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Results for "

CTGF

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Apoptosis (2) Casein Kinase (1) ERK (1) p38 MAPK (1) Ras (1) ROCK (1) Survivin (1) TAM Receptor (1) YAP (8)
By Research Areas:	Cancer (10) Cardiovascular Disease (1) Inflammation/Immunology (1) Neurological Disease (1)

Inhibitors & Agonists

Peptides

Inhibitory Antibodies

Recombinant Proteins

Antibodies

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-P99288

FG-3019 Pamrevlumab; Anti-Human CTGF Recombinant Antibody	Apoptosis	Cancer
FG-3019 (Pamrevlumab) is a recombinant human antibody that binds to connective tissue growth factor (CTGF). FG-3019 can be used for the research of idiopathic pulmonary fibrosis (IPF) .

HY-155310

AF-2112	YAP	Cancer
AF-2112 is a Flufenamic acid-derived TEAD inhibitor hat strongly reduce the expression of CTGF, Cyr61, Axl and NF2.

HY-155309

LM-41	YAP	Cancer
LM-41 is a Flufenamic acid-derived TEAD inhibitor hat strongly reduce the expression of CTGF, Cyr61, Axl and NF2. LM-41 inhibits migration of human MDA-MB-231 breast cancer cells .

HY-120006A

(rel)-AR234960 1 Publications Verification	ERK	Cardiovascular Disease
(rel)-AR234960 is an active relative configuration of AR234960. AR234960, a non-peptide MAS (a G protein-coupled receptor) agonist, increases both mRNA and protein levels of CTGF via ERK1/2 signaling in HEK293-MAS cells and adult human cardiac fibroblasts .

HY-P1727

Super-TDU 4 Publications Verification	YAP	Cancer
Super-TDU is a specific YAP antagonist targeting YAP-TEADs interaction. Super-TDU suppresses tumor growth in gastric cancer mouse model .

HY-130011

CCG-232964	ROCK Ras	Neurological Disease Cancer
CCG-232964 is an orally active inhibitor of Rho/MRTF/SRF. CCG-232964 inhibits LPA-induced CTGF gene expression .

HY-162012

HC-258	YAP	Cancer
HC-258 (compound 26) binds with the cysteine in TEAD’s PA pocket. HC-258 reduces the CTGF, CYR61, AXL, and NF2 transcript levels and inhibits the migration of MDA-MB-231 breast cancer cells .

HY-168704

YAP/TAZ-TEAD-IN-2	YAP TAM Receptor Survivin	Cancer
YAP/TAZ-TEAD-IN-2 (Compound 51) is a YAP/TAZ-TEAD inhibitor that inhibits the interaction between YAP/TAZ and TEAD. YAP/TAZ-TEAD-IN-2 suppresses the transcriptional activity of TEAD, with an IC₅₀ of 1.2 nM. YAP/TAZ-TEAD-IN-2 inhibits YAP/TAZ-TEAD target genes expression (Cyr61, CTGF, AXL and Survivin) and breast cancer cell proliferation .

HY-168085

CV-4-26	YAP Apoptosis	Cancer
CV-4-26 (Compound 22) is a covalent inhibitor of TEAD. CV-4-26 inhibits YAP/TEAD-based transcription, leading to the reduction of CTGF and CYR61 expression. CV-4-26 inhibits Huh7 and HepG2 cell colony formation, induces cell cycle arrest, and apoptosis. CV-4-26 shows antitumor activity against hepatocellular carcinoma (HCC) and hepatoblastoma (HB) .

HY-P1727A

Super-TDU TFA	YAP	Cancer
Super-TDU TFA is a specific YAP antagonist targeting YAP-TEADs interaction. Super-TDU TFA suppresses tumor growth in gastric cancer mouse model .

HY-159912

pan-TEAD-IN-1	YAP	Cancer
pan-TEAD-IN-1 (Compound 3) is an orally active pan-TEAD inhibitor targeting the palmitoylation site of TEAD, disrupting its interaction with the coactivators YAP/TAZ, thereby suppressing the transcriptional upregulation of oncogenes (e.g., *Ctgf* and Cyr61) in the Hippo signaling pathway. pan-TEAD-IN-1 exhibits excellent activity with a luciferase IC₅₀ of 0.36 nM and an H226 cell IC₅₀ of 1.52 nM. It also shows favorable pharmacokinetics (AUC_0–∞ = 228.7 μg/mL·min, T_1/2 = 183.9 min). In TEAD-dependent xenograft mouse models, pan-TEAD-IN-1 significantly inhibited tumor growth, showing promise for research in TEAD-dependent cancers .

