P-18

By Targets:	Biochemical Assay Reagents (1) Endogenous Metabolite (3) Phospholipase (1) Potassium Channel (1) Ras (1) Thrombin (1)
By Research Areas:	Cancer (5) Cardiovascular Disease (1) Inflammation/Immunology (2) Metabolic Disease (3) Neurological Disease (1)
Oligonucleotides:	Phospholipids (3)

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-123535

P18IN003	Others	Inflammation/Immunology
P18IN003 is a potent *p18(INK4C)* inhibitor andspecifically block the activity of p18 protein. P18IN003 has the potential to be aneffective chemical agent for therapeutic expansion of HSC .

HY-100791

NSC23005 sodium 1 Publications Verification	Others	Cancer
NSC23005 sodium is a novel and effective *p18* inhibitor (ED₅₀=5.21 nM) in promoting Hematopoietic stem cells (HSCs) expansion in both murine and human models.

HY-135809

A2764 dihydrochloride	Potassium Channel	Neurological Disease
A2764 dihydrochloride is a highly selective inhibitor of TRESK (TWIK-related spinal cord K ⁺ channel, K2P18.1), which has moderate inhibitory effects on TREK-1 and TALK-1. A2764 dihydrochloride is more sensitive to the activated mTRESK channels (IC₅₀=6.8 μM) than the basal current. A2764 dihydrochloride can lead to cell depolarization and increased excitability in native cells, it has the potential for probing the role of TRESK channel in migraine and nociception .

HY-149025

DPTIP-prodrug 18 P18	Phospholipase	Inflammation/Immunology Cancer
DPTIP-proagent 18 (P18) is a orally active and brain-penetrable proagent of DPTIP (HY-131002). DPTIP-proagent 18 is a potent nSMase2 inhibitor. DPTIP-proagent 18 significantly inhibits IL-1β-induced EV (extracellular vesicle) release by inhibition of nSMase2 (neutral sphingomyelinase-2) activity. DPTIP-proagent 18 can be used for brain injury research .

HY-115893A

P18IN005 hydrochloride	Others	Cancer
P18IN005 hydrochloride is a novel inhibitor of p18, exhibiting potent activity in negatively regulating haematopoietic stem cell (HSC) self-renewal. P18IN005 hydrochloride has been shown to be more effective than p27 in inhibiting HSC self-renewal in mouse models. P18IN005 hydrochloride promotes the expansion of functional HSCs in short-term cultures. P18IN005 hydrochloride serves as a valuable tool for dissecting the signaling pathways involved in stem cell self-renewal.

HY-116923

p18SMI-21	Endogenous Metabolite	Metabolic Disease
p18SMI-21 is a novel INK4C inhibitor that specifically blocks the biological activity of p18 protein. p18SMI-21 exerts its anti-gastric acid effect through direct contact, and the intensity of this effect varies with the dose. p18SMI-21 can significantly reduce the proteolytic activity of pepsin under certain conditions. The inhibitory effect of p18SMI-21 is best achieved in direct contact with the substrate. If it contacts the substrate first, the inhibitory effect will be lost .

HY-P4259

Hirullin P18	Thrombin	Cardiovascular Disease
Hirullin P18 is a potent thrombin inhibitor. Hirullin P18 has an anticoagulant effect .

HY-120942

XIE18-6	Others	Cancer
XIE18-6 is a potent INK4C (p18) inhibitor. XIE18-6 shows potent bioactivity in hematopoietic stem cells (HSCs) expansion with an ED₅₀ of 105.5 nM .

HY-144211

SOS1-IN-7	Ras	Cancer
SOS1-IN-7 (compound 18-p1) is a potent SOS1 inhibitor with IC₅₀s of 20 and 67 nM for SOS1-G12D and SOS1-G12V, respectively .

HY-158750

1-1(Z)-Octadecenyl-2-adrenoyl-sn-glycero-3-pe Pe(P-18:0/22:4)	Biochemical Assay Reagents	Others
1-1(Z)-Octadecenyl-2-adrenoyl-sn-glycero-3-pe 是一种生化试剂。

HY-157698

1-1(Z)-Octadecenyl-2-arachidonoyl-sn-glycero-3-PC C18(plasm)-20:4-PC; 18:0p/20:4-PC; PC(P-18:0/20:4)	Endogenous Metabolite	Metabolic Disease
1-1(Z)-Octadecenyl-2-arachidonoyl-sn-glycero-3-PC is a plasmalogen that contains 1(Z)-octadecenoic acid and arachidonic acid (HY-109590) at the sn-1 and sn-2 positions, respectively. It scavenges singlet oxygen in a cell-free assay.

