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N-oxidation

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Adrenergic Receptor (1) Antibiotic (3) Apoptosis (2) Bacterial (3) Biochemical Assay Reagents (3) Cholinesterase (ChE) (2) CXCR (2) Cytochrome P450 (1) Dopamine Receptor (5) Drug Metabolite (34) EGFR (2) Endogenous Metabolite (12) ERK (1) Fungal (1) GABA Receptor (1) Histamine Receptor (1) Isotope-Labeled Compounds (21) mAChR (3) MEK (1) Monoamine Oxidase (1) NF-κB (2) NOD-like Receptor (NLR) (4) Oxidative Phosphorylation (1) Parasite (2) Phosphodiesterase (PDE) (2) Potassium Channel (1) Reactive Oxygen Species (4) RSV (1) Sodium Channel (1) STAT (1) TGF-beta/Smad (5)
By Research Areas:	Cancer (29) Cardiovascular Disease (9) Endocrinology (6) Infection (11) Inflammation/Immunology (16) Metabolic Disease (11) Neurological Disease (18)

By Targets:

Adrenergic Receptor (1)

Antibiotic (3)

Apoptosis (2)

Bacterial (3)

Biochemical Assay Reagents (3)

Cholinesterase (ChE) (2)

CXCR (2)

Cytochrome P450 (1)

Dopamine Receptor (5)

Drug Metabolite (34)

EGFR (2)

Endogenous Metabolite (12)

ERK (1)

Fungal (1)

GABA Receptor (1)

Histamine Receptor (1)

Isotope-Labeled Compounds (21)

mAChR (3)

MEK (1)

Monoamine Oxidase (1)

NF-κB (2)

NOD-like Receptor (NLR) (4)

Oxidative Phosphorylation (1)

Parasite (2)

Phosphodiesterase (PDE) (2)

Potassium Channel (1)

Reactive Oxygen Species (4)

RSV (1)

Sodium Channel (1)

STAT (1)

TGF-beta/Smad (5)

By Research Areas:

Cancer (29)

Cardiovascular Disease (9)

Endocrinology (6)

Infection (11)

Inflammation/Immunology (16)

Metabolic Disease (11)

Neurological Disease (18)

126

Inhibitors & Agonists

Biochemical Assay Reagents

Natural
Products

Isotope-Labeled Compounds

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-124098

Lignocaine N-oxide Lidocaine N-oxide	Others	Others
Lignocaine N-oxide (Lidocaine N-oxide) is a compound derived from the metabolism of lidocaine. Lidocaine can be metabolized to its N-oxide in rat liver microsomes.

HY-147085

Loratadine n-oxide	Histamine Receptor	Inflammation/Immunology
Loratadine n-oxide is a metabolite of Loratadine. Loratadine n-oxide shows antihistamine activity .

HY-119393

Olanzapine N-oxide	Others	Others
Olanzapine N-oxide is a compound under investigation for the metabolism of antipsychotic compounds. Olanzapine N-oxidation and N-demethylation are catalyzed by different enzymes, and its plasma concentration and clearance are not affected by a single factor, such as a specific genotype or smoking behavior.

HY-116832

Retrorsine N-oxide	Others	Cancer
Retrorsine N-oxide, an N-oxide of pyrrolizidine alkaloid, is a carcinogen. Retrorsine N-oxide-derived DNA adducts are common toxicological biomarkers of pyrrolizidine alkaloid N-oxides .

HY-N9512S

*Lycopsamine N-oxide-d3*	Isotope-Labeled Compounds	Others
Lycopsamine N-oxide-d₃ is the deuterium labeled Lycopsamine N-oxide. Lycopsamine N-oxide, an N-oxide of Lycopsamine which is a pyrrolizidine alkaloid, can be found in honey and bee pollen[1].

HY-N2561

Seneciphylline N-Oxide	Others	Cancer
Seneciphylline N-Oxide is a dehydrogenation product of Senecionine N-oxide. Seneciphylline N-Oxide is a natural compound isolated from root cultures of Senecio erucifolius (Asteraceae) .

HY-100644

Trimethoprim N-oxide Trimethoprim 1-N-oxide	Drug Metabolite	Infection
Trimethoprim N-oxide (Trimethoprim 1-N-oxide) belongs to human urinary metabolites. Trimethoprim N-oxide is generated by oxidation of nitrogen atoms in the pyrimidine ring. Trimethoprim N-oxide is formed predominantly by CYP1A2 in human liver microsomes .

HY-N6637S

*Senecionine N-oxide-d3*	Isotope-Labeled Compounds	Cancer
Senecionine N-oxide-d₃ is the deuterium labeled Senecionine N-oxide. Senecionine n-oxide is the primary product of pyrrolizidine alkaloid biosynthesis in root cultures of Senecio vulgaris. Senecionine N-oxide has anti-cancer activity[1][2].

HY-135586R

*Raloxifene N-Oxide* (Standard)**	Drug Metabolite	Metabolic Disease
Raloxifene N-Oxide (Standard) is the analytical standard of Raloxifene N-Oxide. This product is intended for research and analytical applications. Raloxifene N-Oxide is a Raloxifene oxidative degradation product .

HY-135265

Moclobemide N-Oxide Ro 12-5637	Monoamine Oxidase	Neurological Disease
Moclobemide N-Oxide (Ro 12-5637) is N-oxide metabolite of Moclobemide. Moclobemide N-Oxide retains certain MAO-A (monoamine oxidase) inhibitory activity, but is generally present in low concentrations. Moclobemide N-Oxide can be detected by UV absorption at 240 nm .