HY-10456

TAK-715 Maximum Cited Publications 12 Publications Verification	p38 MAPK Casein Kinase	Inflammation/Immunology
TAK-715 is an orally active and potent p38 MAPK inhibitor with IC₅₀s of 7.1 nM, 200 nM for p38α and p38β, respectively. TAK-715 inhibits casein kinase I (CK1δ/ε) to regulate activation of Wnt/β-catenin signaling. TAK-715 shows good significant efficacy in a rat arthritis model .

Cat. No.	Product Name	Target	Research Area

HY-P1727

Super-TDU 4 Publications Verification	YAP	Cancer
Super-TDU is a specific YAP antagonist targeting YAP-TEADs interaction. Super-TDU suppresses tumor growth in gastric cancer mouse model .

HY-P1727A

Super-TDU TFA	YAP	Cancer
Super-TDU TFA is a specific YAP antagonist targeting YAP-TEADs interaction. Super-TDU TFA suppresses tumor growth in gastric cancer mouse model .

Cat. No.	Product Name	Target	Research Area

HY-P99288

FG-3019 Pamrevlumab; Anti-Human CTGF Recombinant Antibody	Apoptosis	Cancer
FG-3019 (Pamrevlumab) is a recombinant human antibody that binds to connective tissue growth factor (CTGF). FG-3019 can be used for the research of idiopathic pulmonary fibrosis (IPF) .

Recombinant Proteins Recommended:

CTGF

Species:	Human (5) Rhesus Macaque (1) Mouse (1) Rat (1)
Tag:	His (4) Tag Free (2) Avi (1) GST (1) Fc (1)
Source:	HEK293 (6) E. coli (2)

Cat. No.	Compare	Product Name	Species	Source

HY-P70602

	*CCN2/CTGF* Protein, Human (HEK293, Fc)** Connective tissue growth factor; CCN family member 2; Hypertrophic chondrocyte-specific protein 24; Insulin-like growth factor-binding protein 8; CTGF; IGFBP8	Human	HEK293
	CCN2/CTGF (Connective Tissue Growth Factor) is a protein produced primarily by endothelial cells in blood vessels. It plays an important role in various cellular processes. CCN2/CTGF Protein, Human (HEK293, Fc) is the recombinant human-derived CCN2/CTGF protein, expressed by HEK293 , with C-hFc labeled tag. The total length of CCN2/CTGF Protein, Human (HEK293, Fc) is 323 a.a., with molecular weight of ~115.37 kDa (Non-reducing) and 63.5 & 35 kDa (Reducing), respectively.

HY-P72154

	*CCN2/CTGF* Protein, Mouse (GST)** 1 Publications Verification CCN 2; CCN family member 2; CCN2; Connective tissue growth factor; CTGF; CTGF_HUMAN; Hcs 24; Hcs24; Hypertrophic chondrocyte-specific protein 24; IBP-8; IGF-binding protein 8; IGFBP-8; IGFBP8; MGC102839; NOV 2; NOV2	Mouse	E. coli
	CCN2/CTGF protein is a major connective tissue mitochondrial attractant secreted by vascular endothelial cells and promotes chondrocyte proliferation and differentiation. It mediates heparin- and divalent cation-dependent cell adhesion in various cell types, including fibroblasts, myofibroblasts, endothelial cells, and epithelial cells. CCN2/CTGF Protein, Mouse (GST) is the recombinant mouse-derived CCN2/CTGF protein, expressed by E. coli , with N-GST labeled tag. The total length of CCN2/CTGF Protein, Mouse (GST) is 319 a.a., with molecular weight of ~62 kDa.

HY-P72153

	*CCN2/CTGF* Protein, Human (His)** 1 Publications Verification CCN 2; CCN family member 2; CCN2; Connective tissue growth factor; IGFBP-8; IGFBP8; NOV2	Human	E. coli
	CCN2/CTGF Protein, secreted by vascular endothelial cells, crucially promotes chondrocyte proliferation and differentiation, and mediates heparin- and divalent cation-dependent cell adhesion in diverse cell types. Additionally, it enhances fibroblast growth factor-induced DNA synthesis while existing as a monomer and interacting with TSKU. CCN2/CTGF Protein, Human (His) is the recombinant human-derived CCN2/CTGF protein, expressed by E. coli , with N-6*His labeled tag.