HY-157697

1-1(Z)-Octadecenyl-2-arachidonoyl-sn-glycero-3-PE 18:0p/20:4-PE; C18(Plasm)-20:4-PE; PE(P-18:0/20:4)	Endogenous Metabolite	Metabolic Disease
1-1(Z)-Octadecenyl-2-arachidonoyl-sn-glycero-3-PE (18:0p/20:4-PE; C18(Plasm)-20:4-PE) is a plasmalogen that contains 1(Z)-octadecenoic acid and arachidonic acid (HY-109590) at the sn-1 and sn-2 positions, respectively.

HY-165116

1-1(Z)-Octadecenyl-2-docosahexaenoyl-sn-glycero-3-PE 18:0p/22:6-PE; C18(Plasm)-22:6-PE; PE(P-18:0/22:6)	Others	Others
1-1(Z)-Octadecenyl-2-docosahexaenoyl-sn-glycero-3-PE (18:0p/22:6-PE) is a lipid identified in rat brain tissue by mass spectrometry imaging with specific structural and distribution characteristics, and isomers of different fatty acid chains can be identified by improved methods.

Cat. No.	Product Name	Target	Research Area

HY-P4259

Hirullin P18	Thrombin	Cardiovascular Disease
Hirullin P18 is a potent thrombin inhibitor. Hirullin P18 has an anticoagulant effect .

Species:	Human (10)
Tag:	His (9) GST (1)
Source:	E. coli (10)

Cat. No.	Compare	Product Name	Species	Source

HY-P75682

	Cofilin-1 Protein, Human (His) Cofilin-1; 18 kDa phosphoprotein; p18; CFL1; CFL	Human	E. coli
	Cofilin-1 protein has pH-sensitive F-actin depolymerizing activity and can bind to F-actin. It cooperates with the subcortical maternal complex (SCMC) to guide the fertilized egg through initial embryonic cell division by regulating actin dynamics. Cofilin-1 Protein, Human (His) is the recombinant human-derived Cofilin-1 protein, expressed by E. coli , with N-6*His labeled tag. The total length of Cofilin-1 Protein, Human (His) is 166 a.a., with molecular weight of ~21 kDa.

HY-P76314

	EEF1E1 Protein, Human (His) Eukaryotic translation elongation factor 1 epsilon-1; AIMP3; P18	Human	E. coli
	The EEF1E1 protein is an important component of a multi-subunit complex that actively regulates the ATM response to DNA damage. It coordinates tRNA ligases of various amino acids and interacts with both MARS1 and EPRS1 in a core complex with AIMP2. EEF1E1 Protein, Human (His) is the recombinant human-derived EEF1E1 protein, expressed by E. coli , with N-His labeled tag. The total length of EEF1E1 Protein, Human (His) is 174 a.a., with molecular weight of 19-24 KDa.

HY-P71583

	LAMTOR1 Protein, Human (His) C11orf59; LAMTOR1; Late endosomal/lysosomal adaptor and MAPK and MTOR activator 1; Lipid raft adaptor protein p18; LTOR1_HUMAN; p18; p27Kip1-releasing factor from RhoA; p27RF-Rho; PDRO; PP7157; Protein associated with DRMs and endosomes; Ragulator complex protein LAMTOR1; ragulator complex protein PDRO; Ragulator1; RhoA activator C11orf59	Human	E. coli
	The LAMTOR1 protein is an important component of the Ragulator complex and plays dual roles in amino acid sensing and mTORC1 activation. It acts as a guanine nucleotide exchange factor (GEF) for Rag GTPases and mediates their recruitment to the lysosomal membrane. LAMTOR1 Protein, Human (His) is the recombinant human-derived LAMTOR1 protein, expressed by E. coli , with N-His labeled tag. The total length of LAMTOR1 Protein, Human (His) is 160 a.a., with molecular weight of ~24 kDa.

HY-P71403

	UBE2I Protein, Human (GST) SUMO-Conjugating Enzyme UBC9; SUMO-Protein Ligase; Ubiquitin Carrier Protein 9; Ubiquitin Carrier Protein I; Ubiquitin-Conjugating Enzyme E2 I; Ubiquitin-Protein Ligase I; p18; UBE2I; UBC9; UBCE9	Human	E. coli
	UBE2I Protein, a key participant in protein sumoylation, accepts ubiquitin-like proteins SUMO1, SUMO2, SUMO3, SUMO4, and SUMO1P1/SUMO5 from the UBLE1A-UBLE1B E1 complex. Teaming up with E3 ligases like RANBP2, CBX4, and ZNF451, UBE2I catalyzes the covalent attachment of these SUMO proteins to target proteins, including critical substrates FOXL2 and KAT5. Its enzymatic activity extends to forming poly-SUMO chains, influencing diverse cellular processes and playing a pivotal role in specific protein modifications, such as sumoylation of p53/TP53 at 'Lys-386' and ERCC6. UBE2I Protein, Human (GST) is the recombinant human-derived UBE2I protein, expressed by E. coli, with N-GST labeled tag. The total length of UBE2I Protein, Human (GST) is 158 a.a., with molecular weight of ~40.0 kDa.

