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Hydroxylated

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43

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1

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3

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6

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15

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8

Isotope-Labeled Compounds

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Click Chemistry

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-113404
    DL-Dopa

    		Endogenous Metabolite Others
    DL-Dopa is a beta-hydroxylated derivative of phenylalanine.
    DL-Dopa
  • HY-N0169B
    Murideoxycholic acid

    		Endogenous Metabolite Metabolic Disease
    Murideoxycholic acid is a 6 beta-hydroxylated bile acid .
    Murideoxycholic acid
  • HY-109101AS1
    Risdiplam-hydroxylate-d3

    		Isotope-Labeled Compounds DNA/RNA Synthesis Neurological Disease
    Risdiplam-hydroxylate-d3 is a Risdiplam-hydroxylate tritium substitute. Risdiplam (RG7916) is an orally administered, centrally and peripherally distributed SMN2 pre-mRNA splicing modifier that increases survival motor neuron (SMN) protein levels .
    Risdiplam-hydroxylate-d3
  • HY-109101AS2
    Risdiplam-hydroxylate-d6

    		Isotope-Labeled Compounds DNA/RNA Synthesis Neurological Disease
    Risdiplam-hydroxylate-d6 is a Risdiplam-hydroxylate tritium substitute. Risdiplam (RG7916) is an orally administered, centrally and peripherally distributed SMN2 pre-mRNA splicing modifier that increases survival motor neuron (SMN) protein levels .
    Risdiplam-hydroxylate-d6
  • HY-N10475
    4,12-Dimethoxy-6-(7,8-dihydroxy-7,8-dihydrostyryl)-2-pyrone

    		Endogenous Metabolite Others
    4,12-Dimethoxy-6-(7,8-dihydroxy-7,8-dihydrostyryl)-2-pyrone (compound 3) is a hydroxylated microbial metabolite of Yangonin .
    4,12-Dimethoxy-6-(7,8-dihydroxy-7,8-dihydrostyryl)-2-pyrone
  • HY-D0113
    7-Hydroxy-4-methyl-2(1H)-quinolone

    		Reactive Oxygen Species Others
    7-Hydroxy-4-methyl-2(1H)-quinolone (compound 2b) is a fluorescent hydroxylated product. 7-Hydroxy-4-methyl-2(1H)-quinolone can be used for detecting hydroxyl radicals of DNA damage .
    7-Hydroxy-4-methyl-2(1H)-quinolone
  • HY-109502S
    10-OH-NBP-d4

    		Isotope-Labeled Compounds Neurological Disease
    10-OH-NBP-d4 is deuterium labeled 10-OH-NBP. 10-OH-NBP is a Butylphthalide (3-n-Butylphthalide; NBP; HY-B0647) hydroxylated metabolite and can penetrates the blood-brain barrier (BBB). Butylphthalide exerts neuroprotective effects and has potential for cerebral ischemia research[1].
    10-OH-NBP-d4
  • HY-N13097
    Cinerolone

    		Others Others
    Cinerolone is a hydroxylated product of cinerone that can be hydroxylated through a microbial system.
    Cinerolone
  • HY-W017519
    2-Quinoxalinol

    Quinoxalin-2-one

    		 Others Others
    2-Quinoxalinol (2-hydroxyquinoxaline) is a 2-hydroxylated quinoxaline that possesses photocatalytic activity and interacts with various compounds, such as antioxidant vitamins and aromatic metabolites, including neurotransmitters and the pineal hormone melatonin .
    2-Quinoxalinol
  • HY-N11675
    5-Hydroxy-TSU-68

    		Endogenous Metabolite Cancer
    5-Hydroxy-TSU-68 (compound M1) is the 5-hydroxylated indolinone derivative of TSU-68. TSU-68 is an anticancer agent that inhibits angiogenic receptor tyrosine kinases .
    5-Hydroxy-TSU-68
  • HY-W072147
    Fmoc-Ser-OMe

    Fmoc-L-Ser-OMe

    		 Amino Acid Derivatives Others
    Fmoc-Ser-OMe (Fmoc-L-Ser-OMe) is a hydroxylated L-amino acid protected with a 9-fluorenylmethyloxycarbonyl (Fmoc) group. Fmoc-Ser-OMe involves in chlorophyll–amino acid conjugates synthesis, and acts as a chromo/fluorophores modified protein and emits visible to near-infrared lights efficiently. Fmoc-Ser-OMe glycosylates and produces small mucin-related Olinked glycopeptides, as an alcohol acceptor .
    Fmoc-Ser-OMe
  • HY-76801
    24, 25-Dihydroxy VD2
    2 Publications Verification

