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Isoforms Recommended:	PAK1

Results for "

PAK1

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Apoptosis (3) Drug Intermediate (1) Endogenous Metabolite (7) ERK (1) HDAC (1) Isotope-Labeled Compounds (4) LIM Kinase (LIMK) (1) LPL Receptor (6) NF-κB (9) PAK (35) PPAR (9) Ras (2) Reactive Oxygen Species (1) Small Interfering RNA (siRNA) (4)
By Research Areas:	Cancer (34) Inflammation/Immunology (15) Metabolic Disease (1)
Oligonucleotides:	Pre-designed siRNA Sets (4) siRNAs (4)

Inhibitors & Agonists

Natural
Products

Recombinant Proteins

Isotope-Labeled Compounds

Antibodies

Oligonucleotides

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-131043

*NVS-PAK1-C* 1 Publications Verification	PAK	Cancer
NVS-PAK1-C is a potent, ATP-competitive and specific allosteric *PAK1* inhibitor probe with IC₅₀ values of 5 nM and 6 nM for dephosphorylated PAK1 and phosphorylated PAK1, respectively. NVS-PAK1-C is also against dephosphorylated PAK2 (IC₅₀=270 nM) and phosphorylated PAK2 (IC₅₀=720 nM) ^[1].

HY-100519

*NVS-PAK1-1* 3 Publications Verification	PAK	Cancer
NVS-PAK1-1 is a potent and selective allosteric *PAK1* inhibitor with an IC₅₀ of 5 nM.

HY-120940

AZ13705339	PAK	Cancer
AZ13705339 is a highly potent and selective *PAK1* inhibitor with IC₅₀s of 0.33 nM and 59 nM for PAK1 and pPAK1, respectively. AZ13705339 has binding affinities to PAK1 and PAK2, with K_ds of 0.28 nM and 0.32 nM, respectively. AZ13705339 can be used in the research of cancers ^[1].

HY-RS09983

PAK1 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
PAK1 Human Pre-designed siRNA Set A contains three designed siRNAs for PAK1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

PAK1 Human Pre-designed siRNA Set A PAK1 Human Pre-designed siRNA Set A

HY-RS09984

Pak1 Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Pak1 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Pak1 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Pak1 Mouse Pre-designed siRNA Set A Pak1 Mouse Pre-designed siRNA Set A

HY-RS09985

Pak1 Rat Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Pak1 Rat Pre-designed siRNA Set A contains three designed siRNAs for Pak1 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

Pak1 Rat Pre-designed siRNA Set A Pak1 Rat Pre-designed siRNA Set A

HY-146681

PAK1-IN-1	PAK	Cancer
PAK1-IN-1 is a potent and selective *PAK1* inhibitor with an IC₅₀ of 9.8 nM. PAK1-IN-1 inhibits the migration and invasion of PAK1-related tumour cells in a dose-dependent manner ^[1].

HY-RS09986

PAK1IP1 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
PAK1IP1 Human Pre-designed siRNA Set A contains three designed siRNAs for PAK1IP1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

PAK1IP1 Human Pre-designed siRNA Set A PAK1IP1 Human Pre-designed siRNA Set A

HY-131265

Mesalamine impurity P	PPAR PAK NF-κB	Inflammation/Immunology Cancer
Mesalamine impurity P is an impurity of Mesalamine (HY-15027). 5-Aminosalicylic acid (Mesalamine) acts as a specific PPARγ agonist and also inhibits p21-activated kinase 1 (PAK1) and NF-κB ^[1].

HY-146786

ZMF-10	PAK Apoptosis	Cancer
ZMF-10 is a highly potent *PAK1* inhibitor, with IC₅₀s of 174 nM, 1.038 μM and 1.372 μM for PAK1, PAK2 and PAK3, respectively. ZMF-10 can inhibit PAK1 activity to affect PAK1-regulated apoptosis, ER-Stress and migration in MDA-MB-231 cells. ZMF-10 can be used for researching anticancer ^[1].

