Results for "

SHH

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Apoptosis (1) Fluorescent Dye (1) Hedgehog (7) Histone Methyltransferase (2) Small Interfering RNA (siRNA) (1) Smo (4) Wnt (1)
By Research Areas:	Cancer (11) Inflammation/Immunology (2) Neurological Disease (1)
Oligonucleotides:	Pre-designed siRNA Sets (1) siRNAs (1)

Inhibitors & Agonists

Recombinant Proteins

Antibodies

Oligonucleotides

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-100515

Robotnikinin 3 Publications Verification	Hedgehog	Inflammation/Immunology
Robotnikinin is a small molecule capable of binding to and inhibiting the activity of Sonic Hedgehog (Shh) signaling up stream of Smo .

HY-158059

DS-1-38	Hedgehog	Cancer
DS-1-38 is an EYA1 antagonist that blocks Sonic Hedgehog (SHH) signaling. EYA1 is a haloacid dehalogenase phosphatase and transcription factor that regulates tumorigenesis and proliferation in SHH medulloblastoma (SHH-MB) .

HY-108439

Neurodazine	Wnt Hedgehog	Neurological Disease
Neurodazine is a neurogenic inducer, serve as a promoter of neurogenesisin pluripotent cells. Neurodazine promotes neurogenesis by activating Wnt and *Shh* signaling pathways. .

HY-100224

SANT-1 2 Publications Verification	Smo Hedgehog	Cancer
SANT-1, a potent Smo antagonist, inhibits Hedgehog signaling. SANT-1 shows IC₅₀s of 20 nM and 30 nM in Shh-LIGHT2 and SmoA1-LIGHT2 assay, respectively .

HY-RS12865

SHH Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
SHH Human Pre-designed siRNA Set A contains three designed siRNAs for SHH gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

SHH Human Pre-designed siRNA Set A SHH Human Pre-designed siRNA Set A

HY-144881

(S)-HH2853	Histone Methyltransferase	Inflammation/Immunology Cancer
(S)-HH2853 (compound 200), a PYRIDINO five membered aromatic ring compound, is a potent EZH1/2 dual inhibitor with an IC₅₀ of <100 nM for EZH2_Y641F. (S)-HH2853 has the potential to be used in the research of anti-tumor or autoimmune diseases .

HY-147743

SMO-IN-1	Smo	Cancer
SMO-IN-1 (Compound 15) is an orally active Smoothened (SMO) inhibitor with an EC₅₀ of 89 nM against sonic Hh protein (shh) .

HY-147744

AZD7254	Smo	Cancer
AZD7254 is an orally active Smoothened (SMO) inhibitor with an EC₅₀ of 1.0 nM against sonic Hh protein (shh) .

HY-164500

MC3629	Apoptosis Histone Methyltransferase	Cancer
MC3629 is an inhibitor of histone methyltransferase (EZH2) with anti-tumor activity. MC3629 inhibits SHH MB cancer cell proliferation and self-renewal and induces apoptosis. MC3629 can be used to study drug resistance in tumor aggressiveness .

HY-120664

BRD50837	Hedgehog	Cancer
BRD50837 is a potent inhibitor of Sonic Hedgehog (Shh), with the EC₅₀ of 0.09 μM. BRD50837 plays an important role in cancer research .

HY-145387

MRT-81	Smo	Cancer
MRT-81 is a potent antagonist of human and rodent smoothened (Smo) receptors, with an IC₅₀ value of 41 nM in the Shh-light2 cells. MRT-81 has potent hedgehog inhibiting activity. MRT-81 can be used for the research of cancer .

HY-123781A

RUSKI-201 dihydrochloride	Hedgehog	Cancer
RUSKI-201 dihydrochloride is a potent and specific Hedgehog acyltransferase (Hhat) inhibitor with an IC₅₀ of 0.20 μM. RUSKI-201 dihydrochloride is able to block Hh signaling from Shh overexpressing cells and inhibits Hh palmitoylation. RUSKI-201 dihydrochloride is potential Hhat chemical probe in cells and can used in studies of Hhat catalytic function .

HY-123781

RUSKI-201	Hedgehog	Cancer
RUSKI-201 is a potent and specific Hedgehog acyltransferase (Hhat) inhibitor, with an IC₅₀ of 0.20 μM. RUSKI-201 is able to block Hh signaling from Shh overexpressing cells and inhibits Hh palmitoylation. RUSKI-201 is potential Hhat chemical probe in cells and can used in studies of Hhat catalytic function .

HY-116455

BRD-9526	Fluorescent Dye	Cancer
BRD-9526 is a potent and selective Sonic Hedgehog (Shh) pathway inhibitor with potential anti-cancer activity. The mechanism of BRD-9526 is similar in some ways to commonly used inhibitors such as cyclopamine, but is significantly different in other ways. The discovery of BRD-9526 may provide a useful probe for studying complex signaling pathways .

