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Results for "

CCL11

" in MedChemExpress (MCE) Product Catalog:

By Targets:	CCR (3) COX (1) GSNOR (1) NF-κB (1) Small Interfering RNA (siRNA) (1)
By Research Areas:	Endocrinology (2) Inflammation/Immunology (4) Neurological Disease (1)
Oligonucleotides:	Pre-designed siRNA Sets (1) siRNAs (1)

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Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-103361

SB297006 1 Publications Verification	CCR	Neurological Disease Endocrinology
SB297006 is a CCR3 antagonist, which significantly inhibits proliferation and neurosphere formation in CCL11-treated neural progenitor cells.

HY-N2609

7,4'-Dihydroxyflavone 1 Publications Verification	COX CCR NF-κB	Inflammation/Immunology Endocrinology
7,4'-Dihydroxyflavone (7,4'-DHF) is a flavonoid, which can be isolated from Glycyrrhiza uralensis. 7,4'-Dihydroxyflavone is *eotaxin/CCL11* inhibitor and CBR1 inhibitor (IC₅₀=0.28 μM). 7,4'-Dihydroxyflavone has the ability to consistently suppress eotaxin production and prevent dexamethasone (Dex)‐paradoxical adverse effects on eotaxin production . 7,4'-Dihydroxyflavone (7,4'-DHF) inhibits MUC5AC gene expression, mucus production and secretion via regulation of NF-κB, STAT6 and HDAC2.7,4'-Dihydroxyflavone (7,4'-DHF) decreases phorbol 12-myristate 13-acetate (PMA) stimulated NCI-H292 human airway epithelial cell MUC5AC gene expression and mucus production with IC₅₀ value of 1.4 µM .

HY-RS02081

CCL11 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
CCL11 Human Pre-designed siRNA Set A contains three designed siRNAs for CCL11 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

CCL11 Human Pre-designed siRNA Set A CCL11 Human Pre-designed siRNA Set A

HY-P99474

Bertilimumab CAT 213; iCo-008	CCR	Inflammation/Immunology
Bertilimumab (CAT 213; iCo-008) is a human monoclonal antibody targeting eotaxin-1 (CCL11). Bertilimumab has the potential for allergic disorders research .

HY-110295

SPL-334	GSNOR	Inflammation/Immunology
SPL-334 is a potent and selective S-Nitrosoglutathione reductase (GSNOR) inhibitor. SPL-334 causes a significant reduction in the production of Th2 cytokines IL-5 and IL-13 and the levels of the chemokine CCL11 (eotaxin-1) in the airways. SPL-334 can be used in research of allergic airway inflammation .

HY-111198

YM-355179 fumarate	Others	Inflammation/Immunology
YM-355179 fumarate is a newly synthesized selective CCR3 antagonist with the potential to inhibit eosinophil-related allergic inflammatory diseases. YM-355179 can effectively inhibit the binding of CCL11 and CCL5 to CCR3-expressing cells, with IC₅₀ values of 7.6 nM and 24 nM respectively. In functional experiments, YM-355179 can inhibit CCL11-induced intracellular Ca(2+) influx, chemotaxis and eosinophil degranulation, IC₅₀ The values are 8.0 nM, 24 nM and 29 nM respectively .

Cat. No.	Product Name	Target	Research Area

HY-P99474

Bertilimumab CAT 213; iCo-008	CCR	Inflammation/Immunology
Bertilimumab (CAT 213; iCo-008) is a human monoclonal antibody targeting eotaxin-1 (CCL11). Bertilimumab has the potential for allergic disorders research .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N2609