HY-120940A

AZ13705339 hemihydrate	PAK	Cancer
AZ13705339 hemihydrate is a highly potent and selective *PAK1* inhibitor with IC₅₀s of 0.33 nM and 59 nM for PAK1 and pPAK1, respectively. AZ13705339 hemihydrate has binding affinities to PAK1 and PAK2, with K_ds of 0.28 nM and 0.32 nM, respectively. AZ13705339 hemihydrate can be used in the research of cancers ^[1].

HY-164374

AK963/40708899	PAK	Cancer
AK963/40708899 is a potent *PAK1* inhibitor. AK963/40708899 suppresses the proliferation of human gastric cancer cells by downregulation of PAK1-NF-κB-cyclinB1 pathway. AK963/40708899 induces cell cycle arrest at G2 phase and reduces the migration and invasion. AK963/40708899 inhibits the formation of filopodia and promots cell adhesion which in turn inhibits invasive potential of gastric cells by negatively regulating PAK1-LIMKl-cofilin and PAK1-ERK-FAK pathways ^[1].

HY-19635

G-5555 5+ Cited Publications	PAK	Cancer
G-5555 is a potent p21-activated kinase 1 (PAK1) inhibitor with K_is of 3.7 nM and 11 nM for PAK1 and PAK2, respectively.

HY-12810

EHop-016 4 Publications Verification	Ras	Cancer
EHop-016 is a potent and selective Rac GTPase Rac1 and Rac3 inhibitor. EHop-016 inhibits *Rac1* activity with an IC₅₀ of 1.1 μM in MDA-MB-435 cells. EHop-016 inhibits Vav2 interaction with Rac, Rac-activated PAK1, lamellipodia formation, and cell migration ^[1] .

HY-155179

ZMF-23	PAK HDAC	Cancer
ZMF-23 is a *PAK1/HDAC6* dual inhibitor. ZMF-23 inhibits PAK1 and HDAC6 regulated aerobic glycolysis and migration. ZMF-23 induces TNF-α-regulated necroptosis, and further enhances apoptosis. ZMF-23 inhibits the Warburg effect and cell migration. ZMF-23 can be used for research of triple-negative breast cancer (TNBC) ^[1].

HY-19635A

G-5555 hydrochloride 5+ Cited Publications	PAK	Cancer
G-5555 hydrochloride is a potent and selective p21-activated kinase 1 (PAK1) inhibitor with a K_i of 3.7 nM.

HY-110085

2,2′-Dihydroxy-6,6′-dinaphthyl disulfide DDD; Bis(6-hydroxy-2-naphthyl)disulfide; PIR-3.5	PAK	Cancer
2,2′-Dihydroxy-6,6′-dinaphthyl disulfide (PIR-3.5) is a *PAK1* inhibitor ^[1].

HY-19538

FRAX1036 4 Publications Verification	PAK	Cancer
FRAX1036 is a *PAK* inhibitor with K_is of 23.3 nM, 72.4 nM, and 2.4 μM for PAK1, PAK2 and PAK4, respectively.

HY-15542A

FRAX597 5+ Cited Publications	PAK	Cancer
FRAX597 is a potent group I p21-activated Kinases (PAKs) inhibitor with IC₅₀ of 8, 13 and 19 nM for *PAK1*, 2 and 3.

HY-116917

G-9791	PAK	Cancer
G-9791, a poyridone side chain analogue, is a potent PAK inhibitor with K_i values of 0.95 nM and 2.0 nM for PAK1 and PAK2, respectively ^[1].

HY-15663

IPA-3 10+ Cited Publications	PAK	Cancer
IPA-3 is a selective non-ATP competitive *PAK1* inhibitor with IC₅₀ of 2.5 μM, and shows no inhibition to group II PAKs (PAKs 4-6).

HY-15542B

FRAX486 5+ Cited Publications	PAK	Cancer
FRAX486 is a p21-activated kinase (PAK) inhibitor with IC₅₀s of 14, 33 and 39 nM for PAK1, PAK2 and PAK3, respectively.

HY-11063

Fingolimod Maximum Cited Publications 42 Publications Verification FTY720 free base	LPL Receptor PAK	Inflammation/Immunology Cancer
Fingolimod (FTY720 free base) is a sphingosine 1-phosphate (S1P) antagonist with an IC₅₀ of 0.033 nM in K562 and NK cells. Fingolimod also is a *pak1* activator, a immunosuppressant ^[1].

