Search Result

Results for "

Corticosterone

" in MedChemExpress (MCE) Product Catalog:

By Targets:	11β-HSD (2) 5-HT Receptor (1) Androgen Receptor (1) Apoptosis (1) Endogenous Metabolite (10) Glucocorticoid Receptor (7) iGluR (3) Isotope-Labeled Compounds (1) Melanocortin Receptor (1) Mineralocorticoid Receptor (2) mTOR (1) Phospholipase (1) PPAR (2) Reactive Oxygen Species (1) Sigma Receptor (2) Vasopressin Receptor (2)
By Research Areas:	Cancer (3) Cardiovascular Disease (1) Endocrinology (9) Inflammation/Immunology (8) Metabolic Disease (11) Neurological Disease (14)

Inhibitors & Agonists

Peptides

Natural
Products

Isotope-Labeled Compounds

Antibodies

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-B1618

*Corticosterone* Maximum Cited Publications 29 Publications Verification 17-Deoxycortisol; 11β,21-Dihydroxyprogesterone; Kendall's compound B	Glucocorticoid Receptor Endogenous Metabolite iGluR	Neurological Disease Inflammation/Immunology Endocrinology
Corticosterone (17-Deoxycortisol) is an orally active and adrenal cortex-produced glucocorticoid, which plays an important role in regulating neuronal functions of the limbic system (including hippocampus, prefrontal cortex, and amygdala). Corticosterone increases the Rab-mediated AMPAR membrane traffic via SGK-induced phosphorylation of GDI. Corticosterone also interferes with the maturation of dendritic cells and shows a good immunosuppressive effect .

HY-B1618S1

Corticosterone-d4	Glucocorticoid Receptor Endogenous Metabolite	Neurological Disease Endocrinology
Corticosterone-d₄ is the deuterium labeled Corticosterone. Corticosterone is an adrenocortical steroid that has modest but significant activities as a mineralocorticoid and a glucocorticoid.

HY-B1618S

Corticosterone-d8	Glucocorticoid Receptor Endogenous Metabolite	Neurological Disease Endocrinology
Corticosterone-d₈ is the deuterium labeled Corticosterone. Corticosterone is an adrenocortical steroid that has modest but significant activities as a mineralocorticoid and a glucocorticoid.

HY-77839

Cortodoxone 2 Publications Verification 11-Deoxycortisol; cortexolone; Reichstein's substance S	Glucocorticoid Receptor Endogenous Metabolite	Inflammation/Immunology Endocrinology
Cortodoxone (11-Deoxycortisol; cortexolone) is a glucocorticoid steroid hormone and also is a glucocorticoid antagonist. Cortodoxone increases tryptophan oxygenase (TO) activity and induces the secretion of corticosterone. Cortodoxone regulates T cell proliferation and activation .

HY-113020

21-Hydroxypregnenolone	Endogenous Metabolite	Metabolic Disease
21-Hydroxypregnenolone is an essential intermediate in corticosterone synthesis.

HY-W751099

Corticosterone-13C3	Isotope-Labeled Compounds	Others
Corticosterone- ¹³C₃ is a ¹³C-labeled corticosterone (HY-B1618). Corticosterone (17-Deoxycortisol) is an orally available glucocorticoid that can regulate limbic system neurons and has good immunosuppressive activity.

HY-B1618R

Corticosterone (Standard) 17-Deoxycortisol(Standard); 11β,21-Dihydroxyprogesterone(Standard); Kendall's compound B (Standard)	Glucocorticoid Receptor Endogenous Metabolite iGluR	Neurological Disease Inflammation/Immunology Endocrinology
Corticosterone (Standard) is the analytical standard of Corticosterone. This product is intended for research and analytical applications. Corticosterone (17-Deoxycortisol) is an orally active and adrenal cortex-produced glucocorticoid, which plays an important role in regulating neuronal functions of the limbic system (including hippocampus, prefrontal cortex, and amygdala). Corticosterone increases the Rab-mediated AMPAR membrane traffic via SGK-induced phosphorylation of GDI. Corticosterone also interferes with the maturation of dendritic cells and shows a good immunosuppressive effect .

