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Leukotriene receptors

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By Targets:	Leukotriene Receptor (59) 17β-HSD (1) Apoptosis (2) c-Fms (1) COX (2) Drug Metabolite (1) Endogenous Metabolite (2) G protein-coupled Bile Acid Receptor 1 (1) iGluR (1) Isotope-Labeled Compounds (5) Lipoxygenase (2) LPL Receptor (2) Platelet-activating Factor Receptor (PAFR) (1) Prostaglandin Receptor (2) TNF Receptor (2)
By Research Areas:	Cancer (9) Cardiovascular Disease (3) Endocrinology (2) Inflammation/Immunology (59) Metabolic Disease (3) Neurological Disease (1)

Inhibitors & Agonists

Natural
Products

Isotope-Labeled Compounds

Targets Recommended: Leukotriene Receptor

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-118958

Ablukast Ro 23-3544	Leukotriene Receptor	Inflammation/Immunology
Ablukast (Ro 23-3544) is a specific and active **leukotriene receptor** antagonist. Ablukast effectively reduces LTC4- and antigen-induced bronchoconstriction . Ablukast is LTD4 receptor antagonist .

HY-147086

CAY10789	Leukotriene Receptor G protein-coupled Bile Acid Receptor 1 TNF Receptor	Metabolic Disease Inflammation/Immunology
CAY10789 (compound 6) is a potent CysLT1R (cysteinyl leukotriene receptor 1) antagonist (IC₅₀=2.80 μM) and GPBAR1 (G-protein-coupled bile acid receptor 1) agonist (EC₅₀=3 μM). CAY10789 significantly reduces the adhesion of U937 cells to HAEC, reduces the expression of TNF-α. CAY10789 shows very promising metabolic stability and excellent pharmacokinetics. CAY10789 can be used for the research of colitis, metabolic syndromes, and other GPBAR1/CysLT1R-related diseases .

HY-113483

20-Carboxy-Leukotriene B4 20-COOH LTB4	Drug Metabolite Leukotriene Receptor	Metabolic Disease
20-Carboxy-Leukotriene B4 (20-COOH LTB4) is a metabolite of Leukotriene B4 (LTB4; HY-107608). 20-Carboxy-Leukotriene B4 binds to the BLT1 receptor with high affinity. 20-Carboxy-Leukotriene B4 inhibits LTB4-mediated neutrophil responses (migration, degranulation, leukotriene biosynthesis) .

HY-U00253

KP496	Leukotriene Receptor Prostaglandin Receptor	Inflammation/Immunology Endocrinology
KP496 is a selective, dual antagonist for **Leukotriene D4 receptor** and Thromboxane A2 receptor.

HY-112736

RG 14893	Leukotriene Receptor	Inflammation/Immunology
RG 14893 is a high affinity, competitive, orally active **leukotriene B4 receptor** antagonist .

HY-119442

Quininib	Leukotriene Receptor	Cardiovascular Disease
Quininib is a cysteinyl leukotriene 1 and 2 receptor antagonist with IC₅₀s of 1.2 and 52 μM for CysLT₁R and CysLT₂R, respectively. Quininib is a potent inhibitor of developmental angiogenesis in the zebrafish eye. Quininib can be used for the research of ocular neovascular pathologies and may complement current anti-VEGF biological agents .

HY-122124

CAY10583	Leukotriene Receptor	Inflammation/Immunology
CAY10583 is a potent and selective full Leukotriene B4 receptor type 2 (BLT2) agonist. CAY10583 directly promotes keratinocyte migration in vitro and accelerates wound closure in vivo. CAY10583 is a promising pharmaceutical agent for diabetic wounds .

HY-131651

Leukotriene B4 ethanolamide LTB4 ethanolamide	Endogenous Metabolite Leukotriene Receptor	Cancer
Leukotriene B4 ethanolamide (LTB4 ethanolamide) is an antagonist and a partial agonist for Leukotriene B4 (LTB4) receptor 1 (BLTR1). Leukotriene B4 ethanolamide ameliorates the tumor progression, which is only asscociated with inflammation .

HY-U00263

LY210073	Leukotriene Receptor	Inflammation/Immunology
LY210073 is a Leukotriene B₄ (LTB₄) receptor antagonist with an IC₅₀ of 6.2 nM.

