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Isoforms Recommended:	HSF1

Results for "

Hsf1

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Androgen Receptor (1) Apoptosis (2) Bacterial (2) Eukaryotic Initiation Factor (eIF) (1) HIV (2) HSP (15) JNK (1) Keap1-Nrf2 (1) Mitochondrial Metabolism (2) Mitophagy (1) NF-κB (1) PARP (1) Proteasome (2) Small Interfering RNA (siRNA) (3)
By Research Areas:	Cancer (10) Cardiovascular Disease (1) Infection (3) Inflammation/Immunology (4) Metabolic Disease (1) Neurological Disease (3)
Oligonucleotides:	Pre-designed siRNA Sets (3) siRNAs (3)

Inhibitors & Agonists

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Oligonucleotides

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-103000

HSF1A 1 Publications Verification	HSP	Cardiovascular Disease Cancer
HSF1A is a cell-permeable activator of heat shock transcription factor 1 (HSF1) ^[1]. HSF1A also acts as a specific inhibitor of TRiC/CCT. Chaperonin TCP-1 ring complex (TRiC)/chaperonin containing TCP-1 (CCT) plays a pivotal role in toxin translocation and/or refolding .

HY-138280

DTHIB 4 Publications Verification	HSP	Cancer
DTHIB is a direct and selective heat shock factor 1 (HSF1) inhibitor with a K_d of 160 nM for *DTHIB binding to the HSF1* DNA binding domain (DBD). DTHIB inhibits HSF1** cancer gene signature (HSF1 CaSig) and selectively stimulates degradation of nuclear *HSF1*. DTHIB has potently anticancer activities and can be used for prostate cancer research ^[1].

HY-N0754

Eupalinolide A	HSP	Inflammation/Immunology
Eupalinolide A, isolated from Eupatorium lindleyanum, induces the expression of HSP70 via the activation of *HSF1* by inhibiting the interaction between HSF1 and HSP90 ^[1].

HY-101026

CCT251236 3 Publications Verification	HSP	Cancer
CCT251236 is an orally available pirin ligand from a heat shock transcription factor 1 (hsf1) phenotypic screen with an IC₅₀ of 19 nM for inhibition of HSF1-mediated HSP72 induction.

HY-107599

AEG3482	JNK Apoptosis	Neurological Disease
AEG3482 is a potent antiapoptotic compound that inhibits Jun kinase (JNK) activity through induced expression of heat shock protein 70 (HSP70). AEG3482 directly binds HSP90, thereby facilitating *HSF1*-dependent expression of HSP70 and HSP25 ^[1].

HY-RS06406

HSF1 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA) HSP	Others
HSF1 Human Pre-designed siRNA Set A contains three designed siRNAs for HSF1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

HSF1 Human Pre-designed siRNA Set A HSF1 Human Pre-designed siRNA Set A

HY-RS06407

Hsf1 Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA) HSP	Others
Hsf1 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Hsf1 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Hsf1 Mouse Pre-designed siRNA Set A Hsf1 Mouse Pre-designed siRNA Set A

HY-RS06408

Hsf1 Rat Pre-designed siRNA Set A	Small Interfering RNA (siRNA) HSP	Others
Hsf1 Rat Pre-designed siRNA Set A contains three designed siRNAs for Hsf1 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

Hsf1 Rat Pre-designed siRNA Set A Hsf1 Rat Pre-designed siRNA Set A

HY-N3377

Liriodendrin	HSP	Others
Liriodendrin is an *HSF1* agonist can be isolated from E. ulmoides ^[1].

HY-N9615

Azadiradione	HSP	Infection Neurological Disease Inflammation/Immunology
Azadiradione is a bioactive limonoid found in Azadirachta indica. Azadiradione is a *HSF1* activator. Azadiradione has antimycobacterial, anti-nociceptive and anti-inflammatory activities ^[1] .

HY-100872

KRIBB11 15+ Cited Publications	HSP Apoptosis	Cancer
KRIBB11 is an inhibitor of Heat shock factor 1 (HSF1), with IC₅₀ of 1.2 μM.

HY-144867

CCT245232	HSP	Cancer
CCT245232 is a potent inhibitor of heat shock factor 1 (HSF1). HSF1 is the master regulator of the heat shock response, in which multiple genes are induced in response to temperature increase and other stresses. CCT245232 has the potential for the research of proliferative diseases, such as cancer (extracted from patent WO2015049535A1) ^[1].

HY-145927

NXP800 CCT361814	HSP	Cancer
NXP800 (CCT361814) is a potent and orally active *heat shock factor 1 (HSF1) pathway* inhibitor. NXP800 has the potential for cancer research ^[1] .

HY-18669

ML346 3 Publications Verification	HSP	Cancer
ML346 is an activator of Hsp70 expression and HSF-1 activity, with an EC₅₀ of 4.6 μM for Hsp70. ML346 restores protein folding in conformational disease models, without significant cytotoxicity or lack of specificity. ML346 induces specific increases in genes and protein effectors of the heat shock response (HSR), including chaperones such as Hsp70, Hsp40, and Hsp27 ^[1].

