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COX-1/2-IN-2

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34

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Natural
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5

Isotope-Labeled Compounds

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Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-15036
    Diclofenac
    Maximum Cited Publications
    17 Publications Verification

    		 COX Apoptosis Inflammation/Immunology Cancer
    Diclofenac is a potent and nonselective anti-inflammatory agent, acts as a COX inhibitor, with IC50s of 4 and 1.3 nM for human COX-1 and COX-2 in CHO cells , and 5.1 and 0.84 μM for ovine COX-1 and COX-2, respectively . Diclofenac induces apoptosis of neural stem cells (NSCs) via the activation of the caspase cascade .
    Diclofenac
  • HY-15038
    Diclofenac potassium
    Maximum Cited Publications
    17 Publications Verification

    		 COX Apoptosis Inflammation/Immunology Cancer
    Diclofenac potassium is a potent and nonselective anti-inflammatory agent, acts as a COX inhibitor, with IC50s of 4 and 1.3 nM for human COX-1 and COX-2 in CHO cells , and 5.1 and 0.84 μM for ovine COX-1 and COX-2, respectively . Diclofenac potassium induces apoptosis of neural stem cells (NSCs) via the activation of the caspase cascade .
    Diclofenac potassium
  • HY-15036A
    Diclofenac diethylamine
    Maximum Cited Publications
    17 Publications Verification

    		 COX Apoptosis Inflammation/Immunology Cancer
    Diclofenac diethylamine is a potent and nonselective anti-inflammatory agent, acts as a COX inhibitor, with IC50s of 4 and 1.3 nM for human COX-1 and COX-2 in CHO cells , and 5.1 and 0.84 μM for ovine COX-1 and COX-2, respectively . Diclofenac diethylamine induces apoptosis of neural stem cells (NSCs) via the activation of the caspase cascade .
    Diclofenac diethylamine
  • HY-15037
    Diclofenac Sodium
    Maximum Cited Publications
    17 Publications Verification

    GP 45840

    		 COX Apoptosis Inflammation/Immunology Cancer
    Diclofenac Sodium (GP 45840) is a potent and nonselective anti-inflammatory agent, acts as a COX inhibitor, with IC50s of 4 and 1.3 nM for human COX-1 and COX-2 in CHO cells , and 5.1 and 0.84 μM for ovine COX-1 and COX-2, respectively . Diclofenac Sodium induces apoptosis of neural stem cells (NSCs) via the activation of the caspase cascade .
    Diclofenac Sodium
  • HY-B1130
    Isoxicam

    		COX Inflammation/Immunology
    Isoxicam is an orally active, long-acting, non-steroidal anti-inflammatory agent for the research of arthritis . Isoxicam is a nonselective inhibitor of COX-1 and COX-2 .
    Isoxicam
  • HY-15037R
    Diclofenac (Sodium) (Standard)

    GP 45840 (Standard)

    		 COX Apoptosis Inflammation/Immunology Cancer
    Diclofenac (Sodium) (Standard) is the analytical standard of Diclofenac (Sodium). This product is intended for research and analytical applications. Diclofenac Sodium (GP 45840) is a potent and nonselective anti-inflammatory agent, acts as a COX inhibitor, with IC50s of 4 and 1.3 nM for human COX-1 and COX-2 in CHO cells , and 5.1 and 0.84 μM for ovine COX-1 and COX-2, respectively . Diclofenac Sodium induces apoptosis of neural stem cells (NSCs) via the activation of the caspase cascade .
    Diclofenac (Sodium) (Standard)
  • HY-15037S1
    Diclofenac-d4 sodium

    		COX Apoptosis Inflammation/Immunology
    Diclofenac-d4 (sodium) is the deuterium labeled Diclofenac sodium. Diclofenac Sodium (GP 45840) is a potent and nonselective anti-inflammatory agent, acts as a COX inhibitor, with IC50s of 4 and 1.3 nM for human COX-1 and COX-2 in CHO cells[1], and 5.1 and 0.84 μM for ovine COX-1 and COX-2, respectively[2]. Diclofenac Sodium induces apoptosis of neural stem cells (NSCs) via the activation of the caspase cascade[3].
    Diclofenac-d4 sodium
  • HY-115967
    COX-1/2-IN-2

