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Results for "

GAD

" in MedChemExpress (MCE) Product Catalog:

By Targets:	5-HT Receptor (1) Amino acid decarboxylase (2) Amino Acid Derivatives (1) Bacterial (3) Endogenous Metabolite (6) GABA Receptor (5) Histamine Receptor (3) Isotope-Labeled Compounds (3) mGluR (2) MHC (1) nAChR (1) p38 MAPK (2) PKC (2) Serotonin Transporter (6) Sigma Receptor (3) Small Interfering RNA (siRNA) (2) Src (2)
By Research Areas:	Cancer (5) Endocrinology (3) Infection (3) Inflammation/Immunology (7) Metabolic Disease (1) Neurological Disease (18)
Oligonucleotides:	Pre-designed siRNA Sets (2) siRNAs (2)

Inhibitors & Agonists

Peptides

Inhibitory Antibodies

Natural
Products

Recombinant Proteins

Isotope-Labeled Compounds

Antibodies

Oligonucleotides

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-122487

Troriluzole BHV-4157	mGluR	Neurological Disease Cancer
Troriluzole, a third-generation, tripeptide proagent of Riluzole (HY-B0211), is an orally active glutamate modulator. Troriluzole reduces synaptic glutamate level and increases the synaptic glutamate absorption. Troriluzole has the potential for Alzheimer disease and generalized anxiety disorder (GAD) .

HY-112291

SB 220025	p38 MAPK Src PKC	Inflammation/Immunology
SB 220025 is a reversible, orally active, cell-permeable, ATP-competitive and selective human p38 MAPK inhibitor (IC₅₀ = 60 nM). SB 220025 also inhibits p56 ^Lck and PKC with IC₅₀ values of 3.5 and 2.89 µM, respectively. SB 220025 inhibits the expression of IL-8 gene in response to globular adiponectin (gAd), reduces inflammatory cytokine production and inhibits angiogenesis. SB 220025 effectively prevents the progression of arthritis in a chronic inflammatory disease model and can be used in the study of inflammation .

HY-P2525

GAD65 (206-220)	MHC	Inflammation/Immunology
GAD65 (206-220) is glutamic acid decarboxylase (GAD) 65-derived peptide, corresponding to residues 180-188. GAD65 is presented to T cells in association with I-Ag7 MHC class II molecules and a major pancreatic antigens targeted by self-reactive T cells in type I diabetes mellitus .

HY-P5305A

GAD65(247-266) epitope TFA	GABA Receptor	Metabolic Disease
GAD65(247-266) epitope TFA is the T cell epitopes of islet antigens，binding to I-A ^g7 (type I diabetes-associated molecule) competitively with poor affinity. GAD65 refers to Glutamic Acid Decarboxylase 65，involved in the conversion of glutamate to gamma-aminobutyric acid (GABA) .

HY-RS05227

GAD1 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
GAD1 Human Pre-designed siRNA Set A contains three designed siRNAs for GAD1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

GAD1 Human Pre-designed siRNA Set A GAD1 Human Pre-designed siRNA Set A

HY-RS05228

GAD2 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
GAD2 Human Pre-designed siRNA Set A contains three designed siRNAs for GAD2 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

GAD2 Human Pre-designed siRNA Set A GAD2 Human Pre-designed siRNA Set A

HY-P5396

GAD65 (524-543)	Amino acid decarboxylase	Others
GAD65 (524-543) is a biological active peptide. (This is amino acids 524 to 543 fragment of glutamic acid decarboxylase 65 (GAD65). It is one of the first fragments of this islet antigen to induce proliferative T cell responses in the non-obese diabetic (NOD) mouse model of spontaneous autoimmune diabetes. This peptide is a specific, possibly low affinity, stimulus for the spontaneously arising diabetogenic T cell clone BDC2.5. Immunization with p524–543 increases the susceptibility of the NOD mice to type 1 diabetes induced by the adoptive transfer of BDC2.5 T cells.)

