CD14

By Targets:	Aryl Hydrocarbon Receptor (1) Bacterial (1) Biochemical Assay Reagents (1) E1/E2/E3 Enzyme (1) Endogenous Metabolite (1) Interleukin Related (1) p38 MAPK (1) Small Interfering RNA (siRNA) (2) TNF Receptor (1) Toll-like Receptor (TLR) (1)
By Research Areas:	Cancer (1) Infection (2) Inflammation/Immunology (5)
Oligonucleotides:	Mouse Pre-designed siRNA Sets (1) Human Pre-designed siRNA Sets (1) siRNAs (2)

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-P99008

Atibuclimab 1 Publications Verification	Toll-like Receptor (TLR)	Inflammation/Immunology
Atibuclimab, is a chimeric monoclonal antibody directed against *CD14* and is composed of murine variable and human IgG4 Fc regions. Atibuclimab can be used for the research of amyotrophic lateral sclerosis . Atibuclimab attenuates LPS-induced symptoms and strongly inhibits LPS-induced proinflammatory cytokine release, while only delaying the release of the anti-inflammatory cytokines soluble TNF receptor type I and IL-1 receptor antagonist .

HY-135750

VAF347 2 Publications Verification	Aryl Hydrocarbon Receptor	Inflammation/Immunology
VAF347 is a cell permeable and highly affinity aryl hydrocarbon receptor (AhR) agonist and induces AhR signaling. VAF347 inhibits the development of CD14 ⁺CD11b ⁺ monocytes from granulo-monocytic (GM stage) precursors. VAF347 has anti-inflammatory effects .

HY-N9965

2'-Fucosyllactose 2'-FL	TNF Receptor Interleukin Related	Infection Inflammation/Immunology
2'-Fucosyllactose (2'-FL) is an oligosaccharide that could be derived from human milk. 2'-Fucosyllactose regulates the expression of CD14, alleviates colitis and regulates the gut microbiome. 2'-Fucosyllactose stimulates T cells to increase IFN-γ production and decreases IL-6, IL-17, and TNF-α production of cytokines .

HY-W251428

Phosphatidylglycerols (egg) sodium salt Egg PG	Biochemical Assay Reagents	Others
Phosphatidylglycerols (PG) is a selective inhibitor targeting the TLR4 accessory protein *CD14/MD-2* complex, inhibiting LPS or virus (such as RSV)-mediated inflammatory signaling pathways through competitive binding. Phosphatidylglycerols directly bind to viral particles to block infection, inhibit COX-2 expression to reduce the release of inflammatory factors (IL-6, IL-8), and improve oxidative stress by regulating mitochondrial membrane phospholipid remodeling. Phosphatidylglycerols can be taken orally or by inhalation and can be used in the study of chronic inflammatory diseases (such as atherosclerosis) and respiratory viral infections (such as RSV) .

HY-169067

10-Methoxy-canthin-6-one Mtx-C	p38 MAPK	Cancer
0-Methoxy-canthin-6-one (Mtx-C) is a DNA damage inducer. 0-Methoxy-canthin-6-one promotes cell cycle arrest at the G2/M phase by intercalating into DNA, thereby inducing myeloid differentiation of acute myeloid leukemia (AML) cells and leukemic stem cells (LSCs). The myeloid differentiation in AML and LSC cells is characterized by increased expression of myeloperoxidase, CD15, CD11b, and *CD14, as well as activation of p38 MAPK*. 0-Methoxy-canthin-6-one can be used in leukemia research .

HY-RS16726

Cd14 Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA)
Cd14 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Cd14 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Cd14 Mouse Pre-designed siRNA Set A Cd14 Mouse Pre-designed siRNA Set A

HY-RS02189

CD14 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
CD14 Human Pre-designed siRNA Set A contains three designed siRNAs for CD14 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

CD14 Human Pre-designed siRNA Set A CD14 Human Pre-designed siRNA Set A

HY-151399

Antimicrobial agent-5	Bacterial	Infection
Antimicrobial agent-5 is an potent antimicrobial agent, and displays excellent cell selectivity against Gram-negative bacteria and Gram-positive bacteria. Antimicrobial agent-5 blocks the interaction between LPS and CD14/TLR4 receptor, and shows anti-inflammatory activity against LPS-induced inflammation .

