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Pathways Recommended: Cell Cycle/DNA Damage
Results for "

DNA adducts

" in MedChemExpress (MCE) Product Catalog:

39

Inhibitors & Agonists

3

Biochemical Assay Reagents

8

Natural
Products

5

Isotope-Labeled Compounds

1

Oligonucleotides

Targets Recommended:
Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-69014
    2-O-Methylcytosine

    		DNA/RNA Synthesis Endogenous Metabolite Cancer
    2-O-Methylcytosine, an O-alkylated analogue a DNA adduct, is the damaged nucleobase .
    2-O-Methylcytosine
  • HY-W016433
    2-Aminofluorene

    		DNA/RNA Synthesis Others
    2-Aminofluorene is a synthetic chemical insecticide. 2-Aminofluorene is a genotoxin. 2-Aminofluorene can be used in the research of DNA adduct structure, DNA repair, carcinogenesis, and mutagenesis .
    2-Aminofluorene
  • HY-U00279
    Nitracrine

    		DNA/RNA Synthesis Cancer
    Nitracrine inhibits RNA synthesis and covalently, reversibly binds to DNA but also forms covalent adducts with DNA in vivo. Nitracrine, a 1-nitroacridine derivative, is a potent hypoxia-selective agent in vitro and antitumor agent. Nitracrine has cytotoxicity towards most cells .
    Nitracrine
  • HY-119983
    7H-Dibenzo[c,g]carbazole

    DBC

    		 Others Cancer
    7H-Dibenzo[c,g]carbazole (DBC) is an azaarene with high lipophilicity. 7H-Dibenzo[c,g]carbazole has carcinogenic activity and induce DNA adducts in fish, DNA adducts, mutations in diploid human fibroblasts and micronuclei in human blood lymphocytes. 7H-Dibenzo[c,g]carbazole is activated by cytochrome P450 enzymes resulting mainly in the generation of phenolic metabolites .
    7H-Dibenzo[c,g]carbazole
  • HY-W013053
    Dibenz[a,h]anthracene

    DBA; 1,2,5,6-Dibenzanthracene; Benzo[k]tetraphene

    		 DNA/RNA Synthesis Apoptosis MDM-2/p53 Cancer
    Dibenz[a,h]anthracene (DBA) is a polycyclic aromatic hydrocarbon (PAH) of considerable tumorigenicity. Dibenz[a,h]anthracene results in DNA adduct formation leading to the activation of a DNA damage response. Dibenz[a,h]anthracene induces cell cycle arrest and apoptosis via both Tp53-dependent and Tp53-independent mechanisms .
    Dibenz[a,h]anthracene
  • HY-W683760
    N-Nitrosonornicotine

    		DNA/RNA Synthesis Cancer
    N-Nitrosonornicotine is a tobacco-specific nitrosamine that has carcinogenic and mutagenic activity, and it can induce micronuclei in C3A cells. N-Nitrosonornicotine can form DNA adducts .
    N-Nitrosonornicotine
  • HY-U00279A
    Nitracrine dihydrochloride hydrate

    		DNA/RNA Synthesis Cancer
    Nitracrine (dihydrochloride hydrate) inhibits RNA synthesis and covalently, reversibly binds to DNA but also forms covalent adducts with DNA in vivo. Nitracrine (dihydrochloride hydrate), a 1-nitroacridine derivative, is a potent hypoxia-selective agent in vitro and antitumor agent. Nitracrine (dihydrochloride hydrate) has cytotoxicity towards most cells .
    Nitracrine dihydrochloride hydrate
  • HY-U00279B
    Nitracrine hydrochloride

    		DNA/RNA Synthesis Cancer
    Nitracrine hydrochloride is a platinum-based antineoplastic drug with selective toxicity to hypoxic cells. Nitracrine hydrochloride exhibits significant cytotoxicity against the Chinese hamster ovary cell line AA8 under hypoxic conditions and is approximately 100,000 times more potent than misonidazole. Nitracrine hydrochloride exerts its effect by binding to the insertion of DNA and forming covalent adducts. The cytotoxicity of Nitracrine hydrochloride under hypoxic conditions is related to its reductive metabolism to form alkylated substances. At the same time, it may enhance the reactivity to DNA through the insertion of DNA, thereby improving the efficacy. Nitracrine hydrochloride can also inhibit RNA synthesis, contributing to its anti-tumor effect .
    Nitracrine hydrochloride
  • HY-W013053R
    Dibenz[a,h]anthracene (Standard)