HY-P4786

Acetyl-ACTH (7-24) (human, bovine, rat)	Androgen Receptor	Neurological Disease Metabolic Disease
Acetyl-ACTH (7-24) (human, bovine, rat) causes a marked decrease of ACTH-evoked corticosterone and aldosterone release .

HY-77839R

Cortodoxone (Standard)	Glucocorticoid Receptor Endogenous Metabolite	Inflammation/Immunology Endocrinology
Cortodoxone (Standard) is the analytical standard of Cortodoxone. This product is intended for research and analytical applications. Cortodoxone (11-Deoxycortisol; cortexolone) is a glucocorticoid steroid hormone and also is a glucocorticoid antagonist. Cortodoxone increases tryptophan oxygenase (TO) activity and induces the secretion of corticosterone. Cortodoxone regulates T cell proliferation and activation .

HY-121859

RU28362	Glucocorticoid Receptor	Metabolic Disease
RU28362 is a potent and selective glucocorticoid agonist. RU28362 increases the Bnip3 mRNA levels in neurons. RU28362 inhibits adrenocorticotrophic hormone (ACTH) and corticosterone secretion . RU28362 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-W013179

18-Hydroxycorticosterone	Endogenous Metabolite	Metabolic Disease
18-Hydroxycorticosterone is a corticosteroid and a derivative of corticosterone, which can lead to serious electrolyte imbalances.

HY-N12812

Tenuifoliose J	Others	Neurological Disease
Tenuifoliose J is a neuroprotective oligosaccharide. Tenuifoliose J protects SY5Y cells induced by corticosterone (HY-B1618) .

HY-W013179S

18-Hydroxycorticosterone-d4	Endogenous Metabolite	Metabolic Disease
18-Hydroxycorticosterone-d₄ is the deuterium labeled 18-Hydroxycorticosterone. 18-Hydroxycorticosterone is a corticosteroid and a derivative of corticosterone, which can lead to serious electrolyte imbalances.

HY-N12001

6-Epiagarotetrol	Others	Neurological Disease
6-Epiagarotetrol is a neuroprotective agent can be extracted from Aquilaria sinensis. 6-Epiagarotetrol has a protective effect on corticosterone-induced PC12 cell damage .

HY-125088

Oleoylestrone	Others	Others
Oleoyl-estrone (OE) is a signaling molecule derived from adipose tissue that reduces energy intake and body fat while maintaining energy expenditure and blood glucose balance. In studies in adrenalodepleted female rats, administration of OE resulted in significant fat mobilization, reduced food intake, and sustained energy expenditure. However, concomitant administration of corticosterone inhibits OE-induced fat mobilization and aggravates insulin resistance and glycemic imbalance by promoting fat deposition. This suggests that corticosterone has an antagonistic effect on the beneficial metabolic effects of OE, particularly on lipid metabolism and insulin sensitivity .

HY-P1390

d[Cha4]-AVP	Vasopressin Receptor	Endocrinology
d[Cha4]-AVP is a potent and selective vasopressin (AVP) V1b receptor agonist with a K_i of 1.2 nM for human V1b receptor. d[Cha4]-AVP shows more selective for V1b receptor than human V1a receptor, V2 receptor, and oxytocin receptors .

HY-P1390A

d[Cha4]-AVP TFA	Vasopressin Receptor	Endocrinology
d[Cha4]-AVP TFA is a potent and selective vasopressin (AVP) V1b receptor agonist with a K_i of 1.2 nM for human V1b receptor. d[Cha4]-AVP TFA shows more selective for V1b receptor than human V1a receptor, V2 receptor, and oxytocin receptors .

HY-N7666

Prosaikogenin F	Others	Metabolic Disease Cancer
Prosaikogenin F is a monoglycoside with anticancer and hemolytic properties .

HY-N5130

Effusol	Others	Neurological Disease
Effusol, a phenolic constituent from Juncus effuses, exhibits potent scavenging activity for DPPH and ABTS radicals, with IC₅₀ values of 79 μM and 2.73 μM, respectively. Effusol rescues CA1 LTP attenuated by corticosterone, defending the hippocampal function against stress-induced cognitive decline .

