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MST-312 is a telomerase inhibitor. MST-312 is a chemically modified derivative of green tea epigallocatechin gallate (EGCG). MST-312 can be used for the research of cancer, such as multiple myeloma (MM) .
IHMT-MST1-58 is a potent, selective mammalian and orally active STE20-like protein 1 kinase (MST1) inhibitor with IC50 value of 23 nM. IHMT-MST1-58 can be used for the research of Type 1/2 diabetes .
TDI-011536 is a potent Lats kinase inhibitor, interrupts Hippo-Yap signaling and initiates the proliferation of lesioned heartmuscle cells. TDI-011536 can be used in studies of organ conservation and regeneration .
MY-875 is a competitive microtubulin polymerization inhibitor with an IC50 value of 0.92 μM. MY-875 inhibits microtubulin polymerization by targeting colchicine binding sites and activates the Hippo pathway. MY-875 induces apoptosis and has anticancer activity .
VT02956 is a LATS inhibitor (IC50: 0.76 nM for LATS1, 0.52 nM for LATS2). VT02956 targets the Hippo pathway. VT02956 inhibits ESR1 expression and growth of ER+ breast cancer cell lines and patient-derived tumor organoids . VT02956 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
Sobuzoxane (MST-16) is an orally active topoisomerase II inhibitor. Sobuzoxane causes irreversible inhibition of cell division. Sobuzoxane can be used in the study of non-Hodgkin's lymphoma that is resistant to conventional chemotherapy or has recurred .
IHMT-MST1-39 is an orally active inhibitor for MST kinase, with IC50 of 42 nM and 109 nM, for MST1 and MST2. IHMT-MST1-39 activates the AMPK signaling pathway in liver cells, reduces apoptosis of pancreatic β-cells. IHMT-MST1-39 ameliorates diabetes in Streptozotocin (HY-13753)-induced type 1 diabetes (T1D) mouse models .
MST1 Human Pre-designed siRNA Set A contains three designed siRNAs for MST1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
MST1R Human Pre-designed siRNA Set A contains three designed siRNAs for MST1R gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
mCMY020 is a covalent inhibitor of TEAD. mCMY020 effectively reduces YAP (Yes-associated protein)-driven transcription and selectively slows the proliferation of Hippo-deficient cancer cells. mCMY020 can be used in cancer research .
EN171 is a covalent ligand that covalently targets both C38 and C96 on 14-3-3 to enhance 14-3-3 interactions with ERα, YAP and TAZ, leading to impaired estrogen receptor and Hippo pathway transcriptional activity. EN171 can not only be used as a molecular glue to enhance native protein interactions but can also be used as a covalent 14-3-3 recruiter in heterobifunctional molecules to sequester nuclear neo-substrates such as BRD4 and BLC6 into the cytosol .
MR24, a G-5555 (HY-19635) derivative, is a mammalian STE20-like (MST) kinase inhibitor. MR24 selectively target MST3/4, with EC50 values of 57 and 583 nM, respectively .
Amycolatopsin B (compound 2) is a glycosylated polyketide macrolide with antifungal activity that was isolated from the soil isolate Amycolatopsis sp. MST-108494 .
Amycolatopsin A is a 20-membered macrolide, that can be isolated from a strain of the rare actinomycete Amycolatopsis sp. MST‐108494. Amycolatopsin A shows antimycobacterial activity against Mycobacterium bovis (BCG) and M. tuberculosis (H37Rv) with IC50 values of 0.4 µM and 4.4 µM, respectively .
Pim1/AKK1-IN-1 is a potent multi-kinase inhibitor with Kd values of 35 nM/53 nM/75 nM/380 nM for Pim1/AKK1/MST2/LKB1 respectively, and also inhibits MPSK1 and TNIK.
I3MT-3 (HMPSNE) is a potent, selective, and cell-membrane permeable inhibitor of 3-Mercaptopyruvate sulfurtransferase (3MST) (IC50=2.7 μM). I3MT-3 is inactive for other H2S/sulfane sulfur-producing enzymes. I3MT-3 targets a persulfurated cysteine residue located in the active site of 3MST .
Bilaid C, a tetrapeptide, can be isolated from the Australian estuarine isolate of Penicillium sp. MST-MF667. Bilaid C is also a potent and selective μ-Opioid Receptor (MOPr) agonist (Ki=210 nM, hMOPr) .
