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Results for "

SMARCA2/4 degrader

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Apoptosis (1) Drug Intermediate (1) E3 Ligase Ligand-Linker Conjugates (17) Epigenetic Reader Domain (25) Ligands for E3 Ligase (6) Ligands for Target Protein for PROTAC (7) PROTAC Linkers (11) PROTACs (35)
By Research Areas:	Cancer (71)
Click Chemistry:	Azide (11)

Inhibitors & Agonists

Click Chemistry

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-173333

*PROTAC SMARCA2/4* degrader-38**	PROTACs Epigenetic Reader Domain Apoptosis	Cancer
PROTAC SMARCA2/4 degrader-38 is a degrader *SMARCA2/4* PROTAC (DC₅₀: 3.0 nM and 4.0 nM respectively). PROTAC SMARCA2/4 degrader-38 promotes the ubiquitination and degradation of SMARCA2/4. PROTAC SMARCA2/4 degrader-38 blocks the G0/G1 cell cycle and induces apoptosis. PROTAC SMARCA2/4 degrader-38 can be used in acute myeloid leukemia (AML) research. (Pink: SMARCA2/4 ligand; Blue: VHL ligand (HY-112078); Black: linker; Target Protein Ligand-Linker Conjugates (HY-173343)) .

HY-169861

*PROTAC SMARCA2/4* degrader-37**	Epigenetic Reader Domain	Others
PROTAC SMARCA2/4 degrader-37 (Example 4) is a PROTAC-based *SMARCA2/4* degrader, with an IC₅₀ of ≤0.1 μM (Pink: SMARCA2/4 lignad (HY-172446); Black: CRBN ligand (HY-41547); Linker (HY-N2407)) .

HY-170347

*PROTAC SMARCA2/4* degrader-36**	PROTACs Epigenetic Reader Domain	Cancer
PROTAC SMARCA2/4 degrader-36 (Compound 29) is an effective dual degrader of *SMARCA2/4*,with DC₅₀ values of 0.22 nM and 0.85 nM for *SMARCA2* and *SMARCA4, respectively. PROTAC SMARCA2/4* degrader-36 has anti-cell proliferation activity (Pink: Target Protein Ligand (HY-170354); Black: Linker (HY-W895794); Blue: E3 Ligase Ligand (HY-170353); E3 Ligase Ligand-Linker Conjugate (HY-170356)) .

HY-159457

*PROTAC SMARCA2/4-degrader-6*	PROTACs Epigenetic Reader Domain	Cancer
PROTAC SMARCA2/4-degrader-6 (compound I-438) is a *SMARCA2/4* degrader. PROTAC SMARCA2/4-degrader-6 has the potential for the research of cancer. (Pink: SMARCA2/4 ligand, (HY-159545); Black: linker (HY-W006635); Blue: VHL ligand (HY-112078)) .

HY-159459

*PROTAC SMARCA2/4-degrader-32*	PROTACs	Cancer
PROTAC SMARCA2/4-degrader-32 (compound I-446) is a PROTAC degrader targeting *SMARCA2* and *SMARCA4; it degrades* SMARCA2/4 proteins in A549 cells with the DC₅₀s <100 nM, and the maximum degradation rate (Dmax%) >90 after 24 h of treatment .

HY-163869

*PROTAC SMARCA2/4-degrader-16*	PROTACs	Cancer
PROTAC SMARCA2/4-degrader-16 (compound I-337) is a PROTAC degrader targeting *SMARCA2* and *SMARCA4; it degrades* SMARCA2/4 proteins in A549 cells with the DC₅₀s <100 nM, and the maximum degradation rate (Dmax%) >90 after 24 h of treatment .

HY-159458

*PROTAC SMARCA2/4-degrader-7*	PROTACs	Cancer
SMARCA2/4-degrader-7 (compound I-439) is a PROTAC degrader targeting *SMARCA2* and *SMARCA4; it degrades* SMARCA2/4 proteins in A549 cells with the DC₅₀s <100 nM, and the maximum degradation rate (Dmax%) >90 after 24 h of treatment .

HY-159452

*PROTAC SMARCA2/4-degrader-1*	PROTACs	Cancer
SMARCA2/4-degrader-1 (compound I-430) is a PROTAC degrader targeting *SMARCA2* and *SMARCA4; it degrades* SMARCA2/4 proteins in A549 cells with the DC₅₀s <100 nM, and the maximum degradation rate (Dmax%) >90 after 24 h of treatment .