HY-145381

11β-HSD1-IN-6	11β-HSD	Metabolic Disease
11β-HSD1-IN-6 is a an 11β-HSD-1 inhibitor. The 11β hydroxysteroid dehydrogenase enzymes (11β-HSDs) mediate the interconversion of the glucocorticoid (GC) corticosterone or cortisol to an inactive form, 11-dehydrocorticosterone (11-DHC) or Cortisone, respectively .

HY-158081

CRN04894	Melanocortin Receptor	Endocrinology
CRN04894 (compound 17h) is an orally active MC2R antagonist that demonstrates in vivo efficacy in rat model of adrenocorticotropic hormone (ACTH)-stimulated corticosterone secretion[1]. CRN04894 binds to human or rat MC2R with K_B values of 0.34 nM and 0.23 nM, respsectively .

HY-W744098

1-Dehydrocorticosterone 21-acetate 1-DHC 21-acetate	Others	Metabolic Disease
1-Dehydrocorticosterone 21-acetate is an acetylated derivative of corticosterone (HY-B1618) that is dehydrogenated at the one position. It has been used as a precursor in the synthesis of 21-hydroxypregna-1,4-diene-3,11,20-trione, which is a metabolite of 1α-hydroxycorticosterone in the skate.

HY-120160

Darglitazone CP-86325	PPAR	Neurological Disease Metabolic Disease
Darglitazone (CP-86325), a thiazolidinedione, is a potent, selective, and orally active PPAR-γ agonist. Darglitazone is effective in controlling blood glucose and lipid metabolism, and can be used for type II diabetes research .

HY-N6947

Lutein 2 Publications Verification Xanthophyll	Endogenous Metabolite Apoptosis Reactive Oxygen Species	Neurological Disease Inflammation/Immunology
Lutein (Xanthophyll) is a carotenoid with reported anti-inflammatory properties. A large body of evidence shows that lutein has several beneficial effects, especially on eye health . Lutein exerts its biological activities, including anti-inflammation, anti-oxidase and anti-apoptosis, through effects on reactive oxygen species (ROS) . Lutein is able to arrive in the brain and shows antidepressant-like and neuroprotective effects. Lutein is orally active .

HY-16276

Osilodrostat 4 Publications Verification LCI699	Mineralocorticoid Receptor	Inflammation/Immunology Cancer
Osilodrostat (LCI699) is a potent, orally active11β-hydroxylase (CYP11B1) inhibitor with an IC₅₀ value of 35 nM. Osilodrostat is a potent, orally aldosterone synthase (CYP11B2) inhibitor with IC₅₀ values of 0.7 nM and 160 nM for human aldosterone synthase and rat aldosterone synthase, respectively. Osilodrostat inhibits aldosterone and corticosterone synthesis. Osilodrostat has blood pressure lowering ability. Osilodrostat can be used for research of Cushing syndrome (CS) .

HY-16276A

Osilodrostat phosphate 4 Publications Verification LCI699 phosphate	Mineralocorticoid Receptor	Cancer
Osilodrostat (LCI699) phosphate is a potent, orally active11β-hydroxylase (CYP11B1) inhibitor with an IC₅₀ value of 35 nM. Osilodrostat phosphate is a potent, orally aldosterone synthase (CYP11B2) inhibitor with IC₅₀ values of 0.7 nM and 160 nM for human aldosterone synthase and rat aldosterone synthase, respectively. Osilodrostat phosphate inhibits aldosterone and corticosterone synthesis. Osilodrostat phosphate has blood pressure lowering ability. Osilodrostat phosphate can be used for research of Cushing syndrome (CS) .

HY-100942

5-Carboxamidotryptamine maleate 5-CT maleate	5-HT Receptor	Neurological Disease
5-Carboxamidotryptamine maleate (5-CT maleate) is a potent 5-HT_1A, 5-HT_1B, 5-HT_1D, 5-HT₅ and 5-HT₇ receptors agonist .

HY-14156

11β-HSD1-IN-15	11β-HSD	Metabolic Disease
11β-HSD1-IN-15 is an inhibitor of 11β-hydroxysteroid dehydrogenase type I (11β-HSD1). 11β-HSD1-IN-15 blocks the conversion of corticosterone to cortisol by binding to the active site of the 11β-HSD1 enzyme. 11β-HSD1-IN-15 can be used to investigate the role of 11β-HSD1 enzymes IN the development of metabolic syndrome, obesity, cognitive decline and type 2 diabetes .