α-Ionone (alpha-Ionone) is an activator of the olfactory receptor OR10A6. α-Ionone induces apoptosis by activating OR10A6 and increasing the phosphorylation of the LATS-YAP-TAZ signaling axis in the Hippo pathway. α-Ionone can inhibit tumor formation both in vivo and in vitro .
Anticancer agent 137 (8q) is a potent PI3k inhibitor. Anticancer agent 137 has broad-spectrum anticancer activity. Anticancer agent 137 induces G2/M cell cycle arrest and apoptosis. Anticancer agent 137 increases cleaved PARP, caspase 3, and 7. Anticancer agent 137 can be used in research of cancer .
VT02956 is a LATS inhibitor (IC50: 0.76 nM for LATS1, 0.52 nM for LATS2). VT02956 targets the Hippo pathway. VT02956 inhibits ESR1 expression and growth of ER+ breast cancer cell lines and patient-derived tumor organoids . VT02956 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
α-Ionone (Standard) is the analytical standard of α-Ionone. This product is intended for research and analytical applications. α-Ionone (alpha-Ionone) is an activator of the olfactory receptor OR10A6. α-Ionone induces apoptosis by activating OR10A6 and increasing the phosphorylation of the LATS-YAP-TAZ signaling axis in the Hippo pathway. α-Ionone can inhibit tumor formation both in vivo and in vitro .
hnRNPK-IN-1 is a heterogeneous nuclear ribonucleoprotein K (hnRNPK) binding ligand with Kd values of 4.6 μM and 2.6 μM measured with SPR and MST, respectively. hnRNPK-IN-1 inhibits c-myc transcription by disrupting the binding of hnRNPK and c-myc promoter. hnRNPK-IN-1 induces Hela cells apoptosis and has strongly anti-tumor activities .
BMSpep-57 hydrochloride is a potent and competitive macrocyclic peptide inhibitor of PD-1/PD-L1 interaction with an IC50 of 7.68?nM. BMSpep-57 hydrochloride binds to PD-L1 with Kds of 19 nM and 19.88 nM in MST and SPR assays, respectively. BMSpep-57 hydrochloride facilitates T cell function by in creasing IL-2 production in PBMCs .
BMSpep-57 is a potent and competitive macrocyclic peptide inhibitor of PD-1/PD-L1 interaction with an IC50?of 7.68?nM. BMSpep-57 binds to PD-L1 with Kds of 19 nM and 19.88 nM in MST?and SPR assays, respectively.?BMSpep-57?facilitates T cell function by in creasing IL-2 production in PBMCs .
Merestinib (LY2801653) is a potent, orally bioavailable c-Met inhibitor (Ki=2 nM) with anti-tumor activities. Merestinib (LY2801653) also has potent activity against MST1R (IC50=11 nM), FLT3 (IC50=7 nM), AXL (IC50=2 nM), MERTK (IC50=10 nM), TEK (IC50=63 nM), ROS1, DDR1/2 (IC50=0.1/7 nM) and MKNK1/2 (IC50=7 nM) .
MSC-4106 is an orally active and potent inhibitor of YAP/TAZ-TEAD. MSC-4106 inhibits TEAD1 or TEAD3 auto-palmitoylation and shows inhibitory effect on NCI-H226 tumor xenograft model .
GA-017 is a potent and selective LATS1 and LATS2 (large tumor suppressor kinase 1/2) inhibitor, with IC50 values of 4.10 and 3.92 nM, respectively. GA-017 is an activator of cell proliferation. GA-017 promotes YAP/TAZ activation and nuclear translocation. GA-017 promotes cell growth under 3D culture conditions. GA-017 enhances the ex vivo formation of mouse intestinal organoids .
BMSpep-57 is a potent and competitive macrocyclic peptide inhibitor of PD-1/PD-L1 interaction with an IC50?of 7.68?nM. BMSpep-57 binds to PD-L1 with Kds of 19 nM and 19.88 nM in MST?and SPR assays, respectively.?BMSpep-57?facilitates T cell function by in creasing IL-2 production in PBMCs .
Bilaid C, a tetrapeptide, can be isolated from the Australian estuarine isolate of Penicillium sp. MST-MF667. Bilaid C is also a potent and selective μ-Opioid Receptor (MOPr) agonist (Ki=210 nM, hMOPr) .
BMSpep-57 hydrochloride is a potent and competitive macrocyclic peptide inhibitor of PD-1/PD-L1 interaction with an IC50 of 7.68?nM. BMSpep-57 hydrochloride binds to PD-L1 with Kds of 19 nM and 19.88 nM in MST and SPR assays, respectively. BMSpep-57 hydrochloride facilitates T cell function by in creasing IL-2 production in PBMCs .