HY-159453

*PROTAC SMARCA2/4-degrader-2*	PROTACs	Cancer
SMARCA2/4-degrader-2 (compound I-431) is a PROTAC degrader targeting *SMARCA2* and *SMARCA4; it degrades* SMARCA2/4 proteins in A549 cells with the DC₅₀s <100 nM, and the maximum degradation rate (Dmax%) >90 after 24 h of treatment .

HY-162741

*PROTAC SMARCA2/4-degrader-33*	PROTACs	Cancer
PROTAC SMARCA2/4-degrader-33 (compound I-277) is a PROTAC degrader targeting *SMARCA2* and *SMARCA4; it degrades* SMARCA2/4 proteins in A549 cells with the DC₅₀s <100 nM, and the maximum degradation rate (Dmax%) >90 after 24 h of treatment .

HY-163875

*PROTAC SMARCA2/4-degrader-22*	PROTACs	Cancer
SMARCA2 degrader-14 (compound I-408) is a PROTAC degrader targeting *SMARCA2* and *SMARCA4; it degrades* SMARCA2/4 proteins in A549 cells with the DC₅₀s <100 nM, and the maximum degradation rate (Dmax%) >90 after 24 h of treatment .

HY-163876

*PROTAC SMARCA2/4-degrader-23*	PROTACs	Cancer
SMARCA2 degrader-15 (compound I-409) is a PROTAC degrader targeting *SMARCA2* and *SMARCA4; it degrades* SMARCA2/4 proteins in A549 cells with the DC₅₀s <100 nM, and the maximum degradation rate (Dmax%) >90 after 24 h of treatment .

HY-168225

*PROTAC SMARCA2/4-degrader-35*	PROTACs	Others
PROTAC SMARCA2/4-degrader-35 (Ex.43) is a SMARCA2/4 degrader with a DC₅₀ <2.5 nM. (Target ligand: HY-W874018; E3 ligand: HY-168226; linker: HY-168227; E3 ligand+linker: HY-168228)

HY-163872

*PROTAC SMARCA2/4-degrader-10*	PROTACs Epigenetic Reader Domain	Cancer
PROTAC SMARCA2/4-degrader-10 (compound I-399) is a potent *SMARCA2* degrader with an DC₅₀ value of ＜100 nM. PROTAC SMARCA2/4-degrader-10 has the potential for the research of cancer (Blue:SMARCA2/4 ligand, (HY-159542); Black: linker (HY-W088435); Pink:VHL ligand (HY-125845)) .

HY-162813

*PROTAC SMARCA2/4-degrader-25*	PROTACs Epigenetic Reader Domain	Cancer
PROTAC SMARCA2/4-degrader-25 (compound 7d) is a PROTAC targeting *SMARCA2/4. PROTAC SMARCA2/4*-degrader-25 is composed of E3 ligase (2S,4R)-4-Hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide (HY-W998248) (blue part), PROTAC Linker (S)-2-Amino-3,3-dimethylbutanoic acid (HY-59140) (black part), and target protein ligand SMARCA2/4-ligand-3 (HY-162814) (red part). The conjugate of E3 ubiquitin ligase ligand + Linker is (S,R,S)-AHPC (HY-125845) ^{[1] ^.}

HY-169279

*PROTAC SMARCA2/4-degrader-34*	Epigenetic Reader Domain PROTACs	Cancer
PROTAC SMARCA2/4-degrader-34 (compound 38) is a potent is a potent *SMARCA2* and *SMARCA4* PROTAC degrader. PROTAC SMARCA2/4-degrader-34 shows PXR binding affinity with DC₅₀ value of 85.1 nM. PROTAC SMARCA2/4-degrader-34 decreases the protein expression of 3xFLAG-PXR. (Pink: Ligand for target protein (HY-169280); Black: Linker (HY-43048); Blue: Ligand for E3 ligase (HY-125845) .

HY-159454

*PROTAC SMARCA2/4-degrader-3*	PROTACs	Cancer
SMARCA2/4-degrader-3 (compound I-433) is a PROTAC *SMARCA2/4*-degrader based on VH032-NH2, with a degradation potency (DC₅₀) <100 nM in MV4-11 cells .