Species:	Human (4) Mouse (5)
Tag:	His (2) Tag Free (7)
Source:	HEK293 (3) CHO (1) E. coli (5)

Cat. No.	Compare	Product Name	Species	Source

HY-P70467

	SHH Protein, Human Sonic Hedgehog Protein; SHH; HHG-1	Human	E. coli
	SHH, Human, as a recombinant protein, is part of a small group of secreted proteins that are vital for development in both vertebrates and invertebrates. SHH, Human, produced in E.Coli, is a single, non-glycosylated polypeptide chain. SHH plays an important role in prostate cancer progression.

HY-P7290

	SHH Protein, Mouse rMuSHH; HHG-1; SHHNC	Mouse	E. coli
	SHH Protein, Mouse is a morphogenic factor that actively orchestrates many aspects of cerebellar development and maturation.

HY-P7288

	SHH Protein, Mouse (CHO) rMuSHH; HHG-1; SHHNC	Mouse	CHO
	SHH Protein, Mouse (CHO) is a morphogenic factor that actively orchestrates many aspects of cerebellar development and maturation.

HY-P73417

	SHH Protein, Human (HEK293, His) Sonic Hedgehog Protein; SHH; HHG-1; SHHNC	Human	HEK293
	The SHH protein is cleaved into ShhN and ShhC fragments through autoproteolysis and cholesterol transferase activity. In the endoplasmic reticulum, ShhC is degraded, leaving behind lipidated ShhNp that is critical for developmental patterning. SHH Protein, Human (HEK293, His) is the recombinant human-derived SHH protein, expressed by HEK293 , with C-His labeled tag. The total length of SHH Protein, Human (HEK293, His) is 197 a.a., with molecular weight of ~24 kDa.

HY-P73418

	SHH Protein, Mouse (HEK293, His) 1 Publications Verification Sonic Hedgehog Protein; SHH; HHG-1; SHHNC	Mouse	HEK293
	Sonic hedgehog (SHH) undergoes autoproteolysis in the endoplasmic reticulum to produce ShhN and ShhC.ShhN is covalently linked to cholesterol to form ShhNp, a morphogen critical for developmental patterning.SHH Protein, Mouse (HEK293, His) is the recombinant mouse-derived SHH protein, expressed by HEK293 , with C-His labeled tag.

HY-P701100

	SHH Protein, Mouse (HEK293) rMuSHH; HHG-1; SHHNC	Mouse	HEK293
	SHH Protein, Mouse (HEK293) is a morphogenic factor that actively orchestrates many aspects of cerebellar development and maturation.

HY-P7407

	SHH Protein, Human (C24II) rHuSonic Hedgehog, C24II; HHG1	Human	E. coli
	SHH Protein, Human (C24II) is a recombinant human sonic hedgehog variant. SHH Protein is a secreted signal transducer responsible not only for patterning of the anterior–posterior axis during early limb and neuronal development, but also for generating cell-type diversity at later developmental stages.

HY-P7408

	SHH Protein, Human (C24IVI) rHuSonic Hedgehog, C24IVI; HHG1	Human	E. coli
	SHH Protein, Human (C24IVI) is a recombinant human sonic hedgehog variant. SHH Protein is a secreted signal transducer responsible not only for patterning of the anterior–posterior axis during early limb and neuronal development, but also for generating cell-type diversity at later developmental stages.

HY-P7409

	SHH Protein, Mouse (C25II) 2 Publications Verification rMuSonic Hedgehog, C25II; Hhg1	Mouse	E. coli
	SHH Protein, Mouse (C25II) is a recombinant mouse sonic hedgehog variant.

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HY-P81157

	Shh Antibody Sonic hedgehog; Vhh-1; Sonic hedgehog protein; SHH; HHG 1; HHG1; HLP 3; HLP3; Holoprosencephaly 3; HPE 3; HPE3; MCOPCB5; SMMC I; SMMCI; Sonic Hedgehog (Drosophila) homolog; sonic hedgehog homolog (Drosophila); Sonic hedgehog homolog; Sonic hedgehog protein; TPT; TPTPS; Sonic hedgehog protein N-product; SHH_HUMAN.	WB, ELISA, IHC-P, IHC-F, ICC/IF	Human, Mouse, Rat
	Shh Antibody is an unconjugated, approximately 19/47 kDa, rabbit-derived, anti-Shh polyclonal antibody. Shh Antibody can be used for: WB, ELISA, IHC-P, IHC-F, IF expriments in human, mouse, rat, and predicted: chicken, cow, horse, rabbit background without labeling.

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SHH Human Pre-designed siRNA Set A		siRNAs Pre-designed siRNA Sets
SHH Human Pre-designed siRNA Set A contains three designed siRNAs for SHH gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

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