    24,25-Dihydroxy vitamin D2

    		 VD/VDR Drug Metabolite Metabolic Disease
    24, 25-Dihydroxy VD2 is a hydroxylated metabolite of Vitamin D2; a synthetic analog of Vitamin D.
    24, 25-Dihydroxy VD2
  • HY-113404S
    DL-Dopa-d6

    		Isotope-Labeled Compounds Endogenous Metabolite Others
    DL-Dopa-d6 is the deuterium labeled DL-Dopa. DL-Dopa is a beta-hydroxylated derivative of phenylalanine.
    DL-Dopa-d6
  • HY-121711
    5-OH-HxMF

    		Apoptosis Neurological Disease Inflammation/Immunology Cancer
    5-OH-HxMF is a hydroxylated polymethoxyflavone that has anti-inflammatory, anticancer, neurotrophic and neuroprotective activities .
    5-OH-HxMF
  • HY-N0685
    Pseudohypericin

    		HIV Infection
    Pseudohypericin and its congener Hypericin are the major hydroxylated phenanthroperylenediones present in Hypericum species. Pseudohypericin shows anti-HIV activity .
    Pseudohypericin
  • HY-N8621
    (11S)-(-)-Hydroxyjasmonic acid

    		Others Others
    (11S)-(-)-Hydroxyjasmonic acid is a hydroxylated cyclopentane fatty acid of the jasmonic acid type that can be found in the culture filtrate of the fungus Botryodiplodia theobromae< .
    (11S)-(-)-Hydroxyjasmonic acid
  • HY-113404S1
    L-Dopa-d3

    		Endogenous Metabolite Isotope-Labeled Compounds Others
    L-Dopa-d3 is deuterated labeled DL-Dopa (HY-113404). DL-Dopa is a beta-hydroxylated derivative of phenylalanine.
    L-Dopa-d3
  • HY-124669
    RTC-30

    		Others Cancer
    RTC-30 is an optimized phenothiazine with anti-cancer potency. RTC-30 contains a hydroxylated linker (N) that confers increased oral bioavailability .
    RTC-30
  • HY-N7177
    Hydroxytanshinone IIA

    		Drug Metabolite VEGFR Cancer
    Hydroxytanshinone IIA is a hydroxylated metabolite of Tanshinone IIA. Tanshinone IIA may suppress angiogenesis by targeting the protein kinase domains of VEGF/VEGFR2 .
    Hydroxytanshinone IIA
  • HY-149503
    4-Hydroxy nebivolol hydrochloride

    		Adrenergic Receptor Drug Metabolite Inflammation/Immunology
    4-Hydroxy nebivolol (4-OH nebivolol) hydrochloride is an active β-blocking hydroxylated metabolite of Nebivolol (HY-B0203) .
    4-Hydroxy nebivolol hydrochloride
  • HY-W099744
    4-Methyl-5-nonanol

    		Others Others
    4-Methyl-5-nonanol is a pheromone and can be produced by Puberulic acid .
    4-Methyl-5-nonanol
  • HY-113884A
    (±)-Coriolic acid

    (±)-13-HODE

    		 Endogenous Metabolite Metabolic Disease
    (±)13-HODE is one of the two racemic monohydroxy fatty acids resulting from the non-enzymatic oxidation of linoleic acid. It is the principle hydroxylated fatty acid in human psoriatic skin scales, with a mean concentration of 17 ng/mg.
    (±)-Coriolic acid
  • HY-116615
    Methyl 2-hydroxytetracosanoate

    Methyl cerebronate

    		 Biochemical Assay Reagents Others
    Methyl (+/-)-2-hydroxytetracosanoate, a hydroxylated fatty acid methyl ester, has been found in mature and immature strawberry homogenates, Pseudosuberites and S. massa sponges, sediment samples from Hani River and Lake Kivu, and aerial parts of Escherichia coli found in. sun mirror.
    Methyl 2-hydroxytetracosanoate
  • HY-W127423
    Methyl 2-hydroxyoctadecanoate

    		Biochemical Assay Reagents Others
    Methyl (+/-)-2-hydroxystearateis a hydroxylated fatty acid methyl ester that broadens phase transitions in dimyristoylphosphatidylcholine (DMPC) lipid membranes. It has been used in the synthesis of lipid-nucleotide conjugated anti-HIV agents to increase the cleavage of phosphodiester bonds and the number of released intracellular nucleotides.
    Methyl 2-hydroxyoctadecanoate
  • HY-151239
    ONT-993

    AR 00440993

    		 Cytochrome P450 Cancer
    ONT-993 is an aliphatic hydroxylated metabolite. ONT-993 inhibits CYP2D6 (IC50=7.9 µM) and causes metabolism-dependent inactivation of CYP3A (KI=1.6 µM) .
    ONT-993
  • HY-32351
    Calcifediol
    Maximum Cited Publications
    8 Publications Verification