HY-134137S

*Donepezil N-oxide-d5*	Isotope-Labeled Compounds	Others
Donepezil N-oxide-d₅ is deuterium labeled Donepezil N-oxide.

HY-137989

Voriconazole N-oxide Voriconazole oxynitride	Fungal	Infection
Voriconazole N-oxide (Voriconazole oxynitride) is a potent antifungal agent. Voriconazole N-oxide has phototoxicity and photocarcinogenicity. Voriconazole N-oxide does not sensitize keratinocytes to ultraviolet B (UVB) .

HY-119393S

*Olanzapine N-Oxide-d3*	Isotope-Labeled Compounds	Others
Olanzapine N-Oxide-d3 is a deuterated labeled Olanzapine N-Oxide .

HY-133724

Vardenafil N-oxide	Drug Metabolite	Metabolic Disease Inflammation/Immunology Endocrinology
Vardenafil N-oxide is a N-Oxide impurity of Vardenafil (HY-B0442) .

HY-N6828R

*Monocrotaline N-Oxide* (Standard)**	Others	Metabolic Disease
Monocrotaline N-Oxide (Standard) is the analytical standard of Monocrotaline N-Oxide. This product is intended for research and analytical applications. Monocrotaline N-Oxide, a monocrotaline metabolite, leads to DNA adduct formation in vivo .

HY-N2561AR

*Spartioidine N-oxide* (Standard)**	Others	Others
Spartioidine N-oxide (Standard) is the analytical standard of Spartioidine N-oxide. This product is intended for research and analytical applications. Spartioidine N-oxide is a pyrrolizidine alkaloid and can be isolated from Senecio vulgaris .

HY-101407R

*Nicotinamide N-oxide* (Standard)**	CXCR Drug Metabolite Endogenous Metabolite	Inflammation/Immunology Endocrinology
Nicotinamide N-oxide (Standard) is the analytical standard of Nicotinamide N-oxide. This product is intended for research and analytical applications. Nicotinamide N-oxide, an in vivo nicotinamide metabolite, is a potent, and selective antagonist of the CXCR2 receptor.

HY-132447S

Nefopam-d3 N-Oxide	Isotope-Labeled Compounds	Others
Nefopam-d₃ N-Oxide is the deuterium labeled Nefopam N-Oxide[1].

HY-133797S

*Cyclobenzaprine N-oxide-d3*	Isotope-Labeled Compounds	Metabolic Disease
Cyclobenzaprine N-oxide-d₃ is the deuterium labeled Cyclobenzaprine N-oxide[1].

HY-141773S

*Benzydamine N-oxide-d6*	Isotope-Labeled Compounds	Others
Benzydamine N-oxide-d₆ is the deuterium labeled Benzydamine N-oxide[1].

HY-144239S

*Venlafaxine N-oxide-d6*	Isotope-Labeled Compounds	Others
Venlafaxine N-oxide-d₆ is the deuterium labeled Venlafaxine N-oxide[1].

HY-148377

Abiraterone sulfate N-oxide	Others	Cancer
Abiraterone sulfate N-oxide is a carboxylic acid. Abiraterone sulfate N-oxide also is a major metabolite of Abiraterone (HY-70013). Abiraterone sulfate N-oxide can be used for the research of prostate cancer .

HY-N6827R

*Usaramine N-oxide* (Standard)**	Others	Inflammation/Immunology
Usaramine N-oxide (Standard) is the analytical standard of Usaramine N-oxide. This product is intended for research and analytical applications. Usaramine N-oxide, a alkaloid isolated from Crotalaria pallida, possesses anti-inflammatory activities .

HY-G0011S

*Netupitant N-oxide-d6*	Drug Metabolite	Neurological Disease Endocrinology
Netupitant N-oxide-d₆ is the deuterium labeled Netupitant N-oxide, which is a metabolite of Netupitant.

HY-116084S

*Trimethylamine N-oxide-d9* 1 Publications Verification	NOD-like Receptor (NLR) Reactive Oxygen Species TGF-beta/Smad Endogenous Metabolite	Cardiovascular Disease Inflammation/Immunology
Trimethylamine N-oxide-d₉ is the deuterium labeled Trimethylamine N-oxide. Trimethylamine N-oxide is a gut microbe-dependent metabolite of dietary choline and other trimethylamine-containing nutrients. Trimethylamine N-oxide induces inflammation by activating the ROS/NLRP3 inflammasome. Trimethylamine N-oxide also accelerates fibroblast-myofibroblast differentiation and induces cardiac fibrosis by activating the TGF-β/smad2 signaling pathway[1][2][3].

HY-133794S

*Dasatinib N-oxide-d8*	Drug Metabolite	Cancer
Dasatinib N-oxide-d₈ is the deuterium labeled Dasatinib N-oxide. Dasatinib N-oxide is a minor metabolite of Dasatinib. Dasatinib is a potent and orally active dual Src/Bcr-Abl inhibitor[1][2].

HY-133590

Heliotrine N-oxide	Others	Cancer
Heliotrine N-oxide is the corresponding PA (pyrrolizidine alkaloid) N-oxide of Heliotrine (HY-126128). Heliotrine N-oxide leads to the formation of pyrrolic DNA adducts and potential initiation of PA-induced liver tumors in vivo .

HY-N9512

Lycopsamine N-oxide	Others	Others
Lycopsamine N-oxide, an N-oxide of Lycopsamine which is a pyrrolizidine alkaloid, can be found in honey and bee pollen .

HY-146481S

*Lansoprazole sulfone N-oxide-d4*	Isotope-Labeled Compounds	Others
Lansoprazole sulfone N-oxide-d₄ is the deuterium labeled Lansoprazole sulfone N-oxide[1].

