Search Result

Results for "

Drp-1

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Adrenergic Receptor (3) Antibiotic (1) Apoptosis (2) Autophagy (3) Dynamin (13) Mitochondrial Metabolism (3) Mitophagy (1) MyD88 (2) Reactive Oxygen Species (1) Toll-like Receptor (TLR) (2)
By Research Areas:	Cancer (4) Cardiovascular Disease (8) Infection (2) Inflammation/Immunology (5) Neurological Disease (5)

Inhibitors & Agonists

Peptides

Natural
Products

Recombinant Proteins

Antibodies

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-152086A

DRP1i27 dihydrochloride	Dynamin	Cardiovascular Disease
DRP1i27 dihydrochloride is a potent inhibitor of human *Drp1* (dynamin-related protein 1). DRP1i27 dihydrochloride binds to the GTPase site of Drp1, with hydrogen bonds to Gln34 and Asp218. DRP1i27 dihydrochloride targets Drp1-mediated mitochondrial fission in cell line models and protects against simulated ischemia-reperfusion injury ^[1].

HY-125222

Drp1-IN-1	Dynamin	Others
Drp1-IN-1 (comp A-7) is a **dynamin-1-like protein (Drp1) inhibitor, with an IC₅₀** of 0.91 μM ^[1].

HY-13338

Mabuterol	Adrenergic Receptor	Cardiovascular Disease
Mabuterol is a selective and orally active beta-2 adrenergic receptor (ADRB2) agonist. Mabuterol inhibits the proliferation and suppresses the increase of intracellular Ca2+ induced by PDGF-BB. Mabuterol suppresses the protein expressions of Drp-1, cyclinD1 and PCNA and enhanced the expression of Mfn-2 induced by PDGF-BB ^[1] .

HY-164566

POSH-IN-2	Dynamin Mitochondrial Metabolism	Neurological Disease
POSH-IN-2 (MIDI), a mitochondrial division inhibitor, is a *DRP1* inhibitor that potently blocks mitochondrial fragmentation induced by cellular stresses and genetic mitochondrial lesions. POSH-IN-2 covalently interacts with DRP1-C367 to target DRP1 interaction with multiple receptors ^[1].

HY-P10368

P110 heptapeptide	Dynamin	Infection Cardiovascular Disease Neurological Disease Inflammation/Immunology
P110 heptapeptide, a peptide inhibitor of *Drp1-Fis1* interaction, reduces pathology in numerous models of neurodegeneration, ischemia, and sepsis without blocking the physiological functions of Drp1 ^[1].

HY-P2280

TAT-P110 P110	Dynamin	Neurological Disease Inflammation/Immunology
TAT-P110, a peptide inhibitor of *Drp1-Fis1* interaction, reduces pathology in numerous models of neurodegeneration, ischemia, and sepsis without blocking the physiological functions of Drp1 ^[1].

HY-P6437

Drp1 peptide inhibitor P110	Dynamin	Cardiovascular Disease Neurological Disease
Drp1 peptide inhibitor P110 (Compound P110) is a selective *Drp1* peptide inhibitor with neuroprotective properties. Drp1 peptide inhibitor P110 can inhibit the activation of *Drp1, prevent MPTP-induced Drp1* mitochondrial translocation, and alleviate MPTP-induced dopaminergic neuron loss, dopaminergic nerve terminal damage, and behavioral deficits, and can be used in the study of Alzheimer's disease. Additionally, Drp1 peptide inhibitor P110 can reduce mitochondrial damage and organ injury in animal models of Huntington's disease, cerebral ischemic injury, and myocardial infarction ^[1].

HY-152086

DRP1i27	Dynamin	Cardiovascular Disease
DRP1i27 is a potent inhibitor of human *Drp1* (dynamin-related protein 1). DRP1i27 binds to the GTPase site of Drp1, with hydrogen bonds to Gln34 and Asp218. DRP1i27 targets Drp1-mediated mitochondrial fission in cell line models and protects against simulated ischemia-reperfusion injury ^[1].

HY-W755295

Mabuterol hydrochloride	Adrenergic Receptor	Cardiovascular Disease
Mabuterol hydrochloride is a selective and orally active beta-2 adrenergic receptor (ADRB2) agonist. Mabuterol hydrochloride inhibits the proliferation and suppresses the increase of intracellular Ca2+ induced by PDGF-BB. Mabuterol hydrochloride suppresses the protein expressions of Drp-1, cyclinD1 and PCNA and enhanced the expression of Mfn-2 induced by PDGF-BB ^[1] .

