhibitor, used for cancer treatment.

HY-W010836

*Fmoc-Bip(4,4')-OH*	Amino Acid Derivatives	Others
Fmoc-Bip(4,4')-OH is an alanine derivative .

HY-78843

*Boc-Bip(4,4')-OH*	Amino Acid Derivatives	Others
Boc-Bip(4,4')-OH is a phenylalanine derivative .

HY-W010838

*Fmoc-D-Bip(4,4’)-OH*	Amino Acid Derivatives	Others
Fmoc-D-Bip(4,4’)-OH is an alanine derivative .

HY-100437

HA15 Maximum Cited Publications 28 Publications Verification	HSP Autophagy Apoptosis	Cancer
HA15 is a potent and specific inhibitor of ER chaperone *BiP/GRP78/HSPA5, inhibits the ATPase activity of BiP*, with anti-cancerous activity .

HY-N12656

Versipelostatin	HSP	Cancer
Versipelostatin is a *GRP78/Bip* molecular chaperone down-regulator and can be isolated from the culture broth of Streptomyces versipellis 4083-SVS6 .

HY-121459

Neoantimycin	HSP Ras
Neoantimycin is a *GRP78/BiP* and K-Ras regulator with anticancer activity. Its biosynthesis is catalyzed by a hybrid nonribosomal peptide synthetase/polyketide synthase (NRPS/PKS) system .

HY-N7377

Butyl isobutyl phthalate	Glycosidase	Metabolic Disease
Butyl isobutyl phthalate is isolated from the rhizoid of Laminaria japonica. Butyl isobutyl phthalate is a non-competitive α-glucosidase inhibitor with an IC₅₀ value of 38 μM. Butyl isobutyl phthalate shows a hypoglycemic effect and has the potential for diabetes treatment .

HY-125974

HM03 3 Publications Verification	HSP	Cancer
HM03 is a potent and selective HSPA5 (Heat shock 70kDa protein 5, also known as Bip, Grp78) inhibitor. HM03 has anticancer activity .

HY-125974A

HM03 trihydrochloride	HSP	Cancer
HM03 trihydrochloride is a potent and selective HSPA5 (Heat shock 70kDa protein 5, also known as Bip, Grp78) inhibitor. HM03 trihydrochloride has anticancer activity .

HY-108514

(±)-PPCC hemioxalate	Sigma Receptor	Neurological Disease Cancer
(±)-PPCC hemioxalate is a compound that has the ability to regulate the activity of the sigma-1 receptor. (±)-PPCC hemioxalate can selectively bind sigma-1 protein (s1), and then activate s1 receptor leading to dissociation of s1-BIP complex to regulate ER-mitochondrial calcium signaling, which plays an important role in cell bioenergy and cell survival. (±)-PPCC hemioxalate can be used to study sigma-1 receptors in cocaine addiction, forgetting, pain, depression, Alzheimer's disease, stroke, and cancer .

HY-124646

KIRA-7	IRE1	Inflammation/Immunology
KIRA-7, an imidazopyrazine compound, binds the IRE1α kinase (IC₅₀ of 110 nM) to allosterically inhibit its RNase activity. KIRA-7 has an anti-fibrotic effect .

HY-161461

E234G HYPE-IN-1	Amylases	Neurological Disease
E234G HYPE-IN-1 (Compound I2.10) is an inhibitor of AMPylation directed by the Huntingtin-interacting protein E (HYPE), possessing low micromolar bioactivity, low cytotoxicity, and blood-brain barrier permeability. E234G HYPE-IN-1 can inhibit the AMPylation of B-cell immunoglobulin-binding protein (BiP), the primary substrate of HYPE. E234G HYPE-IN-1 is suitable for development as a HYPE-specific therapeutic agent for clinical conditions such as neurodegenerative diseases and diabetes .

HY-145538

2'-Deoxyguanosine 5'-monophosphate disodium hydrate 5'-Deoxyguanylic acid disodium hydrate	DNA/RNA Synthesis	Others
2'-Deoxyguanosine 5'-monophosphate (5'-Deoxyguanylic acid; dGMP) disodium hydrate is an oxidizable target of the photosensitizer pterin (PT) and can be used to evaluate the photosensitizing properties of biopterins (such as Bip, Fop and Cap) . Pterin causes a photosensitive reaction of dGMP under UV-A radiation, causing damage to DNA molecules. There are two main mechanisms for the photosensitive oxidation of purine nucleotides by pterin in vitro: one is the hydrogen abstraction reaction of electron transfer from dGMP to the triplet excited state of pterin (type I mechanism), and the other is the interaction between dGMP and pterin. The reaction produces singlet molecular oxygen (1O2) (Type II mechanism) .

BiP substrate	HSP	Others
BiP substrate is a peptide substrate of BiP that can be used to measure the BiP ATPase activity .

Bax inhibitor peptide V5 10+ Cited Publications BiP-V5; BAX Inhibiting Peptide V5	Bcl-2 Family Apoptosis	Cancer
Bax inhibitor peptide V5 (BIP-V5) is a Bax-mediated apoptosis inhibitor, used for cancer treatment.

*Fmoc-Bip(4,4')-OH*	Amino Acid Derivatives	Others
Fmoc-Bip(4,4')-OH is an alanine derivative .

*Boc-Bip(4,4')-OH*	Amino Acid Derivatives	Others
Boc-Bip(4,4')-OH is a phenylalanine derivative .