HY-101132

VB-201	Endogenous Metabolite	Inflammation/Immunology
VB-201 is an oxidized phospholipid small molecule with anti-inflammatory activity. VB-201 inhibits CD14- and Toll-like receptor 2-dependent innate cell activation. VB-201 limits the progression of atherosclerosis and can be used to study atherosclerosis .

HY-161901

BC-1293	E1/E2/E3 Enzyme	Inflammation/Immunology
BC-1293 is an inhibitor for E3 ligase subunit FBXO24. BC-1293 disrupts the interaction between FBXO24 and aspartyl-tRNA synthetase (DARS2) and increases the level of DARS2. BC-1293 increases levels of IL-1β, IL-9, MIP-2, and TNF α, and exhibits immunostimulatory activity in mice .

Cat. No.	Product Name	Type

HY-W251428

Phosphatidylglycerols (egg) sodium salt Egg PG	Drug Delivery
Phosphatidylglycerols (PG) is a selective inhibitor targeting the TLR4 accessory protein *CD14/MD-2* complex, inhibiting LPS or virus (such as RSV)-mediated inflammatory signaling pathways through competitive binding. Phosphatidylglycerols directly bind to viral particles to block infection, inhibit COX-2 expression to reduce the release of inflammatory factors (IL-6, IL-8), and improve oxidative stress by regulating mitochondrial membrane phospholipid remodeling. Phosphatidylglycerols can be taken orally or by inhalation and can be used in the study of chronic inflammatory diseases (such as atherosclerosis) and respiratory viral infections (such as RSV) .

Phosphatidylglycerols (egg) sodium salt

Egg PG

Drug Delivery

Phosphatidylglycerols (PG) is a selective inhibitor targeting the TLR4 accessory protein CD14/MD-2 complex, inhibiting LPS or virus (such as RSV)-mediated inflammatory signaling pathways through competitive binding. Phosphatidylglycerols directly bind to viral particles to block infection, inhibit COX-2 expression to reduce the release of inflammatory factors (IL-6, IL-8), and improve oxidative stress by regulating mitochondrial membrane phospholipid remodeling. Phosphatidylglycerols can be taken orally or by inhalation and can be used in the study of chronic inflammatory diseases (such as atherosclerosis) and respiratory viral infections (such as RSV) .

Cat. No.	Product Name	Target	Research Area

HY-P99008

Atibuclimab 1 Publications Verification	Toll-like Receptor (TLR)	Inflammation/Immunology
Atibuclimab, is a chimeric monoclonal antibody directed against *CD14* and is composed of murine variable and human IgG4 Fc regions. Atibuclimab can be used for the research of amyotrophic lateral sclerosis . Atibuclimab attenuates LPS-induced symptoms and strongly inhibits LPS-induced proinflammatory cytokine release, while only delaying the release of the anti-inflammatory cytokines soluble TNF receptor type I and IL-1 receptor antagonist .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N9965

2'-Fucosyllactose 2'-FL	Infection Structural Classification Polysaccharides Animals Classification of Application Fields Inflammation/Immunology Disease Research Fields Saccharides	TNF Receptor Interleukin Related
2'-Fucosyllactose (2'-FL) is an oligosaccharide that could be derived from human milk. 2'-Fucosyllactose regulates the expression of CD14, alleviates colitis and regulates the gut microbiome. 2'-Fucosyllactose stimulates T cells to increase IFN-γ production and decreases IL-6, IL-17, and TNF-α production of cytokines .

Recombinant Proteins Recommended:

CD14

Species:	Human (2) Rat (2) Mouse (2) Cynomolgus (1)
Tag:	His (5) Fc (3)
Source:	HEK293 (7)

Cat. No.	Compare	Product Name	Species	Source

HY-P74331

	CD14 Protein, Rat (HEK293, His) Monocyte Differentiation Antigen CD14; CD14	Rat	HEK293
	The CD14 protein acts as a coreceptor for bacterial lipopolysaccharide (LPS), forming a complex with LY96 and TLR4. It binds monomeric LPS to LBP, delivers it to the LY96/TLR4 complex and initiates an immune response. CD14 Protein, Rat (HEK293, His) is the recombinant rat-derived CD14 protein, expressed by HEK293 , with C-His labeled tag. The total length of CD14 Protein, Rat (HEK293, His) is 324 a.a., with molecular weight of 45-57 kDa.