HY-U00252

ONO4057 ONO-LB457	Leukotriene Receptor	Inflammation/Immunology
ONO4057 is a **Leukotriene B₄ receptor antagonist, with an IC₅₀** of 0.7±0.3 μM.

HY-19193

CP-105696 Pfizer 105696	Leukotriene Receptor	Inflammation/Immunology
CP-105696 is a potent and selective Leukotriene B₄ Receptor antagonist, with an IC₅₀ of 8.42 nM.

HY-112532

REV 5901	Leukotriene Receptor Lipoxygenase	Inflammation/Immunology
REV 5901 is a competitive and orally active antagonist of **leukotriene receptor, with a K_i of 0.7 μM. REV 5901 is also a 5-lipoxygenase** inhibitor. REV 5901 can be used for the research of asthma in which leukotriene release be involved .

HY-112532A

REV 5901 hydrochloride	Leukotriene Receptor Lipoxygenase	Inflammation/Immunology
REV 5901 hydrochloride is a competitive and orally active antagonist of **leukotriene receptor, with a K_i of 0.7 μM. REV 5901 hydrochloride is also a 5-lipoxygenase** inhibitor. REV 5901 hydrochloride can be used for the research of asthma in which leukotriene release be involved .

HY-105221

Masilukast ZD-3523	Leukotriene Receptor	Inflammation/Immunology
Masilukast is an orally administered cysteinyl leukotriene D₄ (LTD₄) receptor antagonist with potential to research asthma.

HY-76511

Verlukast MK-679; L 668019	Leukotriene Receptor	Inflammation/Immunology
Verlukast is a potent, selective, and orally active antagonist of **leukotriene receptor**. Verlukast has the potential for the research of asthma .

HY-122175

ZK-158252	Leukotriene Receptor	Inflammation/Immunology
ZK-158252 is a leukotriene B4 type-2 receptor (BLT2) antagonist .

HY-107607

FPL-55712 free base	Leukotriene Receptor	Inflammation/Immunology
FPL-55712 free base is a **leukotriene receptor antagonist. FPL-55712 free base is also an antagonist of slow reacting substance of anaphylaxis (SRS-A). FPL-55712 free base inhibits leukotriene-induced bronchoconstriction .**

HY-14938

Tipelukast KCA 757; MN 001	Leukotriene Receptor	Inflammation/Immunology
Tipelukast (KCA 757) is a sulfidopeptide **leukotriene receptor** antagonist, an orally bioavailable anti-inflammatory agent and used for the treatment of asthma.

HY-112737

LY223982 CGS23131; SKF107324	Leukotriene Receptor	Inflammation/Immunology
LY223982 is a potent and specific inhibitor of **leukotriene B4 receptor, with an IC₅₀** of 13.2 nM against [ ³H]LTB4 binding to LTB4 receptor.

HY-112248

(Rac)-HAMI 3379	Leukotriene Receptor	Cardiovascular Disease Neurological Disease Inflammation/Immunology
(Rac)-HAMI 3379 is the racemate of HAMI 3379. HAMI 3379 is a potent and selective Cysteinyl leukotriene (CysLT₂) receptor antagonist .

HY-108396

γ-Linolenic acid ethyl ester Ethyl γ-linolenate	Leukotriene Receptor	Inflammation/Immunology
γ-Linolenic acid ethyl ester (Ethyl γ-linolenate) is a leukotriene B₄ receptor 4 (LTB₄) antagonist .

HY-117557

LY306669	Leukotriene Receptor	Inflammation/Immunology
LY306669 is a potent and selective leukotriene B4 (LTB4) receptor antagonist that can be used for the research of lung injury .

HY-107607A

FPL-55712	Others	Inflammation/Immunology
FPL-55712 is a cysteine leukotriene type 1 receptor antagonist with anti-inflammatory activity. FPL-55712 can effectively block the biological response caused by leukotrienes, reduce allergic reactions and airway inflammation. FPL-55712 shows potential in suppressing asthma and allergic rhinitis .

HY-122149

L-648051	Leukotriene Receptor	Cardiovascular Disease
L-648051 is a leukotriene D4 receptor (LTD4) antagonist. L-648051 plays an important role in arrhythmias .

HY-107609

BAY-u 9773	Leukotriene Receptor	Inflammation/Immunology
BAY-u 9773 is a non-selective antagonist of the CysLT receptors (cysteinyl leukotrienes receptors) with about the same IC₅₀ for CysLT ¹ and CysLT ². BAY-u9773 is used for the inhibition of LT responses .