    		COX Inflammation/Immunology
    COX-1/2-IN-2 is a potent COX1/2 inhibitor. COX-1/2-IN-2 exhibits significant inhibitory effect against COX-1 and COX-2 inhibitor with IC50 values of 9.7 ± 0.09 µM and 4.6 ± 1.45 µM, respectively .
    COX-1/2-IN-2
  • HY-115966
    COX-1/2-IN-1

    		COX Inflammation/Immunology
    COX-1/2-IN-2 is a potent COX1/2 inhibitor. COX-1/2-IN-2 exhibits significant inhibitory effect against COX-1 and COX-2 inhibitor with IC50 values of 13.9 ± 3.21 µM and 6.4±0.74 µM, respectively .
    COX-1/2-IN-1
  • HY-15036R
    Diclofenac (Standard)

    		COX Apoptosis Inflammation/Immunology Cancer
    Diclofenac (Standard) is the analytical standard of Diclofenac. This product is intended for research and analytical applications. Diclofenac is a potent and nonselective anti-inflammatory agent, acts as a COX inhibitor, with IC50s of 4 and 1.3 nM for human COX-1 and COX-2 in CHO cells , and 5.1 and 0.84 μM for ovine COX-1 and COX-2, respectively . Diclofenac induces apoptosis of neural stem cells (NSCs) via the activation of the caspase cascade .
    Diclofenac (Standard)
  • HY-15038R
    Diclofenac (potassium) (Standard)

    		COX Apoptosis Inflammation/Immunology Cancer
    Diclofenac (potassium) (Standard) is the analytical standard of Diclofenac (potassium). This product is intended for research and analytical applications. Diclofenac potassium is a potent and nonselective anti-inflammatory agent, acts as a COX inhibitor, with IC50s of 4 and 1.3 nM for human COX-1 and COX-2 in CHO cells , and 5.1 and 0.84 μM for ovine COX-1 and COX-2, respectively . Diclofenac potassium induces apoptosis of neural stem cells (NSCs) via the activation of the caspase cascade .
    Diclofenac (potassium) (Standard)
  • HY-15036S
    Diclofenac-d4

    		Isotope-Labeled Compounds COX Apoptosis Inflammation/Immunology
    Diclofenac-d4 is the deuterium labeled Diclofenac. Diclofenac is a potent and nonselective anti-inflammatory agent, acts as a COX inhibitor, with IC50s of 4 and 1.3 nM for human COX-1 and COX-2 in CHO cells[1], and 5.1 and 0.84 μM for ovine COX-1 and COX-2, respectively[2]. Diclofenac induces apoptosis of neural stem cells (NSCs) via the activation of the caspase cascade[3].
    Diclofenac-d4
  • HY-15037S
    Diclofenac-13C6 sodium heminonahydrate

    		Isotope-Labeled Compounds COX Apoptosis Inflammation/Immunology
    Diclofenac- 13C6 (sodium heminonahydrate) is the 13C-labeled Diclofenac Sodium. Diclofenac Sodium (GP 45840) is a potent and nonselective anti-inflammatory agent, acts as a COX inhibitor, with IC50s of 4 and 1.3 nM for human COX-1 and COX-2 in CHO cells[1], and 5.1 and 0.84 μM for ovine COX-1 and COX-2, respectively[2]. Diclofenac Sodium induces apoptosis of neural stem cells (NSCs) via the activation of the caspase cascade[3].
    Diclofenac-13C6 sodium heminonahydrate
  • HY-15036AR
    Diclofenac (diethylamine) (Standard)