HY-P990419

*Anti-GAD65 Antibody*	Amino acid decarboxylase	Inflammation/Immunology
Anti-GAD65 Antibody is a humanized antibody expressed in CHO cells that targets *GAD65. The Anti-GAD65 Antibody has a huIgG1 heavy chain and a huλ light chain, with a predicted molecular weight (MW) of 146.48 kDa. The isotype control for Anti-GAD*65 Antibody can refer to Human IgG1 kappa, Isotype Control (HY-P99001).

HY-112291A

SB 220025 (tri(hydrochloride))	p38 MAPK Src PKC	Inflammation/Immunology
SB 220025 trihydrochloride is a reversible, orally active, cell-permeable, ATP-competitive and selective human p38 MAPK inhibitor (IC₅₀ = 60 nM). SB 220025 trihydrochloride also inhibits p56 ^Lck and PKC with IC₅₀ values of 3.5 and 2.89 μM, respectively. SB 220025 trihydrochloride inhibits the expression of IL-8 gene in response to globular adiponectin (gAd), reduces inflammatory cytokine production and inhibits angiogenesis. SB 220025 trihydrochloride effectively prevents the progression of arthritis in a chronic inflammatory disease model and can be used in the study of inflammation .

HY-B0161AS

Duloxetine D3 hydrochloride (S)-Duloxetine-d₃ (hydrochloride); LY248686-d₃ (hydrochloride)	Serotonin Transporter	Neurological Disease
Duloxetine-d₃ (hydrochloride) is a deuterium labeled Duloxetine hydrochloride. Duloxetine hydrochloride is a serotonin-norepinephrine reuptake inhibitor (SNRI) with a Ki of 4.6 nM, used for treatment of major depressive disorder and generalized anxiety disorder (GAD)[1][2].

HY-Y0367

Maleic Acid 1 Publications Verification	Endogenous Metabolite Bacterial	Infection
Maleic Acid is a Glutamate Decarboxylase (GAD) inhibitor of *E. coli* and *L. monocytogenes*.

HY-B0161S

Duloxetine-d7	Isotope-Labeled Compounds Serotonin Transporter	Neurological Disease
Duloxetine-d₇ ((S)-Duloxetine-d₇) is the deuterium labeled Duloxetine. Duloxetine is a serotonin-norepinephrine reuptake inhibitor with a Ki of 4.6 nM, used for treatment of major depressive disorder and generalized anxiety disorder (GAD)[1][2].

HY-B1115S

Buspirone-d8 hydrochloride	Isotope-Labeled Compounds 5-HT Receptor	Neurological Disease
Buspirone-d₈ (hydrochloride) is the deuterium labeled Buspirone hydrochloride. Buspirone hydrochloride is an anxiolytic psychotropic agent, is used to treat generalized anxiety disorder (GAD).

HY-B0161

Duloxetine LY248686	Serotonin Transporter	Neurological Disease Cancer
Duloxetine is a serotonin-norepinephrine reuptake inhibitor with a K_i of 4.6 nM, used for treatment of major depressive disorder and generalized anxiety disorder (GAD) .

HY-B0161A

Duloxetine hydrochloride 5 Publications Verification (S)-Duloxetine hydrochloride; LY-248686 hydrochloride	Serotonin Transporter	Neurological Disease Cancer
Duloxetine hydrochloride ((S)-Duloxetine hydrochloride) is a serotonin-norepinephrine reuptake inhibitor (SNRI) with a K_i of 4.6 nM, used for treatment of major depressive disorder and generalized anxiety disorder (GAD) .

HY-Y0367S

Maleic Acid-d2 Maleic-2,3-d2 acid	Bacterial Endogenous Metabolite	Infection
Maleic Acid-d₂ is the deuterium labeled Maleic Acid[1]. Maleic Acid is a Glutamate Decarboxylase (GAD) inhibitor of E. coli and L. monocytogenes[2][3].

HY-W023493

DL-Allylglycine 2-Aminopent-4-enoic acid	Amino Acid Derivatives	Neurological Disease
DL-Allylglycine (2-Aminopent-4-enoic acid) is a glutamate decarboxylase (GAD) inhibitor. DL-Allylglycine has convulsant activity that can be used in studies to induce epileptic seizures .