HY-13751A

SR-31747 free base	Sigma Receptor	Inflammation/Immunology
SR-31747 free base is a sigma ligand with immunosuppressive and anti-inflammatory properties. SR-31747 blocks cell proliferation by inhibiting sterol isomerase .

HY-13751

SR-31747	Sigma Receptor	Inflammation/Immunology
SR-31747 is a sigma ligand with immunosuppressive and anti-inflammatory properties. SR-31747 blocks cell proliferation by inhibiting sterol isomerase .

HY-162613

ASM-IN-2	Phospholipase	Neurological Disease
ASM-IN-2 (Compound 46) is a potent ASM inhibitor with an IC₅₀ value of 0.87 μM, displaying good drug-like properties. ASM-IN-2 involves in multiple antidepressant mechanisms of actionin, which are associated with a decline of ceramide. It demostrates remarkable antidepressant effects in the CUMS-induced mouse, which is promising for research in the field of antidepressant drugs .

HY-109046

Tulrampator 1 Publications Verification CX-1632; S-47445	iGluR mTOR	Neurological Disease
Tulrampator (S-47445) is an orally active selective AMPA receptor modulator. Tulrampator possesses procognitive, enhancing synaptic plasticity, anti-depressant-anxiolytic-like, procognitive and potential neuroprotective properties. Tulrampator can be used for research of alzheimer’s disease and in major depressive disorder .

HY-120160A

Darglitazone Sodium CP 86325 Sodium	PPAR	Neurological Disease Metabolic Disease
Darglitazone Sodium, a thiazolidinedione, is an orally active, potent, and selective PPAR-γ (peroxisome proliferator-activated receptor) agonist. Darglitazone Sodium is effective in controlling blood glucose and lipid metabolism, and can be used for type II diabetes research .

Cat. No.	Product Name	Target	Research Area

HY-P1390

d[Cha4]-AVP	Vasopressin Receptor	Endocrinology
d[Cha4]-AVP is a potent and selective vasopressin (AVP) V1b receptor agonist with a K_i of 1.2 nM for human V1b receptor. d[Cha4]-AVP shows more selective for V1b receptor than human V1a receptor, V2 receptor, and oxytocin receptors .

HY-P1245

Neuropeptide SF (human) Neuropeptide NPFF (human)	Peptides	Others
Neuropeptide SF human augments paraventricular corticotrophin-releasing hormone (CRH) release and increases adrenocorticotropic hormone (ACTH) and corticosterone levels in the plasma. Neuropeptide SF human play a physiologic role in the regulation of such circadian functions as the activity of motor centers and the HPA axis, through the release of CRH .

HY-P4786

Acetyl-ACTH (7-24) (human, bovine, rat)	Androgen Receptor	Neurological Disease Metabolic Disease
Acetyl-ACTH (7-24) (human, bovine, rat) causes a marked decrease of ACTH-evoked corticosterone and aldosterone release .

HY-P5950

ACTH (6-24) (human) Adrenocorticotropic hormone (6-24)	Peptides	Cardiovascular Disease
ACTH (6-24) (human) (Adrenocorticotropic hormone (6-24)) is an ACTH fragment. ACTH (6-24) (human) is a competitive inhibitor of steroidogenesis induced by ACTH (1-39) and ACTH (5-24) (K_d:13.4 and 3.4 nM). ACTH (6-24) (human) inhibits corticosterone production and cAMP accumulation induced by hPTH 1-34 .

HY-P1390A

d[Cha4]-AVP TFA	Vasopressin Receptor	Endocrinology
d[Cha4]-AVP TFA is a potent and selective vasopressin (AVP) V1b receptor agonist with a K_i of 1.2 nM for human V1b receptor. d[Cha4]-AVP TFA shows more selective for V1b receptor than human V1a receptor, V2 receptor, and oxytocin receptors .