HY-163868

*PROTAC SMARCA2/4-degrader-15*	PROTACs Epigenetic Reader Domain	Cancer
PROTAC SMARCA2/4-degrader-15 (Compound I-335) is a PROTAC degrader for catalytic subunit of the SWI/SNF complex *SMARCA2* and *SMARCA4. PROTAC SMARCA2/4-degrader-15 degrades* *SMARCA2* in A549 with DC₅₀ <100 nM, degrades *SMARCA4* in MV411 with DC₅₀ <100 nM. (Pink: Ligand for Target Protein (HY-159545); Black: Linker (HY-N3024); Blue: Ligand for E3 Ligase (HY-125845))

HY-163871

*PROTAC SMARCA2/4-degrader-18*	PROTACs Epigenetic Reader Domain	Cancer
PROTAC SMARCA2/4-degrader-18 (Compound I-348) is a PROTAC degrader for catalytic subunit of the SWI/SNF complex *SMARCA2* and *SMARCA4. PROTAC SMARCA2/4-degrader-18 degrades* *SMARCA2* in A549 with DC₅₀ <100 nM, degrades *SMARCA4* in MV411 with DC₅₀ <100 nM. (Pink: Ligand for Target Protein (HY-159531); Black: Linker (HY-76547); Blue: Ligand for E3 Ligase (HY-125845))

HY-163870

*PROTAC SMARCA2/4-degrader-17*	PROTACs Epigenetic Reader Domain	Cancer
PROTAC SMARCA2/4-degrader-17 (Compound I-345) is a PROTAC degrader for catalytic subunit of the SWI/SNF complex *SMARCA2* and *SMARCA4. PROTAC SMARCA2/4-degrader-17 degrades* *SMARCA2* in A549 with DC₅₀ <100 nM, degrades *SMARCA4* in MV411 with DC₅₀ <100 nM. (Pink: Ligand for Target Protein (HY-159545); Black: Linker (HY-W053507); Blue: Ligand for E3 Ligase (HY-125845))

HY-162743

*PROTAC SMARCA2/4-degrader-29*	PROTACs Epigenetic Reader Domain	Cancer
PROTAC SMARCA2/4-degrader-29 (Compound I-279) is a PROTAC degrader for catalytic subunit of the SWI/SNF complex *SMARCA2* and *SMARCA4. PROTAC SMARCA2/4-degrader-29 degrades* *SMARCA2* in A549 with DC₅₀ <100 nM, degrades *SMARCA4* in MV411 with DC₅₀ <100 nM. (Pink: ligand for target protein (HY-163926); Black: linker (HY-159682); Blue: ligand for E3 ligase (HY-W382038)) .

HY-162744

*PROTAC SMARCA2/4-degrader-31*	PROTACs Epigenetic Reader Domain	Cancer
PROTAC SMARCA2/4-degrader-31 (Compound I-280) is a degrader for catalytic subunit of the SWI/SNF complex *SMARCA2* and *SMARCA4. PROTAC SMARCA2/4-degrader-31 degrades* *SMARCA2* in A549 with DC₅₀ <100 nM, degrades *SMARCA4* in MV411 with DC₅₀ <100 nM. (Pink: Ligand for target protein (HY-163926); Black: Linker (HY-159682); Blue: Ligand for E3 ligase (HY-W382038)) .

HY-163877

*PROTAC SMARCA2/4-degrader-19*	PROTACs Epigenetic Reader Domain	Cancer
PROTAC SMARCA2/4-degrader-19 (Compound I-412) is a PROTAC degrader for catalytic subunit of the SWI/SNF complex *SMARCA2* and *SMARCA4. PROTAC SMARCA2/4-degrader-19 degrades* *SMARCA2* in MV411 and in A549 with DC₅₀ <100 nM, degrades *SMARCA4* in MV411 with DC₅₀ <100 nM. (Pink: Ligand for Target Protein (HY-163949); Black: Linker (HY-W006635); Blue: Ligand for E3 Ligase (HY-125845))

