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Isoforms Recommended:	GCN5/PCAF

Results for "

PCAF

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Apoptosis (5) Bacterial (2) CDK (1) Cholinesterase (ChE) (1) Endogenous Metabolite (1) Epigenetic Reader Domain (9) Histone Acetyltransferase (18) HIV (1)
By Research Areas:	Cancer (24) Infection (2) Inflammation/Immunology (3) Neurological Disease (2)

Inhibitors & Agonists

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Recombinant Proteins

Antibodies

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-147894

PCAF-IN-1	Others	Cancer
PCAF-IN-1 is a highly selective *PCAF* inhibitor. PCAF-IN-1 is a antitumor agents, which can be used in tumor research research .

HY-147895

PCAF-IN-2	Histone Acetyltransferase Apoptosis	Cancer
PCAF-IN-2 (compound 17) is a potent *PCAF* inhibitor with an IC₅₀ value of 5.31 µM. PCAF-IN-2 shows anti-tumour activity. CAF-IN-2 induces apoptosis and arrest the cell cycle at the G2/M phase .

HY-147288

NSC 694621	Histone Acetyltransferase	Cancer
NSC 694621 is a potent *PCAF* inhibitor, with an IC₅₀ of 5.71 µM (PCAF/H3_1-21). NSC 694621 exhibits good activity of inhibiting the proliferation of cancer cells .

HY-101125B

D-Moses D-45	Others	Cancer
D-Moses (D-45) is an enantiomer of L-Moses (HY-101125). L-Moses (L-45) is a potent and selective p300/CBP-associated factor (PCAF) bromodomain (Brd) inhibitor. D-Moses shows no observable binding for PCAF Brd. D-Moses can be used as an inactive control compound to L-Moses .

HY-147290

NSC 694623	Histone Acetyltransferase	Cancer
NSC 694623 is a potent histone acetyltransferase (HAT) inhibitor with an IC₅₀ value of 15.9 μM for recombinant HAT p300/CBP-associated factor (PCAF). NSC 694623 has antiproliferative activity against certain cancer cells. NSC 694623 can be used for researching anticancer .

HY-107569

Garcinol 1 Publications Verification	Cholinesterase (ChE) Histone Acetyltransferase Apoptosis Endogenous Metabolite	Inflammation/Immunology Cancer
Garcinol, a polyisoprenylated benzophenone harvested from Garcinia indica, exerts anti-cholinesterase properties towards acetyl cholinesterase (AChE) and butyrylcholinesterase (BChE) with IC₅₀s of 0.66 µM and 7.39 µM, respectively . Garcinol also inhibits histone acetyltransferases (HATs, IC₅₀= 7 μM) and p300/CPB-associated factor (PCAF, IC₅₀ = 5 μM). Garcinol has anti-inflammatory and anti-cancer activity .

HY-101027

GSK 4027 1 Publications Verification	Epigenetic Reader Domain Histone Acetyltransferase	Inflammation/Immunology Cancer
GSK 4027 is a chemical probe for the *PCAF/GCN5* bromodomain with an pIC₅₀ of 7.4±0.11 for PCAF in a time-resolved fluorescence resonance energy transfer (TR-FRET) assay.

HY-147289

NSC 698600	Histone Acetyltransferase	Cancer
NSC 698600 is a potent *PCAF* inhibitor, with IC₅₀ of 6.51 µM (PCAF/H3_1-21). NSC 698600 exhibits good activity of inhibiting the proliferation of cancer cells .

HY-115829

APA-H-MPO hydrochloride	Others	Infection
APA-H-MPO hydrochloride is an inhibitor of PCAF bromodomain/Tat-AcK50 interaction with potential for anti-HIV/AIDS. APA-H-MPO hydrochloride can effectively inhibit the binding of PCAF bromodomain to Tat-AcK50. APA-H-MPO hydrochloride showed low cytotoxicity in preliminary cell studies. APA-H-MPO hydrochloride is considered a potential candidate for a promising inhibitory strategy targeting the host cell protein PCAF BRD to block HIV replication .

HY-115828

APA-APA-MPO dihydrochloride	Others	Infection
APA-APA-MPO dihydrochloride is an inhibitor of PCAF bromodomain/Tat-AcK50 interaction with reduced cytotoxic activity. APA-APA-MPO dihydrochloride can effectively inhibit the binding of PCAF to Tat-AcK50, showing its potential in HIV/AIDS inhibitory strategies. APA-APA-MPO dihydrochloride can be used in studies that hinder HIV replication .

HY-101125A

L-Moses dihydrochloride 2 Publications Verification L-45 dihydrochloride	Epigenetic Reader Domain	Cancer
L-Moses (L-45) dihydrochloride is the first potent, selective, and cell-active p300/CBP-associated factor (PCAF) bromodomain (Brd) inhibitor with a K_d of 126 nM .

