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Results for "

GDNF

" in MedChemExpress (MCE) Product Catalog:

By Targets:	GDNF Receptor (4) Isotope-Labeled Compounds (1) Small Interfering RNA (siRNA) (1)
By Research Areas:	Neurological Disease (6)
Oligonucleotides:	Pre-designed siRNA Sets (1) siRNAs (1)

Inhibitors & Agonists

Recombinant Proteins

Isotope-Labeled Compounds

Antibodies

Oligonucleotides

Targets Recommended: GDNF Receptor

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-111969

BT18 1 Publications Verification	GDNF Receptor	Neurological Disease
BT18 is a molecule mimic with function similar to glial cell line-derived neurotrophic factor (GDNF) . BT18 shows an effect on GDNF family receptor GFRα1 and RET receptor tyrosine kinase RetA function .

HY-119910

(E)-Aminoquinol XIB4035	GDNF Receptor	Neurological Disease
(E)-Aminoquinol (XIB4035) is a GFRα-1 agonist. (E)-Aminoquinol has mimic neurotrophic effects of GDNF, and induces Ret autophosphorylation in Neuro-2A cells. (E)-Aminoquinol can be used for research of Parkinson’s disease .

HY-RS05361

GDNF Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
GDNF Human Pre-designed siRNA Set A contains three designed siRNAs for GDNF gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

GDNF Human Pre-designed siRNA Set A GDNF Human Pre-designed siRNA Set A

HY-W101298S

(Leu-13C6,15N)-Ile-OH TFA L-Leucyl-¹³C₆,¹⁵N-L-isoleucine TFA	Isotope-Labeled Compounds	Neurological Disease
(Leu-13C6,15N)-Ile-OH (L-Leucyl-13C6,15N-L-isoleucine) TFA is the deuterium labeled Leu-Ile-OH. Leu-Ile-OH protects against neuronal death by inducing brain-derived neurotrophic factor (BDNF) and glial cell line-derived neurotrophic factor (GDNF) synthesis .

HY-119910B

Aminoquinol phosphate (E/Z)-XIB4035 phosphate	GDNF Receptor	Neurological Disease
Aminoquinol ((E/Z)-XIB4035) phosphate is a GFRα-1 agonist. Aminoquinol phosphate exhibits neurotrophic effects similar to GDNF and induces Ret autophosphorylation in Neuro-2A cells. Aminoquinol phosphate can be used in research related to Parkinson's disease .

HY-119910C

Aminoquinol triphosphate (E/Z)-XIB4035 triphosphate	GDNF Receptor	Neurological Disease
Aminoquinol ((E/Z)-XIB4035) phosphate is a GFRα-1 agonist. Aminoquinol phosphate exhibits neurotrophic effects similar to GDNF and induces Ret autophosphorylation in Neuro-2A cells. Aminoquinol phosphate can be used in research related to Parkinson's disease .

HY-123439

FTY720-C2	Others	Neurological Disease
FTY720-C2 is a derivative of FTY72 (HY-12005). FTY720-C2 promotes the expression of brain-derived neurotrophic factor (BDNF) and glial cell-derived neurotrophic factor (GDNF) in multiple system atrophy (MSA) models, without causing immunosuppression. FTY720-C2 improves motor dysfunction and reduces the levels of insoluble alpha-synuclein (αSyn) in MSA mouse models. FTY720-C2 is blood-brain barrier penetrate .

Recombinant Proteins Recommended:

Glial Cell Line-derived Neurotrophic Factor (GDNF)

Species:	Human (11) Rat (4) Mouse (6) Canine (2)
Tag:	His (16) SUMO (1) Tag Free (4) Strep (1) Fc (4)
Source:	HEK293 (14) CHO (1) Sf9 insect cells (3) E. coli (5)

Cat. No.	Compare	Product Name	Species	Source

HY-P7182

	GDNF Protein, Human 1 Publications Verification rHuGDNF; ATF	Human	E. coli
	Glial-cell-line-derived neurotrophic factor (GDNF), a neurotrophic factor belongs to the GDNF family ligands (GFLs)., promotes survival of dopamine neurons. GDNF demonstrates a variety of neuroprotective roles for mammalian neurons. GDNF Protein, Human is produced in E.coil, and consists of 134 amino acids (S78-I211).