HY-163873

*PROTAC SMARCA2/4-degrader-20*	PROTACs Epigenetic Reader Domain	Cancer
PROTAC SMARCA2/4-degrader-20 (Compound I-405) is a PROTAC degrader for catalytic subunit of the SWI/SNF complex *SMARCA2. PROTAC SMARCA2/4-degrader-20 degrades* *SMARCA2* in A549 and MV411 with DC₅₀ <100 nM, degrades *SMARCA4* in MV411 with DC₅₀ of 100-500 nM. (Pink: Ligand for Target Protein (HY-159545); Black: Linker (HY-W006635); Blue: Ligand for E3 Ligase (HY-163932))

HY-162748

*PROTAC SMARCA2/4-degrader-30*	PROTACs Epigenetic Reader Domain	Cancer
PROTAC SMARCA2/4-degrader-30 (Compound I-291) is a PROTAC degrader for catalytic subunit of the SWI/SNF complex *SMARCA2* and *SMARCA4. PROTAC SMARCA2/4-degrader-30 degrades* *SMARCA2* in A549 and in MV411 with DC₅₀ <100 nM, degrades *SMARCA4* in MV411 with DC₅₀ <100 nM. (Pink: ligand for target protein (HY-163926); Black: linker (HY-159684); Blue: ligand for E3 ligase (HY-W382038)) .

HY-159455

*PROTAC SMARCA2/4-degrader-4*	PROTACs Epigenetic Reader Domain	Cancer
PROTAC SMARCA2/4-degrader-4 (Compound I-434) is a PROTAC degrader for catalytic subunit of the SWI/SNF complex *SMARCA2* and *SMARCA4. PROTAC SMARCA2/4-degrader-4 degrades* *SMARCA2* in MV411 and in A549 with DC₅₀ <100 nM, degrades *SMARCA4* in MV411 with DC₅₀ <100 nM. (Pink: Ligand for target protein (HY-159472); Black: Linker (HY-159478); Blue: Ligand for E3 ligase (S,R,S)-AHPC (HY-125845))

HY-159456

*PROTAC SMARCA2/4-degrader-5*	PROTACs Epigenetic Reader Domain	Cancer
PROTAC SMARCA2/4-degrader-5 (Compound I-437) is a PROTAC degrader for catalytic subunit of the SWI/SNF complex *SMARCA2* and *SMARCA4. PROTAC SMARCA2/4-degrader-5 degrades* *SMARCA2* in MV411 and in A549 with DC₅₀ <100 nM, degrades *SMARCA4* in MV411 with DC₅₀ of 100-500 nM. (Pink: Ligand for target protein (HY-159545); Black: Linker (HY-159557); Blue: Ligand for E3 ligase (S,R,S)-AHPC (HY-125845))

HY-159460

*PROTAC SMARCA2/4-degrader-8*	PROTACs Epigenetic Reader Domain	Cancer
PROTAC SMARCA2/4-degrader-8 (Compound I-502) is a PROTAC degrader for catalytic subunit of the SWI/SNF complex *SMARCA2. PROTAC SMARCA2/4-degrader-8 degrades* *SMARCA2* with DC₅₀ <100 nM in A549 and in MV411, degrades *SMARCA4* with DC₅₀<100 nM in MV411(Pink: Ligand for target protein (HY-159545); Black: Linker (HY-W063924); Blue: Ligand for E3 ligase (S,R,S)-AHPC (HY-125845))

HY-162815

*PROTAC SMARCA2/4-degrader-26*	PROTACs Epigenetic Reader Domain	Cancer
PROTAC SMARCA2/4-degrader-26 (compound 6) is a PROTAC targeting SMARCA2/4. SMARCA2 and SMARCA4 are genes and cancer targets with complementary functions that catalyze nucleosome movement. PROTAC SMARCA2/4-degrader-25 is composed of PROTAC target protein ligand 2-(4-(3-Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)piperazin-1-yl)acetic acid (HY-46618) (red part), E3 ligase ligand (2S,4R)-4-Hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide (HY-W998248) (blue part), PROTAC linker (S)-2-Amino-3,3-dimethylbutanoic acid (HY-59140) (black part), and the conjugate composed of E3 ubiquitin ligase ligand + Linker is (S,R,S)-AHPC (HY-125845) ^{[1] ^.}