    		DNA/RNA Synthesis Apoptosis MDM-2/p53 Cancer
    Dibenz[a,h]anthracene (Standard) is the analytical standard of Dibenz[a,h]anthracene. This product is intended for research and analytical applications. Dibenz[a,h]anthracene (DBA) is a polycyclic aromatic hydrocarbon (PAH) of considerable tumorigenicity. Dibenz[a,h]anthracene results in DNA adduct formation leading to the activation of a DNA damage response. Dibenz[a,h]anthracene induces cell cycle arrest and apoptosis via both Tp53-dependent and Tp53-independent mechanisms .
    Dibenz[a,h]anthracene (Standard)
  • HY-W141077
    1-Nitrosopyrrolidine

    		Biochemical Assay Reagents Others
    1-Nitrosopyrrolidine is a molecule that primarily interacts with DNA and proteins, leading to the formation of DNA adducts and protein adducts.
    1-Nitrosopyrrolidine
  • HY-W141077R
    1-Nitrosopyrrolidine (Standard)

    		Biochemical Assay Reagents Others
    1-Nitrosopyrrolidine (Standard) is the analytical standard of 1-Nitrosopyrrolidine. This product is intended for research and analytical applications. 1-Nitrosopyrrolidine is a molecule that primarily interacts with DNA and proteins, leading to the formation of DNA adducts and protein adducts.
    1-Nitrosopyrrolidine (Standard)
  • HY-111375
    Azoxymethane
    Maximum Cited Publications
    10 Publications Verification

    AOM

    		 DNA Alkylator/Crosslinker Cancer
    Azoxymethane is a colon carcinogen which leads to the formation of DNA adducts.
    Azoxymethane
  • HY-147740
    WEHI-150

    		DNA Alkylator/Crosslinker Cancer
    WEHI-150 is a replica of mitoxantrone, is a portent DNA interstrand crosslinkadduct half-lives of 12.5 h. WEHI-150 forms covalent adducts at CpG sequences and exhibits a preference for methylated CpG sites. Formaldehyde-activated WEHI-150 induces DNA interstrand crosslinks. Formaldehyde-activated WEHI-150 shows Concentration-dependent transcription blockages. WEHI-150 can mediate covalent adducts that are independent of interactions with the N-2 of guanine and is capable of adduct formation at novel DNA sequences .
    WEHI-150
  • HY-118517
    α-Hydroxytamoxifen

    (E)-α-Hydroxy tamoxifen; α-OHTAM

    		 Drug Metabolite Cancer
    α-Hydroxytamoxifen is a metabolite of tamoxifen, reacts with DNA in the absence of metabolizing enzymes, and causes formation of DNA adducts .
    α-Hydroxytamoxifen
  • HY-N6828
    Monocrotaline N-Oxide

    		Others Metabolic Disease
    Monocrotaline N-Oxide, a monocrotaline metabolite, leads to DNA adduct formation in vivo .
    Monocrotaline N-Oxide
  • HY-N0510A
    Aristolochic acid sodium salt
    5+ Cited Publications

    Aristolochic acid I sodium; TR 1736 sodium; Sodium aristolochate

    		 Biochemical Assay Reagents Others
    Aristolochic acid sodium salt (Sodium aristolate 1) is a component of some Chinese herbal medicines and is responsible for nephrotoxicity. It is a proagent that is activated by reduction of nitro groups to amines, resulting in the formation of cytotoxic DNA adducts.
    Aristolochic acid sodium salt
  • HY-101160
    SG2057

    DRG16

    		 DNA Alkylator/Crosslinker ADC Cytotoxin Cancer
    SG2057 (DRG16) is a PBD dimer containing a pentyldioxy linkage which binds sequence selectively in the minor groove of DNA forming DNA interstrand and intrastrand cross-linked adducts. SG2057 is a highly active antitumor agent .
    SG2057
  • HY-116832
    Retrorsine N-oxide

    		Others Cancer
    Retrorsine N-oxide, an N-oxide of pyrrolizidine alkaloid, is a carcinogen. Retrorsine N-oxide-derived DNA adducts are common toxicological biomarkers of pyrrolizidine alkaloid N-oxides .
    Retrorsine N-oxide
  • HY-124489
    2-Hydroxyestradiol
    1 Publications Verification