HY-P75169

	GDNF Protein, Canine (HEK293, Fc) Glial cell line-derived neurotrophic factor; ATF; HFB1-GDNF; HGDNF; HSCR3	Canine	HEK293
	Glial-cell-line-derived neurotrophic factor (GDNF), a neurotrophic factor belongs to the GDNF family ligands (GFLs)., promotes survival of dopamine neurons. GDNF demonstrates a variety of neuroprotective roles for mammalian neurons. GDNF Protein, Canine (HEK293, Fc) is produced in HEK293 cells with a N-Terminal Fc-tag. It consists of 103 amino acids (R109-I211).

HY-P73074

	GDNF Protein, Human (HEK293) Glial cell line-derived neurotrophic factor; ATF; HFB1-GDNF; HGDNF; HSCR3	Human	HEK293
	Glial-cell-line-derived neurotrophic factor (GDNF), a neurotrophic factor belongs to the GDNF family ligands (GFLs)., promotes survival of dopamine neurons. GDNF demonstrates a variety of neuroprotective roles for mammalian neurons. GDNF Protein, Human (HEK293) is produced in HEK293 cells, and consists of 103 amino acids (R83-I185).

HY-P73075

	GDNF Protein, Rat (sf9, His) Glial cell line-derived neurotrophic factor; ATF; HFB1-GDNF; HGDNF; HSCR3	Rat	Sf9 insect cells
	Glial-cell-line-derived neurotrophic factor (GDNF), a neurotrophic factor belongs to the GDNF family ligands (GFLs)., promotes survival of dopamine neurons. GDNF demonstrates a variety of neuroprotective roles for mammalian neurons. GDNF Protein, Rat (sf9, His) is produced in Sf9 insect cells with a N-Terminal His-tag. It consists of 134 amino acids (S78-I211).

HY-P7359

	GDNF Protein, Mouse (CHO) rMuGDNF; GDNF; ATF	Mouse	CHO
	Glial-cell-line-derived neurotrophic factor (GDNF), a neurotrophic factor belongs to the GDNF family ligands (GFLs)., promotes survival of dopamine neurons. GDNF demonstrates a variety of neuroprotective roles for mammalian neurons. GDNF Protein, Mouse (CHO) is produced in CHO cells, and consists of 134 amino acids (S78-I211).

HY-P7182A

	GDNF Protein, Human (His) rHuGDNF; ATF	Human	E. coli
	Glial-cell-line-derived neurotrophic factor (GDNF), a neurotrophic factor belongs to the GDNF family ligands (GFLs)., promotes survival of dopamine neurons. GDNF demonstrates a variety of neuroprotective roles for mammalian neurons. GDNF Protein, Human (His) is produced in E.coil with six N-Terminal His-tags. It consists of 134 amino acids (S78-I211).

HY-P700179AF

	*Animal-Free GDNF* Protein, Mouse (His)** rMuGDNF; GDNF; ATF	Mouse	E. coli
	Glial-cell-line-derived neurotrophic factor (GDNF), a neurotrophic factor belongs to the GDNF family ligands (GFLs)., promotes survival of dopamine neurons. GDNF demonstrates a variety of neuroprotective roles for mammalian neurons. Animal-Free GDNF Protein, Mouse (His), a recombinant animal-free protein, is produced in E.coil with a C-Terminal His-tag. It consists of 134 amino acids (S78-I211).

HY-P700084AF

	*Animal-Free GDNF* Protein, Human (His)** Glial cell line-derived neurotrophic factor; ATF; HFB1-GDNF; HGDNF; HSCR3	Human	E. coli
	Glial-cell-line-derived neurotrophic factor (GDNF), a neurotrophic factor belongs to the GDNF family ligands (GFLs)., promotes survival of dopamine neurons. GDNF demonstrates a variety of neuroprotective roles for mammalian neurons. Animal-Free GDNF Protein, Human (His), a recombinant animal-free protein, is produced in E.coil with a C-Terminal His-tag. It consists of 134 amino acids (S78-I211).