HY-P75445

	CD14 Protein, Cynomolgus (HEK293, His) Monocyte Differentiation Antigen CD14; CD14	Cynomolgus	HEK293
	CD14 protein is a key coreceptor that cooperates with LBP to bind LPS and deliver it to the LY96/TLR4 complex to generate an immune response. CD14 activates NF-kappa-B through MyD88, TIRAP and TRAF6, triggering inflammation and cytokine release. CD14 Protein, Cynomolgus (HEK293, His) is the recombinant cynomolgus-derived CD14 protein, expressed by HEK293 , with C-His labeled tag. The total length of CD14 Protein, Cynomolgus (HEK293, His) is 344 a.a., with molecular weight of 45-56 kDa.

HY-P75444

	CD14 Protein, Mouse (HEK293, His-Fc) 1 Publications Verification Monocyte Differentiation Antigen CD14; CD14	Mouse	HEK293
	CD14 protein is a key protein in the innate immune response and is significantly expressed in monocytes/macrophages. It acts as a coreceptor that binds various microbial and fungal molecules, including lipopolysaccharide (LPS). CD14 Protein, Mouse (HEK293, His-Fc) is the recombinant mouse-derived CD14 protein, expressed by HEK293 , with C-hFc, C-His, C-6*His labeled tag.

HY-P7786

	CD14 Protein, Human (HEK293, His) rHuCD14, His; Monocyte Differentiation Antigen CD14; Myeloid Cell-Specific Leucine-Rich Glycoprotein; CD14	Human	HEK293
	CD14 Protein, Human (HEK293, His) is a recombinant human CD14 expressed in HEK 293 cells with a His tag at the N-terminus. CD14 Protein is an efficient target for recombinant immunoglobulin vaccine constructs that deliver T cell epitopes.

HY-P73531

	CD14 Protein, Mouse (HEK293, His) rHuCD14, His; Monocyte Differentiation Antigen CD14; Myeloid Cell-Specific Leucine-Rich Glycoprotein; CD14	Mouse	HEK293
	CD14 protein is a key protein in the innate immune response and is significantly expressed in monocytes/macrophages. It acts as a coreceptor that binds various microbial and fungal molecules, including lipopolysaccharide (LPS). CD14 Protein, Mouse (HEK293, His) is the recombinant mouse-derived CD14 protein, expressed by HEK293 , with C-6*His labeled tag.

HY-P74332

	CD14 Protein, Rat (HEK293, Fc) Monocyte Differentiation Antigen CD14; CD14	Rat	HEK293
	The CD14 protein acts as a coreceptor for bacterial lipopolysaccharide (LPS), forming a complex with LY96 and TLR4. It binds monomeric LPS to LBP, delivers it to the LY96/TLR4 complex and initiates an immune response. CD14 Protein, Rat (HEK293, Fc) is the recombinant rat-derived CD14 protein, expressed by HEK293 , with C-hFc labeled tag. The total length of CD14 Protein, Rat (HEK293, Fc) is 341 a.a., with molecular weight of ~72 kDa.

HY-P74333

	CD14 Protein, Human (HEK293, Fc) Monocyte Differentiation Antigen CD14; CD14	Human	HEK293
	The CD14 protein binds to LBP, binds to monomeric lipopolysaccharide (LPS), and delivers it to the LY96/TLR4 complex, promoting the innate immune response against bacterial LPS. CD14 Protein, Human (HEK293, Fc) is the recombinant human-derived CD14 protein, expressed by HEK293 , with N-hFc labeled tag. The total length of CD14 Protein, Human (HEK293, Fc) is 333 a.a., with molecular weight of 75-85 kDa.

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HY-P81096

	CD14 Antibody CD14 antigen; CD14 molecule; Lipopolysaccharide receptor; LPSR; Monocyte Differentiation Antigen 14; Monocyte differentiation antigen CD14; Myeloid cell specific leucine rich glycoprotein; CD14_MOUSE; Myeloid cell-specific leucine-rich glycoprotein.	WB, IHC-P, ICC/IF	Human
	CD14 Antibody is an unconjugated, approximately 40 kDa, rabbit-derived, anti-CD14 monoclonal antibody. CD14 Antibody can be used for: WB,IHC-P, ICC/IF expriments in human background without labeling.

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Cat. No.	Product Name		Classification

HY-RS16726

Cd14 Mouse Pre-designed siRNA Set A		siRNAs Mouse Pre-designed siRNA Sets
Cd14 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Cd14 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS02189

CD14 Human Pre-designed siRNA Set A		siRNAs Human Pre-designed siRNA Sets
CD14 Human Pre-designed siRNA Set A contains three designed siRNAs for CD14 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

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