2. Metabolic Enzyme/Protease Apoptosis NF-κB Immunology/Inflammation
  3. Endogenous Metabolite Apoptosis Reactive Oxygen Species
  4. Lutein

Lutein  (Synonyms: Xanthophyll)

Cat. No.: HY-N6947 Purity: ≥90.0%
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Lutein (Xanthophyll) is a carotenoid with reported anti-inflammatory properties. A large body of evidence shows that lutein has several beneficial effects, especially on eye health. Lutein exerts its biological activities, including anti-inflammation, anti-oxidase and anti-apoptosis, through effects on reactive oxygen species (ROS). Lutein is able to arrive in the brain and shows antidepressant-like and neuroprotective effects. Lutein is orally active.

For research use only. We do not sell to patients.

Lutein Chemical Structure

Lutein Chemical Structure

CAS No. : 127-40-2

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Based on 3 publication(s) in Google Scholar

Other Forms of Lutein:

Lutein Related Antibodies

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Description

Lutein (Xanthophyll) is a carotenoid with reported anti-inflammatory properties. A large body of evidence shows that lutein has several beneficial effects, especially on eye health[1]. Lutein exerts its biological activities, including anti-inflammation, anti-oxidase and anti-apoptosis, through effects on reactive oxygen species (ROS)[2][3]. Lutein is able to arrive in the brain and shows antidepressant-like and neuroprotective effects. Lutein is orally active[4].

In Vitro

Lutein (100 or 200 μM) protects against A2-PE (a bis-retinoid compound that is the immediate precursor of the lipofuscin fluorophore A2E) photooxidation and reduces A2E photooxidation[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Lutein Related Antibodies
In Vivo

Lutein (40-160 mg/kg; in diet for 5 weeks) protects against severe traumatic brain injury through anti-inflammation and anti-oxidative effects via ICAM-1/Nrf-2 in rats[3].
Lutein (0.1-10 mg/kg; p.o.; once or daily for 7 and 21 days) prevents Corticosterone (HY-B1618)-induced depressive-like behavior in mice with the involvement of antioxidant and neuroprotective activities[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Sprague-Dawley rats, severe traumatic brain injury (STBI) model[3]
Dosage: 40, 80 and 160 mg/kg
Administration: In diet for 5 weeks
Result: Suppressed, interleukin (IL)-1β, IL-6 and monocyte chemoattractant protein-1 expression, reduced serum ROS levels, and reduced superoxide dismutase and glutathione peroxidase activities. Effectively downregulated the expression of NF-κB p65 and cyclooxygenase-2, intercellular adhesion molecule (ICAM)-1 protein, and upregulated nuclear factor erythroid 2 like 2 (Nrf-2) and endothelin-1 protein levels.
Animal Model: Male Swiss mice, chronic Corticosterone (HY-B1618) model of depression[4]
Dosage: 0.1, 1 and 10 mg/kg
Administration: Oral administration, once or daily for 7 and 21 days
Result: Decreased immobility time at the dose 10 mg/kg. Counteracted the behavioral changes displayed by Corticosterone (HY-B1618) showing antidepressant-like effect. Presented antioxidant effect in the hippocampus, prefrontal cortex and plasma of mice, and exhibited a capability to protect hippocampal and prefrontal cortex slices against glutamatergic toxicity.
Clinical Trial
Molecular Weight

568.87

Formula

C40H56O2
CAS No.
Appearance

Solid

Color

Orange to red

SMILES

CC(/C=C/[C@@H](C(C)=C[C@H](O)C1)C1(C)C)=C\C=C\C(C)=C\C=C\C=C(C)\C=C\C=C(C)\C=C\C(C(C)(C[C@H](O)C2)C)=C2C
Structure Classification
Initial Source

egg's yolk
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, protect from light, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)

Solvent & Solubility
In Vitro: 

DMSO : 25 mg/mL (43.95 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.7579 mL 8.7894 mL 17.5787 mL
5 mM 0.3516 mL 1.7579 mL 3.5157 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
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Working solution concentration: mg/mL
Purity & Documentation

Purity: ≥90.0%

SDS (393 KB)

COA (240 KB) HNMR (294 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.7579 mL 8.7894 mL 17.5787 mL 43.9468 mL
5 mM 0.3516 mL 1.7579 mL 3.5157 mL 8.7894 mL
10 mM 0.1758 mL 0.8789 mL 1.7579 mL 4.3947 mL
15 mM 0.1172 mL 0.5860 mL 1.1719 mL 2.9298 mL
20 mM 0.0879 mL 0.4395 mL 0.8789 mL 2.1973 mL
25 mM 0.0703 mL 0.3516 mL 0.7031 mL 1.7579 mL
30 mM 0.0586 mL 0.2930 mL 0.5860 mL 1.4649 mL
40 mM 0.0439 mL 0.2197 mL 0.4395 mL 1.0987 mL
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Lutein Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Lutein127-40-2XanthophyllEndogenous MetaboliteApoptosisReactive Oxygen SpeciesA2-PEA2Emacular degenerationICAM-1Nrf-2CorticosteroneInhibitorinhibitorinhibit

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