HY-138199S1

*Omeprazole sulfone N-oxide-d3*	Isotope-Labeled Compounds	Others
Omeprazole sulfone N-oxide-d₃ is the deuterium labeled Omeprazole sulfone N-Oxide[1].

HY-116084S1

*Trimethylamine-N-oxide-13C3*	NOD-like Receptor (NLR) Reactive Oxygen Species TGF-beta/Smad Endogenous Metabolite	Cardiovascular Disease Inflammation/Immunology
Trimethylamine-N-oxide- ¹³C₃ is the ¹³C-labeled Trimethylamine N-oxide. Trimethylamine N-oxide is a gut microbe-dependent metabolite of dietary choline and other trimethylamine-containing nutrients. Trimethylamine N-oxide induces inflammation by activating the ROS/NLRP3 inflammasome. Trimethylamine N-oxide also accelerates fibroblast-myofibroblast differentiation and induces cardiac fibrosis by activating the TGF-β/smad2 signaling pathway[1][2][3].

HY-W087967S

*4-Nitropyridine N-oxide-d4*	Isotope-Labeled Compounds	Others
4-Nitropyridine N-oxide-d₄ is the deuterium labeled 4-Nitropyridine N-oxide[1].

HY-N9511

Jacobine N-oxide	Others	Others
Jacobine N-oxide, an N-oxide of Jacobine which is a pyrrolizidine alkaloid, can be found in Senecio hybrids that has thrips resistance .

HY-N11425

Benzydamine N-Oxide	Others	Others
Benzydamine N-Oxide is a metabolite of Benzydamine. Benzydamine N-Oxide can be used to measure flavin-containing monooxygenase activity .

HY-W707957

Intermedine N-oxide	Others	Cancer
Intermedine N-oxide is a pyrrolizidine alkaloid indicine that can be found in Crotalaria spectabilis. Intermedine N-oxide shows anticancer activity .

HY-142440S

*Apatinib 25-N-oxide-d8 dihydrochloride*	Isotope-Labeled Compounds	Others
Apatinib 25-N-oxide-d₈ (dihydrochloride) is the deuterium labeled Apatinib 25-N-oxide dihydrochloride[1].

HY-N6848

Acetylseneciphylline N-oxide	Others	Infection
Acetylseneciphylline N-oxide is a pyrrolizine alkaloid that is seneciphylline in which the hydroxy hydrogen is replaced by an acetyl group and the tertiary amino function is oxidised to the corresponding N-oxide .

HY-131574

Heliosupine N-oxide	mAChR	Neurological Disease
Heliosupine N-oxide, Heliosupin metabolite, inhibits muscarinic acetylcholine receptor (mAChR) with the IC₅₀ of 350 μM. Heliosupine N-oxide is a pyrrolizidine alkaloid (PA) .

HY-138199S

*Omeprazole sulfone N-oxide-13C,d3*	Isotope-Labeled Compounds	Others
Omeprazole sulfone N-oxide- ¹³C,d₃ is the deuterium and ¹³C labeled Omeprazole sulfone N-Oxide[1].

HY-100664

Zopiclone N-oxide RP 29753	Drug Metabolite GABA Receptor	Neurological Disease
Zopiclone N-oxide (RP 29753) is a less active metabolite of Zopiclone. Zopiclone N-oxide is also an impurity of Eszopiclone and is formed by the oxidation of Eszopiclone .

HY-100636

Gefitinib N-oxide	EGFR	Cancer
Gefitinib N-oxide is the N-oxide derivative of Gefitinib. Gefitinib is an EGFR tyrosine kinase inhibitor, with IC₅₀ of 2-37 nM in NR6wtEGFR cells .

HY-N6637

Senecionine N-oxide	Others	Cancer
Senecionine n-oxide is the primary product of pyrrolizidine alkaloid biosynthesis in root cultures of Senecio vulgaris. Senecionine N-oxide has anti-cancer activity .

HY-108226S

*Regorafenib N-oxide* and N-desmethyl (M5)-d3** N-Desmethyl regorafenib N-oxide-d₃	Isotope-Labeled Compounds	Others
Regorafenib N-oxide and N-desmethyl (M5)-d₃ is deuterium labeled Regorafenib N-oxide and N-desmethyl (M5).

HY-100636A

*Gefitinib N-oxide* hydrochloride**	EGFR	Cancer
Gefitinib N-oxide hydrochloride is the N-oxide derivative of Gefitinib. Gefitinib is an EGFR tyrosine kinase inhibitor, with IC₅₀ of 2-37 nM in NR6wtEGFR cells .

HY-N7263

Galanthamine N-Oxide	Cholinesterase (ChE)	Neurological Disease
Galanthamine N-Oxide is an alkaloid obtained from the bulbs of Zephyranthes concolor. Galanthamine N-Oxide inhibits electric eel acetylcholinesterase (AChE) with an EC₅₀ of 26.2 μM. Galanthamine N-Oxide is a prominent inhibitor of substrate accommodation in the active site of the Torpedo californica AChE (TcAChE), hAChE and hBChE enzymes .

HY-108226S1

*Regorafenib N-oxide* and N-desmethyl (M5)-13C6**	Isotope-Labeled Compounds	Others
Regorafenib N-oxide and N-desmethyl (M5)- ¹³C₆ is the ¹³C-labeled Regorafenib N-oxide and N-desmethyl (M5)[1].

HY-133798

Sorafenib N-oxide	Cytochrome P450 Drug Metabolite	Cancer
Sorafenib N-oxide is an active metabolite of sorafenib (HY-10201). Sorafenib N-oxide is a linear-mixed inhibitor of microsomal CYP3A4, with a K_i of 15 μM .