α-Ionone (alpha-Ionone) is an activator of the olfactory receptor OR10A6. α-Ionone induces apoptosis by activating OR10A6 and increasing the phosphorylation of the LATS-YAP-TAZ signaling axis in the Hippo pathway. α-Ionone can inhibit tumor formation both in vivo and in vitro .
Amycolatopsin B (compound 2) is a glycosylated polyketide macrolide with antifungal activity that was isolated from the soil isolate Amycolatopsis sp. MST-108494 .
Amycolatopsin A is a 20-membered macrolide, that can be isolated from a strain of the rare actinomycete Amycolatopsis sp. MST‐108494. Amycolatopsin A shows antimycobacterial activity against Mycobacterium bovis (BCG) and M. tuberculosis (H37Rv) with IC50 values of 0.4 µM and 4.4 µM, respectively .
α-Ionone (Standard) is the analytical standard of α-Ionone. This product is intended for research and analytical applications. α-Ionone (alpha-Ionone) is an activator of the olfactory receptor OR10A6. α-Ionone induces apoptosis by activating OR10A6 and increasing the phosphorylation of the LATS-YAP-TAZ signaling axis in the Hippo pathway. α-Ionone can inhibit tumor formation both in vivo and in vitro .
MST1/STK4 protein is a stress-activated kinase that is critical in the Hippo signaling pathway and can induce apoptosis and regulate hepatocyte proliferation. Cleaved MST1/STK4 enters the nucleus, causing chromatin condensation and DNA fragmentation. MST1/STK4 Protein, Human (sf9, His) is the recombinant human-derived MST1/STK4 protein, expressed by Sf9 insect cells , with N-10*His labeled tag. The total length of MST1/STK4 Protein, Human (sf9, His) is 486 a.a., with molecular weight of ~58 kDa.
MST4/STK26 is a kinase that mediates cell growth, regulates apoptosis, and, together with STK24, is involved in negatively affecting Golgi reorientation during RHO-triggered polarized cell migration. MST4/STK26 enhances autophagic flux by phosphorylating ATG4B at 'Ser-383'. MST4/STK26 Protein, Human (sf9, GST) is the recombinant human-derived MST4/STK26 protein, expressed by Sf9 insect cells , with GST labeled tag.
MST2 protein is a stress-activated kinase that plays an important role in the Hippo signaling pathway, regulates organ size and inhibits tumors. Cleaved MST2 enters the nucleus and induces apoptosis through chromatin condensation. MST2 Protein, Human (Sf9, GST) is the recombinant human-derived MST2 protein, expressed by Sf9 insect cells , with N-GST labeled tag. The total length of MST2 Protein, Human (Sf9, GST) is 491 a.a., .
RON/MSPR protein is a receptor tyrosine kinase that transduces signals by binding to MST1 ligand and regulates cell survival, migration, and differentiation. Ligand binding induces RON autophosphorylation, creating docking sites for downstream molecules. RON/MSPR Protein, Human (HEK293, His) is the recombinant human-derived RON/MSPR protein, expressed by HEK293 , with C-His labeled tag.
The MSP/MST1 protein, encoded by this gene, is predicted to have receptor tyrosine kinase binding activity. It is involved in various processes, including embryo implantation, mammary duct growth, and regulation of mammary gland cell proliferation. The protein is mainly found in the vacuole and expressed in tissues like the esophagus, liver, pharynx, and stomach. Notably, the gene shows liver-biased expression in both adult and embryonic stages. MSP/MST1 Protein, Mouse (C677A, HEK293) is the recombinant mouse-derived MSP/MST1 protein, expressed by HEK293 , with tag free. and C677A, , , , mutation.
MST3/STK24 is a serine/threonine protein kinase that induces apoptosis in response to stress and caspase activation. It mediates oxidative stress-induced cell death by regulating the phosphorylation of JNK1-JNK2 and p38 during oxidative stress. MST3/STK24 Protein, Human (sf9, GST) is the recombinant human-derived MST3/STK24, expressed by Sf9 insect cells , with GST labeled tag. ,
The MSP/MST1 protein exists as a dimer consisting of α and β chains linked by disulfide bonds. The β-chain of MSP/MST1 interacts with MST1R through its SEMA domain. MSP/MST1 Protein, Human (Sf9, GST) is the recombinant human-derived MSP/MST1 protein, expressed by Sf9 insect cells , with N-GST labeled tag. The total length of MSP/MST1 Protein, Human (Sf9, GST) is 710 a.a., .