HY-U00072

RS-601	Leukotriene Receptor Prostaglandin Receptor	Inflammation/Immunology Endocrinology
RS-601 is a novel leukotriene D4 (LTD4)/thromboxane A2 (TxA2) dual receptor antagonist, with antiasthmatic activities.

HY-112650

12-OxoETE 12-KETE	Endogenous Metabolite	Inflammation/Immunology
12-OxoETE induces a rapid, dose dependent increase of cytoplasmic free calcium via leukotriene B4 receptor or a common activation sequence .

HY-17492

Zafirlukast 3 Publications Verification ICI 204219	Leukotriene Receptor	Inflammation/Immunology Cancer
Zafirlukast (ICI 204219) is a potent orally active leukotriene D₄ (LTD₄) *receptor* antagonist. Zafirlukast shows anti-asthmatic, anti-inflammatory and anti-bacterial effects.

HY-76511S

Verlukast-d6 MK-679-d₆; L 668019-d₆	Leukotriene Receptor	Inflammation/Immunology
Verlukast-d₆ is a deuterium labeled Verlukast. Verlukast is a potent, selective, and orally active antagonist of leukotriene receptor. Verlukast has the potential for the research of asthma[1].

HY-108162A

Ataquimast	COX Leukotriene Receptor TNF Receptor c-Fms	Inflammation/Immunology
Ataquimast is a COX-2 inhibitor that inhibits the release of leukotrienes, TNF-α and GM-CSF. Ataquimast can be used in the study of advanced receptor-positive breast cancer .

HY-120486

LY203647	Leukotriene Receptor	Inflammation/Immunology
LY203647 is an orally active antagonist for **leukotriene receptor LTD4 and LTE4**. LY203647 can be used in research about asthma and other inflammation diseases .

HY-100316

CP-96486	Leukotriene Receptor	Inflammation/Immunology
CP-96486 is a potent and orally active leukotriene D₄ (LTD₄)/platelet activating factor (PAF) receptor antagonist with K_is of 20 and 24 nM, respectively.

HY-117706

LY 292728	Leukotriene Receptor	Inflammation/Immunology
LY 292728 is a potent leukotriene B4 (LTB4) receptor antagonist. LY 292728 binds to human neutrophils with a K_i of 0.47 nM and binds to guinea pig lung membranes with a K_i of 0.04 nM .

HY-101731

CP-96021 hydrochloride	Leukotriene Receptor	Inflammation/Immunology
CP-96021 hydrochloride is a balanced, combined, potent and orally active leukotriene D4 (LTD4)/platelet activating factor (PAF) receptor antagonist with K_i values of 34 nM and 37 nM, respectively .

HY-108162

Ataquimast free base	COX	Inflammation/Immunology
Ataquimast free base is a COX-2 inhibitor that inhibits the release of leukotrienes, TNF-α and GM-CSF. Ataquimast free base can be used in the study of advanced receptor-positive breast cancer .

HY-149083

LTB4 antagonist 2	Leukotriene Receptor	Inflammation/Immunology
LTB4 antagonist 2, a carboxamide-acid compound, is an antagonist of leukotriene B4 (LTB4) with potentially anti-inflammatory activity. LTB4 antagonist 2 shows good affinity for the LTB4 receptor with IC₅₀ of 439 nM .

HY-114641A

BIIL-260 hydrochloride	Leukotriene Receptor	Inflammation/Immunology
BIIL-260 hydrochloride is a potent and long-acting orally active leukotriene B(4) receptor LTB₄ antagonist, with anti-inflammatory activity. BIIL-260 hydrochloride interacts with the LTB₄ receptor in a saturable, reversible, and competitive manner, has high affinity to the LTB₄ receptor on isolated human neutrophil cell membranes with K_i values of 1.7 nM .

HY-114641

BIIL-260	Leukotriene Receptor	Inflammation/Immunology
BIIL-260 is a potent and long-acting orally active leukotriene B(4) receptor LTB₄ antagonist, with anti-inflammatory activity. BIIL-260 interacts with the LTB₄ receptor in a saturable, reversible, and competitive manner, has high affinity to the LTB₄ receptor on isolated human neutrophil cell membranes with the K_i value of 1.7 nM .