HY-12005

Fingolimod hydrochloride Maximum Cited Publications 42 Publications Verification FTY720	LPL Receptor PAK	Inflammation/Immunology Cancer
Fingolimod (FTY720) hydrochloride is a sphingosine 1-phosphate (S1P) antagonist with IC₅₀ of 0.033 nM in K562 and NK cells. Fingolimod hydrochloride is also a *pak1* activator and immunosuppressant ^[1] .

HY-143704S

5-Aminosalicylic acid-13C6 hydrochloride Mesalamine-¹³C₆ hydrochloride; 5-ASA-¹³C₆ hydrochloride; Mesalazine-¹³C₆ hydrochloride	PPAR NF-κB PAK	Metabolic Disease
5-Aminosalicylic acid-13C6 hydrochloride?(Mesalamine-13C6 hydrochloride; 5-ASA-13C6 hydrochloride; Mesalazine-13C6 hydrochloride) is the 13C labeled 5-Aminosalicylic Acidhydrochloride. 5-Aminosalicylic acid-13C6 hydrochloride?acts as a PPARγ agonist, and also inhibits p21-activated kinase 1 (PAK1) and NF-κB ^[1] .

HY-146783

ZINC194100678	PAK	Cancer
ZINC194100678 is a potent *PAK1* inhibitor with an IC₅₀ value of 8.37 μM. ZINC194100678 can inhibit MDA-MB-231 cell proliferation. ZINC194100678 can be used for researching anticancer ^[1].

HY-15027

5-Aminosalicylic Acid 15+ Cited Publications Mesalamine; 5-ASA; Mesalazine	PPAR PAK NF-κB Endogenous Metabolite	Inflammation/Immunology Cancer
5-Aminosalicylic acid (Mesalamine) acts as a specific PPARγ agonist and also inhibits p21-activated kinase 1 (PAK1) and NF-κB. 5-Aminosalicylic acid can inhibit the activity of osteopontin (OPN).

HY-11063S1

Fingolimod-d4 hydrochloride FTY720-d₄	LPL Receptor PAK	Inflammation/Immunology Cancer
Fingolimod-d₄ (hydrochloride) is the deuterium labeled Fingolimod hydrochloride. Fingolimod hydrochloride (FTY720) is a sphingosine 1-phosphate (S1P) antagonist with an IC50 of 0.033 nM in K562 and NK cells. Fingolimod hydrochloride (FTY720) also is a pak1 activator, a immunosuppressant[1].

HY-15027S

5-Aminosalicylic Acid-d3 hydrochloride Mesalamine-d₃ hydrochloride; 5-ASA-d₃ hydrochloride; Mesalazine-d₃ hydrochloride	Isotope-Labeled Compounds PPAR PAK NF-κB Endogenous Metabolite	Inflammation/Immunology Cancer
5-Aminosalicylic Acid-d₃ (hydrochloride) is the deuterium labeled 5-Aminosalicylic Acid. 5-Aminosalicylic acid (Mesalamine) hydrochloride acts as a specific PPARγ agonist and also inhibits p21-activated kinase 1 (PAK1) and NF-κB.

HY-11063S

Fingolimod-d4 FTY720 free based-d₄	LPL Receptor PAK	Inflammation/Immunology Cancer
Fingolimod-d₄ is the deuterium labeled Fingolimod. Fingolimod (FTY720 free base) is a sphingosine 1-phosphate (S1P) antagonist with an IC50 of 0.033 nM in K562 and NK cells. Fingolimod also is a pak1 activator, a immunosuppressant[1].

HY-164488

KT D606	PAK	Cancer
KT D606 is an inhibitor of the *PAK* kinase family, with an IC₅₀ value of 4 μM. KT D606 selectively blocks the proliferation of cancer cells transformed by oncogenic RAS mutants and can be used for research on RAS/PAK1-induced cancers ^[1].

HY-11063R

Fingolimod (Standard)	LPL Receptor PAK	Inflammation/Immunology Cancer
Fingolimod (Standard) is the analytical standard of Fingolimod. This product is intended for research and analytical applications. Fingolimod (FTY720 free base) is a sphingosine 1-phosphate (S1P) antagonist with an IC₅₀ of 0.033 nM in K562 and NK cells. Fingolimod also is a pak1 activator, a immunosuppressant ^[1].