HY-P71708

	*Caspase-8/CASP8 subunit p18* Protein, Human (His)** ALPS2B; CASP-8; ICE-like apoptotic protease 5	Human	E. coli
	The Caspase-8/CASP8 subunit p18 protein is a key thiol protease that acts as a molecular switch in programmed cell death processes, including apoptosis, necroptosis, and pyroptosis. It is essential for preventing tissue damage by inducing exogenous apoptosis by cleaving and activating effector caspases. Caspase-8/CASP8 subunit p18 Protein, Human (His) is the recombinant human-derived Caspase-8/CASP8 subunit p18 protein, expressed by E. coli , with N-6*His labeled tag. The total length of Caspase-8/CASP8 subunit p18 Protein, Human (His) is 158 a.a., with molecular weight of ~21.9 kDa.

HY-P71121

	Stathmin Protein, Human (C-His) Stathmin; Leukemia-Associated Phosphoprotein p18; Metablastin; Oncoprotein 18; Op18; Phosphoprotein p19; pp19; Prosolin; Protein Pr22; pp17; STMN1; C1orf215; LAP18; OP18	Human	E. coli
	Stathmin proteins critically regulate the microtubule filament system by actively destabilizing microtubules, inhibiting assembly, and promoting disassembly. Phosphorylation of Ser-16 is critical for axon formation during neurogenesis, highlighting its importance in neuronal development. Stathmin Protein, Human (C-His) is the recombinant human-derived Stathmin protein, expressed by E. coli , with C-6*His labeled tag.

HY-P71121A

	Stathmin Protein, Human (His) "Stathmin; Leukemia-Associated Phosphoprotein p18; Metablastin; Oncoprotein 18; Op18; Phosphoprotein p19; pp19; Prosolin; Protein Pr22; pp17; STMN1; C1orf215; LAP18; OP18 "	Human	E. coli
	Stathmin Protein, a widely distributed cytosolic phosphoprotein, integrates regulatory signals and destabilizes microtubules, crucial for their assembly and disassembly. It exhibits broad expression in various tissues, highlighting its versatile role in cellular processes. Stathmin Protein, Human (His) is the recombinant human-derived Stathmin protein, expressed by E. coli , with N-6*His labeled tag.

HY-P70034

	CDKN2C Protein, Human (His) rHuCyclin-dependent kinase 4 inhibitor C/CDKN2C, His; Cyclin-Dependent Kinase 4 Inhibitor C; Cyclin-Dependent Kinase 6 Inhibitor; p18-INK4c; p18-INK6; CDKN2C; CDKN6	Human	E. coli
	The CDKN2C protein (also known as p18) interacts strongly with CDK6 and weakly with CDK4. Its functional effects inhibit cell growth and proliferation and are significantly related to the presence of endogenous retinoblastoma protein RB. CDKN2C Protein, Human (His) is the recombinant human-derived CDKN2C protein, expressed by E. coli , with N-6*His labeled tag. The total length of CDKN2C Protein, Human (His) is 168 a.a., with molecular weight of ~17.0 kDa.

HY-P77253

	TPPP2 Protein, Human (His) Tubulin polymerization-promoting protein family member 2; Protein p25-beta; TPPP/p18; C14orf8	Human	E. coli
	The TPPP2 protein may be a regulator of microtubule dynamics and is critical for sperm motility. Unlike other family members, TPPP2 lacks microtubule bundling activity, suggesting a unique functional role. TPPP2 Protein, Human (His) is the recombinant human-derived TPPP2 protein, expressed by E. coli , with N-His labeled tag. The total length of TPPP2 Protein, Human (His) is 170 a.a., with molecular weight of 18-21 kDa.

HY-P71028

	ZNHIT1 Protein, Human (His) inc finger HIT domain-containing protein 1; cyclin-G1-binding protein 1; zinc finger protein subfamily 4A member 1; p18 hamlet; CGBP1; ZNFN4A1; ZNHIT1	Human	E. coli
	ZNHIT1 is a key chromatin remodeling protein that regulates gene expression by promoting the incorporation of histone variants H2AZ1/H2A.Z. In muscle differentiation, ZNHIT1 is recruited to the MYOG promoter, mediating H2AZ1 binding and inducing muscle-specific gene expression. ZNHIT1 Protein, Human (His) is the recombinant human-derived ZNHIT1 protein, expressed by E. coli , with N-6*His labeled tag. The total length of ZNHIT1 Protein, Human (His) is 154 a.a., with molecular weight of ~21.0 kDa.