7,4'-Dihydroxyflavone 1 Publications Verification	Structural Classification Flavonoids Classification of Application Fields Flavones Leguminosae Source classification Phenols Polyphenols Plants Glycyrrhiza uralensis Fisch. Disease Research Fields Endocrinology	COX CCR NF-κB
7,4'-Dihydroxyflavone (7,4'-DHF) is a flavonoid, which can be isolated from Glycyrrhiza uralensis. 7,4'-Dihydroxyflavone is *eotaxin/CCL11* inhibitor and CBR1 inhibitor (IC₅₀=0.28 μM). 7,4'-Dihydroxyflavone has the ability to consistently suppress eotaxin production and prevent dexamethasone (Dex)‐paradoxical adverse effects on eotaxin production . 7,4'-Dihydroxyflavone (7,4'-DHF) inhibits MUC5AC gene expression, mucus production and secretion via regulation of NF-κB, STAT6 and HDAC2.7,4'-Dihydroxyflavone (7,4'-DHF) decreases phorbol 12-myristate 13-acetate (PMA) stimulated NCI-H292 human airway epithelial cell MUC5AC gene expression and mucus production with IC₅₀ value of 1.4 µM .

Species:	Human (2) Rhesus Macaque (1) Rat (1) Mouse (1)
Tag:	His (2) Tag Free (3)
Source:	E. coli (5)

Cat. No.	Compare	Product Name	Species	Source

HY-P71901

	CCL11 Protein, Rat CCL11; Scya11Eotaxin; C-C motif chemokine 11; Eosinophil chemotactic protein; Small-inducible cytokine A11	Rat	E. coli
	CCL11 protein directly promotes eosinophil accumulation in allergic reactions, selectively affecting eosinophils without influencing other immune cells. It binds to CCR3, emphasizing its role in eosinophil-mediated processes. The interaction between CCL11 and its receptor provides insights into the regulation of allergic reactions. CCL11 Protein, Rat is the recombinant rat-derived CCL11 protein, expressed by E. coli , with tag free. The total length of CCL11 Protein, Rat is 74 a.a., with molecular weight of ~10 kDa.

HY-P700285

	CCL11 Protein, Rhesus macaque (N-His) CCL11; SCYA11Eotaxin; C-C motif chemokine 11; Small-inducible cytokine A11	Rhesus Macaque	E. coli
	The CCL11 protein directly promotes eosinophil accumulation in response to allergens, a key feature of allergic inflammation, without significantly affecting lymphocytes, macrophages, or neutrophils. This selective recruitment highlights the specificity of CCL11 in the coordination of immune responses, particularly in allergy. CCL11 Protein, Rhesus macaque (N-His) is the recombinant Rhesus Macaque-derived CCL11 protein, expressed by E. coli , with N-6*His labeled tag. The total length of CCL11 Protein, Rhesus macaque (N-His) is 74 a.a., with molecular weight of ~11 kDa.

HY-P7159

	*Eotaxin/CCL11* Protein, Human** rHuEotaxin/CCL11; C-C motif chemokine 11; Eosinophil chemotactic protein; SCYA11	Human	E. coli
	Eotaxin/CCL11 Protein, Human is a potent chemoattractant for eosinophil cells and provides a new mechanism to explain tissue eosinophilia.

HY-P7160

	*Eotaxin/CCL11* Protein, Mouse** rMuEotaxin/CCL11; C-C motif chemokine 11; Eosinophil chemotactic protein; SCYA11	Mouse	E. coli
	Eotaxin/CCL11 Protein, Mouse is a potent chemoattractant for eosinophil cells and provides a new mechanism to explain tissue eosinophilia.

HY-P700963

	*Eotaxin/CCL11* Protein, Human (His)** Eotaxin; C-C motif chemokine 11; Small-inducible cytokine A11; SCYA11; eotaxin-1	Human	E. coli
	Eotaxin/CCL11 Protein actively promotes eosinophil accumulation in response to allergens, a distinctive feature of allergic inflammation, emphasizing its pivotal role in immune response orchestration during allergies. This regulatory function is achieved through binding to the CCR3 receptor, underscoring its specific interaction with cellular receptors to modulate eosinophil migration and activation in response to allergenic stimuli. Eotaxin/CCL11 Protein, Human (His) is the recombinant human-derived Eotaxin/CCL11 protein, expressed by E. coli , with N-His labeled tag. The total length of Eotaxin/CCL11 Protein, Human (His) is 74 a.a., with molecular weight of 13-15 kDa.

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CCL11 Human Pre-designed siRNA Set A		siRNAs Pre-designed siRNA Sets
CCL11 Human Pre-designed siRNA Set A contains three designed siRNAs for CCL11 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

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