HY-13207

ONX-0914 10+ Cited Publications PR-957	Proteasome Bacterial HIV	Infection Inflammation/Immunology
ONX-0914 (PR-957) is a selective inhibitor of low-molecular mass polypeptide-7 (LMP7), the chymotrypsin-like subunit of the immunoproteasome. ONX-0914 blocks cytokine production and attenuates progression of experimental arthritis. ONX-0914 is a noncompetitive irreversible inhibitor of the mycobacterial proteasome (K_i=5.2 μM). ONX-0914 reactivates latent HIV-1 through p-TEFb activation mediated by HSF-1 ^[1] .

HY-13207A

ONX-0914 TFA 10+ Cited Publications PR-957 TFA	Proteasome Bacterial HIV	Infection Inflammation/Immunology
ONX-0914 (PR-957) TFA is a selective inhibitor of low-molecular mass polypeptide-7 (LMP7), the chymotrypsin-like subunit of the immunoproteasome. ONX-0914 TFA blocks cytokine production and attenuates progression of experimental arthritis. ONX-0914 TFA is a noncompetitive irreversible inhibitor of the mycobacterial proteasome (K_i=5.2 μM). ONX-0914 TFA reactivates latent HIV-1 through p-TEFb activation mediated by HSF-1 ^[1] .

HY-149127

Rosolutamide ASC-JM17; ALZ-003	Keap1-Nrf2 Androgen Receptor HSP Mitophagy	Metabolic Disease
Rosolutamide (ASC-JM17), a curcumin analog, is an orally active, potent *Nrf1* and Nrf2 activator. Rosolutamide activates Nrf1, Nrf2 and heat shock factor 1 (Hsf1), thereby the expression of proteasome subunits, antioxidant enzymes and molecular chaperones. Rosolutamide degrades the polyglutamine (polyQ) androgen receptor (AR) via the ubiquitin-proteasome pathway and improves motor function in mouse models of spinal and bulbar muscular atrophy (SBMA). Rosolutamide improves mitochondrial function and promotes autophagy, decreases mutant protein aggregates, and attenuates intracellular/mitochondrial reactive oxygen species (ROS) levels ^[1] .

HY-19356

Rocaglamide Maximum Cited Publications 20 Publications Verification Roc-A; MG-002	NF-κB HSP Eukaryotic Initiation Factor (eIF)	Cancer
Rocaglamide (Roc-A) is isolated from the genus Aglaia and can be used for coughs, injuries, asthma and inflammatory skin diseases. Rocaglamide is a potent inhibitor of NF-κB activation in T-cells. Rocaglamide is a potent and selective heat shock factor 1 (HSF1) activation inhibitor with an IC₅₀ of ~50 nM. Rocaglamide inhibits the function of the translation initiation factor eIF4A. Rocaglamide also has anticancer properties in leukemia ^[1] .

HY-N12887

Mycothiazole	Mitochondrial Metabolism	Others Cancer
Mycothiazole is an inhibitor for mitochondrial electron transport chain (ETC) complex I. Mycothiazole exhibits cytotoxicity in cancer cells Huh7 (IC₅₀ is 55.8 μM), U87 and MCF7. Mycothiazole induces apoptosis in Huh7. Mycothiazole utilizes the unfolded protein response (UPR) and heat shock response (HSR) pathway involved transcription factors ATFS-1 and HSF1, to extend the lifespan of C. elegans ^[1].

HY-162363

MD6a	PARP	Neurological Disease
MD6a is a melatonin derivative with inhibitroy activity towards *PARP-1, which maintains proteins hemostasis and improves mitochondrial function through TOR/HSF-1* signaling. MD6a a neuroprotective effect ^[1].

HY-162515

8-OAc	Mitochondrial Metabolism	Cancer
8-OAc is a potent and selective mitochondrial electron transport chain (ETC) complex I inhibitor. 8-OAc exhibits cytotoxicity against cancer cell lines ^[1].

Eupalinolide A	Classification of Application Fields Melilotus albus Desr. Terpenoids Sesquiterpenes Source classification Plants Compositae Disease Research Fields Inflammation/Immunology	HSP
Eupalinolide A, isolated from Eupatorium lindleyanum, induces the expression of HSP70 via the activation of *HSF1* by inhibiting the interaction between HSF1 and HSP90 ^[1].

Rocaglamide 15+ Cited Publications Roc-A; MG-002	Alkaloids Structural Classification Classification of Application Fields Other Alkaloids Source classification Plants Meliaceae Disease Research Fields Aglaia elliptifolia Cancer	NF-κB HSP Eukaryotic Initiation Factor (eIF)
Rocaglamide (Roc-A) is isolated from the genus Aglaia and can be used for coughs, injuries, asthma and inflammatory skin diseases. Rocaglamide is a potent inhibitor of NF-κB activation in T-cells. Rocaglamide is a potent and selective heat shock factor 1 (HSF1) activation inhibitor with an IC₅₀ of ~50 nM. Rocaglamide inhibits the function of the translation initiation factor eIF4A. Rocaglamide also has anticancer properties in leukemia ^[1] .