*Fmoc-D-Bip(4,4’)-OH*	Amino Acid Derivatives	Others
Fmoc-D-Bip(4,4’)-OH is an alanine derivative .

Butyl isobutyl phthalate	Natural Products other families Classification of Application Fields Source classification Metabolic Disease Plants Disease Research Fields	Glycosidase
Butyl isobutyl phthalate is isolated from the rhizoid of Laminaria japonica. Butyl isobutyl phthalate is a non-competitive α-glucosidase inhibitor with an IC₅₀ value of 38 μM. Butyl isobutyl phthalate shows a hypoglycemic effect and has the potential for diabetes treatment .

Versipelostatin	Structural Classification Natural Products Microorganisms Source classification	HSP
Versipelostatin is a *GRP78/Bip* molecular chaperone down-regulator and can be isolated from the culture broth of Streptomyces versipellis 4083-SVS6 .

Species:	Human (2) Mouse (2)
Tag:	His (4)
Source:	P. pastoris (2) E. coli (2)

Cat. No.	Compare	Product Name	Species	Source

HY-P7332

	BMP-3B/GDF10 Protein, Human (His) 1 Publications Verification rHuBMP-3B; BiP; BMP-3B; GDF-10	Human	E. coli
	Bone morphogenetic protein 3 (BMP-3; GDF10) is a polymorphic ligand protein belonging to the TGF-β family. BMP-3 is the main component of osteoblast and has osteogenic activity. BMP-3 plays an inhibitory role in the carcinogenic process, and inhibits the occurrence of colon tumors through ActRIIB/ SMad2-dependent and TAK1/JNK signaling pathways. BMP-3B/GDF10 Protein, Human has a total length of 110 amino acids (Q369-R478), is expressed in E. coli cells.

HY-P72239

	HSPA5/GRP-78 Protein, Human (His) Endoplasmic reticulum chaperone BiP; GRP-78; BiP; GRP78	Human	E. coli
	HSPA5/GRP-78 is an endoplasmic reticulum chaperone that coordinates protein folding and quality control. It cooperates with DNAJC10/ERdj5 to facilitate correct protein folding and participates in the degradation of misfolded proteins, potentially releasing DNAJC10/ERdj5. HSPA5/GRP-78 Protein, Human (His) is the recombinant human-derived HSPA5/GRP-78 protein, expressed by E. coli , with N-6*His labeled tag. The total length of HSPA5/GRP-78 Protein, Human (His) is 269 a.a., with molecular weight of ~33.6 kDa.

HY-P71742

	HSPA5/GRP-78 Protein, Mouse (P.pastoris, His) Hspa5; Grp78; Endoplasmic reticulum chaperone BiP; EC 3.6.4.10; 78kDa glucose-regulated protein; GRP-78; HSP70 family protein 5	Mouse	P. pastoris
	The HSPA5/GRP-78 protein is an endoplasmic reticulum chaperone involved in protein folding and quality control. It interacts with DNAJC10/ERdj5 to fold and degrade misfolded proteins. HSPA5/GRP-78 Protein, Mouse (P.pastoris, His) is the recombinant mouse-derived HSPA5/GRP-78 protein, expressed by P. pastoris , with N-6*His, N-His labeled tag. The total length of HSPA5/GRP-78 Protein, Mouse (P.pastoris, His) is 636 a.a., with molecular weight of ~72.5 kDa.

HY-P71742Y

	HSPA5/GRP-78 Protein, Mouse (P.pastoris, His, solution) Hspa5; Grp78; Endoplasmic reticulum chaperone BiP; EC 3.6.4.10; 78kDa glucose-regulated protein; GRP-78; HSP70 family protein 5	Mouse	P. pastoris
	The HSPA5/GRP-78 protein is an endoplasmic reticulum chaperone involved in protein folding and quality control. It interacts with DNAJC10/ERdj5 to fold and degrade misfolded proteins. HSPA5/GRP-78 Protein, Mouse (P.pastoris, His, solution) is the recombinant mouse-derived HSPA5/GRP-78 protein, expressed by P. pastoris , with N-His labeled tag. The total length of HSPA5/GRP-78 Protein, Mouse (P.pastoris, His, solution) is 636 a.a., with molecular weight of ~72.5 kDa.

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HY-P80496

	*GRP78 BiP* Antibody**	WB, IHC-P, ICC/IF	Human, Mouse
	GRP78 BiP Antibody is a non-conjugated and Mouse origined monoclonal antibody about 72kDa, targeting to GRP78 BiP. It can be used for WB,ICC,IHC-P assays with tag free, in the background of Human, Mouse.

HY-P80696

	*GRP78 BiP* Antibody (YA746)** HSPA5; GRP78; 78 kDa glucose-regulated protein; GRP-78; Endoplasmic reticulum lumenal Ca(2+)-binding protein grp78; Heat shock 70 kDa protein 5; Immunoglobulin heavy chain-binding protein; BiP	WB, ICC/IF, IP	Human, Mouse, Rat
	GRP78 BiP Antibody (YA746) is a non-conjugated and Mouse origined monoclonal antibody about 72 kDa, targeting to GRP78 BiP (4F11). It can be used for WB,ICC/IF,IP assays with tag free, in the background of Human, Mouse, Rat.

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BiP

Inhibitors & Agonists

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NaturalProducts

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