HY-165155

CysLT1 receptor antagonist-1	Leukotriene Receptor	Inflammation/Immunology
CysLT1 receptor antagonist-1 (Compound 4) is an antagonist for *cysteinyl leukotriene* receptor 1 (CysLT1R) with an IC₅₀** of 3.9 μM. CysLT1 receptor antagonist-1 exhibits weak agonist activity against *G-protein-coupled bile acid receptor* 1 (GPBAR1*) with an efficact of 23% at 10 μM. CysLT1 receptor* antagonist-1 can be used for asthma and allergic diseases researchs .

HY-17492R

Zafirlukast (Standard)	Leukotriene Receptor	Inflammation/Immunology Cancer
Zafirlukast (Standard) is the analytical standard of Zafirlukast. This product is intended for research and analytical applications. Zafirlukast (ICI 204219) is a potent orally active leukotriene D₄ (LTD₄) *receptor* antagonist. Zafirlukast shows anti-asthmatic, anti-inflammatory and anti-bacterial effects.

HY-17492S

Zafirlukast-d7	Isotope-Labeled Compounds Leukotriene Receptor	Inflammation/Immunology Cancer
Zafirlukast-d₇ is the deuterium labeled Zafirlukast. Zafirlukast (ICI 204219) is a potent orally active leukotriene D4 (LTD4) receptor antagonist. Zafirlukast shows anti-asthmatic, anti-inflammatory and anti-bacterial effects[1][2].

HY-17492S3

Zafirlukast-d6 ICI 204219-d₆	Leukotriene Receptor Isotope-Labeled Compounds	Inflammation/Immunology Cancer
Zafirlukast-d₆ is deuterated labeled Zafirlukast (HY-17492). Zafirlukast (ICI 204219) is a potent orally active leukotriene D₄ (LTD₄) *receptor* antagonist. Zafirlukast shows anti-asthmatic, anti-inflammatory and anti-bacterial effects.

HY-117896

SC-50605	Leukotriene Receptor	Inflammation/Immunology
SC-50605 and SC-51146 are second-generation leukotriene B4 (LTB4) receptor antagonists that effectively inhibit LTB4-induced chemotaxis in guinea pigs. SC-50605 targets the LTB4 receptor and has the potential to inhibit inflammatory diseases such as asthma, rheumatoid arthritis, and skin diseases. .

HY-17492S1

Zafirlukast-13C,d3 ICI 204219-¹³C,d₃	Isotope-Labeled Compounds Leukotriene Receptor	Inflammation/Immunology Cancer
Zafirlukast- ¹³C,d₃ is the ¹³C- and deuterium labeled Zafirlukast. Zafirlukast (ICI 204219) is a potent orally active leukotriene D4 (LTD4) receptor antagonist. Zafirlukast shows anti-asthmatic, anti-inflammatory and anti-bacterial effects.

HY-17492S2

Zafirlukast-13C,d6 ICI 204219-¹³C,d₆	Isotope-Labeled Compounds Leukotriene Receptor	Inflammation/Immunology Cancer
Zafirlukast- ¹³C,d₆ is the ¹³C- and deuterium labeled Zafirlukast. Zafirlukast (ICI 204219) is a potent orally active leukotriene D4 (LTD4) receptor antagonist. Zafirlukast shows anti-asthmatic, anti-inflammatory and anti-bacterial effects.

HY-156978

Ritolukast Wy-48252	Leukotriene Receptor	Others
Ritolukast (Wy-48252) is an orally active aerosol leukotriene (LTD₄/E₄) receptor antagonist. Ritolukast can be used to inhibit the bronchoconstriction caused by aerosol LTD₄ in guinea pigs, with an ID₅₀ of 0.5mg/kg .

HY-130138A

(5S,6R)-DiHETE	Others	Inflammation/Immunology
(5S,6R)-DiHETE is an enantiomer of (5,6)-DiHETEs. (5S,6R)-DiHETE can be recognized by leukotriene receptors (LTD4 receptors). (5S,6R)-DiHETE can induce guinea pig isolated ileum contraction? with an EC₅₀ of 1.3 μM, and this effect can be inhibited by LTD4 receptor antagonists .