HY-159461

*PROTAC SMARCA2/4-degrader-9*	PROTACs Epigenetic Reader Domain	Cancer
PROTAC SMARCA2/4-degrader-9 (Compound I-503) is a PROTAC degrader for catalytic subunit of the SWI/SNF complex *SMARCA2* and *SMARCA4. PROTAC SMARCA2* degrader-9 degrades *SMARCA2* in MV411 and in A549 with DC₅₀ <100 nM, degrades *SMARCA4* in MV411 with DC₅₀ <100 nM . (Pink: Ligand for target protein (HY-159545); Black: Linker (HY-W006635); Blue: Ligand for E3 ligase (S,R,S)-AHPC (HY-125845))

HY-162835

*PROTAC SMARCA2/4-degrader-28*	PROTACs Epigenetic Reader Domain	Cancer
PROTAC SMARCA2/4-degrader-28 (PROTAC 1) is a PROTAC-based partial degrader of *SMARCA2* and *SMARCA4*(Bliue: CRL2 ^VHL ligand (S,R,S)-AHPC (HY-125845); Black: linker (HY-159680); Pink: a SMARCA-BD ligand (+)-JQ-1 (HY-13030)) .

HY-162834

*PROTAC SMARCA2/4-degrader-27*	PROTACs Epigenetic Reader Domain	Cancer
PROTAC SMARCA2/4-degrader-27 (PROTAC 2) is a PROTAC-based degrader of *SMARCA2* and *SMARCA4. (Blue: CRL2 ^VHL ligand VH032-cyclopropane-F (HY-125905); Black: linker (HY-159678);Pink: a SMARCA*-BD ligand 1 for PROTAC (HY-44012)) .

HY-172446

SMARCA2/4-ligand-5	Ligands for Target Protein for PROTAC Epigenetic Reader Domain	Others
SMARCA2/4-ligand-5 is a SMARCA2/4 ligand for PROTAC SMARCA2/4 degrader-37 (Example 4). PROTAC SMARCA2/4 degrader-37 (Example 4) is a PROTAC-based *SMARCA2/4* degrader, with an IC₅₀ of ≤0.1 μM .

HY-170354

SMARCA2/4-ligand-4	Ligands for Target Protein for PROTAC	Cancer
SMARCA2/4-ligand-4 is a PROTAC target protein ligand (Ligands for Target Protein for PROTACs). SMARCA2/4-ligand-4 can be used for the synthesis of PROTAC SMARCA2/4 degrader-36 (HY-170347) .

HY-153425

*PROTAC SMARCA2* degrader-2**	PROTACs	Cancer
PROTAC SMARCA2 degrader-2 is a potent and selective SMARCA2/4 PROTAC degrader with an IC₅₀ of <0.1 μΜ in HeLa HiBiT assay. PROTAC SMARCA2 degrader-2 is extracted from patent WO2023287787A1 and has the potential for SMARCA4-related or deficient cancer research .

HY-170353

E3 ligase Ligand 46	Ligands for E3 Ligase	Cancer
E3 ligase Ligand 46 is a ligand for E3 ligase, used for the synthesis of PROTAC SMARCA2/4 degrader-36 (HY-170347) .

HY-156568

SMD-3040	PROTACs Epigenetic Reader Domain	Cancer
SMD-3040 is a potent and selective of *SMARCA2* PROTAC degrader (DC₅₀: 12 nM). SMD-3040 contains SMARCA2/4 ligand, linker and VHL ligand. SMD-3040 demonstrates excellent degradation selectivity for SMARCA2 protein over SMARCA4 protein.SMD-3040 achieves strong tumor growth inhibition in xenograft models .

HY-156568A

SMD-3040 TFA	PROTACs Epigenetic Reader Domain	Cancer
SMD-3040 TFA is a selective degrader of *SMARCA2. SMD-3040 TFA contains SMARCA2/4* ligands, linker and VHL ligands and can be used for PROTAC drug synthesis. SMD-3040 TFA exhibits strong tumor growth inhibition in tumor xenograft models .

HY-163926

SMARCA2/4-IN-2	Ligands for Target Protein for PROTAC	Cancer
SMARCA2/4-IN-2 is a PROTAC target protein ligand (Ligands for Target Protein for PROTACs). SMARCA2/4-IN-2 can be used for synthesis PROTAC SMARCA2/4-degrader-5 (HY-159456) .

HY-163949

SMARCA2/4-IN-3	Ligands for Target Protein for PROTAC	Cancer
SMARCA2/4-IN-3 is a PROTAC target protein ligand (Ligands for Target Protein for PROTACs). SMARCA2/4-IN-3 can be used for synthesis PROTAC SMARCA2/4-degrader-19 (HY-163877) .