HY-W206016

3-Aminosalicylic acid	Drug Intermediate	Inflammation/Immunology Cancer
3-Aminosalicylic acid is the impurity found during the 5-Aminosalicylic acid (HY-15027) production. 5-Aminosalicylic acid is the agonist for PPARγ and the inhibitor for p21-activated kinase 1 (PAK1) and NF-κB ^[1]. Crohn's disease, ulcerative proctitis

HY-15027S1

5-Aminosalicylic acid-d3 Mesalamine-d₃; 5-ASA-d₃; Mesalazine-d₃	Isotope-Labeled Compounds Endogenous Metabolite NF-κB PAK PPAR	Inflammation/Immunology Cancer
5-Aminosalicylic acid-d₃ is the deuterium labeled 5-Aminosalicylic Acid. 5-Aminosalicylic acid (Mesalamine) acts as a specific PPARγ agonist and also inhibits p21-activated kinase 1 (PAK1) and NF-κB[1][2][3][4].

HY-15027S2

5-Aminosalicylic acid-13C6 Mesalamine-¹³C₆; 5-ASA-¹³C₆; Mesalazine-¹³C₆	PPAR PAK NF-κB Endogenous Metabolite	Inflammation/Immunology
5-Aminosalicylic acid- ¹³C₆ is the ¹³C labeled 5-Aminosalicylic Acid[1]. 5-Aminosalicylic acid (Mesalamine) acts as a specific PPARγ agonist and also inhibits p21-activated kinase 1 (PAK1) and NF-κB[2][3][4].

HY-116269

AZA197	Ras Apoptosis PAK ERK	Cancer
AZA197 is a selective small molecule inhibitor of Cdc42.AZA197 suppresses colon cancer cell proliferation, cell migration, invasion and increases apoptosis by down-regulating the *PAK1* and ERK signaling pathways in vitro. AZA197 reduces tumor growth and significantly increases mouse survival in SW620 tumor xenografts ^[1].

HY-15027R

5-Aminosalicylic Acid (Standard)	PPAR PAK NF-κB Endogenous Metabolite	Inflammation/Immunology Cancer
5-Aminosalicylic Acid (Standard) is the analytical standard of 5-Aminosalicylic Acid. This product is intended for research and analytical applications. 5-Aminosalicylic acid (Mesalamine) acts as a specific PPARγ agonist and also inhibits p21-activated kinase 1 (PAK1) and NF-κB. 5-Aminosalicylic acid can inhibit the activity of osteopontin (OPN).

HY-15027S3

5-Aminosalicylic acid-d3 disodium Mesalamine-d₃ disodium; 5-ASA-d₃ disodium; Mesalazine-d₃ disodium	PPAR NF-κB Endogenous Metabolite PAK Isotope-Labeled Compounds	Inflammation/Immunology
5-Aminosalicylic acid-d₃ disodium is deuterated labeled 5-Aminosalicylic Acid (HY-15027). 5-Aminosalicylic acid (Mesalamine) acts as a specific PPARγ agonist and also inhibits p21-activated kinase 1 (PAK1) and NF-κB.5-Aminosalicylic acid can inhibit the activity of osteopontin (OPN).

HY-12005R

Fingolimod (hydrochloride) (Standard) FTY720 (Standard)	LPL Receptor PAK	Inflammation/Immunology Cancer
Fingolimod (hydrochloride) (Standard) is the analytical standard of Fingolimod (hydrochloride). This product is intended for research and analytical applications. Fingolimod hydrochloride (FTY720), an analog of sphingosine, is a potent sphingosine 1-phosphate (S1P) receptors modulator. Fingolimod hydrochloride is phosphorylated by sphingosine kinases, particularly by SK2, and then binds S1PR1, 3, 4, and 5. Fingolimod hydrochloride induces the internalization of S1P1, and consequently, inhibits S1P activity. Fingolimod hydrochloride also is a *pak1* activator ^[1] .