HY-101125

L-Moses 2 Publications Verification L-45	Epigenetic Reader Domain	Cancer
L-Moses (L-45) is the first potent, selective, and cell-active p300/CBP-associated factor (PCAF) bromodomain (Brd) inhibitor with a K_d of 126 nM .

HY-N2020

Anacardic Acid 5+ Cited Publications Hydroginkgolic acid; Ginkgolic Acid C15:0	Histone Acetyltransferase Epigenetic Reader Domain Bacterial	Cancer
Anacardic Acid, extracted from cashew nut shell liquid, is a histone acetyltransferase inhibitor, inhibits HAT activity of p300 and PCAF, with IC₅₀s of ∼8.5 μM and ∼5 μM, respectively.

HY-128597

BRD-IN-3	Epigenetic Reader Domain	Cancer
BRD-IN-3 ((R,R)-36n) is a highly potent PCAF bromodomain (BRD) inhibitor, with an IC₅₀ of 7 nM. BRD-IN-3 also exhibits activity against GCN5 and FALZ .

HY-15887

MG 149 Maximum Cited Publications 11 Publications Verification Tip60 HAT inhibitor	Histone Acetyltransferase Epigenetic Reader Domain Apoptosis	Cancer
MG149 (Tip60 HAT inhibitor) is a selective and potent Tip60 inhibitor with IC₅₀ of 74 uM, similar potentcy for MOF (IC₅₀= 47 uM); little potent for PCAF and p300 (IC₅₀ >200 uM) .

HY-101027A

GSK4028 1 Publications Verification	Epigenetic Reader Domain Histone Acetyltransferase	Inflammation/Immunology Cancer
GSK4028 is the enantiomeric negative control of GSK4027, which is a PCAF/GCN5 bromodomain chemical probe, the pIC₅₀ of GSK4028 is 4.9 in a time-resolved fluorescence resonance energy transfer (TR-FRET) assay.

HY-N2020R

Anacardic Acid (Standard)	Histone Acetyltransferase Epigenetic Reader Domain Bacterial	Cancer
Anacardic Acid (Standard) is the analytical standard of Anacardic Acid. This product is intended for research and analytical applications. Anacardic Acid, extracted from cashew nut shell liquid, is a histone acetyltransferase inhibitor, inhibits HAT activity of p300 and PCAF, with IC₅₀s of ～8.5 μM and ～5 μM, respectively.

HY-16531

YF-2 2 Publications Verification	Histone Acetyltransferase	Neurological Disease Cancer
YF-2 is a highly selective, blood-brain-barrier permeable histone acetyltransferase activator, acetylates H3 in the hippocampus, with EC₅₀s of 2.75 μM, 29.04 μM and 49.31 μM for CBP, PCAF, and GCN5, respectively, shows no effect on HDAC. Anti-cancer and anti-Alzheimer's disease .

HY-16531A

YF-2 hydrochloride 2 Publications Verification	Histone Acetyltransferase	Neurological Disease Cancer
YF-2 hydrochloride is a highly selective, blood-brain-barrier permeable histone acetyltransferase activator, acetylates H3 in the hippocampus, with EC₅₀s of 2.75 μM, 29.04 μM and 49.31 μM for CBP, PCAF, and GCN5, respectively, shows no effect on HDAC. Anti-cancer and anti-Alzheimer's disease .

HY-110127

NU9056 5 Publications Verification	Histone Acetyltransferase Apoptosis	Cancer
NU9056 is a potent and selective Tip60 (KAT5) histone acetyltransferase inhibitor with an of 2 µM. NU9056 shows >16-fold selectivity for Tip60 over PCAF, p300 and GCN5. NU9056 induces apoptosis of prostate cancer cells .

HY-117617

CAY10669	Histone Acetyltransferase	Cancer
CAY10669 (compound 6d) is an anacardic acid (HY-N2020) derivative that inhibits histone acetyltransferase *PCAF* with an IC₅₀ of 662 μM . CAY10669 enhances the SAHA-induced acetylation in HEPG2 cells, exhibits cytotoxicity in zebrafish embryo, promotes transgene expression in CHO-K1 cells .

HY-131035

Lys-CoA TFA	Histone Acetyltransferase	Cancer
Lys-CoA TFA is a selective p300 histone acetyltransferase (HAT) inhibitor (IC₅₀=50-500 nM). Lys-CoA TFA displays >100-fold selectivity for p300 over PCAF (IC₅₀=200 μM). Lys-CoA TFA inhibits p300 HAT activity-dependent transcriptional activation .