HY-13628A

Etalocib sodium LY293111 sodium; VML 295 sodium	Leukotriene Receptor Apoptosis	Inflammation/Immunology Cancer
Etalocib (LY293111) sodium, an orally active **leukotriene B₄ receptor antagonist, inhibits the binding of [ ³H]LTB₄, with a K_i of 25 nM. Etalocib sodium prevents LTB₄-induced calcium mobilization with an lC₅₀** of 20 nM. Etalocib sodium induces apoptosis .

HY-112741

SB-209247	Leukotriene Receptor	Inflammation/Immunology
SB-209247 is a selective, high affinity and orally active **leukotriene B4 (LTB4) receptor antagonist with a K_i of 0.78 nM. SB-209247 blocks LTB4-induced Ca ²⁺ mobilization with an IC₅₀** of 6.6 nM. SB-209247 shows a potent anti-inflammatory activity .

HY-13315S1

Montelukast-d6 sodium MK0476-d₆	Leukotriene Receptor	Inflammation/Immunology
Montelukast-d₆ (sodium) is the deuterium labeled Montelukast (sodium). Montelukast sodium is a potent, selective and orally active antagonist of cysteinyl leukotriene receptor 1 (Cysltr1). Montelukast sodium can be used for the reseach of asthma and liver injury. Montelukast sodium also has an antioxidant effect in intestinal ischemia-reperfusion injury, and could reduce cardiac damage[1].

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-112650

12-OxoETE 12-KETE	Classification of Application Fields Ketones, Aldehydes, Acids Source classification Endogenous metabolite Disease Research Fields Inflammation/Immunology	Endogenous Metabolite
12-OxoETE induces a rapid, dose dependent increase of cytoplasmic free calcium via leukotriene B4 receptor or a common activation sequence .

Cat. No.	Product Name	Chemical Structure

HY-76511S

Verlukast-d6
Verlukast-d₆ is a deuterium labeled Verlukast. Verlukast is a potent, selective, and orally active antagonist of leukotriene receptor. Verlukast has the potential for the research of asthma[1].

HY-17492S

Zafirlukast-d7
Zafirlukast-d₇ is the deuterium labeled Zafirlukast. Zafirlukast (ICI 204219) is a potent orally active leukotriene D4 (LTD4) receptor antagonist. Zafirlukast shows anti-asthmatic, anti-inflammatory and anti-bacterial effects[1][2].

HY-17492S3

Zafirlukast-d6
Zafirlukast-d₆ is deuterated labeled Zafirlukast (HY-17492). Zafirlukast (ICI 204219) is a potent orally active leukotriene D₄ (LTD₄) *receptor* antagonist. Zafirlukast shows anti-asthmatic, anti-inflammatory and anti-bacterial effects.

HY-17492S1

Zafirlukast-13C,d3
Zafirlukast- ¹³C,d₃ is the ¹³C- and deuterium labeled Zafirlukast. Zafirlukast (ICI 204219) is a potent orally active leukotriene D4 (LTD4) receptor antagonist. Zafirlukast shows anti-asthmatic, anti-inflammatory and anti-bacterial effects.

HY-17492S2

Zafirlukast-13C,d6
Zafirlukast- ¹³C,d₆ is the ¹³C- and deuterium labeled Zafirlukast. Zafirlukast (ICI 204219) is a potent orally active leukotriene D4 (LTD4) receptor antagonist. Zafirlukast shows anti-asthmatic, anti-inflammatory and anti-bacterial effects.

HY-13315S1

Montelukast-d6 sodium
Montelukast-d₆ (sodium) is the deuterium labeled Montelukast (sodium). Montelukast sodium is a potent, selective and orally active antagonist of cysteinyl leukotriene receptor 1 (Cysltr1). Montelukast sodium can be used for the reseach of asthma and liver injury. Montelukast sodium also has an antioxidant effect in intestinal ischemia-reperfusion injury, and could reduce cardiac damage[1].

HY-13315S

Montelukast-d6
Montelukast-d₆ is the deuterium labeled Montelukast (sodium). Montelukast sodium is a potent, selective and orally active antagonist of cysteinyl leukotriene receptor 1 (Cysltr1). Montelukast sodium can be used for the reseach of asthma and liver injury. Montelukast sodium also has an antioxidant effect in intestinal ischemia-reperfusion injury, and could reduce cardiac damage[1].

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Leukotriene receptors

Inhibitors & Agonists

NaturalProducts

Isotope-Labeled Compounds

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