HY-151241

Sinomenine N-oxide (+)-Sinomenine N-oxide	Others	Inflammation/Immunology
Sinomenine N-oxide has anti-angiogenic, anti-inflammatory and anti-rheumatic effects. Sinomenine N-oxide is also a NO production inhibitor, with an IC₅₀ value of 23.04 μM .

HY-N1402

Oxysophoridine Sophoridine N-oxide	Apoptosis	Inflammation/Immunology
Oxysophoridine (Sophoridine N-oxide) is a bioactive alkaloid extracted from the Sophora alopecuroides Linn. Oxysophoridine (Sophoridine N-oxide) shows anti inflammatory, anti oxidative stress and anti apoptosis effects .

HY-137989A

*Voriconazole N-oxide* hydrochloride** Voriconazole oxynitride hydrochloride	Drug Metabolite	Infection
Voriconazole N-oxide (Voriconazole oxynitride) (hydrochloride) is the main metabolite of Voriconazole (HY-76200) , a widely used triazole antibiotic (fungal). Voriconazole N-oxide (hydrochloride) provides information on the patient's drug metabolism capacity .

Cat. No.	Product Name	Type

HY-W127785

N-ethyl-N-oxido-dodecan-1-amine

N,N-Dimethyldodecylamine N-oxide; Dodecyldimethylamine oxide

Chelators

N-ethyl-N-oxido-dodecan-1-amine is an amine oxide surfactant commonly used as a detergent, emulsifier and wetting agent in various industrial processes, especially in personal care products and household cleaning in the production of agents. N,N-Dimethyldodecylamine N-oxide has unique chemical properties that make it an effective ingredient in many product formulations to help reduce surface tension and enhance cleaning power.

HY-W127842

N,N-Dimethyldecylamine N-oxide

Decyldimethylamine oxide

Surfactants

N,N-Dimethyldecylamine N-oxide is an organic compound belonging to the family of amine oxides. It is commonly used as a surfactant and cleaning agent in a variety of industrial and household applications, including detergents, personal care products and paints. N,N-Dimethyldecylamine N-oxide has various properties suitable for these applications, including the ability to lower surface tension, increase solubility, and act as a blowing agent. In addition, it can be used as a corrosion inhibitor in metalworking fluids and a flotation agent in mineral processing.

HY-W127785R

N-ethyl-N-oxido-dodecan-1-amine (Standard)

Chelators

N-ethyl-N-oxido-dodecan-1-amine (Standard) is the analytical standard of N-ethyl-N-oxido-dodecan-1-amine. This product is intended for research and analytical applications. N-ethyl-N-oxido-dodecan-1-amine is an amine oxide surfactant commonly used as a detergent, emulsifier and wetting agent in various industrial processes, especially in personal care products and household cleaning in the production of agents. N,N-Dimethyldodecylamine N-oxide has unique chemical properties that make it an effective ingredient in many product formulations to help reduce surface tension and enhance cleaning power.

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N11425

Benzydamine N-Oxide	Structural Classification Natural Products Source classification Endogenous metabolite	Others
Benzydamine N-Oxide is a metabolite of Benzydamine. Benzydamine N-Oxide can be used to measure flavin-containing monooxygenase activity .

HY-116832

Retrorsine N-oxide	Alkaloids Pyrrole Alkaloids Classification of Application Fields Source classification Plants Compositae Baptisia australis (L.) R. Br. Disease Research Fields Cancer	Others
Retrorsine N-oxide, an N-oxide of pyrrolizidine alkaloid, is a carcinogen. Retrorsine N-oxide-derived DNA adducts are common toxicological biomarkers of pyrrolizidine alkaloid N-oxides .

HY-N2561

Seneciphylline N-Oxide	Alkaloids Pyrrole Alkaloids Classification of Application Fields Erinacea anthyllis Link Source classification Plants Compositae Disease Research Fields Cancer	Others
Seneciphylline N-Oxide is a dehydrogenation product of Senecionine N-oxide. Seneciphylline N-Oxide is a natural compound isolated from root cultures of Senecio erucifolius (Asteraceae) .

HY-N6828R

*Monocrotaline N-Oxide* (Standard)**	Alkaloids Structural Classification Pyrrole Alkaloids Leguminosae Source classification Crotalaria pallida Ait. Plants	Others
Monocrotaline N-Oxide (Standard) is the analytical standard of Monocrotaline N-Oxide. This product is intended for research and analytical applications. Monocrotaline N-Oxide, a monocrotaline metabolite, leads to DNA adduct formation in vivo .

HY-N2561AR

*Spartioidine N-oxide* (Standard)**	Pterogyne nitens Tul. Structural Classification Alkaloids Other Alkaloids Source classification Plants Compositae	Others
Spartioidine N-oxide (Standard) is the analytical standard of Spartioidine N-oxide. This product is intended for research and analytical applications. Spartioidine N-oxide is a pyrrolizidine alkaloid and can be isolated from Senecio vulgaris .

HY-101407R

*Nicotinamide N-oxide* (Standard)**	Structural Classification Alkaloids Classification of Application Fields Source classification Endogenous metabolite Disease Research Fields Endocrinology	CXCR Drug Metabolite Endogenous Metabolite
Nicotinamide N-oxide (Standard) is the analytical standard of Nicotinamide N-oxide. This product is intended for research and analytical applications. Nicotinamide N-oxide, an in vivo nicotinamide metabolite, is a potent, and selective antagonist of the CXCR2 receptor.