HY-124696

PU139 3 Publications Verification	Histone Acetyltransferase	Cancer
PU139 is a potent pan-histone acetyltransferase (HAT) inhibitor. PU139 blocks the HATs Gcn5, p300/CBP-associated factor (PCAF), CREB (cAMP response element-binding) protein (CBP) and p300 with IC₅₀s of 8.39, 9.74, 2.49 and 5.35 μM, respectively .

HY-146277

CBP/p300-IN-19	Histone Acetyltransferase	Cancer
CBP/p300-IN-19 is a potent p300/CBP HAT inhibitor with IC₅₀s of 1.4, 2.2, >100, >100 µM for p300-HAT, CBP-HAT, PCAF, Myst3, respectively. CBP/p300-IN-19 shows antitumor activity .

HY-146277A

CBP/p300-IN-19 hydrochloride	Histone Acetyltransferase	Cancer
CBP/p300-IN-19 hydrochloride is a potent and selective p300/CBP HAT inhibitor with IC₅₀s of 1.4, 2.2, >100, >100 µM for p300-HAT, CBP-HAT, PCAF, Myst3, respectively. CBP/p300-IN-19 hydrochloride shows antitumor activity .

HY-15815

Bromosporine 3 Publications Verification	Epigenetic Reader Domain Apoptosis CDK HIV	Cancer
Bromosporine is a potent BET inhibitor with an IC₅₀ value of 2.1 μM for PCAF. Bromosporine can arrest cell cycle and induce apoptosis in cancer cells. Bromosporine exhibits excellent antitumor activity in xenograft mice model when combined with 5-FU (HY-90006). Bromosporine can increase CDK9 T-loop phosphorylation in HIV-1 latency models, resulting the protection of reactivate HIV-1 replication from latency. Bromosporine can be used to research colorectal cancer, acute myeloid leukemia (AML) and AIDS .

Garcinol 1 Publications Verification	Structural Classification Classification of Application Fields Guttiferae Phenols Polyphenols Plants Inflammation/Immunology Disease Research Fields Garcinia indica	Cholinesterase (ChE) Histone Acetyltransferase Apoptosis Endogenous Metabolite
Garcinol, a polyisoprenylated benzophenone harvested from Garcinia indica, exerts anti-cholinesterase properties towards acetyl cholinesterase (AChE) and butyrylcholinesterase (BChE) with IC₅₀s of 0.66 µM and 7.39 µM, respectively . Garcinol also inhibits histone acetyltransferases (HATs, IC₅₀= 7 μM) and p300/CPB-associated factor (PCAF, IC₅₀ = 5 μM). Garcinol has anti-inflammatory and anti-cancer activity .

Anacardic Acid 5+ Cited Publications Hydroginkgolic acid; Ginkgolic Acid C15:0	Structural Classification Ginkgoaceae Classification of Application Fields Source classification Plants Ginkgo biloba Monophenols Ketones, Aldehydes, Acids Phenols Anacardium occidentaleL. Disease Research Fields Anacardiaceae Cancer	Histone Acetyltransferase Epigenetic Reader Domain Bacterial
Anacardic Acid, extracted from cashew nut shell liquid, is a histone acetyltransferase inhibitor, inhibits HAT activity of p300 and PCAF, with IC₅₀s of ∼8.5 μM and ∼5 μM, respectively.

Anacardic Acid (Standard)	Structural Classification Monophenols Ginkgoaceae Ketones, Aldehydes, Acids Source classification Phenols Plants Anacardium occidentaleL. Ginkgo biloba Anacardiaceae	Histone Acetyltransferase Epigenetic Reader Domain Bacterial
Anacardic Acid (Standard) is the analytical standard of Anacardic Acid. This product is intended for research and analytical applications. Anacardic Acid, extracted from cashew nut shell liquid, is a histone acetyltransferase inhibitor, inhibits HAT activity of p300 and PCAF, with IC₅₀s of ～8.5 μM and ～5 μM, respectively.

Cat. No.	Compare	Product Name	Species	Source

HY-P702904

	PCAF Protein, Human (His) PCAF; KAT2B	Human	E. coli
	PCAF Protein, Human (His) is the recombinant human-derived PCAF, expressed by E. coli , with N-6*His labeled tag. ,

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HY-P83155

	KAT2A Antibody (YA2900) GCN5; hGCN5; GCN5L2; PCAF-b	WB, IP	Human
	KAT2A Antibody (YA2900) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA2900), targeting KAT2A, with a predicted molecular weight of 94 kDa (observed band size: 94 kDa). KAT2A Antibody (YA2900) can be used for WB, IP experiment in human background.

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PCAF

Inhibitors & Agonists

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Recombinant Proteins

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