    		COX Apoptosis Inflammation/Immunology Cancer
    Diclofenac (diethylamine) (Standard) is the analytical standard of Diclofenac (diethylamine). This product is intended for research and analytical applications. Diclofenac diethylamine is a potent and nonselective anti-inflammatory agent, acts as a COX inhibitor, with IC50s of 4 and 1.3 nM for human COX-1 and COX-2 in CHO cells , and 5.1 and 0.84 μM for ovine COX-1 and COX-2, respectively . Diclofenac diethylamine induces apoptosis of neural stem cells (NSCs) via the activation of the caspase cascade .
    Diclofenac (diethylamine) (Standard)
  • HY-13913
    NS-398
    15+ Cited Publications

    		 COX Inflammation/Immunology Cancer
    NS-398 is a non-steroidal an-inflammatory agent with analgesic and antipyretic effects, and selectively inhibits prostaglandin G/H synthase 2/cyclooxygenase 2 (COX-2) activity, with an IC50 of 3.8 μM, and has no effect on COX-1 at 100 μM.
    NS-398
  • HY-19384
    Enflicoxib

    E 6087

    		 COX Inflammation/Immunology
    Enflicoxib (E 6087) is a nonsteroidal anti-inflammatory compound that selectively inhibits cyclooxygenase-2 (COX-2).?Enflicoxib does not inhibit cyclooxygenase-1 (COX-1). E-6087 shows anti-inflammatory, analgesic and antipyretic activities in animal models .
    Enflicoxib
  • HY-B1130R
    Isoxicam (Standard)

    		COX Inflammation/Immunology
    Isoxicam (Standard) is the analytical standard of Isoxicam. This product is intended for research and analytical applications. Isoxicam is an orally active, long-acting, non-steroidal anti-inflammatory agent for the research of arthritis . Isoxicam is a nonselective inhibitor of COX-1 and COX-2 .
    Isoxicam (Standard)
  • HY-B0580S1
    Ketorolac-d4

    		Isotope-Labeled Compounds COX Inflammation/Immunology
    Ketorolac-d4 (RS37619 D4) is the deuterium labeled Ketorolac. Ketorolac is a non-steroidal anti-inflammatory agent, acting as a nonselective COX inhibitor, with IC50s of 20 nM for COX-1 and 120 nM for COX-2[1][2].
    Ketorolac-d4
  • HY-N0607R
    Ginsenoside Ro (Standard)

    		Calcium Channel Prostaglandin Receptor Cardiovascular Disease Endocrinology
    Ginsenoside Ro (Standard) is the analytical standard of Ginsenoside Ro. This product is intended for research and analytical applications. Ginsenoside Ro (Polysciasaponin P3; Chikusetsusaponin 5; Chikusetsusaponin V) exhibits a Ca2+-antagonistic antiplatelet effect with an IC50 of 155 μM. Ginsenoside Ro reduces the production of TXA2 more than it reduces the activities of COX-1 and TXAS.
    Ginsenoside Ro (Standard)
  • HY-114200
    Imrecoxib

    BAP-909

    		 COX Inflammation/Immunology
    Imrecoxib (BAP-909) is a novel and selective cyclooxygenase 2 (COX-2) inhibitor with an IC50 value of 18 nM, it also inhibits COX1- activity with an IC50 value of 115 nM. Imrecoxib (BAP-909) has anti-inflammatory effect .
    Imrecoxib
  • HY-121537
    CAY10404

    		COX Akt Apoptosis Neurological Disease Inflammation/Immunology Cancer
    CAY10404 is a potent and selective cyclooxygenase-2 (COX-2) inhibitor with an IC50 of 1 nM and a selectivity index (SI; COX-1 IC50/COX-2 IC50) of >500000. CAY10404 is a potent PKB/Akt and MAPK signaling pathways inhibitor and induces apoptosis in non-small cell lung cancer (NSCLC) cells. CAY10404, a diarylisoxazole, has good analgesic, anti-inflammatory, and anti-cancer activities .
    CAY10404
  • HY-114200R
    Imrecoxib (Standard)

