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Results for "

FPR

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Formyl Peptide Receptor (FPR) (33) Apoptosis (4) Bacterial (3) Bombesin Receptor (2) Calcium Channel (2) CXCR (1) PERK (2) Reactive Oxygen Species (1) Small Interfering RNA (siRNA) (3) TNF Receptor (1)
By Research Areas:	Cancer (7) Cardiovascular Disease (1) Infection (7) Inflammation/Immunology (26) Metabolic Disease (2) Neurological Disease (7)
Oligonucleotides:	Pre-designed siRNA Sets (3) siRNAs (3)

Inhibitors & Agonists

Peptides

Natural
Products

Oligonucleotides

Targets Recommended: Formyl Peptide Receptor (FPR)

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-103472

FPR-A14	Formyl Peptide Receptor (FPR)	Neurological Disease
FPR-A14 is a potent formyl peptide receptor (FPR) agonist. FPR-A14 is a potent activator of neutrophil Ca ²⁺ mobilization and chemotaxis with EC₅₀s of 630 nM and 42 nM, respectively. FPR-A14 induces cell differentiation .

HY-19574

FPR Agonist 43 2 Publications Verification	Formyl Peptide Receptor (FPR)	Inflammation/Immunology
FPR Agonist 43 (compound 43) is a dual formyl peptide receptor 1 (FPR1) and formyl peptide receptor 2 (FPR2)/ALX agonist .

HY-144604

FPR2 agonist 2	Formyl Peptide Receptor (FPR)	Infection Neurological Disease
FPR2 agonist 2 is a potent and permeates the blood?brain barrier *FPR2* agonist with an EC₅₀ of 0.13 μM, 1.1 μM for FPR2 and FPR1, respectively. FPR2 agonist 2 inhibits the production of pro-inflammatory cytokines, counterbalances the changes in mitochondrial function, and inhibits caspase-3 activity .

HY-156293

FPR1 antagonist 1	Formyl Peptide Receptor (FPR) Apoptosis	Cancer
FPR1 antagonist 1 (compound 24a) is a formyl peptide receptor 1 (FPR1) antagonist with an IC₅₀ of 25 nM. FPR1 antagonist 1 inhibits cell growth through a combined effect on cell proliferation and apoptosis and reduces cell migration, while inducing an increase in angiogenesis .

HY-155335

FPR2 agonist 3	Formyl Peptide Receptor (FPR)	Inflammation/Immunology
FPR2 agonist 3 (compound CMC23) can limit the lactate dehydrogenase release in LPS (HY-D1056) -stimulated cultures and decrease the levels of pro-inflammatory IL-1β and IL-6. FPR2 agonist 3 decrease the level of phosphor-STAT3 via the STAT3/SOCS3 signaling pathway .

HY-159583

FPR2 agonist 4	Formyl Peptide Receptor (FPR)	Cancer
FPR2 agonist 4 (compound 20) is a selective agonist of *FPR2* with an EC₅₀ of 0.2 nM .

HY-156294

FPR1 antagonist 2	Formyl Peptide Receptor (FPR) Apoptosis	Cancer
FPR1 antagonist 2 (compound 25b) is a formyl peptide receptor 1 (FPR1) antagonist with an IC₅₀ of 70 nM. FPR1 antagonist 2 inhibits cell growth through a combined effect on cell proliferation and apoptosis and reduces cell migration, while inducing an increase in angiogenesis .

HY-RS05085

FPR1 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
FPR1 Human Pre-designed siRNA Set A contains three designed siRNAs for FPR1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

FPR1 Human Pre-designed siRNA Set A FPR1 Human Pre-designed siRNA Set A

HY-RS05086

FPR2 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
FPR2 Human Pre-designed siRNA Set A contains three designed siRNAs for FPR2 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

FPR2 Human Pre-designed siRNA Set A FPR2 Human Pre-designed siRNA Set A

HY-RS05087

FPR3 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
FPR3 Human Pre-designed siRNA Set A contains three designed siRNAs for FPR3 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

FPR3 Human Pre-designed siRNA Set A FPR3 Human Pre-designed siRNA Set A

HY-103473

Boc-MLF 3 Publications Verification Boc-Met-Leu-Phe-OH	Formyl Peptide Receptor (FPR)	Inflammation/Immunology
Boc-MLF is a formyl peptide receptor (FPR) antagonist, and reduces superoxide production induced by fMLF with an IC₅₀ of 0.63 μM .

HY-P2355A

{Boc}-Phe-Leu-Phe-Leu-Phe TFA	Formyl Peptide Receptor (FPR)	Inflammation/Immunology
{Boc}-Phe-Leu-Phe-Leu-Phe TFA is a formyl peptide receptor (FPR) family antagonist that preferentially inhibits activity triggered through the formyl peptide receptor .