HY-15027S4

5-Aminosalicylic acid-d7 5-ASA-d₇; Mesalamie-d₇; Mesalazie-d₇	Isotope-Labeled Compounds PPAR PAK Endogenous Metabolite NF-κB	Inflammation/Immunology Cancer
5-Aminosalicylic acid-d₇ (5-ASA-d₇; Mesalamie-d₇; Mesalazie-d₇) is deuterium labeled 5-Aminosalicylic Acid. 5-Aminosalicylic acid (Mesalamine) acts as a specific PPARγ agonist and also inhibits p21-activated kinase 1 (PAK1) and NF-κB. 5-Aminosalicylic acid can inhibit the activity of osteopontin (OPN) ^[1].

HY-159897

PAK4-IN-5	PAK LIM Kinase (LIMK) Apoptosis Reactive Oxygen Species	Cancer
PAK4-IN-5 (Compound 12i) is a *PAK4* inhibitor (IC₅₀: 7.68 nM for PAK4, 1872.01 nM for PAK1). PAK4-IN-5 binds to PAK4 stably via multiple interactions. PAK4-IN-5 inhibits the proliferation and the migratory potential of MDA-MB-231 cells by inhibiting the phosphorylation of PAK4 and LIMK1. PAK4-IN-5 arrests cell cycle in the G0/G1 phase, induces apoptosis and ROS production. LD₅₀: >500 mg/kg for mice (p.o.) ^[1].

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-15027

5-Aminosalicylic Acid 15+ Cited Publications Mesalamine; 5-ASA; Mesalazine	Structural Classification Monophenols Classification of Application Fields Ketones, Aldehydes, Acids Source classification Phenols Endogenous metabolite Disease Research Fields Cancer	PPAR PAK NF-κB Endogenous Metabolite
5-Aminosalicylic acid (Mesalamine) acts as a specific PPARγ agonist and also inhibits p21-activated kinase 1 (PAK1) and NF-κB. 5-Aminosalicylic acid can inhibit the activity of osteopontin (OPN).

HY-15027R

5-Aminosalicylic Acid (Standard)	Structural Classification Monophenols Ketones, Aldehydes, Acids Source classification Phenols Endogenous metabolite	PPAR PAK NF-κB Endogenous Metabolite
5-Aminosalicylic Acid (Standard) is the analytical standard of 5-Aminosalicylic Acid. This product is intended for research and analytical applications. 5-Aminosalicylic acid (Mesalamine) acts as a specific PPARγ agonist and also inhibits p21-activated kinase 1 (PAK1) and NF-κB. 5-Aminosalicylic acid can inhibit the activity of osteopontin (OPN).

Species:	Human (2)
Tag:	SUMO (1) His (2) Flag (1)
Source:	Sf9 insect cells (1) E. coli (1)

Cat. No.	Compare	Product Name	Species	Source

HY-P71530

	PAK1 Protein, Human (His-SUMO) Serine/threonine-protein kinase PAK 1; Alpha-PAK; p21-activated kinase 1 ; p65-PAK; PAK1	Human	E. coli
	PAK1 is a dynamic protein kinase that plays an important role in multiple intracellular signaling pathways, affecting cytoskeletal dynamics, adhesion, migration, proliferation, apoptosis, mitosis, and vesicle trafficking. Multifunctional PAK1 directly phosphorylates BAD to provide antiapoptotic cell protection. PAK1 Protein, Human (His-SUMO) is the recombinant human-derived PAK1 protein, expressed by E. coli , with N-SUMO, N-6*His labeled tag.

HY-P702648

	PKN1 Protein, Human (sf9, His, Flag) PKN1; protein kinase N1; PRKCL1, protein kinase C like 1; serine/threonine-protein kinase N1; DBK; MGC46204; PAK1; PKN; PRK1; protein kinase C-like 1; protein kinase PKN-alpha; protein kinase C-like PKN; serine-threonine kinase N; protease-activated kinase 1; protein kinase C-related kinase 1; protein-kinase C-related kinase 1; serine-threonine protein kinase N; serine/threonine protein kinase N; PAK-1; PRKCL1; PKN-ALPHA	Human	Sf9 insect cells
	PKN1 Protein, Human (sf9, His, Flag) is the recombinant human-derived PKN1, expressed by Sf9 insect cells , with His, Flag labeled tag. ,

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