HY-118901

Opipramol Ensidon; G-33040	Sigma Receptor	Neurological Disease
Opipramol (Ensidon) is an atypical tricyclic antidepressant (TCA). Opipramol acts primarily as a sigma (σ) receptor agonist and can potently interact with sigma recognition sites with a K_i value of 50 nM. Opipramol can be used for the research of generalized anxiety disorder (GAD) .

HY-B0161AR

Duloxetine (hydrochloride) (Standard) (S)-Duloxetine hydrochloride (Standard); LY-248686 hydrochloride (Standard)	Serotonin Transporter	Neurological Disease Cancer
Duloxetine (hydrochloride) (Standard) is the analytical standard of Duloxetine (hydrochloride). This product is intended for research and analytical applications. Duloxetine hydrochloride ((S)-Duloxetine hydrochloride) is a serotonin-norepinephrine reuptake inhibitor (SNRI) with a K_i of 4.6 nM, used for treatment of major depressive disorder and generalized anxiety disorder (GAD) .

HY-118901A

Opipramol dihydrochloride Ensidon dihydrochloride; G-33040 dihydrochloride	Sigma Receptor	Neurological Disease
Opipramol (Ensidon) is an atypical tricyclic antidepressant (TCA). Opipramol acts primarily as a sigma (σ) receptor agonist and can potently interact with sigma recognition sites with a K_i value of 50 nM. Opipramol can be used for the research of generalized anxiety disorder (GAD) .

HY-122487A

Troriluzole hydrochloride BHV-4157 hydrochloride	mGluR	Neurological Disease
Troriluzole hydrochloride is a third-generation peptide precursor of Riluzole (HY-B0211) and is an orally active glutamate modulator. Troriluzole hydrochloride can reduce synaptic glutamate levels and enhance the uptake of synaptic glutamate. Troriluzole hydrochloride shows potential for treating Alzheimer's disease and Generalized Anxiety Disorder (GAD) .

HY-B0161AS1

Duloxetine-d7 hydrochloride (S)-Duloxetine-d₇ hydrochloride; LY248686-d₇ hydrochloride	Isotope-Labeled Compounds Serotonin Transporter	Neurological Disease Cancer
Duloxetine-d7 hydrochloride ((S)-Duloxetine-d7 hydrochloride) is the deuterium labeled Duloxetine hydrochloride (HY-B0161A). Duloxetine hydrochloride ((S)-Duloxetine hydrochloride) is a serotonin-norepinephrine reuptake inhibitor (SNRI) with a K_i of 4.6 nM, used for treatment of major depressive disorder and generalized anxiety disorder (GAD) .

HY-Y0367R

Maleic Acid (Standard)	Endogenous Metabolite Bacterial	Infection
Maleic Acid (Standard) is the analytical standard of Maleic Acid. This product is intended for research and analytical applications. Maleic Acid is a Glutamate Decarboxylase (GAD) inhibitor of *E. coli* and *L. monocytogenes. IC₅₀* & Target: GAD . In Vitro: The MICs of WT 10403S for the acids (e.g., Maleic Acid) are 34 mM, 25 mM, 31 mM and 30 mM which correspond to pH values prior to growth of 4.84, 5.14, 5.32 and 5.02 respectively. Of all compounds tested, Maleic Acid is the least inhibitory despite acting at a lower pH (4.84). The most acid resistant (10403S) and the weakest (EGD-e) strain are challenged with 8.6 mM and 4.3 mM of each organic acid at pH 3 and 3.3 respectively. On both strains, Maleic Acid is the most bactericidal .

HY-115685

3-Methyl-GABA	GABA Receptor	Neurological Disease
3-Methyl-GABA is a potent GABA aminotransferase activator. 3-Methyl-GABA can fit the binding pocket of GABA_A receptor (GABAaR). 3-Methyl-GABA can activate L-glutamic acid decarboxylase (GAD). 3-Methyl-GABA has anticonvulsant activity .