HY-W755295R

Mabuterol hydrochloride (Standard)	Adrenergic Receptor	Cardiovascular Disease
Mabuterol (hydrochloride) (Standard) is the analytical standard of Mabuterol (hydrochloride). This product is intended for research and analytical applications. Mabuterol hydrochloride is a selective and orally active beta-2 adrenergic receptor (ADRB2) agonist. Mabuterol hydrochloride inhibits the proliferation and suppresses the increase of intracellular Ca2+ induced by PDGF-BB. Mabuterol hydrochloride suppresses the protein expressions of Drp-1, cyclinD1 and PCNA and enhanced the expression of Mfn-2 induced by PDGF-BB ^[1] .

HY-15886

Mdivi-1 Maximum Cited Publications 163 Publications Verification Mitochondrial division inhibitor 1	Dynamin Mitophagy Autophagy Apoptosis	Cancer
Mdivi-1 is a selective dynamin-related protein 1 (Drp1) inhibitor. Mdivi-1 is a mitochondrial division/mitophagy inhibitor.

HY-P6374

IIQLPEIVVV TFA	Dynamin	Neurological Disease
IIQLPEIVVV TFA is a specific inhibitor of *Drp1-Mff* interaction. IIQLPEIVVV TFA can distinguish physiological from pathological fission and block physiological fission, thus leading to mitochondrial dysfunction. IIQLPEIVVV TFA can be used in the study of Huntington's disease ^[1].

HY-155656

Anti-inflammatory agent 49	Others	Inflammation/Immunology
nti-inflammatory agent 49 (compound SC9) is a quite potent and selective inhibitor of *Drp1-Fis1* interaction and can reduce FIS1-mediated mitochondrial dysfunction. The IC₅₀ of SC9 inhibiting GTPase in vitro is 270 nM ^[1].

HY-N0703

Schaftoside 4 Publications Verification	Toll-like Receptor (TLR) MyD88 Dynamin Mitochondrial Metabolism Autophagy	Inflammation/Immunology
Schaftoside is a flavonoid found in a variety of Chinese herbal medicines, such as Eleusine indica. Schaftoside inhibits the expression of TLR4 and Myd88. Schaftoside also decreases Drp1 expression and phosphorylation, and reduces mitochondrial fission ^[1].

HY-125918

Bleomycin A5 hydrochloride Pingyangmycin hydrochloride	Apoptosis Antibiotic	Infection Cancer
Bleomycin A5 (Pingyangmycin) hydrochloride is an anti-neoplastic glycoprotein antibiotic. Bleomycin A5 suppresses Drp1-mediated mitochondrial fission and induces apoptosis in human nasal polyp-derived fibroblasts. Bleomycin A5 hydrochloride has anticancer activities relying on its ability to produce RNA and DNA breaks, thus, leading to cell death ^[1] ..

HY-131037

MB-0223	Dynamin	Cancer
MB-0223 is a potent and selective dynamin-related GTPase Drp1 partial inhibitor (IC₅₀=1.3 μM) over other dynamin family members, Opa 1 and dynamin-1 (IC₅₀>100 μM) ^[1].

HY-161119

Drpitor1a	Dynamin Reactive Oxygen Species	Cardiovascular Disease Cancer
Drpitor1a is a potent *Drp1* inhibitor. Drpitor1a inhibits mitochondrial ROS production, preventes mitochondrial fission, and improves right ventricular diastolic dysfunction during IR (ischemia reperfusion) injury. Drpitor1a has the potential for the research of lung cancer ^[1]

HY-N0703R

Schaftoside (Standard)	Toll-like Receptor (TLR) MyD88 Dynamin Mitochondrial Metabolism Autophagy	Inflammation/Immunology
Schaftoside (Standard) is the analytical standard of Schaftoside. This product is intended for research and analytical applications. Schaftoside is a flavonoid found in a variety of Chinese herbal medicines, such as Eleusine indica. Schaftoside inhibits the expression of TLR4 and Myd88. Schaftoside also decreases Drp1 expression and phosphorylation, and reduces mitochondrial fission ^[1].

Cat. No.	Product Name	Target	Research Area

HY-P10368

P110 heptapeptide	Dynamin	Infection Cardiovascular Disease Neurological Disease Inflammation/Immunology
P110 heptapeptide, a peptide inhibitor of *Drp1-Fis1* interaction, reduces pathology in numerous models of neurodegeneration, ischemia, and sepsis without blocking the physiological functions of Drp1 ^[1].