HY-P2355

{Boc}-Phe-Leu-Phe-Leu-Phe	Formyl Peptide Receptor (FPR)	Inflammation/Immunology
{Boc}-Phe-Leu-Phe-Leu-Phe ({Boc}-FLFLF) is a formyl peptide receptor (FPR) family antagonist that preferentially inhibits activity triggered through the formyl peptide receptor .

HY-P1121A

WKYMVM-NH2 TFA	Formyl Peptide Receptor (FPR)	Inflammation/Immunology
WKYMVM-NH2 TFA is a potent N-formyl peptide receptor (FPR1) and FPRL1/2 agonist, also activates several leukocyte effector functions such as chemotaxis, mobilization of complement receptor-3, and activation of the NADPH oxidase .

HY-P1744

N-Formyl-Met-Leu-Phe-Lys fMLFK	Formyl Peptide Receptor (FPR)	Inflammation/Immunology
N-Formyl-Met-Leu-Phe-Lys (fMLFK) is a peptide, acts as a potent and selective agonist of *FPR1, with EC₅₀s of 3.5 nM, 6.7 μM and 0.88 μM for FPR1, FPR2 and FPR*2-D281 ^7.32G, respectively .

HY-116216

PD 168368	Bombesin Receptor	Cancer
PD 168368 is a potent, competitive, and selective neuromedin B receptor (NMB-R) antagonist with the K_i of 15–45 nM . PD 168368 is neuromedin B receptor (NMBR; IC₅₀=96 nM) / gastrin-releasing peptide receptor (GRPR IC₅₀=3500 nM) antagonist . PD 168368 also is a mixed *FPR1/FPR2/FPR3* agonist with EC₅₀s of 0.57, 0.24, and 2.7 nM, respectively .

HY-124071

ACT-389949	Formyl Peptide Receptor (FPR)	Inflammation/Immunology
ACT-389949 is a first-in-class, potent and selective and agonist of *formyl peptide receptor type 2 (FPR2)/Lipoxin A4 receptor (ALX), with an EC₅₀* of 3 nM for FPR2/ALX internalization into monocytes. ACT-389949 has potential for the treatment of inflammatory disorders .

HY-117971

BVT173187	CXCR Formyl Peptide Receptor (FPR)	Others
BVT173187 is a selective inhibitor of the neutrophil formyl peptide receptor FPR1, with activity that inhibits FPR1 activation. BVT173187 inhibits FPR1 agonist-induced activation in neutrophils, reduces adhesion molecule mobilization and superoxide anion production, and has inhibitory activity on FPR1 similar to that of earlier described peptide antagonists, but also has effects on C5aR and CXCR signaling.

HY-128113

AG-09/1	Formyl Peptide Receptor (FPR)	Inflammation/Immunology
AG-09/1 is a specific formyl peptide receptor 1 (FPR1) agonist. N-formyl peptide receptors (FPR) are important in host defense .

HY-101283

HCH6-1 3 Publications Verification	Formyl Peptide Receptor (FPR)	Inflammation/Immunology
HCH6-1 is a potent and competitive dipeptide antagonist of Formyl peptide receptor 1 (FPR1). HCH6-1 inhibits chemotaxis, superoxide anion generation, and elastase release in human neutrophils specifically activated by fMLF (an FPR1 agonist). HCH6-1 has protective effects against acute lung injury (ALI) in vivo and can be used for the research of FPR1-involved inflammatory lung diseases .

HY-P1118

Ac9-25	Formyl Peptide Receptor (FPR)	Inflammation/Immunology
Ac9-25, a N-terminal peptide of Annexin I, acts as a formyl peptide receptor (FPR) agonist and activates the neutrophil NADPH oxidase through FPR .

HY-P1118A

Ac9-25 TFA	Formyl Peptide Receptor (FPR)	Inflammation/Immunology
Ac9-25 TFA, a N-terminal peptide of Annexin I, acts as a formyl peptide receptor *(FPR)* agonist and activates the neutrophil NADPH oxidase through FPR .

HY-N8152

Randialic acid B	Reactive Oxygen Species	Inflammation/Immunology
Randialic acid B, a triterpenoid compound, is a formyl peptide receptor 1 (FPR1) antagonist. Randialic acid B blocks *FPR1* in human neutrophils and attenuates psoriasis-like inflammation in vivo .