HY-P1245A

Neuropeptide SF (human) acetate Neuropeptide NPFF (human) acetate	Peptides	Others
Neuropeptide SF (human) acetate augments paraventricular corticotrophin-releasing hormone (CRH) release and increases adrenocorticotropic hormone (ACTH) and corticosterone levels in the plasma. Neuropeptide SF (human) acetate play a physiologic role in the regulation of such circadian functions as the activity of motor centers and the HPA axis, through the release of CRH .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-B1618

*Corticosterone* Maximum Cited Publications 29 Publications Verification 17-Deoxycortisol; 11β,21-Dihydroxyprogesterone; Kendall's compound B	Structural Classification Neurological Disease Classification of Application Fields Source classification Endogenous metabolite Disease Research Fields Endocrinology Steroids	Glucocorticoid Receptor Endogenous Metabolite iGluR
Corticosterone (17-Deoxycortisol) is an orally active and adrenal cortex-produced glucocorticoid, which plays an important role in regulating neuronal functions of the limbic system (including hippocampus, prefrontal cortex, and amygdala). Corticosterone increases the Rab-mediated AMPAR membrane traffic via SGK-induced phosphorylation of GDI. Corticosterone also interferes with the maturation of dendritic cells and shows a good immunosuppressive effect .

HY-77839

Cortodoxone 2 Publications Verification 11-Deoxycortisol; cortexolone; Reichstein's substance S	Structural Classification Classification of Application Fields Source classification Endogenous metabolite Disease Research Fields Endocrinology Steroids	Glucocorticoid Receptor Endogenous Metabolite
Cortodoxone (11-Deoxycortisol; cortexolone) is a glucocorticoid steroid hormone and also is a glucocorticoid antagonist. Cortodoxone increases tryptophan oxygenase (TO) activity and induces the secretion of corticosterone. Cortodoxone regulates T cell proliferation and activation .

HY-113020

21-Hydroxypregnenolone	Structural Classification Classification of Application Fields Source classification Metabolic Disease Endogenous metabolite Disease Research Fields Steroids	Endogenous Metabolite
21-Hydroxypregnenolone is an essential intermediate in corticosterone synthesis.

HY-N7666

Prosaikogenin F	Triterpenes Classification of Application Fields Terpenoids Source classification Metabolic Disease Plants Umbelliferae Disease Research Fields Carphephorus corymbosus (Nutt.) Torr. & A.Gray	Others
Prosaikogenin F is a monoglycoside with anticancer and hemolytic properties .

HY-N5130

Effusol	Juncus effusus Linn. Juncaceae Source classification Phenols Polyphenols Plants	Others
Effusol, a phenolic constituent from Juncus effuses, exhibits potent scavenging activity for DPPH and ABTS radicals, with IC₅₀ values of 79 μM and 2.73 μM, respectively. Effusol rescues CA1 LTP attenuated by corticosterone, defending the hippocampal function against stress-induced cognitive decline .

HY-B1618R

Corticosterone (Standard) 17-Deoxycortisol(Standard); 11β,21-Dihydroxyprogesterone(Standard); Kendall's compound B (Standard)	Structural Classification Neurological Disease Classification of Application Fields Source classification Endogenous metabolite Disease Research Fields Endocrinology Steroids	Glucocorticoid Receptor Endogenous Metabolite iGluR
Corticosterone (Standard) is the analytical standard of Corticosterone. This product is intended for research and analytical applications. Corticosterone (17-Deoxycortisol) is an orally active and adrenal cortex-produced glucocorticoid, which plays an important role in regulating neuronal functions of the limbic system (including hippocampus, prefrontal cortex, and amygdala). Corticosterone increases the Rab-mediated AMPAR membrane traffic via SGK-induced phosphorylation of GDI. Corticosterone also interferes with the maturation of dendritic cells and shows a good immunosuppressive effect .

HY-77839R

Cortodoxone (Standard)	Structural Classification Source classification Endogenous metabolite Steroids	Glucocorticoid Receptor Endogenous Metabolite
Cortodoxone (Standard) is the analytical standard of Cortodoxone. This product is intended for research and analytical applications. Cortodoxone (11-Deoxycortisol; cortexolone) is a glucocorticoid steroid hormone and also is a glucocorticoid antagonist. Cortodoxone increases tryptophan oxygenase (TO) activity and induces the secretion of corticosterone. Cortodoxone regulates T cell proliferation and activation .