Liriodendrin	Structural Classification Natural Products Eucommia ulmoides Oliver Source classification Eucommiaceae Plants	HSP
Liriodendrin is an *HSF1* agonist can be isolated from E. ulmoides ^[1].

Azadiradione	Triterpenes other families Neurological Disease Classification of Application Fields Terpenoids Source classification Plants Inflammation/Immunology Disease Research Fields Biological Pesticide Research Agricultural Research	HSP
Azadiradione is a bioactive limonoid found in Azadirachta indica. Azadiradione is a *HSF1* activator. Azadiradione has antimycobacterial, anti-nociceptive and anti-inflammatory activities ^[1] .

Mycothiazole	Structural Classification Natural Products Marine natural products Source classification Sponge	Mitochondrial Metabolism
Mycothiazole is an inhibitor for mitochondrial electron transport chain (ETC) complex I. Mycothiazole exhibits cytotoxicity in cancer cells Huh7 (IC₅₀ is 55.8 μM), U87 and MCF7. Mycothiazole induces apoptosis in Huh7. Mycothiazole utilizes the unfolded protein response (UPR) and heat shock response (HSR) pathway involved transcription factors ATFS-1 and HSF1, to extend the lifespan of C. elegans ^[1].

Cat. No.	Compare	Product Name	Species	Source

HY-P73918

	HSF1 Protein, Human (His) Heat shock factor protein 1; Hsf1; HSTF 1	Human	E. coli
	HSF1, a stress-inducible transcription factor, orchestrates the heat shock response by activating heat shock genes through binding to heat shock elements (HSEs). In unstressed cells, it remains inactive in a multichaperone complex. Upon stress, HSF1 undergoes homotrimerization, binds to HSEs, and activates HSP gene transcription. It also participates in various cellular functions, including regulation of mitotic progression, repression of c-fos gene, and negative regulation of non-homologous end joining repair. Additionally, HSF1 plays a role in HIV-1 transcriptional reactivation. HSF1 Protein, Human (His) is the recombinant human-derived HSF1 protein, expressed by E. coli , with N-His, N-6*His labeled tag. The total length of HSF1 Protein, Human (His) is 528 a.a., with molecular weight of ~67 kDa.

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HY-P81050

	*Phospho-HSF1* (Ser326) Antibody(YA894)** Hsf1; HSTF1; Heat shock factor protein 1; Hsf 1; Heat shock transcription factor 1; HSTF 1	WB, ICC/IF, IHC-P, IP, FC	Human
	Phospho-HSF1 (Ser326) Antibody(YA894) is an unconjugated, approximately 57 kDa, rabbit-derived, anti-HSF1 (Ser326)(YA894) monoclonal antibody. Phospho-HSF1 (Ser326) Antibody(YA894) can be used for: WB, IF-Cell, IHC-P, IP, FC expriments in human background without labeling.

HY-P81052

	HSF1 Antibody (YA896) Hsf1; HSTF1; Heat shock factor protein 1; Hsf 1; Heat shock transcription factor 1; HSTF 1	WB, IHC-P, ICC/IF, IP, FC	Human
	HSF1 Antibody (YA896) is an unconjugated, approximately 57-80 kDa, rabbit-derived, anti-HSF1 (YA896) monoclonal antibody. HSF1 Antibody (YA896) can be used for: WB, IHC-P, ICC/IF, IP, FC expriments in human background without labeling.

HY-P80822

	*Phospho-HSF1* (Ser303/Ser307) Antibody** Hsf1; HSTF1; Heat shock factor protein 1; Hsf 1; Heat shock transcription factor 1; HSTF 1	WB, IHC-P	Human
	Phospho-HSF1 (Ser303/Ser307) Antibody is a non-conjugated and Rabbit origined monoclonal antibody about 57 kDa, targeting to Phospho-HSF1 (Ser303/Ser307). It can be used for WB,IHC-P assays with tag free, in the background of Human.

HY-P83421

	Steroidogenic Factor 1 Antibody (YA3166) AD4BP; ELP; FTZ1; FTZF1; Hsf 1; NR5A1; POF7; SF1; SPGF8; SRXY3; STF1; SF-1	WB	Human, Mouse, Rat
	Steroidogenic Factor 1 Antibody (YA3166) is a biotin-conjugated non-conjugated IgG antibody, targeting Steroidogenic Factor 1, with a predicted molecular weight of 52 kDa. Steroidogenic Factor 1 Antibody (YA3166) can be used for WB experiment in human, mouse, rat background.

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HSF1 Human Pre-designed siRNA Set A		siRNAs Pre-designed siRNA Sets
HSF1 Human Pre-designed siRNA Set A contains three designed siRNAs for HSF1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

Hsf1 Mouse Pre-designed siRNA Set A		siRNAs Pre-designed siRNA Sets
Hsf1 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Hsf1 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Hsf1 Rat Pre-designed siRNA Set A		siRNAs Pre-designed siRNA Sets
Hsf1 Rat Pre-designed siRNA Set A contains three designed siRNAs for Hsf1 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

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