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Results for "

ClpP

" in MedChemExpress (MCE) Product Catalog:

By Targets:	ClpP (13) Akt (2) Antibiotic (1) Apoptosis (4) Bacterial (8) COX (2) E1/E2/E3 Enzyme (1) Endogenous Metabolite (2) Interleukin Related (2) JNK (2) Mitochondrial Metabolism (2) MMP (1) p38 MAPK (2) Proteasome (1) Reactive Oxygen Species (3) Small Interfering RNA (siRNA) (1)
By Research Areas:	Cancer (8) Cardiovascular Disease (2) Infection (9) Inflammation/Immunology (3)
Oligonucleotides:	Human Pre-designed siRNA Sets (1) siRNAs (1)

Inhibitors & Agonists

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Oligonucleotides

Targets Recommended: ClpP

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-N2360

Hinokiflavone 3 Publications Verification	E1/E2/E3 Enzyme Apoptosis MMP ClpP	Infection Inflammation/Immunology Cancer
Hinokiflavone is a novel modulator of pre-mRNA splicing activity extracted from plants with anti-inflammatory, anti-tumor and antiviral activities. Hinokiflavone is also a potent inhibitor for matrix metalloproteinases (MMPs). Hinokiflavone attenuates the virulence of Methicillin (HY-121544)-resistant staphylococcus aureus by inhibiting caseinolytic protease P (ClpP) with an IC₅₀ value of 34.36 mg/mL. Hinokiflavone induces apoptosis via the reactive oxygen species-mitochondria-mediated apoptotic pathway and inhibits tumor cell migration and invasion. Hinokiflavone is a SUMO protease inhibitor against sentrin-specific protease 1 (SENP1) activity .

HY-111532

(3R,4R)-A2-32-01 1 Publications Verification	ClpP Bacterial	Infection
(3R,4R)-A2-32-01 (compound 24(R,R)), the (R,R)-enantiomer of A2-32-01, is a Staphylococcus aureus caseinolytic protease (SaClpP) inhibitor .

HY-N1181

Tamarixetin 1 Publications Verification 4'-O-Methyl Quercetin	Endogenous Metabolite ClpP Bacterial Apoptosis Akt Interleukin Related COX JNK p38 MAPK Reactive Oxygen Species	Infection Cardiovascular Disease Inflammation/Immunology Cancer
Tamarixetin (4'-O-Methyl Quercetin) is an orally active natural flavonoid derivative of quercetin and caseinolytic protease p (ClpP) inhibitor with anti-inflammatory, antioxidant and antitumor effects. Tamarixetin inhibits the hydrolytic activity of *ClpP* to the fluorescent substrate Suc-LY-AMC with an IC₅₀ of 49.73 μM, which can be used for the study of Staphylococcus aureus infection. Tamarixetin inhibits tumor cell growth, induces apoptosis, and cell cycle arrest. Tamarixetin prevents cardiac hypertrophy by inhibiting the NFAT and AKT pathways .

HY-173048

CLPP-2068	ClpP Apoptosis Reactive Oxygen Species	Cancer
CLPP-2068 is the orally active activator for human caseinolytic protease P (HsClpP) with an EC₅₀ of 50.4 nM. CLPP-2068 exhibits anti-proliferative efficacy in OCI-LY10 cancer cell with an IC₅₀ of 5.2 nM. CLPP-2068 decreases mitochondrial membrane potential, increases mitochondrial ROS levels, and induces mitochondrial dysfunction. CLPP-2068 arrests the cell cycle at G1 phase, and induces apoptosis in cell OCI-LY10. CLPP-2068 exhibits antitumor activity in mouse xenograft models .

HY-RS02831

CLPP Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
CLPP Human Pre-designed siRNA Set A contains three designed siRNAs for CLPP gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

CLPP Human Pre-designed siRNA Set A CLPP Human Pre-designed siRNA Set A

HY-P4399

Z-Gly-Gly-Leu-AMC	Bacterial ClpP	Others
Z-Gly-Gly-Leu-AMC is the substrate of ClpP1 and ClpP2, to detect the enzymatic activity in the presence of the activating peptide Z-Leu-Leu .

HY-126046

ACP1b	ClpP Bacterial	Infection
ACP1b is an activator for ClpP protease with K_d of 3.2 μM, and exhibits antibacterial activity. ACP1b inhibits N. meningitidis and H. influenzae with MBC of 16 and 8 μg/mL .

HY-P4284

Z-GGF-CMK	ClpP Proteasome	Others
Z-GGF-CMK is a protease inhibitor, inhibits ClpP1P2 and proteasome. Z-GGF-CMK exhibits cytotoxic activity against HepG2 cells with a CC₅₀ value of 125 μM .