HY-B0548

Hydroxyzine	Histamine Receptor	Inflammation/Immunology Endocrinology
Hydroxyzine, a benzodiazepine antihistamine agent, acts as an orally active histamine H1-receptor and serotonin antagonist. Hydroxyzine has anxiolytic effect and can be used for the research of generalised anxiety disorder .

HY-B0548A

Hydroxyzine dihydrochloride	Histamine Receptor	Inflammation/Immunology Endocrinology
Hydroxyzine dihydrochloride, a benzodiazepine antihistamine agent, acts as a orally active histamine?H1-receptor and serotonin antagonist. Hydroxyzine dihydrochloride has anxiolytic effect and can be used forthe research of generalised anxiety disorder .

HY-105858

BNC210 H-Ile-Trp-OH; IW-2143	nAChR	Neurological Disease
BNC210 (H-Ile-Trp-OH) is an orally active α7 nAChR negative alteration modulator (NAM) with no apparent side effects. BNC210 exhibits acute anxiolytic activity in rodent models of anxiety. BNC210 inhibits rat and human α7 nAChR currents (in stably transfected cell lines) induced by acetylcholine, nicotine, choline, and the a7-specific agonist PNU-282987 with IC₅₀ values in the range of 1.2 to 3 μM. BNC210 can be used in studies of anxiety, trauma, and stressor-related disorders .

HY-B0548R

Hydroxyzine (Standard)	Histamine Receptor	Inflammation/Immunology Endocrinology
Hydroxyzine (Standard) is the analytical standard of Hydroxyzine. This product is intended for research and analytical applications. Hydroxyzine, a benzodiazepine antihistamine agent, acts as an orally active histamine H1-receptor and serotonin antagonist. Hydroxyzine has anxiolytic effect and can be used for the research of generalised anxiety disorder .

HY-118901R

Opipramol (Standard)	Sigma Receptor	Neurological Disease
Opipramol (Standard) is the analytical standard of Opipramol. This product is intended for research and analytical applications. Opipramol (Ensidon) is an atypical tricyclic antidepressant (TCA). Opipramol acts primarily as a sigma (σ) receptor agonist and can potently interact with sigma recognition sites with a K_i value of 50 nM. Opipramol can be used for the research of generalized anxiety disorder (GAD) .

HY-W012123

3,4,5-Trimethoxycinnamic acid	GABA Receptor Endogenous Metabolite	Neurological Disease
3,4,5-Trimethoxycinnamic acid is a phenylpropanoid isolated from the roots of Polygala tenuifolia WILLD, with anti-stress effect, prolonging the sleeping time in animals . 3,4,5-Trimethoxycinnamic acid increases expression of GAD65 and γ-subunit of GABAA receptor, but shows no effect on the amounts of α-, β-subunits .

HY-N0067

γ-Aminobutyric acid 3 Publications Verification 4-Aminobutyric acid	GABA Receptor Endogenous Metabolite	Neurological Disease
γ-Aminobutyric acid (4-Aminobutyric acid) is a major inhibitory neurotransmitter in the adult mammalian brain, binding to the ionotropic GABA receptors (GABA_A receptors) and metabotropic receptors (GABA_B receptors. γ-Aminobutyric acid shows calming effect by blocking specific signals of central nervous system .

HY-N0067R

γ-Aminobutyric acid (Standard) 4-Aminobutyric acid (Standard)	Endogenous Metabolite GABA Receptor	Neurological Disease
γ-Aminobutyric acid (Standard) is the analytical standard of γ-Aminobutyric acid. This product is intended for research and analytical applications. γ-Aminobutyric acid (4-Aminobutyric acid) is a major inhibitory neurotransmitter in the adult mammalian brain, binding to the ionotropic GABA receptors (GABAA receptors) and metabotropic receptors (GABAB receptors. γ-Aminobutyric acid shows calming effect by blocking specific signals of central nervous system .

Cat. No.	Product Name	Target	Research Area