HY-162814

SMARCA2/4-ligand-3	Ligands for Target Protein for PROTAC	Cancer
SMARCA2/4-ligand-3 is a PROTAC target protein ligand (Ligands for Target Protein for PROTACs). SMARCA2/4-ligand-3 can be used for synthesis PROTAC SMARCA2/4-degrader-25 (HY-162813) .

HY-400685

SMD-3040 intermediate-2	Drug Intermediate	Cancer
SMD-3040 intermediate-2 is an intermediate in the synthesis of SMD-3040 (HY-156568). SMD-3040 contains SMARCA2/4 ligands, linker and VHL ligands and is a selective SMARCA2 degrader. MD-3040 can be used for ADC drug synthesis and has strong tumor growth inhibition in tumor xenograft models .

HY-W874018

SMARCA2 ligand-8	Ligands for Target Protein for PROTAC	Cancer
SMARCA2 ligand-8 can be used as the ligand of target protein *SMARCA2* for synthesis of PROTAC SMARCA2/4-degrader-35 (HY-168225) .

HY-170356

E3 Ligase Ligand-linker Conjugate 151	E3 Ligase Ligand-Linker Conjugates	Others
E3 Ligase Ligand-linker Conjugate 151 is a conjugate of the E3 ligase Ligand (HY-170353) and linker (HY-W895794). E3 Ligase Ligand-linker Conjugate 151 can be used to synthesize PROTAC SMARCA2/4 degrader-36 (HY-170347) .

HY-169280

PXR Ligand 2	Ligands for Target Protein for PROTAC	Cancer
PXR Ligand 2 (Compound 55) is the target protein ligand for PROTAC SMARCA2/4-degrader-34 (HY-169279) .

HY-43048

2-(2-((6-Chlorohexyl)oxy)ethoxy)acetic acid	PROTAC Linkers	Others
2-(2-((6-Chlorohexyl)oxy)ethoxy)acetic acid is a PROTACT linker in PROTAC SMARCA2/4-degrader-34 (HY-169279) .

HY-W560922

Piperazine-Ac-OMe	PROTAC Linkers	Cancer
Piperazine-Ac-OMe is a PROTAC linker. Piperazine-Ac-OMe can be used in the synthesis of PROTAC SMARCA2/4-degrader-32 (HY-159459) .

HY-W063924

Bpin-Cyclohexene-C-COOEt Ethyl-2-(4-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)cyclohex-3- enyl)acetate	PROTAC Linkers	Cancer
Bpin-Cyclohexene-C-COOEt is a PROTAC linker. Bpin-Cyclohexene-C-COOEt can be used in synthesis PROTAC SMARCA2/4-degrader-8 (HY-159460) .

HY-159592

Piperazine-Pyrimidine-Cyclohexane-COOEt	PROTAC Linkers	Cancer
Piperazine-Pyrimidine-Cyclohexane-COOEt is a PROTAC linker. Piperazine-Pyrimidine-Cyclohexane-COOEt can be used in the synthesis of PROTAC SMARCA2/4-degrader-1 (HY-159452) .

HY-168226

E3 ligase Ligand 34	Ligands for E3 Ligase	Others
E3 ligase Ligand 34 is the E3 ligase ligand part of PROTAC SMARCA2/4-degrader-35 (HY-168225) and can be utilized in the synthesis of PROTACs .

Cat. No.	Product Name		Classification

HY-159457

*PROTAC SMARCA2/4-degrader-6*		Azide
PROTAC SMARCA2/4-degrader-6 (compound I-438) is a *SMARCA2/4* degrader. PROTAC SMARCA2/4-degrader-6 has the potential for the research of cancer. (Pink: SMARCA2/4 ligand, (HY-159545); Black: linker (HY-W006635); Blue: VHL ligand (HY-112078)) .

HY-159459

*PROTAC SMARCA2/4-degrader-32*		Azide
PROTAC SMARCA2/4-degrader-32 (compound I-446) is a PROTAC degrader targeting *SMARCA2* and *SMARCA4; it degrades* SMARCA2/4 proteins in A549 cells with the DC₅₀s <100 nM, and the maximum degradation rate (Dmax%) >90 after 24 h of treatment .

