Antibacterial agent 199

Cat. No.: HY-125524: Data Sheet Handling Instructions Technical Support

Antibacterial agent 199 (Compound 2) is an activator for caseinolytic protease (ClpP) with a K_d of 0.7 μM. Antibacterial agent 199 exhibits antibacterial efficacy against Gram-positive strains Staphylococcus aureus, Streptococcus pneumoniae and Gram-negative strain Neisseria meningitidis, with MICs of 16, 0.5 and 0.5 μg/mL, respectively.

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Antibacterial agent 199 Chemical Structure

CAS No. : 1629166-56-8

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Based on 1 publication(s) in Google Scholar

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Description	Antibacterial agent 199 (Compound 2) is an activator for caseinolytic protease (ClpP) with a K_d of 0.7 μM. Antibacterial agent 199 exhibits antibacterial efficacy against Gram-positive strains Staphylococcus aureus, Streptococcus pneumoniae and Gram-negative strain Neisseria meningitidis, with MICs of 16, 0.5 and 0.5 μg/mL, respectively^[1].
Molecular Weight	704.81
Formula	C₃₇H₄₈N₆O₈
CAS No.	1629166-56-8
SMILES	O=C(N[C@H](C(N1[C@@H](CCC1)C(N(C)[C@H](C(N[C@@H](C)C(N2[C@H]3CCC2)=O)=O)C)=O)=O)COC3=O)[C@H](CC4=CC=CC=C4)NC(/C=C/C=C/C=C/C)=O
Structure Classification	Others
Initial Source	Microorganisms Streptomyces hawaiiensis
Shipping	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation	Data Sheet (275 KB) Handling Instructions (2659 KB)
References	[1]. Goodreid JD, et al., Total synthesis and antibacterial testing of the A54556 cyclic acyldepsipeptides isolated from Streptomyces hawaiiensis. J Nat Prod. 2014 Oct 24;77(10):2170-81. [Content Brief]