    		COX Inflammation/Immunology
    Imrecoxib (Standard) is the analytical standard of Imrecoxib. This product is intended for research and analytical applications. Imrecoxib (BAP-909) is a novel and selective cyclooxygenase 2 (COX-2) inhibitor with an IC50 value of 18 nM, it also inhibits COX1- activity with an IC50 value of 115 nM. Imrecoxib (BAP-909) has anti-inflammatory effect .
    Imrecoxib (Standard)
  • HY-111310
    ML351
    1 Publications Verification

    		 Lipoxygenase Neurological Disease Metabolic Disease
    ML351 is a potent and highly specific 15-LOX-1 inhibitor with an IC50 of 200 nM. ML351 shows excellent selectivity (>250-fold) versus the related isozymes, 5-LOX, platelet 12-LOX, 15-LOX-2, ovine COX-1, and human COX-2 . ML351 prevents dysglycemia and reduces β-cell oxidative stress in nonobese diabetic mouse model of T1D .
    ML351
  • HY-170938
    AChE-IN-82

    		Cholinesterase (ChE) Monoamine Oxidase Beta-secretase COX LOX-1 Neurological Disease
    AChE-IN-82 (compound 49) is an acetylcholinesterase (AChE) inhibitor. AChE-IN-82 inhibits eeAChE, eqBChE, hMAO-A, hMAO-B, and BACE-1 with IC50s of 0.072, 9.81, 14.52, 0.024, 2.42 μM, respectively. AChE-IN-82 inhibits COX-1, COX-2 and 5-LOX with IC50s of 60.41, 0.187, 0.18 μM, respectively. AChE-IN-82 shows an excellent neuroprotective effect by significantly reducing oxidative stress induced by H2 O2 .
    AChE-IN-82
  • HY-121828
    TX-1123

    		Src CaMK PKA EGFR PKC COX Cancer
    TX-1123 is a potent protein tyrosine kinase (PTK) inhibitor for Src, eEF2-K, and PKA, and EGFR-K/PKC. TX-1123 is a cyclo-oxygenase (COX) inhibitor with IC50 values of 1.16 μM and 15.7 μM for COX2 and COX1, respectively. TX-1123 has low mitochondrial toxicity. TX-1123 can be used in research of cancer .
    TX-1123
  • HY-146295
    COX-2/5-LOX-IN-2

    		COX Inflammation/Immunology
    COX-2/5-LOX-IN-2 (5b) is a potent and dual inhibitor of COX-2/5-LOX. COX-2/5-LOX-IN-2 is a benzothiophen-2-yl pyrazole carboxylic acid derivative. COX-2/5-LOX-IN-2 shows the most potent analgesic and anti-inflammatory activities surpassing that of Celecoxib and Indomethacin. COX-2/5-LOX-IN-2 shows potent COX-1, COX-2 and 5-LOX inhibitory activity with IC50s of 5.40, 0.01 and 1.78 μM, respectively .
    COX-2/5-LOX-IN-2
  • HY-146294
    COX-2/5-LOX-IN-1

    		COX Inflammation/Immunology
    COX-2/5-LOX-IN-1 (compound 3a) is a potent and dual inhibitor of COX-2/5-LOX. COX-2/5-LOX-IN-1 is a benzothiophen-2-yl pyrazole carboxylic acid derivative. COX-2/5-LOX-IN-1 shows the most potent analgesic and anti-inflammatory activities surpassing that of Celecoxib and Indomethacin. COX-2/5-LOX-IN-1 shows potent COX-1, COX-2 and 5-LOX inhibitory activity with IC50s of 12.13, 0.4 and 4.96 μM, respectively .
    COX-2/5-LOX-IN-1
  • HY-170932
    EGFR/COX-2-IN-1

