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Pathways Recommended:	Stem Cell/Wnt Cell Cycle/DNA Damage

Results for "

Sickle Cell Disease

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Biochemical Assay Reagents (1) Histone Demethylase (1) Histone Methyltransferase (5) Molecular Glues (1) P-selectin (1) Phosphodiesterase (PDE) (1) Pyruvate Kinase (3)
By Research Areas:	Cancer (2) Cardiovascular Disease (11) Metabolic Disease (1) Neurological Disease (1)
Click Chemistry:	Azide (1)

Inhibitors & Agonists

Biochemical Assay Reagents

Inhibitory Antibodies

Click Chemistry

Targets Recommended: Itk TOPK NAMPT ALCAM/CD166 GDNF Receptor BCL6 Tim3 BMI1

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-148788

Osivelotor GBT-601; GBT-021601	Others	Others
Osivelotor is an orally effective small molecule. Osivelotor is an allosteric regulator of deoxyhemoglobin S (HbS). Osivelotor increases the affinity of HbS to oxygen, inhibits HbS polymerization, and thus prevents erythrocyte sickling in the blood. Osivelotor can be used for research of sickle cell disease (SCD) .

HY-18681

Voxelotor 5+ Cited Publications GBT 440	Others	Cardiovascular Disease
Voxelotor (GBT 440) is a potent inhibitor of haemoglobin S (HbS) polymerization. Voxelotor has the potential for sickle cell disease (SCD) treatment .

HY-109193

Tovinontrine IMR-687	Phosphodiesterase (PDE)	Cardiovascular Disease
Tovinontrine (IMR-687) is a highly potent and selective phosphodiesterase-9 (PDE9) inhibitor specifically for the treatment of sickle cell disease. IC₅₀s are 8.19 nM and 9.99 nM for PDE9A1 and PDE9A2, respectively .

HY-P9987

Crizanlizumab	P-selectin	Cardiovascular Disease
Crizanlizumab is an anti-P-selectin monoclonal antibody. Crizanlizumab binds to P-selectin and blocks its interaction with P-selectin glycoprotein ligand 1 (PSGL-1). Crizanlizumab prevents vaso-occlusive crises (VOCs) and can be used for research of sickle cell disease .

HY-139293

PF-07059013	Others	Cardiovascular Disease
PF-07059013 is an orally active and potent noncovalent modulator of sickled hemoglobin (HbS). PF-07059013 specifically binds to Hb with nanomolar affinity and displays strong partitioning into red blood cells (RBCs). PF-07059013 can be used for sickle cell disease (SCD) research .

HY-163823

WIZ degrader 6	Others	Others
WIZ degrader 6 (compound 10) is a WIZ degrader with the EC₅₀ of ＜0.01μM. WIZ degrader 6 can be used for study of sickle cell disease .

HY-163822

WIZ degrader 5	Others	Others
WIZ degrader 5 (compound 41) is a WIZ degrader and induces the degradation of WIZ with maximum degradation of 88.6% in 293T cells. WIZ degrader 5 can be used for study of sickle cell disease .

HY-159098

dWIZ-1	Others	Others
dWIZ-1 is a potent WIZ molecular glue degrader. dWIZ-1 recruitments WIZ(ZF7) to cereblon (CRBN) induces WIZ degradation. dWIZ-1 has the potential for the research of sickle cell disease (SCD) .

HY-161787

G9a-IN-2	Histone Methyltransferase	Others
G9a-IN-2 (Compound 7i) is an inhibitor for histone methyltransferases G9a with IC₅₀ of 0.024 μM. G9a-IN-2 reduces H3K9me2 levels and induces the mRNA expression of γ-globin mRNA. G9a-IN-2 shows the potential in ameliorating sickle cell disease (SCD) .

HY-163819

WIZ degrader 3	Others	Cardiovascular Disease
WIZ degrader 3 (Compound 29) is a degrader for widely interspaced zinc finger motifs (WIZ), with an AC₅₀ of 6.4 nM. WIZ degrader 3 induces the expression of fetal hemoglobin (HbF), with an EC₅₀ of 45 nM. WIZ degrader 3 can be used for the research of blood disorders, such as sickle cell disease and β- thalassemia .

HY-106509

Velaresol BW 12C; 12C79; BW 12C79	Others	Others
Velaresol (BW 12C) is a potent left-shifting anti-sickling compound in vitro . Sickle cell disease is an inherited disorder of the hemoglobin molecule. When hemoglobin molecules are exposed to a variety of environments, the red blood cell hemoglobin polymerizes, twists, and morphs into a sickle shape.

HY-P3180

Hemoglobin S	Biochemical Assay Reagents	Others
Abnormality of Hemoglobin is the main cause of sickle cell disease (SCD). Hemoglobin can be used in the determination of fetal hemoglobin by time-resolved immunofluorescence assay .

HY-163820

WIZ degrader 4	Others	Others
WIZ degrader 4 (Example 1) is a WIZ degrader with an AC₅₀ value of 160 nM. WIZ degrader 4 can be used to investigate sickle cell disease (SCD) and thalassemia .

HY-163824

WIZ degrader 7	Others	Others
WIZ degrader 7 (Example 16) is a WIZ degrader with an IC₅₀ value of < 0.01 μM. WIZ degrader 7 can be used to investigate sickle cell disease (SCD) and thalassemia .