HY-P2280

TAT-P110 P110	Dynamin	Neurological Disease Inflammation/Immunology
TAT-P110, a peptide inhibitor of *Drp1-Fis1* interaction, reduces pathology in numerous models of neurodegeneration, ischemia, and sepsis without blocking the physiological functions of Drp1 ^[1].

HY-P6374

IIQLPEIVVV TFA	Dynamin	Neurological Disease
IIQLPEIVVV TFA is a specific inhibitor of *Drp1-Mff* interaction. IIQLPEIVVV TFA can distinguish physiological from pathological fission and block physiological fission, thus leading to mitochondrial dysfunction. IIQLPEIVVV TFA can be used in the study of Huntington's disease ^[1].

HY-P6437

Drp1 peptide inhibitor P110	Dynamin	Cardiovascular Disease Neurological Disease
Drp1 peptide inhibitor P110 (Compound P110) is a selective *Drp1* peptide inhibitor with neuroprotective properties. Drp1 peptide inhibitor P110 can inhibit the activation of *Drp1, prevent MPTP-induced Drp1* mitochondrial translocation, and alleviate MPTP-induced dopaminergic neuron loss, dopaminergic nerve terminal damage, and behavioral deficits, and can be used in the study of Alzheimer's disease. Additionally, Drp1 peptide inhibitor P110 can reduce mitochondrial damage and organ injury in animal models of Huntington's disease, cerebral ischemic injury, and myocardial infarction ^[1].

Schaftoside 4 Publications Verification	Structural Classification Flavonoids Eleusine indica (Linn.) Gaertn. Classification of Application Fields Flavones Leguminosae Gramineae Source classification Plants Glycyrrhiza uralensis Fisch. Inflammation/Immunology Disease Research Fields	Toll-like Receptor (TLR) MyD88 Dynamin Mitochondrial Metabolism Autophagy
Schaftoside is a flavonoid found in a variety of Chinese herbal medicines, such as Eleusine indica. Schaftoside inhibits the expression of TLR4 and Myd88. Schaftoside also decreases Drp1 expression and phosphorylation, and reduces mitochondrial fission ^[1].

Bleomycin A5 hydrochloride Pingyangmycin hydrochloride	Structural Classification Microorganisms Antibiotics Source classification	Apoptosis Antibiotic
Bleomycin A5 (Pingyangmycin) hydrochloride is an anti-neoplastic glycoprotein antibiotic. Bleomycin A5 suppresses Drp1-mediated mitochondrial fission and induces apoptosis in human nasal polyp-derived fibroblasts. Bleomycin A5 hydrochloride has anticancer activities relying on its ability to produce RNA and DNA breaks, thus, leading to cell death ^[1] ..

Schaftoside (Standard)	Structural Classification Flavonoids Eleusine indica (Linn.) Gaertn. Flavones Leguminosae Gramineae Source classification Plants Glycyrrhiza uralensis Fisch.	Toll-like Receptor (TLR) MyD88 Dynamin Mitochondrial Metabolism Autophagy
Schaftoside (Standard) is the analytical standard of Schaftoside. This product is intended for research and analytical applications. Schaftoside is a flavonoid found in a variety of Chinese herbal medicines, such as Eleusine indica. Schaftoside inhibits the expression of TLR4 and Myd88. Schaftoside also decreases Drp1 expression and phosphorylation, and reduces mitochondrial fission ^[1].

Species:	Human (3)
Tag:	His (2) SUMO (1) Tag Free (1) GST (1)
Source:	Sf9 insect cells (1) E. coli (2)

Cat. No.	Compare	Product Name	Species	Source

HY-P71547

	CRMP1 Protein, Human Collapsin response mediator protein 1; CRMP 1; CRMP-1; Crmp1; Dihydropyrimidinase like 1; Dihydropyrimidinase related protein 1; Dihydropyrimidinase-related protein 1; DPYL1_HUMAN; DPYSL1; Drp 1; Drp-1; Drp1; ULIP-3; Ulip3; Unc-33-like phosphoprotein 3	Human	E. coli
	The CRMP1 protein is indispensable for class 3 semaphorin-mediated signaling that drives cytoskeletal remodeling critical for axonal guidance. CRMP1 downstream of SEMA3A induces FLNA dissociation from F-actin, promoting actin cytoskeleton reorganization and growth cone collapse. CRMP1 Protein, Human is the recombinant human-derived CRMP1 protein, expressed by E. coli , with tag free. The total length of CRMP1 Protein, Human is 572 a.a., with molecular weight of ~62.2 kDa.