HY-N6827R

*Usaramine N-oxide* (Standard)**	Alkaloids Structural Classification Pyrrole Alkaloids Leguminosae Source classification Crotalaria pallida Ait. Plants	Others
Usaramine N-oxide (Standard) is the analytical standard of Usaramine N-oxide. This product is intended for research and analytical applications. Usaramine N-oxide, a alkaloid isolated from Crotalaria pallida, possesses anti-inflammatory activities .

HY-N9512

Lycopsamine N-oxide	Alkaloids other families Pyrrole Alkaloids Classification of Application Fields Source classification Other Diseases Plants Disease Research Fields	Others
Lycopsamine N-oxide, an N-oxide of Lycopsamine which is a pyrrolizidine alkaloid, can be found in honey and bee pollen .

HY-N9511

Jacobine N-oxide	Alkaloids Pyrrole Alkaloids Classification of Application Fields Source classification Other Diseases Plants Compositae Baptisia australis (L.) R. Br. Disease Research Fields	Others
Jacobine N-oxide, an N-oxide of Jacobine which is a pyrrolizidine alkaloid, can be found in Senecio hybrids that has thrips resistance .

HY-W707957

Intermedine N-oxide	Pyrrolizidine Alkaloids Structural Classification Alkaloids Animals Source classification	Others
Intermedine N-oxide is a pyrrolizidine alkaloid indicine that can be found in Crotalaria spectabilis. Intermedine N-oxide shows anticancer activity .

HY-131574

Heliosupine N-oxide	Alkaloids Pyrrole Alkaloids Source classification Cynoglossumofficinale Linn. Plants Boraginaceae	mAChR
Heliosupine N-oxide, Heliosupin metabolite, inhibits muscarinic acetylcholine receptor (mAChR) with the IC₅₀ of 350 μM. Heliosupine N-oxide is a pyrrolizidine alkaloid (PA) .

HY-N6637

Senecionine N-oxide	Pterogyne nitens Tul. Alkaloids Pyrrole Alkaloids Classification of Application Fields Source classification Plants Compositae Disease Research Fields Cancer	Others
Senecionine n-oxide is the primary product of pyrrolizidine alkaloid biosynthesis in root cultures of Senecio vulgaris. Senecionine N-oxide has anti-cancer activity .

HY-N7263

Galanthamine N-Oxide	Alkaloids Structural Classification other families Source classification Plants	Cholinesterase (ChE)
Galanthamine N-Oxide is an alkaloid obtained from the bulbs of Zephyranthes concolor. Galanthamine N-Oxide inhibits electric eel acetylcholinesterase (AChE) with an EC₅₀ of 26.2 μM. Galanthamine N-Oxide is a prominent inhibitor of substrate accommodation in the active site of the Torpedo californica AChE (TcAChE), hAChE and hBChE enzymes .

HY-N1402

Oxysophoridine Sophoridine N-oxide	Alkaloids Structural Classification other families Classification of Application Fields Source classification Pyridine Alkaloids Plants Inflammation/Immunology Disease Research Fields	Apoptosis
Oxysophoridine (Sophoridine N-oxide) is a bioactive alkaloid extracted from the Sophora alopecuroides Linn. Oxysophoridine (Sophoridine N-oxide) shows anti inflammatory, anti oxidative stress and anti apoptosis effects .

HY-116084

Trimethylamine N-oxide 4 Publications Verification	Cardiovascular Disease Structural Classification Natural Products Microorganisms Other disease Classification of Application Fields Source classification Disease markers Endogenous metabolite Inflammation/Immunology Disease Research Fields Cancer	Drug Metabolite NOD-like Receptor (NLR) Reactive Oxygen Species TGF-beta/Smad Endogenous Metabolite
Trimethylamine N-oxide is a gut microbe-dependent metabolite of dietary choline and other trimethylamine-containing nutrients. Trimethylamine N-oxide induces inflammation by activating the ROS/NLRP3 inflammasome. Trimethylamine N-oxide also accelerates fibroblast-myofibroblast differentiation and induces cardiac fibrosis by activating the TGF-β/smad2 signaling pathway .

HY-108915

*Trimethylamine N-oxide* dihydrate** 4 Publications Verification	Structural Classification Natural Products Classification of Application Fields Source classification Metabolic Disease Endogenous metabolite Disease Research Fields	NOD-like Receptor (NLR) Reactive Oxygen Species TGF-beta/Smad Endogenous Metabolite
Trimethylamine N-oxide dihydrate is a gut microbe-dependent metabolite of dietary choline and other trimethylamine-containing nutrients. Trimethylamine N-oxide dihydrate induces inflammation by activating the ROS/NLRP3 inflammasome. Trimethylamine N-oxide dihydrate also accelerates fibroblast-myofibroblast differentiation and induces cardiac fibrosis by activating the TGF-β/smad2 signaling pathway .

HY-131587

Integerrimine N-oxide	Sabina vulgaris Ant. Alkaloids Cupressaceae Pyrrole Alkaloids Classification of Application Fields Source classification Other Diseases Plants Disease Research Fields	Others
Integerrimine N-oxide, the main pyrrolizidine alkaloid found in the butanolic residue (BR) of Senecio brasiliensis. Prenatal exposure to integerrimine N-oxide induces maternal toxicity, impairment of maternal care and delays in physical and behavioral development of the offspring .

HY-136486

Lasiocarpine N-oxide	Pyrrolizidine Alkaloids Structural Classification Alkaloids Heliotropium rotundifolium Classification of Application Fields Other Alkaloids Source classification Plants Disease Research Fields Boraginaceae Cancer	Others
Lasiocarpine N-oxide is a natural compound with antitumor activity .