HY-103286

PD176252	Bombesin Receptor	Cancer
PD176252 is a potent antagonist of neuromedin-B preferring (BB₁) and gastrin-releasing peptide-preferring (BB₂) receptor with K_is of 0.17 nM and 1 nM for human BB₁ and BB₂ receptors, and 0.66 nM, 16 nM for Rat BB₁ and BB₂ receptors, respectively; PD176252 is also an agonist of N-Formyl peptide receptor1/2 (FPR1/FPR2), with EC₅₀s of 0.31 and 0.66 μM in HL-60 cells.

HY-P10738A

N-Formyl-MMYALF TFA	Formyl Peptide Receptor (FPR)	Infection
N-Formyl-MMYALF TFA is a mitochondrial N-formyl peptide that has the activity of depleting calcium ions in the endoplasmic reticulum. N-Formyl-MMYALF TFA can inhibit the *FPR-1*-mediated chemotactic response of PMNs to bacterial peptides .

HY-P10738

N-Formyl-MMYALF	Formyl Peptide Receptor (FPR)	Infection
N-Formyl-MMYALF is a potent mitochondrial N-formyl peptide (mtFP) that has the activity of depleting calcium ions in the endoplasmic reticulum. N-Formyl-MMYALF can inhibit the *FPR-1*-mediated chemotactic response of polymorphonuclear leukocytes (PMNs) to bacterial peptides .

HY-P1117

MMK1	Formyl Peptide Receptor (FPR) Calcium Channel	Neurological Disease Inflammation/Immunology
MMK1 is a potent and selective human formyl peptide receptor like-1 (FPRL-1/FPR2) agonist with EC₅₀s of <2 nM and >10000 nM for FPRL-1 and FPR1, respectively. MMK1 is a potent chemotactic and calcium-mobilizing agonist. MMK1 potently activates phagocytic leukocytes and enhances Pertussis Toxin-sensitive production by human monocytes of proinflammatory cytokines IL-1b and IL-6. MMK1 exerts anxiolytic-like activity .

HY-P1117A

MMK1 TFA	Formyl Peptide Receptor (FPR) Calcium Channel	Neurological Disease Inflammation/Immunology
MMK1 TFA is a potent and selective human formyl peptide receptor like-1 (FPRL-1/FPR2) agonist with EC₅₀s of <2 nM and >10000 nM for FPRL-1 and FPR1, respectively. MMK1 TFA is a potent chemotactic and calcium-mobilizing agonist. MMK1 TFA potently activates phagocytic leukocytes and enhances Pertussis Toxin-sensitive production by human monocytes of proinflammatory cytokines IL-1b and IL-6. MMK1 TFA exerts anxiolytic-like activity .

HY-P1116

PBP10	Bacterial	Infection Inflammation/Immunology
PBP10 is a cell permeable and selective gelsolin-derived peptide inhibitor of formyl peptide receptor 2 (FPR2) over FPR1 . PBP10 is a 10-AA peptide with rhodamine conjugated at its N terminus, exerts bactericidal activity against gram-positive and gram-negative bacteria and limits microbial-induced inflammatory effects .

HY-P1116A

PBP10 TFA 1 Publications Verification	Bacterial	Infection Inflammation/Immunology
PBP10 is a cell permeable and selective gelsolin-derived peptide inhibitor of formyl peptide receptor 2 (FPR2) over FPR1 . PBP10 is a 10-AA peptide with rhodamine conjugated at its N terminus, exerts bactericidal activity against gram-positive and gram-negative bacteria and limits microbial-induced inflammatory effects .

HY-P1795

Boc-FLFLF 1 Publications Verification	Formyl Peptide Receptor (FPR)	Neurological Disease
Boc-FLFLF is a formyl peptide receptor 1 (FPR1) antagonist, which increases pain effects and inhibits antinociceptive activity of annexin .

HY-110246

Quin C1	Formyl Peptide Receptor (FPR)	Inflammation/Immunology
Quin C1 is a highly specific and potent agonist for formyl peptide receptor 2 (FPR2/ALX). Quin-C1 significantly reduces the neutrophil and lymphocyte counts in BALF, diminishes expression of TNF-α, IL-1β, KC, and TGF-β1, and decreases collagen deposition in lung tissue. Quin C1 has the potential for the research of lung injury .

HY-P1122

Cyclosporin H 1 Publications Verification	Formyl Peptide Receptor (FPR)	Infection Inflammation/Immunology
Cyclosporin H is a selective and potent inhibitor of FPR-1 (formyl peptide receptor 1). Cyclosporin H, a viral transduction enhancer, increases lentiviral transduction up to 10-fold in human cord blood-derived hematopoietic stem and progenitor cells (HSPCs). Cyclosporin H displays an additive effect when combined with Rapamycin (HY-10219) or Prostaglandin E2 (HY-101952). Cyclosporin H lacks immunosuppressant activity of Cyclosporin A.