    		 Endogenous Metabolite Metabolic Disease
    2-Hydroxyestradiol, a metabolite of 17β-estradiol with minimal estrogenic activity, possesses antioxidant effects and reacts with DNA to form stable adducts and exerts genotoxicity .
    2-Hydroxyestradiol
  • HY-W347492
    6-O-Methyldeoxyguanosine

    O6-Methyl-2′-deoxyguanosine

    		 Nucleoside Antimetabolite/Analog Cancer
    O6-Methyldeoxy guanosine; DNA adduct is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc .
    6-O-Methyldeoxyguanosine
  • HY-W016286
    2,6-Dithiopurine

    2,6-Dimercaptopurine

    		 Others Cancer
    2,6-Dithiopurine (2,6-Dimercaptopurine) is a nucleophilic scavenger for electrophilic carcinogens. 2,6-Dithiopurine abolishes both DNA adduct formation and the initiation of carcinogenesis .
    2,6-Dithiopurine
  • HY-N6828R
    Monocrotaline N-Oxide (Standard)

    		Others Metabolic Disease
    Monocrotaline N-Oxide (Standard) is the analytical standard of Monocrotaline N-Oxide. This product is intended for research and analytical applications. Monocrotaline N-Oxide, a monocrotaline metabolite, leads to DNA adduct formation in vivo .
    Monocrotaline N-Oxide (Standard)
  • HY-154406
    2′-Deoxy-N-methylguanosine

    		Nucleoside Antimetabolite/Analog Cancer
    2’-Deoxy-N2-methylguanosine, DNA adduct is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc .
    2′-Deoxy-N-methylguanosine
  • HY-154578
    N1-Methyl-2'-deoxyadenosine

    		Nucleoside Antimetabolite/Analog Cancer
    N1-Methyl-2'-deoxyadenosine, DNA adduct is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc .
    N1-Methyl-2'-deoxyadenosine
  • HY-N0769
    Isopimpinellin
    1 Publications Verification

    		 DNA/RNA Synthesis Parasite Infection Inflammation/Immunology Cancer
    Isopimpinellin, an orally active compound isolated from Glomerella cingulata. Isopimpinellin blocks DNA adduct formation and skin tumor initiation by 7,12-dimethylbenz[a]anthracene. Isopimpinellin possesses anti-leishmania effect .
    Isopimpinellin
  • HY-133590
    Heliotrine N-oxide

    		Others Cancer
    Heliotrine N-oxide is the corresponding PA (pyrrolizidine alkaloid) N-oxide of Heliotrine (HY-126128). Heliotrine N-oxide leads to the formation of pyrrolic DNA adducts and potential initiation of PA-induced liver tumors in vivo .
    Heliotrine N-oxide
  • HY-W011640
    7,8,9,10-Tetrahydrobenzo[pqr]tetraphen-7-ol

    		Others Cancer
    7,8,9,10-Tetrahydrobenzo[a]pyren-7-ol is a benzopyrene derivative that is activated by hepatic cytosol into electrophilic sulfuric acid esters , which are capable of forming covalent DNA adducts and inducing mutations .
    7,8,9,10-Tetrahydrobenzo[pqr]tetraphen-7-ol
  • HY-W010482S
    3-Ethylaniline-d5

    		Isotope-Labeled Compounds Cancer
    3-Ethylaniline-d5 is the deuterium labeled 3-Ethylaniline (HY-W010482). 3-Ethylaniline is metabolized in vivo to electrophilic intermediates that covalently bind to DNA and that adducts are formed in the DNA of bladder. 3-Ethylaniline can be used for the research of bladder cancer[1][2].
    3-Ethylaniline-d5
  • HY-W016433S
    2-Aminofluorene-13C

    		DNA/RNA Synthesis Others
    2-Aminofluorene- 13C is the 13C labeled 2-Aminofluorene[1]. 2-Aminofluorene is a synthetic chemical insecticide. 2-Aminofluorene is a genotoxin. 2-Aminofluorene can be used in the research of DNA adduct structure, DNA repair, carcinogenesis, and mutagenesis[2][3][4].
    2-Aminofluorene-13C
  • HY-W016433S1
    2-Aminofluorene-d11

    		DNA/RNA Synthesis Others
    2-Aminofluorene-d11 is the deuterium labeled 2-Aminofluorene[1]. 2-Aminofluorene is a synthetic chemical insecticide. 2-Aminofluorene is a genotoxin. 2-Aminofluorene can be used in the research of DNA adduct structure, DNA repair, carcinogenesis, and mutagenesis[2][3][4].
    2-Aminofluorene-d11
  • HY-137316
    Phosphoramide mustard