HY-W013179

18-Hydroxycorticosterone	Structural Classification Classification of Application Fields Ketones, Aldehydes, Acids Source classification Disease markers Endocrine diseases Metabolic Disease Endogenous metabolite Disease Research Fields	Endogenous Metabolite
18-Hydroxycorticosterone is a corticosteroid and a derivative of corticosterone, which can lead to serious electrolyte imbalances.

HY-N12812

Tenuifoliose J	Structural Classification Source classification Polygalaceae Phenols Polyphenols Plants Polygala tenuifolia Willd.	Others
Tenuifoliose J is a neuroprotective oligosaccharide. Tenuifoliose J protects SY5Y cells induced by corticosterone (HY-B1618) .

HY-N12001

6-Epiagarotetrol	Structural Classification Natural Products Thymelaeaceae Source classification Plants Aquilaria sinensis (Lour.) Spreng.	Others
6-Epiagarotetrol is a neuroprotective agent can be extracted from Aquilaria sinensis. 6-Epiagarotetrol has a protective effect on corticosterone-induced PC12 cell damage .

HY-N6947

Lutein 2 Publications Verification Xanthophyll	Structural Classification Classification of Application Fields Source classification Whitening Agent Food Research Microorganisms Animals Terpenoids Pigments Diterpenoids Cosmetic Research Inflammation/Immunology Disease Research Fields	Endogenous Metabolite Apoptosis Reactive Oxygen Species
Lutein (Xanthophyll) is a carotenoid with reported anti-inflammatory properties. A large body of evidence shows that lutein has several beneficial effects, especially on eye health . Lutein exerts its biological activities, including anti-inflammation, anti-oxidase and anti-apoptosis, through effects on reactive oxygen species (ROS) . Lutein is able to arrive in the brain and shows antidepressant-like and neuroprotective effects. Lutein is orally active .

Cat. No.	Product Name	Chemical Structure

HY-B1618S1

Corticosterone-d4
Corticosterone-d₄ is the deuterium labeled Corticosterone. Corticosterone is an adrenocortical steroid that has modest but significant activities as a mineralocorticoid and a glucocorticoid.

HY-B1618S

Corticosterone-d8
Corticosterone-d₈ is the deuterium labeled Corticosterone. Corticosterone is an adrenocortical steroid that has modest but significant activities as a mineralocorticoid and a glucocorticoid.

HY-W751099

Corticosterone-13C3
Corticosterone- ¹³C₃ is a ¹³C-labeled corticosterone (HY-B1618). Corticosterone (17-Deoxycortisol) is an orally available glucocorticoid that can regulate limbic system neurons and has good immunosuppressive activity.

HY-W013179S

18-Hydroxycorticosterone-d4
18-Hydroxycorticosterone-d₄ is the deuterium labeled 18-Hydroxycorticosterone. 18-Hydroxycorticosterone is a corticosteroid and a derivative of corticosterone, which can lead to serious electrolyte imbalances.

Cat. No.	Compare	Product Name	Application	Reactivity

HY-P83672

	Corticosterone Antibody 11-dehydro-17-hydroxyCorticosterone, cortisone	ELISA	Species independent

Compare Products


Products	In-stock - + Add to Cart
Cat. No.
Host
Reactivity
Application
Dilution Ratio
Molecular Weight
Conjugation
Clonality
Immunogen
Appearance
Isotype
Gene ID
SwissProt ID
Purity
Formulation
Free Sample	Yes No
Size	* This product has been "discontinued". Optimized version of product available: / In-stock - + Add to Cart Get quote

Inquiry Online

Your information is safe with us. * Required Fields.

MCE Japan Authorized Agent ナミキ商事株式会社コスモ・バイオ株式会社
Salutation			Country or Region *
Applicant Name *			Organization Name *
Department *
Email Address *			Product Name *
Cat. No.			Requested quantity *
Phone Number *
Remarks

Inquiry Online

Inquiry Information

Product Name:
Cat. No.:
Quantity:
MCE Japan Authorized Agent:

Corticosterone

Inhibitors & Agonists

Peptides

NaturalProducts

Isotope-Labeled Compounds

Antibodies

Natural
Products