HY-114202

delta-Valerobetaine	Classification of Application Fields Ketones, Aldehydes, Acids Source classification Other Diseases Endogenous metabolite Disease Research Fields	Endogenous Metabolite
delta-Valerobetaine is a precursor of trimethylamine N-oxide (TMAO).

HY-N7774

Echinatine N-oxide	Alkaloids Pyrrole Alkaloids Classification of Application Fields Source classification Heliotropium indicum L. Other Diseases Plants Disease Research Fields Boraginaceae	Others
Echinatine N-oxide is a pyrrolizidine alkaloid found in R. graeca .

HY-131578

Rinderine N-oxide	Alkaloids Pyrrole Alkaloids Classification of Application Fields Source classification Cynoglossumofficinale Linn. Metabolic Disease Plants Disease Research Fields Boraginaceae	Others
Rinderine N-oxide is a pyrrolizidine alkaloid that can be found in R. graeca .

HY-118288

Aurachin B	Structural Classification Alkaloids Microorganisms Source classification Quinoline Alkaloids	Parasite
Aurachin B is an alkaloid with a 3-hydroxyquinoline N-oxide core .

HY-N13343

1-Methoxycarbonyl-beta-carboline-N-oxide	Structural Classification Alkaloids Simaroubaceae Source classification Plants Picrasma quassioides(D．Don)Benn．	Others
1-Methoxycarbonyl-beta-carboline-N-oxide is a natural product .

HY-N3105

Paxiphylline D Longistylumphylline A N-oxide	Daphniphyllum paxianum K. Rosenth. Structural Classification Alkaloids Pyrrole Alkaloids Source classification Plants	Others
Paxiphylline D (Longistylumphylline A N-oxide) is a product that can be isolated from .

HY-N6828

Monocrotaline N-Oxide	Alkaloids Pyrrole Alkaloids Classification of Application Fields Leguminosae Source classification Metabolic Disease Plants Crotalaria pallida Ait. Disease Research Fields	Others
Monocrotaline N-Oxide, a monocrotaline metabolite, leads to DNA adduct formation in vivo .

HY-N3416

Koumine N-oxide	Structural Classification Alkaloids Source classification Loganiaceae Plants Gelsemium eleganis (Gardn. et Champ.) Benth. Indole Alkaloids	Others
Koumine N-oxide is an alkaloid compound isolated from the herb Gelsemium elegans .

HY-N2561A

Spartioidine N-oxide	Pterogyne nitens Tul. Structural Classification Alkaloids Other Alkaloids Source classification Plants Compositae	Others
Spartioidine N-oxide is a pyrrolizidine alkaloid and can be isolated from Senecio vulgaris .

HY-101407

Nicotinamide N-oxide	Alkaloids Structural Classification Classification of Application Fields Source classification Pyridine Alkaloids Endogenous metabolite Disease Research Fields Endocrinology	Oxidative Phosphorylation CXCR Drug Metabolite Endogenous Metabolite
Nicotinamide N-oxide, an in vivo nicotinamide metabolite, is a potent, and selective antagonist of the CXCR2 receptor.

HY-N9501

Retronecine N-oxide	Structural Classification Alkaloids Pyrrole Alkaloids Source classification Plants Boraginaceae Arnebia euchroma (Royle) Johnst.	Others
Retronecine N-oxide is a Alkaloids product that can be isolated from the roots of Arnebia euchroma .

HY-N8655

Sarracine N-oxide	Structural Classification Alkaloids Erinacea anthyllis Link Source classification Plants Compositae	Others
Sarracine N-oxide is a Alkaloids product that can be isolated from the herbs of Senecio scandens .

HY-N1105

Vallesamine N-oxide	Apocynaceae Structural Classification Alkaloids Other Alkaloids Source classification Alstonia scholaris (L.) R. Br. Plants	Others
Vallesamine N-oxide is a Alkaloids product that can be isolated from the leaves of Alstonia scholaris .

HY-N6827

Usaramine N-oxide	Alkaloids Pyrrole Alkaloids Classification of Application Fields Leguminosae Source classification Plants Crotalaria pallida Ait. Disease Research Fields Inflammation/Immunology	Others
Usaramine N-oxide, a alkaloid isolated from Crotalaria pallida, possesses anti-inflammatory activities .

HY-N8965

Scandine N-oxide	Apocynaceae Structural Classification Alkaloids Piperidine Alkaloids Source classification Melodinus fusiformis Champ. ex Benth. Plants	Others
Scandine N-oxide is a Alkaloids product that can be isolated from the dried herbs of Melodinus fusiformis. .

HY-N11812

Erucifoline N-oxide	Structural Classification Alkaloids Erinacea anthyllis Link Source classification Pyridine Alkaloids Plants Compositae	Others
Erucifoline N-oxide, a natural compound that can be isolated from Senecio persoonia, possesses hepatotoxic activity .

HY-N8681

9-Angeloylretronecine N-oxide	Structural Classification Alkaloids Pyrrole Alkaloids Source classification Plants Boraginaceae Arnebia euchroma (Royle) Johnst.	Others
9-Angeloylretronecine N-oxide is a Alkaloids product that can be isolated from the roots of Arnebia euchroma .

HY-105529

Indicine N-oxide (+)-Indicine N-oxide; NSC 132319	Alkaloids Structural Classification Pyrrole Alkaloids Classification of Application Fields Tournefortia argentea Linnaeus f. Source classification Plants Disease Research Fields Boraginaceae Cancer	Others
Indicine N-oxide (NSC 132319), a pyrrolizidine alkaloid, is an antitumor agent for pediatric cancer and solid tumors research .