HY-P72172

	DENR Protein, Human (His-SUMO) denr; DENR_HUMAN; Density regulated protein; Density-regulated protein; Drp; Drp1; Drp1 protein; Protein Drp1; SMAP-3; SMAP3; Smooth muscle cell associated protein 3; Smooth muscle cell-associated protein 3	Human	E. coli
	DENR proteins play a key role in the translation process, participating in mRNA scanning and start codon recognition. It crucially promotes the recruitment of aminoacylated initiator tRNA to the 40S ribosomal P site during translation initiation. DENR Protein, Human (His-SUMO) is the recombinant human-derived DENR protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag. The total length of DENR Protein, Human (His-SUMO) is 197 a.a., with molecular weight (affected by relative charge) of ~46 KDa.

HY-P702658

	DAPK2 Protein, Human (sf9, His, GST) DAPK2; death associated protein kinase 2; Drp1; Drp-1	Human	Sf9 insect cells
	DAPK2 Protein, Human (sf9, His, GST) is the recombinant human-derived DAPK2, expressed by Sf9 insect cells , with His, GST labeled tag. The total length of DAPK2 Protein, Human (sf9, His, GST) is 369 a.a.,

Compare Products


Products	In-stock - + Add to Cart
Cat. No.
Species
Source
Tag
Accession
Gene ID
Molecular Weight
Purity
Endotoxin Level
Biological Activity
Appearance
Formulation
Storage & Stability
Shipping
Free Sample	Yes No
Size	* This product has been "discontinued". Optimized version of product available: / In-stock - + Add to Cart Get quote

Cat. No.	Compare	Product Name	Application	Reactivity

HY-P80644

	DRP1 Antibody 1 Publications Verification DNM1L; DLP1; Drp1; Dynamin-1-like protein; Dnm1p/Vps1p-like protein; DVLP; Dynamin family member proline-rich carboxyl-terminal domain less; Dymple; Dynamin-like protein; Dynamin-like protein 4; Dynamin-like protein IV; HdynIV; Dynamin-rela	WB, IHC-P	Human, Mouse, Rat
	DRP1 Antibody is a non-conjugated and Rabbit origined polyclonal antibody about 82 kDa, targeting to DRP1. It can be used for WB,IHC-P assays with tag free, in the background of Human, Mouse, Rat.

HY-P82196

	CRMP1 Antibody (YA1941) CRMP 1; Crmp1; DPYSL1; Drp1; ULIP-3; Ulip3	WB, IHC-P, ICC/IF, IP, FC	Human, Mouse, Rat
	CRMP1 Antibody (YA1941) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA1941), targeting CRMP1, with a predicted molecular weight of 62 kDa (observed band size: 64-80 kDa). CRMP1 Antibody (YA1941) can be used for WB, IHC-P, ICC/IF, IP, FC experiment in human, mouse, rat background.

HY-P82898

	DAPK2 Antibody (YA2643) DAPK2; Death-associated protein kinase 2; DAP kinase 2; DAP-kinase-related protein 1; Drp-1	WB, IHC-P	Rat
	DAPK2 Antibody (YA2643) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA2643), targeting DAPK2, with a predicted molecular weight of 43 kDa (observed band size: 43 kDa). DAPK2 Antibody (YA2643) can be used for WB, IHC-P experiment in rat background.

Compare Products


Products	In-stock - + Add to Cart
Cat. No.
Host
Reactivity
Application
Dilution Ratio
Molecular Weight
Conjugation
Clonality
Immunogen
Appearance
Isotype
Gene ID
SwissProt ID
Purity
Formulation
Free Sample	Yes No
Size	* This product has been "discontinued". Optimized version of product available: / In-stock - + Add to Cart Get quote

Inquiry Online

Your information is safe with us. * Required Fields.

MCE Japan Authorized Agent ナミキ商事株式会社コスモ・バイオ株式会社
Salutation			Country or Region *
Applicant Name *			Organization Name *
Department *
Email Address *			Product Name *
Cat. No.			Requested quantity *
Phone Number *
Remarks

Inquiry Online

Inquiry Information

Product Name:
Cat. No.:
Quantity:
MCE Japan Authorized Agent:

Drp-1

Inhibitors & Agonists

Peptides

NaturalProducts

Recombinant Proteins

Antibodies

Natural
Products