HY-P700701

	*CCN2/CTGF* Protein, Human (HEK293, His)** IGFBP8; IBP-8; CCN2; NOV2; HCS24; CTGF; CTGRP; Fisp12; MGC102839	Human	HEK293
	CCN2/CTGF (Connective Tissue Growth Factor) is a protein produced primarily by endothelial cells in blood vessels. It plays an important role in various cellular processes. CCN2/CTGF Protein, Human (HEK293, His) is the recombinant human-derived CCN2/CTGF protein, expressed by HEK293 , with C-His labeled tag. The total length of CCN2/CTGF Protein, Human (HEK293, His) is 323 a.a., with molecular weight of 45-60 kDa.

HY-P78104

	*CCN2/CTGF* Protein, Human (Biotinylated, HEK293, His-Avi)** 1 Publications Verification IGFBP8; IBP-8; CCN2; NOV2; HCS24; CTGF; CTGRP; Fisp12; MGC102839	Human	HEK293
	CCN2/CTGF (Connective Tissue Growth Factor) is a protein produced primarily by endothelial cells in blood vessels. It plays an important role in various cellular processes. CCN2/CTGF Protein, Human (Biotinylated, HEK293, His-Avi) is the recombinant human-derived CCN2/CTGF protein, expressed by HEK293 , with C-Avi, C-His labeled tag. The total length of CCN2/CTGF Protein, Human (Biotinylated, HEK293, His-Avi) is 323 a.a., with molecular weight of 43-55 kDa.

HY-P79369

	*CCN2/CTGF* Protein, Rat (HEK293)** CCN family member 2; Ccn2; Cellular communication network factor 2; Connective tissue growth factor; Connective tissue growth-related protein; CTGF	Rat	HEK293
	The CCN2/CTGF protein is a major connective tissue mitochondrial attractant secreted by vascular endothelial cells and critical for chondrocyte proliferation and differentiation. Additionally, it mediates heparin- and divalent cation-dependent cell adhesion in various cell types, including fibroblasts, myofibroblasts, endothelial cells, and epithelial cells. CCN2/CTGF Protein, Rat (HEK293) is the recombinant rat-derived CCN2/CTGF protein, expressed by HEK293 , with tag free.

HY-P70106

	*CCN2/CTGF* Protein, Human (HEK293)** 1 Publications Verification rHuConnective tissue growth factor/CTGF; Connective tissue growth factor; CCN family member 2; Hypertrophic chondrocyte-specific protein 24; Insulin-like growth factor-binding protein 8; IBP-8; IGF-binding protein 8; IGFBP-8	Human	HEK293
	CCN2/CTGF (Connective Tissue Growth Factor) is a protein produced primarily by endothelial cells in blood vessels. It plays an important role in various cellular processes. CCN2/CTGF Protein, Human (HEK293) is the recombinant human-derived CCN2/CTGF protein, expressed by HEK293 , with tag free. The total length of CCN2/CTGF Protein, Human (HEK293) is 154 a.a., with molecular weight of ~21.15 kDa.

HY-P78713

	*CCN2/CTGF* Protein, Rhesus macaque (HEK293, His)** CCN2; NOV2; HCS24; IGFBP8; IBP-8; IGFBP-8; IGF-binding protein 8	Rhesus Macaque	HEK293
	CCN2 is a mitogen secreted by vascular endothelial cells and a mechanosensor of mesenchymal cell differentiation that secretes stromal cell proteins. CCN2 can sense appropriate mechanical stress and downregulate its expression accordingly. CCN2 is a classic epithelial-to-mesenchymal transition (EMT) and fibrosis marker. CCN2/CTGF Protein, Rhesus macaque (HEK293, His) is the recombinant Rhesus Macaque-derived CCN2/CTGF protein, expressed by HEK293, with C-His labeled tag. The total length of CCN2/CTGF Protein, Rhesus macaque (HEK293, His) is 323 a.a., with molecular weight of 39-45 kDa.

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HY-P81103

	CTGF Antibody CCN 2; CCN-2; CCN2; Connective Tissue Growth Factor; Hcs 24; Hcs24; Hypertrophic chondrocyte specific protein 24; Hypertrophic chondrocyte-specific gene product 24; Insulin-like Growth Factor-Binding Protein 8; MGC102839; NOV 2; NOV2; Connective tissue growth factor; CCN family member 2; Hypertrophic chondrocyte-specific protein 24; Insulin-like growth-binding protein 8; IBP-8; IGF-binding protein 8; IGFBP8; IGFBP-8; connective tissue growth factor precursor; CTGF_HUMAN.	WB, ELISA	Mouse, Rat
	CTGF Antibody is an unconjugated, approximately 36 kDa, rabbit-derived, anti-CTGF polyclonal antibody. CTGF Antibody can be used for: WB, ELISA expriments in mouse, rat, and predicted: human,chicken, dog, pig, cow background without labeling.

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