    		EGFR COX Apoptosis Cancer
    EGFR/COX-2-IN-1 is an EGFR/COX-2 inhibitor. EGFR/COX-2-IN-1 inhibits EGFR WT, EGFR T790M, COX-1 and COX-2 with IC50s of 0.12, 0.076, 20.1 and 1.52 μM respectively. EGFR/COX-2-IN-1 inhibits and with IC50s of , respectively. EGFR/COX-2-IN-1 inhibits MCF-7, HT-29 and A-549 with IC50s of 1.20, 5.14 and 14.81 μM, respectively. EGFR/COX-2-IN-1 displays Apoptosis induction by up-regulating Bax and down-regulating Bcl-2 protein levels. EGFR/COX-2-IN-1 results in a significant increase in the percentage of cells at the G2/M in MFC-7 cells. EGFR/COX-2-IN-1 exhibits broad-spectrum antitumor effects .
    EGFR/COX-2-IN-1
  • HY-B1398
    Ampyrone
    1 Publications Verification

    4-AmINophenazone

    		 COX Drug Metabolite Inflammation/Immunology
    Ampyrone is a metabolite of Metamizole sodium (HY-B1279A). Ampyrone is a PGE2-dependent blocker and inhibitor of COX .
    Ampyrone
  • HY-B1398S
    Ampyrone-d3

    4-AmINoantipyrINe-d3

    		 Isotope-Labeled Compounds COX Drug Metabolite Inflammation/Immunology
    Ampyrone-d3 is the deuterium labeled Ampyrone. Ampyrone is a metabolite of Metamizole sodium (HY-B1279A). Ampyrone is a PGE2-dependent blocker and inhibitor of COX .
    Ampyrone-d3
  • HY-121585
    CAY10698

    		Lipoxygenase Inflammation/Immunology
    CAY10698 (compound 1) is a potent and selective inhibitor of 12-Lipoxygenase (12-LOX) with an IC50 of 5.1 μM. CAY10698 is inactive against 5-LOX, 15-LOX-1, 15-LOX-2 and COX-1/2 .
    CAY10698
  • HY-W268542
    4-Acetylaminoantipyrine

    		COX SOD PGE synthase Inflammation/Immunology Cancer
    4-Acetylaminoantipyrine (4-AA) is a derivative of antipyrine (HY-B0171). 4-Acetylaminoantipyrine acts as a PGE2-dependent blocker and inhibitor of cyclooxygenase (COX) . 4-Acetylaminoantipyrine can inhibit Cu/ZnSOD . 4-Acetylaminoantipyrine can spontaneously bind with bovine serum albumin (BSA) and alter its conformation .
    4-Acetylaminoantipyrine
  • HY-W268542R
    4-Acetylaminoantipyrine (Standard)

    		COX SOD PGE synthase Inflammation/Immunology Cancer
    4-Acetylaminoantipyrine (Standard) is the analytical standard of 4-Acetylaminoantipyrine. This product is intended for research and analytical applications. 4-Acetylaminoantipyrine (4-AA) is a derivative of antipyrine (HY-B0171). 4-Acetylaminoantipyrine acts as a PGE2-dependent blocker and inhibitor of cyclooxygenase (COX) . 4-Acetylaminoantipyrine can inhibit Cu/ZnSOD . 4-Acetylaminoantipyrine can spontaneously bind with bovine serum albumin (BSA) and alter its conformation .
    4-Acetylaminoantipyrine (Standard)
  • HY-169430
    AGU654

    		PGE synthase
    AGU654 (Compound 44) is a selective mPGES-1 inhibitor with an IC50 of 2.9 nM against mPGES-1. AGU654 inhibits mPGES-1 to block the pathway converting arachidonic acid into prostaglandin E2 (PGE2) by COX-1/2, thereby alleviating inflammatory responses, pain, and fever. In activated human monocyte-derived macrophages and human whole blood models, AGU654 selectively suppresses bacterial exotoxin-induced PGE2 production while preserving the production of other prostaglandins. In guinea pig models, AGU654 significantly alleviates fever, inflammation, and inflammatory pain, exhibiting excellent anti-inflammatory, analgesic, and antipyretic effects. AGU654 holds promise as a strategy for studying inflammatory diseases and pain .
    AGU654

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