HY-P702624

	GFRAL Protein, Rat (HEK293, His) GDNF family receptor alpha-like	Rat	HEK293
	GFRAL Protein, Rat (HEK293, His) is the recombinant rat-derived GFRAL, expressed by HEK293 , with N-His labeled tag. The total length of GFRAL Protein, Rat (HEK293, His) is 331 a.a.,

HY-P76951

	GFRA3/GDNFR-alpha-3 Protein, Mouse (HEK293, Fc) GDNF family receptor alpha-3; GFR-alpha-3	Mouse	HEK293
	GFRA3/GDNFR-alpha-3 Protein, a receptor for glial cell line-derived neurotrophic factor (artemin), facilitates artemin-induced autophosphorylation and RET receptor tyrosine kinase activation. Interacting with SORL1, it hints at potential involvement in signaling cascades linked to neurotrophic responses. GFRA3/GDNFR-alpha-3 Protein, Mouse (HEK293, Fc) is the recombinant mouse-derived GFRA3/GDNFR-alpha-3 protein, expressed by HEK293 , with C-hFc labeled tag.

HY-P76952

	GFRA3/GDNFR-alpha-3 Protein, Mouse (HEK293, His) GDNF family receptor alpha-3; GFR-alpha-3	Mouse	HEK293
	GFRA3/GDNFR-alpha-3 Protein, a receptor for glial cell line-derived neurotrophic factor (artemin), facilitates artemin-induced autophosphorylation and RET receptor tyrosine kinase activation. Interacting with SORL1, it hints at potential involvement in signaling cascades linked to neurotrophic responses. GFRA3/GDNFR-alpha-3 Protein, Mouse (HEK293, His) is the recombinant mouse-derived GFRA3/GDNFR-alpha-3 protein, expressed by HEK293 , with C-His labeled tag.

HY-P70192

	GFRA2/GDNFR-alpha-2 Protein, Human (HEK293, His) rHuGDNF family receptor alpha-2/GFRA2, His ; GDNF Family Receptor Alpha-2; GDNF Receptor Alpha-2; GDNFR-Alpha-2; GFR-Alpha-2; GDNF Receptor Beta; GDNFR-Beta; Neurturin Receptor Alpha; NRTNR-Alpha; NTNR-Alpha; RET Ligand 2; TGF-Beta-Related Neurotrophic Factor Receptor 2; GFRA2; GDNFRB; RETL2; TRNR2	Human	HEK293
	GFRA2, also known as GDNFR-α-2, acts as a receptor for neurotrophic factor (NRTN) and promotes NRTN-induced autophosphorylation and RET receptor activation. In addition to neurotrophic factor signaling, GFRA2 can also mediate GDNF signaling through the RET tyrosine kinase. GFRA2/GDNFR-alpha-2 Protein, Human (HEK293, His) is the recombinant human-derived GFRA2/GDNFR-alpha-2 protein, expressed by HEK293 , with C-6*His labeled tag.

HY-P77373

	GFRA3/GDNFR-alpha-3 Protein, Human (HEK293, His) GDNF family receptor alpha-3; GFR-alpha-3; GFRA3	Human	HEK293
	GFRA3/GDNFR-alpha-3 Protein, as the receptor for glial cell line-derived neurotrophic factor ARTN, is crucial for mediating RET receptor tyrosine kinase autophosphorylation and activation upon artemin stimulation. Its interaction with SORL1 suggests involvement in diverse cellular signaling pathways. GFRA3/GDNFR-alpha-3 Protein, Human (HEK293, His) is the recombinant human-derived GFRA3/GDNFR-alpha-3 protein, expressed by HEK293 , with C-His labeled tag. The total length of GFRA3/GDNFR-alpha-3 Protein, Human (HEK293, His) is 351 a.a., with molecular weight of ~50-57 kDa.

HY-P76360

	GFRA1/GDNFR-alpha-1 Protein, Mouse (HEK293, His) GDNF family receptor alpha-1; GFR-alpha-1; GDNFRA; TRNR1	Mouse	HEK293
	GFRA1/GDNFR-alpha-1, a receptor for GDNF, mediates GDNF-induced autophosphorylation and activation of the RET receptor. It interacts with RET and forms a complex with disulfide-linked GDNF dimer, and interacts with SORL1. The SORL1-GFRA1 interaction results in GFRA1 internalization without degradation. GFRA1/GDNFR-alpha-1 Protein, Mouse (HEK293, His) is the recombinant mouse-derived GFRA1/GDNFR-alpha-1 protein, expressed by HEK293 , with C-His labeled tag. The total length of GFRA1/GDNFR-alpha-1 Protein, Mouse (HEK293, His) is 401 a.a., with molecular weight of 55-65 KDa.