HY-159458

*PROTAC SMARCA2/4-degrader-7*		Azide
SMARCA2/4-degrader-7 (compound I-439) is a PROTAC degrader targeting *SMARCA2* and *SMARCA4; it degrades* SMARCA2/4 proteins in A549 cells with the DC₅₀s <100 nM, and the maximum degradation rate (Dmax%) >90 after 24 h of treatment .

HY-159452

*PROTAC SMARCA2/4-degrader-1*		Azide
SMARCA2/4-degrader-1 (compound I-430) is a PROTAC degrader targeting *SMARCA2* and *SMARCA4; it degrades* SMARCA2/4 proteins in A549 cells with the DC₅₀s <100 nM, and the maximum degradation rate (Dmax%) >90 after 24 h of treatment .

HY-159453

*PROTAC SMARCA2/4-degrader-2*		Azide
SMARCA2/4-degrader-2 (compound I-431) is a PROTAC degrader targeting *SMARCA2* and *SMARCA4; it degrades* SMARCA2/4 proteins in A549 cells with the DC₅₀s <100 nM, and the maximum degradation rate (Dmax%) >90 after 24 h of treatment .

HY-159454

*PROTAC SMARCA2/4-degrader-3*		Azide
SMARCA2/4-degrader-3 (compound I-433) is a PROTAC *SMARCA2/4*-degrader based on VH032-NH2, with a degradation potency (DC₅₀) <100 nM in MV4-11 cells .

HY-159455

*PROTAC SMARCA2/4-degrader-4*		Azide
PROTAC SMARCA2/4-degrader-4 (Compound I-434) is a PROTAC degrader for catalytic subunit of the SWI/SNF complex *SMARCA2* and *SMARCA4. PROTAC SMARCA2/4-degrader-4 degrades* *SMARCA2* in MV411 and in A549 with DC₅₀ <100 nM, degrades *SMARCA4* in MV411 with DC₅₀ <100 nM. (Pink: Ligand for target protein (HY-159472); Black: Linker (HY-159478); Blue: Ligand for E3 ligase (S,R,S)-AHPC (HY-125845))

HY-159456

*PROTAC SMARCA2/4-degrader-5*		Azide
PROTAC SMARCA2/4-degrader-5 (Compound I-437) is a PROTAC degrader for catalytic subunit of the SWI/SNF complex *SMARCA2* and *SMARCA4. PROTAC SMARCA2/4-degrader-5 degrades* *SMARCA2* in MV411 and in A549 with DC₅₀ <100 nM, degrades *SMARCA4* in MV411 with DC₅₀ of 100-500 nM. (Pink: Ligand for target protein (HY-159545); Black: Linker (HY-159557); Blue: Ligand for E3 ligase (S,R,S)-AHPC (HY-125845))

HY-159460

*PROTAC SMARCA2/4-degrader-8*		Azide
PROTAC SMARCA2/4-degrader-8 (Compound I-502) is a PROTAC degrader for catalytic subunit of the SWI/SNF complex *SMARCA2. PROTAC SMARCA2/4-degrader-8 degrades* *SMARCA2* with DC₅₀ <100 nM in A549 and in MV411, degrades *SMARCA4* with DC₅₀<100 nM in MV411(Pink: Ligand for target protein (HY-159545); Black: Linker (HY-W063924); Blue: Ligand for E3 ligase (S,R,S)-AHPC (HY-125845))

HY-159461

*PROTAC SMARCA2/4-degrader-9*		Azide
PROTAC SMARCA2/4-degrader-9 (Compound I-503) is a PROTAC degrader for catalytic subunit of the SWI/SNF complex *SMARCA2* and *SMARCA4. PROTAC SMARCA2* degrader-9 degrades *SMARCA2* in MV411 and in A549 with DC₅₀ <100 nM, degrades *SMARCA4* in MV411 with DC₅₀ <100 nM . (Pink: Ligand for target protein (HY-159545); Black: Linker (HY-W006635); Blue: Ligand for E3 ligase (S,R,S)-AHPC (HY-125845))

HY-163926

SMARCA2/4-IN-2		Azide
SMARCA2/4-IN-2 is a PROTAC target protein ligand (Ligands for Target Protein for PROTACs). SMARCA2/4-IN-2 can be used for synthesis PROTAC SMARCA2/4-degrader-5 (HY-159456) .

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