HY-139573

Etavopivat FT-4202	Pyruvate Kinase	Cardiovascular Disease
Etavopivat is a potent, selective, and orally active erythrocyte pyruvate kinase (PKR) activator. Etavopivat has potent antisickling effects that can be used in studies of sickle cell disease and other haemoglobinopathies .

HY-139573A

(Rac)-Etavopivat (Rac)-FT-4202	Pyruvate Kinase	Cardiovascular Disease
(Rac)-Etavopivat ((Rac)-FT-4202) is an isomer of Etavopivat (HY-139573). Etavopivat is an orally active erythrocyte pyruvate kinase-R (PKR) activator that can be used in studies of sickle cell disease and other haemoglobinopathies .

HY-159095

PKR activator 5	Pyruvate Kinase	Others
PKR activator 5 (Compound 18) is an activator for pyruvate kinase R (PKR) with an AC₅₀ of 28 nM .

HY-139400A

Pociredir hydrochloride FTX-6058 hydrochloride	Histone Methyltransferase	Cardiovascular Disease
Pociredir (FTX-6058) hydrochloride is a potent and orally active inhibitor of Embryonic Ectoderm Development (EED). Pociredir hydrochloride can induce HbF protein expression in cell and murine models. Pociredir hydrochloride can be used for the research of select hemoglobinopathies, including sickle cell disease and β-thalassemia .

HY-139400

Pociredir FTX-6058	Histone Methyltransferase	Cardiovascular Disease
Pociredir (FTX-6058) is a potent and orally active inhibitor of Embryonic Ectoderm Development (EED). Pociredir can induce HbF protein expression in cell and murine models. Pociredir can be used for the research of select hemoglobinopathies, including sickle cell disease and β-thalassemia .

HY-152775A

RK-0133114	Histone Methyltransferase	Metabolic Disease
RK-0133114 is a G9a inhibitor and a R-enantiomer of RK-701 (HY-152775). RK-0133114 inhibits G9a with an IC₅₀ value of 3.7 μM. RK-0133114 can be used for the research of sickle cell disease (SCD) .

HY-162665

WIZ degrader 1	Others	Others
WIZ degrader 1 (Compound 141) is a degrader for widely interspaced zinc finger motifs (WIZ) with an AC₅₀ of 2 nM. WIZ degrader 1 induces the expression of fetal hemoglobin (HbF) with an EC₅₀ of 6 mM. WIZ degrader 1 is used in research of inherited blood disorders .

HY-153182

GBT1118	Others	Cardiovascular Disease
GBT1118 is a potent and orally active allosteric modifier of hemoglobin oxygen affinity. GBT1118 increases tolerance to severe hypoxia .

HY-150510

MS8511	Histone Methyltransferase	Neurological Disease Cancer
MS8511 is a selective G9a/GLP covalent irreversible inhibitor by targeting a cysteine residue at the substrate binding site, with IC₅₀ values of 100 nM (G9a) and 140 nM (GLP), and K_d values of 44 nM (G9a) and 46 nM (GLP). MS8511 reduces the cellular H3K9me2 level and enhances antiproliferation activity. MS8511 can be used for the research of several types of cancers including brain, breast, ovarian, lung, bladder, melanoma, colorectal cancer, and other disease such as Alzheimer’s disease (AD), sickle cell disease, Prader−Willi syndrome (PWS) .

HY-110130

RN-1 dihydrochloride	Histone Demethylase	Cardiovascular Disease Cancer
RN-1 dihydrochloride is a potent, brain-penetrant, irreversible and selective lysine-specific demethylase 1 (LSD1) inhibitor with an IC₅₀ of 70 nM. RN-1 dihydrochloride exhibits selectivity for LSD1 over MAO-A and MAO-B with IC₅₀ values of 0.51 μM and 2.785 μM respectively .

HY-159099

HbF inducer 2	Molecular Glues	Others
HbF inducer 3 (Compound dWIZ-2) is an orally active molecular glue, which degrades the WIZ transcription factor (DC₅₀=13 nM in primary human erythroid precursor cell) and induces the expression of fetal hemoglobin (HbF) (EC₅₀=100 nM). HbF inducer 3 exhibits good pharmacokinetic characteristics in cynomolgus monkeys .

HY-163818

WIZ degrader 2	Others	Others
WIZ degrader 2 (Compound 142) is a degrader for widely interspaced zinc finger motifs with an AC₅₀ of 0.011 μM. WIZ degrader 2 induces the expression of fetal hemoglobin (HbF) with an EC₅₀ of 0.038 μM. WIZ degrader 2 can be used in research about inherited blood disorders .

Cat. No.	Product Name	Type

HY-P3180

Hemoglobin S	Native Proteins
Abnormality of Hemoglobin is the main cause of sickle cell disease (SCD). Hemoglobin can be used in the determination of fetal hemoglobin by time-resolved immunofluorescence assay .

Cat. No.	Product Name	Target	Research Area

HY-P9987

Crizanlizumab	P-selectin	Cardiovascular Disease
Crizanlizumab is an anti-P-selectin monoclonal antibody. Crizanlizumab binds to P-selectin and blocks its interaction with P-selectin glycoprotein ligand 1 (PSGL-1). Crizanlizumab prevents vaso-occlusive crises (VOCs) and can be used for research of sickle cell disease .

Cat. No.	Product Name		Classification

HY-159095

PKR activator 5		Azide
PKR activator 5 (Compound 18) is an activator for pyruvate kinase R (PKR) with an AC₅₀ of 28 nM .

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