HY-P77371

	GFRA1/GDNFR-alpha-1 Protein, Canine (HEK293, His) GDNF family receptor alpha-1; GFR-alpha-1; GDNFRA; TRNR1	Canine	HEK293
	GFRA1 is a co-receptor that recognizes the GDNF ligand family and is involved in the regulation of proliferation, differentiation and migration of neuronal cells. GFRA1 promotes autophagy through the SRC-AMP-activated protein kinase (AMPK) signaling pathway, thereby contributing to the development of cisplatin-induced chemotherapy resistance to osteosarcoma. GFRA1/GDNFR-alpha-1 Protein, Canine (HEK293, His) is the recombinant canine-derived GFRA1/GDNFR-alpha-1 protein, expressed by HEK293 , with C-His labeled tag.

HY-P77372

	GFRA3/GDNFR-alpha-3 Protein, Human (HEK293, His-Fc) GDNF family receptor alpha-3; GFR-alpha-3; GFRA3	Human	HEK293
	GFRA3/GDNFR-alpha-3 Protein, as the receptor for glial cell line-derived neurotrophic factor ARTN, is crucial for mediating RET receptor tyrosine kinase autophosphorylation and activation upon artemin stimulation. Its interaction with SORL1 suggests involvement in diverse cellular signaling pathways. GFRA3/GDNFR-alpha-3 Protein, Human (HEK293, His-Fc) is the recombinant human-derived GFRA3/GDNFR-alpha-3 protein, expressed by HEK293 , with C-hFc, C-His labeled tag.

HY-P70384

	GFRA1/GDNFR-alpha-1 Protein, Human (HEK293, His) rHuGDNF family receptor alpha-1/GFRA1, His; GFRα1; GDNF Family Receptor Alpha-1; GDNF Receptor Alpha-1; GDNFR-Alpha-1; GFR-Alpha-1; RET Ligand 1; TGF-Beta-Related Neurotrophic Factor Receptor 1; GFRA1; GDNFRA; RETL1; TRNR1	Human	HEK293
	The GFRA1/GDNFR-alpha-1 Protein serves as a receptor for GDNF, facilitating GDNF-induced autophosphorylation and activation of the RET receptor. In a complex, two molecules of GDNFR-alpha-1 are believed to associate with the disulfide-linked GDNF dimer and two molecules of RET. It interacts with RET and SORL1, either alone or in a complex with GDNF, leading to GFRA1 internalization without degradation. GFRA1/GDNFR-alpha-1 Protein, Human (HEK293, His) is the recombinant human-derived GFRA1/GDNFR-alpha-1 protein, expressed by HEK293 , with C-6*His labeled tag.

HY-P76950

	GFRA2/GDNFR-alpha-2 Protein, Mouse (HEK293, His) GDNF Family Receptor Alpha-2; GFR-Alpha-2; GDNFR-Beta; NRTNR-Alpha; GDNFRB; RETL2; TRNR2	Mouse	HEK293
	GFRA2/GDNFR-α-2 protein acts as a receptor for neurotrophic factors and promotes NRTN-induced autophosphorylation and RET receptor activation. It also mediates GDNF signaling through the RET tyrosine kinase receptor. GFRA2/GDNFR-alpha-2 Protein, Mouse (HEK293, His) is the recombinant mouse-derived GFRA2/GDNFR-alpha-2 protein, expressed by HEK293 , with C-His labeled tag.

HY-P76948

	GFRA1/GDNFR-alpha-1 Protein, Rat (HEK293, Fc) GFRα1; GDNF Family Receptor Alpha-1; GFR-Alpha-1; RET Ligand 1; GDNFRA; RETL1; TRNR1	Rat	HEK293
	GFRA1/GDNFR-α-1 protein is a receptor for GDNF and critically mediates GDNF-induced autophosphorylation and RET receptor activation.Presumably, two GDNFR-α-1 molecules form a complex with disulfide-linked GDNF, two RET molecules, and SORL1, suggesting the existence of a coordinated signaling mechanism.GFRA1/GDNFR-alpha-1 Protein, Rat (HEK293, Fc) is the recombinant rat-derived GFRA1/GDNFR-alpha-1 protein, expressed by HEK293 , with C-hFc labeled tag.

