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Results for "

Toll-like receptor 4

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Toll-like Receptor (TLR) (24) Autophagy (1) Biochemical Assay Reagents (1) Cytochrome P450 (2) EBV (2) Endogenous Metabolite (2) Interleukin Related (1) MyD88 (1) TNF Receptor (1)
By Research Areas:	Cancer (6) Infection (4) Inflammation/Immunology (22) Metabolic Disease (2)
Oligonucleotides:	Solvents (1) Preservatives (1)

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Targets Recommended: Toll-like Receptor (TLR) Polo-like Kinase (PLK) NOD-like Receptor (NLR) KLF ANGPTL PERK ULK METTL3 MASTL ADAMTS IGF-1R LOX-1 Nuclear Hormone Receptor 4A/NR4A FLT3

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-U00435

Neoseptin 3 2 Publications Verification	Toll-like Receptor (TLR)	Cancer
Neoseptin 3 is a Toll-like receptor 4/myeloid differentiation factor 2 (mTLR4/MD-2) agonist with an EC₅₀ of 18.5 μM.

HY-130320

Monophosphoryl lipid A Glucopyranosyl lipid A	Toll-like Receptor (TLR)	Inflammation/Immunology Cancer
Monophosphoryl lipid A (Glucopyranosyl lipid A) is a **toll-like receptor 4** agonist. Monophosphoryl lipid A is derived from the cell wall of nonpathogenic Salmonella. Monophosphoryl lipid A can be used for the research of immunization and vaccine .

HY-P10208A

RKH acetate	Toll-like Receptor (TLR)	Infection Inflammation/Immunology
RKH acetate exerts protective effects against sepsis-induced death and organ damage. RKH acetate can directly bind to **Toll-like receptor** 4 (TLR4) and block TLR4 signal transduction in immune cells .

HY-159670B

Monophosphoryl Lipid A-12 triethylamine MPLA-12 triethylamine	Toll-like Receptor (TLR)	Inflammation/Immunology
Monophosphoryl Lipid A-12 (triethylamine) is a **toll-like receptor 4** agonist. Monophosphoryl Lipid A-12 (triethylamine) can be used for the research of immunization and vaccine .

HY-159670A

Monophosphoryl Lipid A-12 free acid MPLA-12 free acid	Toll-like Receptor (TLR)	Inflammation/Immunology
Monophosphoryl Lipid A-12 (free acid) is a **toll-like receptor 4** agonist. Monophosphoryl Lipid A-12 (free acid) can be used for the research of immunization and vaccine .

HY-164173

LPS-PG	Toll-like Receptor (TLR) MyD88	Inflammation/Immunology
LPS-PG is a lipopolysaccharide from Porphyromonas gingivalis (P. gingivalis). LPS-PG is an important virulence factor in the pathogenesis of periodontal disease and activates immune cells via Toll-like receptor 2 (TLR2), rather than the receptor for Escherichia coli (E. coli), Toll-like receptor 4 (TLR4). A lipoprotein from LPS-PG has been shown to be the major component responsible for TLR2-mediated cell activation .

HY-130320A

Monophosphoryl lipid A free acid Glucopyranosyl lipid A free acid	Toll-like Receptor (TLR)	Inflammation/Immunology
Monophosphoryl lipid A (free acid) is a **toll-like receptor 4** agonist. Monophosphoryl lipid A (free acid) is derived from the cell wall of nonpathogenic Salmonella. Monophosphoryl lipid A (free acid) can be used for the research of immunization and vaccine .

HY-130320B

Monophosphoryl lipid A Triethylamine Glucopyranosyl lipid A Triethylamine	Toll-like Receptor (TLR)	Inflammation/Immunology
Monophosphoryl lipid A (Triethylamine) is a **toll-like receptor 4** agonist. Monophosphoryl lipid A (Triethylamine) is derived from the cell wall of nonpathogenic Salmonella. Monophosphoryl lipid A (Triethylamine) can be used for the research of immunization and vaccine .