HY-N1181R

Tamarixetin (Standard)	Endogenous Metabolite ClpP Bacterial Apoptosis Akt Interleukin Related COX JNK p38 MAPK Reactive Oxygen Species	Infection Cardiovascular Disease Inflammation/Immunology Cancer
Tamarixetin (Standard) is the analytical standard of Tamarixetin. This product is intended for research and analytical applications. Tamarixetin (4'-O-Methyl Quercetin) is an orally active natural flavonoid derivative of quercetin and caseinolytic protease p (ClpP) inhibitor with anti-inflammatory, antioxidant and antitumor effects. Tamarixetin inhibits the hydrolytic activity of *ClpP* to the fluorescent substrate Suc-LY-AMC with an IC₅₀ of 49.73 μM, which can be used for the study of Staphylococcus aureus infection. Tamarixetin inhibits tumor cell growth, induces apoptosis, and cell cycle arrest. Tamarixetin prevents cardiac hypertrophy by inhibiting the NFAT and AKT pathways .

HY-152096

(R)-ZG197	ClpP Bacterial	Infection
(R)-ZG197 is a highly selective Staphylococcus aureus Caseinolytic protease P (SaClpP) activator with an EC₅₀ of 1.5 μM. (R)-ZG197 also activates Homo sapiens ClpP (HsClpP) with an EC₅₀ of 31.4 μM .

HY-164064

Anticancer agent 230	ClpP	Cancer
Anticancer agent 230 (example 65) is a caseinolytic protease P (ClpP) activator with anticancer activity. Anticancer agent 230 is able to induce the degradation of mitochondrial proteins in SUM159 and MDA-MB-231 triple-negative breast cancer cells in a time-dependent manner .

HY-111532B

(3S,4S)-A2-32-01	ClpP	Infection
(3S,4S)-A2-32-01 (compound 24(S,S)), a less active (S,S)-enantiomer of A2-32-01. A2-32-01 is a potent caseinolytic protein proteases (ClpP) inhibitor .

HY-155556

ZG36	ClpP	Cancer
ZG36 is a human Caseinolytic protease P (ClpP) agonist. ZG36 non-selectively degrades respiratory chain complexes and reduces mitochondrial DNA, ultimately leading to mitochondrial dysfunction and leukemic cell death. ZG36 also inhibits the development of acute myeloid leukemia in a xenograft mouse model .

HY-125524

Antibacterial agent 199	Bacterial	Infection
Antibacterial agent 199 (Compound 2) is an activator for caseinolytic protease (ClpP) with a K_d of 0.7 μM. Antibacterial agent 199 exhibits antibacterial efficacy against Gram-positive strains Staphylococcus aureus, Streptococcus pneumoniae and Gram-negative strain Neisseria meningitidis, with MICs of 16, 0.5 and 0.5 μg/mL, respectively .

HY-170398

ZG297	Antibiotic Bacterial	Infection
ZG297 is an agonist for Staphylococcus aureus *ClpP* (SaClpP ) with an EC₅₀ of 0.26 μM. ZG297 degrades SaFtsZ, inhibits the bacterial cell division, thereby exhibiting antistaphylococcal activity, that inhibits S. aureus 8325-4 strains and MRSA strains with MIC of 0.063-256 μg/mL. ZG297 exhibits anti-infectious efficacy in mouse models .

HY-172199

THX6	ClpP Mitochondrial Metabolism	Cancer
THX6 is the activator for human mitochondrial protease *ClpP* with an EC₅₀ of 1.18 μM. THX6 exhibits cytotoxicity in ONC201-resistant cell SU-DIPG-VI with IC₅₀ of 0.13 μM. THX6 inhibits the expression of mitochondrial-related proteins (such as parkin, TFAM, NRF1, SDHA), leads to impaired mitochondrial function. THX6 affects the lipid metabolism in cell membran, and exhibits antitumor potential .

HY-149677

ZK53	Mitochondrial Metabolism	Cancer
ZK53 is a selective activator of mitochondrial caseinolytic protease P (HsClpP) (EC₅₀: 1.37?μM for α-casein hydrolysis by HsClpP). ZK53 is is inactive toward bacterial ClpP proteins. ZK53 induces apoptosis in H1703, H520 and SK-MES-1 cells. ZK53 induces dysregulation of mitochondrial functions in lung squamous cell carcinoma (LUSC) cells. ZK53 inhibits tumor growth in H1703 xenograft mouse model .

Cat. No.	Product Name	Target	Research Area

HY-P4399

Z-Gly-Gly-Leu-AMC	Bacterial ClpP	Others
Z-Gly-Gly-Leu-AMC is the substrate of ClpP1 and ClpP2, to detect the enzymatic activity in the presence of the activating peptide Z-Leu-Leu .