HY-P76949

	GFRA1/GDNFR-alpha-1 Protein, Rat (HEK293, His) GFRα1; GDNF Family Receptor Alpha-1; GFR-Alpha-1; RET Ligand 1; GDNFRA; RETL1; TRNR1	Rat	HEK293
	GFRA1/GDNFR-α-1 protein is a receptor for GDNF and critically mediates GDNF-induced autophosphorylation and RET receptor activation.Presumably, two GDNFR-α-1 molecules form a complex with disulfide-linked GDNF, two RET molecules, and SORL1, suggesting the existence of a coordinated signaling mechanism.GFRA1/GDNFR-alpha-1 Protein, Rat (HEK293, His) is the recombinant rat-derived GFRA1/GDNFR-alpha-1 protein, expressed by HEK293 , with C-His, C-6*His labeled tag.

HY-P71580

	GFRAL Protein, Human (His-SUMO) bA360D14.1; C6orf144; GDNF family receptor alpha-like; Gfral; GFRAL_HUMAN; GRAL; IVFI9356; UNQ9356; UNQ9356/PRO34128	Human	E. coli
	The GFRAL protein is a brainstem-restricted receptor for GDF15 that regulates food intake, energy expenditure, and body weight in response to metabolic and toxin-induced stress. GFRAL binds to its ligand GDF15, interacts with RET, and activates the MAPK and AKT signaling pathways. GFRAL Protein, Human (His-SUMO) is the recombinant human-derived GFRAL protein, expressed by E. coli , with N-His, N-SUMO labeled tag. The total length of GFRAL Protein, Human (His-SUMO) is 333 a.a., with molecular weight of ~53.8 kDa.

HY-P701524

	GZF1 Protein, Human (Sf9) GZF1; GDNF-inducible zinc finger protein 1; Zinc finger and BTB domain-containing protein 23; Zinc finger protein 336	Human	Sf9 insect cells
	GZF1, a transcriptional repressor, regulates gene expression by binding to the GZF1 responsive element (GRE) with the consensus sequence 5'-TGCGCN[TG][CA]TATA-3'. Its role includes potential regulation of VSX2/HOX10 expression, and it interacts with NCL, suggesting a molecular association that contributes to its transcriptional modulatory activities. GZF1 Protein, Human (Sf9) is the recombinant human-derived GZF1 protein, expressed by Sf9 insect cells , with tag free. The total length of GZF1 Protein, Human (Sf9) is 710 a.a., .

HY-P701525

	GZF1 Protein, Human (Sf9, His, Strep) GZF1; GDNF-inducible zinc finger protein 1; Zinc finger and BTB domain-containing protein 23; Zinc finger protein 336	Human	Sf9 insect cells
	GZF1, a transcriptional repressor, regulates gene expression by binding to the GZF1 responsive element (GRE) with the consensus sequence 5'-TGCGCN[TG][CA]TATA-3'. Its role includes potential regulation of VSX2/HOX10 expression, and it interacts with NCL, suggesting a molecular association that contributes to its transcriptional modulatory activities. GZF1 Protein, Human (Sf9, His, Strep) is the recombinant human-derived GZF1 protein, expressed by Sf9 insect cells , with N-Strep, N-8*His labeled tag. The total length of GZF1 Protein, Human (Sf9, His, Strep) is 710 a.a., .

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HY-W101298S

(Leu-13C6,15N)-Ile-OH TFA
(Leu-13C6,15N)-Ile-OH (L-Leucyl-13C6,15N-L-isoleucine) TFA is the deuterium labeled Leu-Ile-OH. Leu-Ile-OH protects against neuronal death by inducing brain-derived neurotrophic factor (BDNF) and glial cell line-derived neurotrophic factor (GDNF) synthesis .

Cat. No.	Compare	Product Name	Application	Reactivity

HY-P82746

	GDNF Antibody (YA2491) ATF1; ATF2; GDNF; HFB1 GDNF; hGDNF; HSCR3	WB, FC	Human, Mouse, Rat
	GDNF Antibody (YA2491) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA2491), targeting GDNF, with a predicted molecular weight of 24 kDa (observed band size: 24 kDa). GDNF Antibody (YA2491) can be used for WB, FC experiment in human, mouse, rat background.

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GDNF Human Pre-designed siRNA Set A		siRNAs Pre-designed siRNA Sets
GDNF Human Pre-designed siRNA Set A contains three designed siRNAs for GDNF gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

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