HY-N3104

Paxiphylline E Daphnilongeranine A N-oxide	Daphniphyllum paxianum K. Rosenth. Structural Classification Alkaloids Pyrrole Alkaloids Source classification Plants	Others
Paxiphylline E (Daphnilongeranine A N-oxide) is a Alkaloids product that can be isolated from the mycelia of the basidiomycete Hericium erinaceum. .

HY-N9513

Echimidine N-oxide	Alkaloids Pyrrole Alkaloids Source classification Plants Boraginaceae Echium vulgare L.	Cholinesterase (ChE)
Echimidine N-oxide, a pyrrolizidine alkaloid, has acetylcholinesterase (AChE) inhibitory activity (IC_{50=0.347 mM) .}

HY-N8620

9-Methoxycanthin-6-one-N-oxide	Structural Classification Alkaloids Simaroubaceae Ailanthus altissima (Mill.) Swingle Source classification Plants Indole Alkaloids	Others
9-Methoxycanthin-6-one-N-oxide is a Alkaloids product that can be isolated from the barks of Ailanthus altissima .

HY-B1340

Carbadox	Infection Structural Classification Alkaloids Classification of Application Fields Other Alkaloids Source classification Endogenous metabolite Disease Research Fields	Bacterial Antibiotic Endogenous Metabolite
Carbadox is a quinoxaline-di-N-oxide antibiotic compound which is widely fed to nursery-age pigs to control enteric diseases and improve feed efficiency.

HY-N8723

(1′S,2′S)-Nicotine-1'-oxide	Natural Products Nicotiana tabacum L. Source classification Plants Solanaceae	Others
(1′S,2′S)-Nicotine-1'-oxide is an alkaloid N-oxide from the leaves, stems and roots of Nicotiana tabacum .

HY-129130

Canthin-6-one N-oxide Canthin-6-one 3-oxide	Structural Classification Alkaloids Simaroubaceae Other Alkaloids Source classification Eurycoma harmandiana Pierre Plants	Parasite
Canthin-6-one N-oxide (Canthin-6-one 3-oxide) is an orally active antiparasitic agent with limited activity .

HY-121390

Lasiocarpine	Alkaloids Pyrrole Alkaloids Classification of Application Fields Source classification Plants Disease Research Fields Boraginaceae Heliotropium europaeum L. Cancer	Endogenous Metabolite
Lasiocarpine, a hepatotoxic pyrrolizidine alkaloid (PA), causes fatal liver veno-occlusive disease in vivo. Lasiocarpine is toxic only after its metabolic conversion to the toxic intermediate, including dehydrolasiocarpine and N-oxide .

HY-W012977

3,3-Dimethyl-1-butanol DMB; Neohexanol	Structural Classification Natural Products Classification of Application Fields Source classification Metabolic Disease Endogenous metabolite Inflammation/Immunology Disease Research Fields	TGF-beta/Smad NF-κB Endogenous Metabolite
3,3-Dimethyl-1-butanol (DMB) is an orally active inhibitor of trimethylamine (TMA) and trimethylamine N-oxide (TMAO). 3,3-Dimethyl-1-butanol inhibits the signaling pathway of p65 NF-κB and TGF-β1/Smad3. 3,3-Dimethyl-1-butanol has potential applications in cardiovascular disease (CVD) .

Cat. No.	Product Name	Chemical Structure

HY-116084S

Trimethylamine N-oxide-d9

1 Publications Verification

Trimethylamine N-oxide-d₉ is the deuterium labeled Trimethylamine N-oxide. Trimethylamine N-oxide is a gut microbe-dependent metabolite of dietary choline and other trimethylamine-containing nutrients. Trimethylamine N-oxide induces inflammation by activating the ROS/NLRP3 inflammasome. Trimethylamine N-oxide also accelerates fibroblast-myofibroblast differentiation and induces cardiac fibrosis by activating the TGF-β/smad2 signaling pathway[1][2][3].

HY-N9512S

*Lycopsamine N-oxide-d3*
Lycopsamine N-oxide-d₃ is the deuterium labeled Lycopsamine N-oxide. Lycopsamine N-oxide, an N-oxide of Lycopsamine which is a pyrrolizidine alkaloid, can be found in honey and bee pollen[1].

HY-N6637S

*Senecionine N-oxide-d3*
Senecionine N-oxide-d₃ is the deuterium labeled Senecionine N-oxide. Senecionine n-oxide is the primary product of pyrrolizidine alkaloid biosynthesis in root cultures of Senecio vulgaris. Senecionine N-oxide has anti-cancer activity[1][2].

HY-134137S

*Donepezil N-oxide-d5*
Donepezil N-oxide-d₅ is deuterium labeled Donepezil N-oxide.

HY-119393S

*Olanzapine N-Oxide-d3*
Olanzapine N-Oxide-d3 is a deuterated labeled Olanzapine N-Oxide .

HY-132447S

Nefopam-d3 N-Oxide
Nefopam-d₃ N-Oxide is the deuterium labeled Nefopam N-Oxide[1].

HY-133797S

*Cyclobenzaprine N-oxide-d3*
Cyclobenzaprine N-oxide-d₃ is the deuterium labeled Cyclobenzaprine N-oxide[1].

HY-141773S

*Benzydamine N-oxide-d6*
Benzydamine N-oxide-d₆ is the deuterium labeled Benzydamine N-oxide[1].

HY-144239S

*Venlafaxine N-oxide-d6*
Venlafaxine N-oxide-d₆ is the deuterium labeled Venlafaxine N-oxide[1].

HY-G0011S

*Netupitant N-oxide-d6*
Netupitant N-oxide-d₆ is the deuterium labeled Netupitant N-oxide, which is a metabolite of Netupitant.