HY-P4284

Z-GGF-CMK	ClpP Proteasome	Others
Z-GGF-CMK is a protease inhibitor, inhibits ClpP1P2 and proteasome. Z-GGF-CMK exhibits cytotoxic activity against HepG2 cells with a CC₅₀ value of 125 μM .

Hinokiflavone 3 Publications Verification	Structural Classification Flavonoids Classification of Application Fields Source classification Phenols Polyphenols Selaginellaceae Plants Biflavones Selaginella tamariscina (P. Beauv.) Spring Disease Research Fields Cancer	E1/E2/E3 Enzyme Apoptosis MMP ClpP
Hinokiflavone is a novel modulator of pre-mRNA splicing activity extracted from plants with anti-inflammatory, anti-tumor and antiviral activities. Hinokiflavone is also a potent inhibitor for matrix metalloproteinases (MMPs). Hinokiflavone attenuates the virulence of Methicillin (HY-121544)-resistant staphylococcus aureus by inhibiting caseinolytic protease P (ClpP) with an IC₅₀ value of 34.36 mg/mL. Hinokiflavone induces apoptosis via the reactive oxygen species-mitochondria-mediated apoptotic pathway and inhibits tumor cell migration and invasion. Hinokiflavone is a SUMO protease inhibitor against sentrin-specific protease 1 (SENP1) activity .

Tamarixetin 1 Publications Verification 4'-O-Methyl Quercetin	Flavonols Structural Classification Classification of Application Fields Tamarix chinensis Lour. Source classification Plants Endogenous metabolite Flavonoids Tamaricaceae Phenols Polyphenols Inflammation/Immunology Disease Research Fields	Endogenous Metabolite ClpP Bacterial Apoptosis Akt Interleukin Related COX JNK p38 MAPK Reactive Oxygen Species
Tamarixetin (4'-O-Methyl Quercetin) is an orally active natural flavonoid derivative of quercetin and caseinolytic protease p (ClpP) inhibitor with anti-inflammatory, antioxidant and antitumor effects. Tamarixetin inhibits the hydrolytic activity of *ClpP* to the fluorescent substrate Suc-LY-AMC with an IC₅₀ of 49.73 μM, which can be used for the study of Staphylococcus aureus infection. Tamarixetin inhibits tumor cell growth, induces apoptosis, and cell cycle arrest. Tamarixetin prevents cardiac hypertrophy by inhibiting the NFAT and AKT pathways .

Tamarixetin (Standard)	Flavonols Structural Classification Flavonoids Tamaricaceae Tamarix chinensis Lour. Source classification Phenols Polyphenols Plants Endogenous metabolite	Endogenous Metabolite ClpP Bacterial Apoptosis Akt Interleukin Related COX JNK p38 MAPK Reactive Oxygen Species
Tamarixetin (Standard) is the analytical standard of Tamarixetin. This product is intended for research and analytical applications. Tamarixetin (4'-O-Methyl Quercetin) is an orally active natural flavonoid derivative of quercetin and caseinolytic protease p (ClpP) inhibitor with anti-inflammatory, antioxidant and antitumor effects. Tamarixetin inhibits the hydrolytic activity of *ClpP* to the fluorescent substrate Suc-LY-AMC with an IC₅₀ of 49.73 μM, which can be used for the study of Staphylococcus aureus infection. Tamarixetin inhibits tumor cell growth, induces apoptosis, and cell cycle arrest. Tamarixetin prevents cardiac hypertrophy by inhibiting the NFAT and AKT pathways .

Antibacterial agent 199	Structural Classification Natural Products Microorganisms Source classification	Bacterial
Antibacterial agent 199 (Compound 2) is an activator for caseinolytic protease (ClpP) with a K_d of 0.7 μM. Antibacterial agent 199 exhibits antibacterial efficacy against Gram-positive strains Staphylococcus aureus, Streptococcus pneumoniae and Gram-negative strain Neisseria meningitidis, with MICs of 16, 0.5 and 0.5 μg/mL, respectively .

Cat. No.	Compare	Product Name	Application	Reactivity

HY-P81930

	CLPP Antibody (YA1675) Endopeptidase Clp	WB, IHC-P, IP	Human, Mouse, Rat
	CLPP Antibody (YA1675) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA1675), targeting CLPP, with a predicted molecular weight of 30 kDa (observed band size: 26 kDa). CLPP Antibody (YA1675) can be used for WB, IHC-P, IP experiment in human, mouse, rat background.

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CLPP Human Pre-designed siRNA Set A		siRNAs Human Pre-designed siRNA Sets
CLPP Human Pre-designed siRNA Set A contains three designed siRNAs for CLPP gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

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