BZW2 is a translation initiation regulator that inhibits non-AUG and RAN-initiated translation. As a competitive inhibitor of EIF5, it improves initiation accuracy by preventing EIF5-dependent translation of non-AUG codons. BZW2 Protein, Human (GST) is the recombinant human-derived BZW2 protein, expressed by E. coli , with N-GST labeled tag.
NRG1 Protein is a direct ligand for ERBB3 and ERBB4 tyrosine kinase receptors. Concomitantly recruits ERBB1 and ERBB2 coreceptors, resulting in ligand-stimulated tyrosine phosphorylation and activation of the ERBB receptors. Perform diverse functions such as inducing growth and differentiation of epithelial, glial, neuronal, and skeletal muscle cells. Binds to ERBB4 and ERBB3. Neuregulin-1/NRG1 Protein, Mouse (HEK293, His) is the recombinant mouse-derived Neuregulin-1/NRG1 protein, expressed by HEK293 , with C-6*His labeled tag. The total length of Neuregulin-1/NRG1 Protein, Mouse (HEK293, His) is 227 a.a..
Mst2 Antibody is a non-conjugated and Rabbit origined monoclonal antibody about 56 kDa, targeting to Mst2. It can be used for WB,IHC-P,IP assays with tag free, in the background of Human, Mouse.
RPA70 Antibody (YA678) is a non-conjugated and Mouse origined monoclonal antibody about 68 kDa, targeting to RPA70 (8C3). It can be used for WB,ICC/IF,IP assays with tag free, in the background of Human, Monkey, Mouse, Rat.
MST4 Antibody (YA3253) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA3253), targeting MST4, with a predicted molecular weight of 47 kDa (observed band size: 52 kDa). MST4 Antibody (YA3253) can be used for WB, ICC/IF, IP experiment in human, rat background.
MST1 Antibody (YA2368) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA2368), targeting MST1, with a predicted molecular weight of 80 kDa (observed band size: 85 kDa). MST1 Antibody (YA2368) can be used for WB, IHC-P, FC experiment in human, mouse, rat background.
STK3 Antibody (YA2083) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA2083), targeting STK3, with a predicted molecular weight of 56 kDa (observed band size: 56 kDa). STK3 Antibody (YA2083) can be used for WB, IHC-P, IP experiment in human, mouse, rat, hamster background.
MSP Antibody (YA1648) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA1648), targeting MSP, with a predicted molecular weight of 56 kDa (observed band size: 60 kDa). MSP Antibody (YA1648) can be used for WB, ICC/IF, IP experiment in human, mouse, rat background.
DNAJA4 Antibody (YA2702) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA2702), targeting DNAJA4, with a predicted molecular weight of 45 kDa (observed band size: 45 kDa). DNAJA4 Antibody (YA2702) can be used for WB, IP experiment in human, rat background.
CDK5RAP3 Antibody (YA1928) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA1928), targeting CDK5RAP3, with a predicted molecular weight of 57 kDa (observed band size: 70 kDa). CDK5RAP3 Antibody (YA1928) can be used for WB, IHC-P, IP experiment in human, mouse background.
RON Antibody (YA1129) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA1129), targeting RON. RON Antibody (YA1129) can be used for IHC-P experiment in human background.
TOMM22 Antibody (YA2111) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA2111), targeting TOMM22, with a predicted molecular weight of 16 kDa (observed band size: 16 kDa). TOMM22 Antibody (YA2111) can be used for WB, IHC-P, ICC/IF, IP, FC experiment in human background.
Ferroportin 1; Ferroportin-1; FPN1; HFE4; IREG1; Iron regulated transporter 1; Iron-regulated transporter 1; MTP1; S40A1_HUMAN; SLC40A1; Solute carrier family 40 member 1; MST079; MSTP079; MTP1; SLC11A3.
WB, ELISA
Human
SLC40A1 Antibody is an unconjugated, approximately 63 kDa, rabbit-derived, anti-SLC40A1 polyclonal antibody. SLC40A1 Antibody can be used for: WB, ELISA expriments in human, and predicted: mouse, rat, dog, pig, rabbit background without labeling.
MST1 Human Pre-designed siRNA Set A contains three designed siRNAs for MST1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
MST1R Human Pre-designed siRNA Set A contains three designed siRNAs for MST1R gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
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