    25-hydroxy Vitamin D3

    		 VD/VDR Endogenous Metabolite Metabolic Disease
    Calcifediol (25-hydroxy Vitamin D3) is an effective VDR ligand and VD supplement. Calcifediol is a prohormone of the vitamin D endocrine system (VDES) and is hydroxylated in the liver to produce the active form, calcitriol. Calcifediol can rapidly increase serum VD levels .
    Calcifediol
  • HY-32351A
    Calcifediol monohydrate
    Maximum Cited Publications
    8 Publications Verification

    25-hydroxy Vitamin D3 monohydrate

    		 VD/VDR Endogenous Metabolite Metabolic Disease
    Calcifediol monohydrate (25-hydroxy Vitamin D3 monohydrate), is an effective VDR ligand and VD supplement. Calcifediol is a prohormone of the vitamin D endocrine system (VDES) and is hydroxylated in the liver to produce the active form, calcitriol. Calcifediol can rapidly increase serum VD levels .
    Calcifediol monohydrate
  • HY-32351S
    Calcifediol-d3

    25-hydroxy Vitamin D3-d3

    		 VD/VDR Endogenous Metabolite Metabolic Disease
    Calcifediol-d3 is a deuterium labeled Calcifediol. Calcifediol, is an effective VDR ligand and VD supplement. Calcifediol is a prohormone of the vitamin D endocrine system (VDES) and is hydroxylated in the liver to produce the active form, calcitriol. Calcifediol can rapidly increase serum VD levels .
    Calcifediol-d3
  • HY-160624
    CD 10899

    		Polo-like Kinase (PLK) Cancer
    CD 10899 is a hydroxylated metabolite of Volasertib (HY-12137). CD 10899 is pharmacologically active against Polo-like kinase 1 (PLK1) (IC50: 6 nM). Volasertib is an orally active, highly potent and ATP-competitive PLK1 inhibitor. CD 10899 can be used for research of cancer .
    CD 10899
  • HY-W001160
    5-Hydroxyindole

    		Endogenous Metabolite Others
    5-Hydroxyindole, a hydroxylated indole, can be found in a vast array of pharmacologically active agents and natural products. 5-Hydroxyindole slows desensitization of the 5-HT3 receptor-mediated ion current in N1E-115 neuroblastoma cells .
    5-Hydroxyindole
  • HY-32351AS
    Calcifediol-d6 monohydrate

    25-hydroxy Vitamin D3-d6 monohydrate

    		 Isotope-Labeled Compounds VD/VDR Endogenous Metabolite Metabolic Disease
    Calcifediol-d6 monohydrate is the deuterium labeled Calcifediol monohydrate. Calcifediol monohydrate (25-hydroxy Vitamin D3 monohydrate), is an effective VDR ligand and VD supplement. Calcifediol is a prohormone of the vitamin D endocrine system (VDES) and is hydroxylated in the liver to produce the active form, calcitriol. Calcifediol can rapidly increase serum VD levels .
    Calcifediol-d6 monohydrate
  • HY-P3100
    Orfamide A

    		Parasite Infection
    Orfamide A is a major metabolite of insecticidal biosurfactant in Pseudomonas sp. F6 and has aphidicidal activity. Orfamide A can be used for aphid control in organic agriculture. Orfamide A exhibits dose-dependent mortality against aphids with an LC50 value of 34.5 μg/mL .
    Orfamide A
  • HY-32351AR
    Calcifediol monohydrate (Standard)

    		VD/VDR Endogenous Metabolite Metabolic Disease
    Calcifediol monohydrate (Standard) is the analytical standard of Calcifediol (monohydrate). This product is intended for research and analytical applications. Calcifediol monohydrate (25-hydroxy Vitamin D3 monohydrate), is an effective VDR ligand and VD supplement. Calcifediol is a prohormone of the vitamin D endocrine system (VDES) and is hydroxylated in the liver to produce the active form, calcitriol. Calcifediol can rapidly increase serum VD levels .
    Calcifediol monohydrate (Standard)
  • HY-32351AS1
    Calcifediol-13C5 monohydrate

    25-Hydroxy Vitamin D3-13C5 monohydrate

    		 Isotope-Labeled Compounds VD/VDR Endogenous Metabolite Metabolic Disease
    Calcifediol- 13C5 monohydrate is the 13C-labeled Calcifediol monohydrate. Calcifediol monohydrate (25-hydroxy Vitamin D3 monohydrate), is an effective VDR ligand and VD supplement. Calcifediol is a prohormone of the vitamin D endocrine system (VDES) and is hydroxylated in the liver to produce the active form, calcitriol. Calcifediol can rapidly increase serum VD levels .
    Calcifediol-13C5 monohydrate
  • HY-32351R
    Calcifediol (Standard)