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Cat. No.	Compare	Product Name	Application	Reactivity

HY-P80048

	*Caspase-6 p18* Antibody**	WB	Human
	Caspase-6 p18 Antibody is a non-conjugated and Rabbit origined monoclonal antibody about 33 kDa, targeting to Caspase-6 p18. It can be used for WB assays with tag free, in the background of Human.

HY-P81003

	CDKN2C Antibody CDKN2C; CDKN6; Cyclin-dependent kinase 4 inhibitor C; Cyclin-dependent kinase 6 inhibitor; p18-INK4c; p18-INK6	WB, IHC-P, ICC/IF, IP	Human, Mouse, Rat
	CDKN2C Antibody is an unconjugated, approximately 15 kDa, rabbit-derived, anti-CDKN2C monoclonal antibody. CDKN2C Antibody can be used for: WB, IHC-P, ICC/IF, IP expriments in background without labeling.

HY-P83077

	Cofilin Antibody (YA2822) CFL1; CFL; Cofilin-1; 18 kDa phosphoprotein; p18; Cofilin; non-muscle isoform	WB, IHC-F, IHC-P, ICC/IF	Human
	Cofilin Antibody (YA2822) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA2822), targeting Cofilin, with a predicted molecular weight of 19 kDa (observed band size: 19 kDa). Cofilin Antibody (YA2822) can be used for WB, IHC-F, IHC-P, ICC/IF experiment in human background.

HY-P83556

	SUMO Conjugating Enzyme UBC9 Antibody (YA3301) UBE2I; UBC9; UBCE9; SUMO-conjugating enzyme UBC9; SUMO-protein ligase; Ubiquitin carrier protein 9; Ubiquitin carrier protein I; Ubiquitin-conjugating enzyme E2 I; Ubiquitin-protein ligase I; p18	WB, IHC-F, IHC-P, ICC/IF, IP	Human, Mouse, Rat
	SUMO Conjugating Enzyme UBC9 Antibody (YA3301) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA3301), targeting SUMO Conjugating Enzyme UBC9, with a predicted molecular weight of 18 kDa (observed band size: 18 kDa). SUMO Conjugating Enzyme UBC9 Antibody (YA3301) can be used for WB, IHC-F, IHC-P, ICC/IF, IP experiment in human, mouse, rat background.

HY-P81566

	Cofilin 1 Antibody (YA1311) 18 kDa phosphoprotein antibody; CFL 1 antibody; CFL antibody; CFL1 antibody; COF1_HUMAN antibody; Cofilin 1 antibody; Cofilin 1 non muscle antibody; Cofilin antibody; Cofilin non muscle isoform antibody; Cofilin-1 antibody; epididymis secretory protein Li 15 antibody; HEL-S-15 antibody; non-muscle isoform antibody; p18 antibody	WB, ICC/IF, FC	Human, Mouse, Rat, Monkey
	Cofilin 1 Antibody (YA1311) is a non-conjugated IgG antibody, targeting Cofilin 1, with a predicted molecular weight of 19 kDa (observed band size: 19 kDa). Cofilin 1 Antibody (YA1311) can be used for WB, IF-Cell, FC experiment in Human, Mouse, Rat, Monkey background.

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Cat. No.	Product Name		Classification

HY-157698

1-1(Z)-Octadecenyl-2-arachidonoyl-sn-glycero-3-PC C18(plasm)-20:4-PC; 18:0p/20:4-PC; PC(P-18:0/20:4)		Phospholipids
1-1(Z)-Octadecenyl-2-arachidonoyl-sn-glycero-3-PC is a plasmalogen that contains 1(Z)-octadecenoic acid and arachidonic acid (HY-109590) at the sn-1 and sn-2 positions, respectively. It scavenges singlet oxygen in a cell-free assay.

HY-157697

1-1(Z)-Octadecenyl-2-arachidonoyl-sn-glycero-3-PE 18:0p/20:4-PE; C18(Plasm)-20:4-PE; PE(P-18:0/20:4)		Phospholipids
1-1(Z)-Octadecenyl-2-arachidonoyl-sn-glycero-3-PE (18:0p/20:4-PE; C18(Plasm)-20:4-PE) is a plasmalogen that contains 1(Z)-octadecenoic acid and arachidonic acid (HY-109590) at the sn-1 and sn-2 positions, respectively.

HY-157695

1-(1Z-Octadecenyl)-2-docosahexaenoyl-sn-glycero-3-phosphocholine C18(Plasm)-22:6-PC; PC(P-18:0/22:6); 18:0p/22:6-PC		Phospholipids
1-(1Z-Octadecenyl)-2-docosahexaenoyl-sn-glycero-3-phosphocholine (C18(Plasm)-22:6-PC) is a phospholipid identified in fish viscera by lipidomics strategy. It has different content and distribution in different fish species and can be used as an indicator of fish species differentiation.

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