HY-P1591

N-Formyl-Nle-Leu-Phe-Nle-Tyr-Lys For-Nle-Leu-Phe-Nle-Tyr-Lys-OH	Formyl Peptide Receptor (FPR)	Inflammation/Immunology
N-Formyl-Nle-Leu-Phe-Nle-Tyr-Lys TFA (For-Nle-Leu-Phe-Nle-Tyr-Lys-OH TFA) is a formyl peptide receptor (FPR) agonist .

HY-P1591A

N-Formyl-Nle-Leu-Phe-Nle-Tyr-Lys TFA For-Nle-Leu-Phe-Nle-Tyr-Lys-OH TFA	Formyl Peptide Receptor (FPR)	Inflammation/Immunology
N-Formyl-Nle-Leu-Phe-Nle-Tyr-Lys TFA (For-Nle-Leu-Phe-Nle-Tyr-Lys-OH TFA) is a formyl peptide receptor (FPR) agonist .

HY-103473A

Boc-MLF TFA 3 Publications Verification Boc-Met-Leu-Phe-OH TFA	Formyl Peptide Receptor (FPR)	Inflammation/Immunology
Boc-MLF (TFA) is a peptide, used as a specific formyl peptide receptor (FPR) antagonist, also inhibits the signaling through formyl peptide receptor like 1 (FPRL1) at higher concentrations .

HY-P1120

WKYMVm	Formyl Peptide Receptor (FPR) PERK Apoptosis	Neurological Disease Metabolic Disease Inflammation/Immunology Cancer
WKYMVm is a selective formylpeptide receptor 2 (FPR2) agonist. WKYMVm has a powerful anti-inflammatory effect that can reduce lung injury and spinal cord injury. WKYMVm ameliorates obesity by regulating lipid metabolism and leptin signaling. WKYMVm is involved in the regulation of immune cells by activating FPRs. WKYMVm can promote the chemotactic migration of immune cells and inhibit the apoptosis of phagocytes. In addition, WKYMVm may play a favorable or unfavorable role in tumors, depending on the type of tumor .

HY-P1120A

WKYMVm TFA	Formyl Peptide Receptor (FPR) PERK Apoptosis	Neurological Disease Metabolic Disease Inflammation/Immunology Cancer
WKYMVm (TFA) is a selective formylpeptide receptor 2 (FPR2) agonist. WKYMVm has a powerful anti-inflammatory effect that can reduce lung injury and spinal cord injury. WKYMVm ameliorates obesity by regulating lipid metabolism and leptin signaling. WKYMVm is involved in the regulation of immune cells by activating FPRs, and WKYMVm can promote the chemotactic migration of immune cells and inhibit the apoptosis of phagocytes. In addition, WKYMVm may play a favorable or unfavorable role in tumors, depending on the type of tumor .

HY-P0224

N-Formyl-Met-Leu-Phe Maximum Cited Publications 9 Publications Verification fMLP; N-Formyl-MLF	TNF Receptor	Inflammation/Immunology
N-Formyl-Met-Leu-Phe (fMLP; N-Formyl-MLF) is a chemotactic peptide and a specific ligand of N-formyl peptide receptor (FPR). N-Formyl-Met-Leu-Ph is reported to inhibit TNF-alpha secretion.

HY-P10724

fMIFL	Formyl Peptide Receptor (FPR) Bacterial	Infection
fMIFL is an *FPR1* agonist. fMIFL can activate several signaling pathways responsible for various neutrophil functions, such as adhesion, chemotaxis, secretion of granule exocytosis, and the production of superoxide anions. fMIFL can be used in research on bacterial infections and tissue damage .

HY-P10432

SHAAGtide	Formyl Peptide Receptor (FPR)	Others Inflammation/Immunology
SHAAGtide is a FPRL1 activator. SHAAGtide has anti-inflammatory activity, mediates its biological activity via *FPR2* and is used to reduce the expression of inflammatory cytokines in mouse models. SHAAGtide can be used in the study of diseases such as lung inflammation and fibrosis .

HY-131180

BMS-986235 1 Publications Verification LAR-1219	Formyl Peptide Receptor (FPR)	Cardiovascular Disease
BMS-986235 (LAR-1219) is a selective, orally active formyl peptide receptor 2 *(FPR2)* agonist, with EC₅₀s of 0.41 nM and 3.4 nM for hFPR2 and mFPR2, respectively. BMS-986235 has potential for the prevention of heart failure .

Cat. No.	Product Name	Target	Research Area