HY-133794S

*Dasatinib N-oxide-d8*
Dasatinib N-oxide-d₈ is the deuterium labeled Dasatinib N-oxide. Dasatinib N-oxide is a minor metabolite of Dasatinib. Dasatinib is a potent and orally active dual Src/Bcr-Abl inhibitor[1][2].

HY-146481S

*Lansoprazole sulfone N-oxide-d4*
Lansoprazole sulfone N-oxide-d₄ is the deuterium labeled Lansoprazole sulfone N-oxide[1].

HY-138199S1

*Omeprazole sulfone N-oxide-d3*
Omeprazole sulfone N-oxide-d₃ is the deuterium labeled Omeprazole sulfone N-Oxide[1].

HY-116084S1

Trimethylamine-N-oxide-13C3

Trimethylamine-N-oxide- ¹³C₃ is the ¹³C-labeled Trimethylamine N-oxide. Trimethylamine N-oxide is a gut microbe-dependent metabolite of dietary choline and other trimethylamine-containing nutrients. Trimethylamine N-oxide induces inflammation by activating the ROS/NLRP3 inflammasome. Trimethylamine N-oxide also accelerates fibroblast-myofibroblast differentiation and induces cardiac fibrosis by activating the TGF-β/smad2 signaling pathway[1][2][3].

HY-W087967S

*4-Nitropyridine N-oxide-d4*
4-Nitropyridine N-oxide-d₄ is the deuterium labeled 4-Nitropyridine N-oxide[1].

HY-142440S

*Apatinib 25-N-oxide-d8 dihydrochloride*
Apatinib 25-N-oxide-d₈ (dihydrochloride) is the deuterium labeled Apatinib 25-N-oxide dihydrochloride[1].

HY-138199S

*Omeprazole sulfone N-oxide-13C,d3*
Omeprazole sulfone N-oxide- ¹³C,d₃ is the deuterium and ¹³C labeled Omeprazole sulfone N-Oxide[1].

HY-108226S

*Regorafenib N-oxide* and N-desmethyl (M5)-d3**
Regorafenib N-oxide and N-desmethyl (M5)-d₃ is deuterium labeled Regorafenib N-oxide and N-desmethyl (M5).

HY-108226S1

*Regorafenib N-oxide* and N-desmethyl (M5)-13C6**
Regorafenib N-oxide and N-desmethyl (M5)- ¹³C₆ is the ¹³C-labeled Regorafenib N-oxide and N-desmethyl (M5)[1].

HY-136428S

Desoxycarbadox-d3
Desoxycarbadox-d₃ is the deuterium labeled Desoxycarbadox. Desoxycarbadox is a metabolite of Carbadox (HY-B1340). Carbadox is a quinoxaline-di-N-oxide antibiotic compound.

HY-114202S

delta-Valerobetaine-d9 chloride
delta-Valerobetaine-d₉ chlorideis the deuterium labeleddelta-Valerobetaine(HY-114202) . delta-Valerobetaine is a precursor of trimethylamine N-oxide (TMAO) .

HY-14538S2

Haloperidol-d4 N-Oxide
Haloperidol-d₄ N-Oxide is the deuterium labeled Haloperidol. Haloperidol is a potent dopamine D2 receptor antagonist, widely used as an antipsychotic[1][2].

HY-B1340S

Carbadox-d3
Carbadox-d₃ is the deuterium labeled Carbadox. Carbadox is a quinoxaline-di-N-oxide antibiotic compound which is widely fed to nursery-age pigs to control enteric diseases and improve feed efficiency.

HY-14545S1

Amisulpride-d5 N-Oxide
Amisulpride-d₅ N-Oxide is the deuterium labeled Amisulpride. Amisulpride is a dopamine D2/D3 receptor antagonist with Kis of 2.8 and 3.2 nM for human dopamine D2 and D3, respectively[1][2].

HY-12987S1

Pimozide-d5 N-Oxide
Pimozide-d₅ N-Oxide is the deuterium labeled Pimozide. Pimozide is a dopamine receptor antagonist, with Kis of 1.4 nM, 2.5 nM and 588 nM for dopamine D2, D3 and D1 receptors, respectively, and also has affinity at α1-adrenoceptor, with a Ki of 39 nM; Pimozide also inhibits STAT3 and STAT5[1][2].

HY-W016099S

3-Methyl-2-quinoxalinecarboxylic acid-d4
3-Methyl-2-quinoxalinecarboxylic acid-d₄ is the deuterium labeled 3-Methyl-2-quinoxalinecarboxylic acid. 3-Methyl-2-quinoxalinecarboxylic acid (MQCA), an important N-oxide reductive metabolite of Quinocetone or Olaquindox, potently inhibits the growth of Chang liver cells through S phase arrest of the cell cycle[1].

HY-15455S1

Roflumilast-d4 N-Oxide
Roflumilast-d₄ N-Oxide is the deuterium labeled Roflumilast. Roflumilast is a selective PDE4 inhibitor with IC50s of 0.7, 0.9, 0.7, and 0.2 nM for PDE4A1, PDEA4, PDEB1, and PDEB2, respectively, without affecting PDE1, PDE2, PDE3 or PDE5 isoenzymes from various cells[1][2].

HY-B0185S

Lidocaine-d10 N-Oxide

N-Oxide Lidocaine-d₁₀ is the deuterium labeled Lidocaine. Lidocaine (Lignocaine) inhibits sodium channels involving complex voltage and using dependence[1]. Lidocaine decreases growth, migration and invasion of gastric carcinoma cells via up-regulating miR-145 expression and further inactivation of MEK/ERK and NF-κB signaling pathways. Lidocaine is an amide derivative and has potential for the research of ventricular arrhythmia[2].

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