    		DNA Alkylator/Crosslinker Drug Metabolite Cancer
    Phosphoramide mustard is a biologically active metabolite of Cyclophosphamide (HY-17420), with anticancer activitiy. Phosphoramide mustard induces DNA damage .
    Phosphoramide mustard
  • HY-137316A
    Phosphoramide mustard cyclohexanamine
    3 Publications Verification

    		 DNA Alkylator/Crosslinker Drug Metabolite Cancer
    Phosphoramide mustard cyclohexanamine is a biologically active metabolite of Cyclophosphamide (HY-17420), with anticancer activitiy. Phosphoramide mustard cyclohexanamine induces DNA damage .
    Phosphoramide mustard cyclohexanamine
  • HY-124489S1
    2-Hydroxyestradiol-d5

    		Endogenous Metabolite Infection
    2-Hydroxyestradiol-d5 is the deuterium labeled 2-Hydroxyestradiol. 2-Hydroxyestradiol, a metabolite of 17β-estradiol with minimal estrogenic activity, possesses antioxidant effects and reacts with DNA to form stable adducts and exerts genotoxicity[[1][3][4].
    2-Hydroxyestradiol-d5
  • HY-124489S
    2-Hydroxyestradiol-13C6

    		Isotope-Labeled Compounds Endogenous Metabolite Metabolic Disease
    2-Hydroxyestradiol- 13C6 is the 13C-labeled 2-Hydroxyestradiol. 2-Hydroxyestradiol, a metabolite of 17β-estradiol with minimal estrogenic activity, possesses antioxidant effects and reacts with DNA to form stable adducts and exerts genotoxicity[1][3].
    2-Hydroxyestradiol-13C6
  • HY-N0769R
    Isopimpinellin (Standard)

    		DNA/RNA Synthesis Parasite Infection Inflammation/Immunology Cancer
    Isopimpinellin (Standard) is the analytical standard of Isopimpinellin. This product is intended for research and analytical applications. Isopimpinellin, an orally active compound isolated from Glomerella cingulata. Isopimpinellin blocks DNA adduct formation and skin tumor initiation by 7,12-dimethylbenz[a]anthracene. Isopimpinellin possesses anti-leishmania effect .
    Isopimpinellin (Standard)
  • HY-N8022
    Lucidin primeveroside

    Lucidin 3-O-β-primeveroside

    		 Biochemical Assay Reagents Cancer
    Lucidin primeveroside (Lucidin 3-O-β-primeveroside) is an anthraquinone derivative present in madder root, which has been used as a coloring agent and food additive. Lucidin primeveroside can be metabolically converted to genotoxic compound Lucidin, which subsequently forms lucidin-specific DNA adducts .
    Lucidin primeveroside
  • HY-107767
    Antibiotic DC 81

    DC 81

    		 Antibiotic Apoptosis DNA/RNA Synthesis Cancer
    Antibiotic DC 81 (DC 81), an antitumor antibiotic produced by Streptomyces species, is a PBD (pyrrolo[2,1-c][1,4]benzodiazepine). Antibiotic DC 81 is potent inhibitor of nucleic acid synthesis. Antibiotic DC 81 can recognize and bind to specific sequences of DNA and form a labile covalent adduct .
    Antibiotic DC 81
  • HY-124421
    5F-203

    NSC-703786

    		 Aryl Hydrocarbon Receptor Others
    5F-203 (NSC-703786) is a cytotoxic molecule that forms DNA adducts and cell cycle arrest. 5F-203 induces aryl hydrocarbon receptor (AhR) signaling and elevates expression of CYP1A1. 5F-203 also increases the levels of reactive oxygen species as well as activates JNK, ERK, and p38 .
    5F-203
  • HY-118043
    RK-1441B

    		Antibiotic Infection
    RK-1441B is an anti-phage antibiotic produced by Streptomyces sp. RK-1441 and belongs to the pyrrolo[1,4]benzodiazepine class. RK-1441B has antiphage activity but no significant antimicrobial activity against a supersusceptible E. coli strain to an antitumor antibiotic. RK-1441B is inactive in vitro and may be converted to the active form in the host organism. Its fellow antibiotic RK-1441A can form an adduct with guanine residues in the DNA chain to exert resistance .
    RK-1441B

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