    		VD/VDR Endogenous Metabolite Metabolic Disease
    Calcifediol (Standard) is the analytical standard of Calcifediol. This product is intended for research and analytical applications. Calcifediol (25-hydroxy Vitamin D3) is an effective VDR ligand and VD supplement. Calcifediol is a prohormone of the vitamin D endocrine system (VDES) and is hydroxylated in the liver to produce the active form, calcitriol. Calcifediol can rapidly increase serum VD levels .
    Calcifediol (Standard)
  • HY-153100A
    (S)-mchm5U

    		Others Others
    (S)-mchm5U is a hydroxylated form of mcm5U, may be present in tRNA from the silkworm Bombyx mori. (S)-mchm5U may be present also in mammalian tRNA, and that the ALKBH8 oxygenase could be responsible for its formation. (S)-mchm5U can be used for RNA modification synthesis .
    (S)-mchm5U
  • HY-123934
    VU6007477

    		P-glycoprotein Neurological Disease
    VU6007477 is a brain-penetrant, selective M1 positive allosteric modulator (PAM) with an EC50 value of 230 nM. VU6007477 is also a human P-glycoprotein (P-gp) substrate with moderate permeability. VU6007477 displays improved central nervous system (CNS) penetration over the hydroxylated congeners. VU6007477 a pyranyl amide derivative, which is promising for research of robust cholinergic seizure activity .
    VU6007477
  • HY-15977
    (S)-P7C3-OMe

    		Others Neurological Disease
    (S)-P7C3-OMe, P7C3-A20 hydroxylated analog, is the (S)-enantiomer of P7C3-OMe. P7C3-OMe is a pro-neurogenic compound, can be used for the research of neuropsychiatric and/or neurodegenerative disease .
    (S)-P7C3-OMe
  • HY-129431
    U-89843A

    		Others Others
    U-89843A is a precursor of U-97924 and forms U-97924 as the major metabolite. Although U-97924 showed mutagenic potential in rat hepatocytes in a serum-free in vitro assay, no genotoxicity of U-97924 was observed in rats at high oral doses. Rat serum also inhibited the in vitro metabolism of U-89843 and the formation of the corresponding hydroxylated metabolite, U-97924 .
    U-89843A
  • HY-124626
    (R)-(+)-Mequitazine

    		Histamine Receptor Inflammation/Immunology
    (R)-(+)-Mequitazine is a histamine H1 receptor antagonist that mainly undergoes bio-transformation via human liver microsomes, resulting in hydroxylated and S-oxidized metabolites. (R)-(+)-Mequitazine competitively binds to the H1 receptors in gastrointestinal, vascular, and respiratory effect cells, thus blocking the endogenous activity of histamine. (R)-(+)-Mequitazine has an inhibitory effect on CYP3A-catalyzed midazolam 1’-hydroxylase. (R)-(+)-Mequitazine can be used in the study of various allergic diseases .
    (R)-(+)-Mequitazine
  • HY-113058
    3-Hydroxyoctanoic acid

    		Biochemical Assay Reagents Others
    3-Hydroxyoctanoic acid is a hydroxylated fatty acid that has been found in the LPS of Pseudomonas aeruginosa and in methyl-branched poly(3-hydroxyalkanoate) (PHA) polymers produced by Pseudomonas oleophores. It is an agonist of the orphan receptor GPR109B, increasing intracellular calcium in human neutrophils endogenously expressing GPR109B. 3-Hydroxycaprylic acid prevents lipolysis in human adipocytes and is upregulated in human plasma in response to a ketogenic diet. Plasma levels of 3-hydroxyoctanoic acid were also increased 3.41-fold in human male runners exhausted on a treadmill and in a mouse model of autism spectrum disorder (ASD) fed a high-glycemic diet.
    3-Hydroxyoctanoic acid
  • HY-P10447
    Plipastatin A1

    Fengycin IX; SNA-60-367-3

    		 Phospholipase Inflammation/Immunology
    Plipastatin A1 is a lipopeptide with enzyme inhibitory and immunosuppressive activities. Plipastatin A1 is found in Bacillus cereus and inhibits phospholipase A2 (PLA2), PLC, and PLD .
    Plipastatin A1
  • HY-N7844
    N6-Benzyladenosine

    Benzyladenosine

    		 Apoptosis Adenosine Receptor Inflammation/Immunology Cancer
    N6-Benzyladenosine is an adenosine receptor agonist, has a cytoactive activity. N6-Benzyladenosine arrests cell cycle at G0/G1 phase and induces cell apoptosis. N6-Benzyladenosine also exerts inhibitory effect on T. gondii adenosine kinase and glioma - .
    N6-Benzyladenosine

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