HY-149650

TLR4 agonist-1	Toll-like Receptor (TLR)	Inflammation/Immunology
TLR4 agonist-1 (compound 17a) is a potent agonist of Toll-like Receptor 4 (TLR4), and induces the generation of MIP-1β in RAW 264.7 and MM6 cells .

HY-149650A

TLR4 agonist-1 TEA	Toll-like Receptor (TLR)	Inflammation/Immunology
TLR4 agonist-1 (TEA) (compound 17a) is a potent agonist of Toll-like Receptor 4 (TLR4), and induces the generation of MIP-1β in RAW 264.7 and MM6 cells .

HY-B0892

Benzyl alcohol Benzenemethanol	Cytochrome P450 Toll-like Receptor (TLR)	Inflammation/Immunology
Benzyl alcohol is an aromatic alcohol, a colorless liquid with a mild aromatic odor. Benzyl alcohol is an inhibitor of P450 enzyme. Benzyl alcohol mediated **Toll-Like Receptor 4** to reduce the inflammatory response of liver injury in mice .

HY-144002

RIBI-529 RC-529	Biochemical Assay Reagents	Inflammation/Immunology
RIBI-529 (RC-529), a lipid A mimetic (aminoalkyl glucosaminide 4-phosphate), is a adjuvant with a similar efficacy to MPL (Corixa). RIBI-529 signals through Toll-like receptor 4 to stimulate the innate immune system .

HY-N10521

6'-Sialyllactose	Toll-like Receptor (TLR)	Inflammation/Immunology
6'-Sialyllactose is a sialylated human milk oligosaccharide that can promote the proliferation of bifidobacteria and shaping the gut microbiota. 6'-Sialyllactose also inhibits **toll-like receptor 4** signaling and protects against the development of necrotizing enterocolitis .

HY-103639

M62812 free base	Toll-like Receptor (TLR)	Inflammation/Immunology
M62812 (free base) is a toll-like receptor 4 (TLR4) signal transduction inhibitor. M62812 can suppress endothelial cell and leukocyte activation and prevents lethal septic shock in mice. M62812 can be used for the research of sepsis .

HY-103639A

M62812	Toll-like Receptor (TLR)	Infection
M62812 is a toll-like receptor 4 (TLR4) signaling inhibitor. M62812 inhibits endothelial and leukocyte activation and prevents lethal septic shock in mice. M62812 can reduces LPS-induced coagulation and inflammatory responses. M62812 can be used for the research of sepsis .

HY-B0892R

Benzyl alcohol (Standard) Benzenemethanol (Standard)	Toll-like Receptor (TLR) Cytochrome P450	Inflammation/Immunology
Benzyl alcohol (Standard) is the analytical standard of Benzyl alcohol. This product is intended for research and analytical applications. Benzyl alcohol is an aromatic alcohol, a colorless liquid with a mild aromatic odor. Benzyl alcohol is an inhibitor of P450 enzyme. Benzyl alcohol mediated **Toll-Like Receptor 4** to reduce the inflammatory response of liver injury in mice .

HY-141537

ABR-238901 4 Publications Verification	Toll-like Receptor (TLR)	Inflammation/Immunology
ABR-238901 is an orally active and potent S100A8/A9 blocker and inhibits S100A8/A9 interaction with its receptors RAGE (receptor for advanced glycation endproducts) and TLR4 (toll-like receptor 4). ABR-238901 has the potential for myocardial infarction (MI) research .

HY-105070

Eritoran E5564 free base	EBV Toll-like Receptor (TLR)	Infection
Eritoran （E5564 free base） is a **Toll-like receptor 4 (TLR4**) antagonist. Eritoran protects mice against lethal influenza virus infection, such as Ebola virus (EBOV), Marburg virus (MARV). Eritoran decreases the level of granulocytosis, may alleviate the severity of the "cytokine storm". Eritoran inhibits pathogenesis of filovirus infection. Eritoran has anti-inflammatory activity .

HY-105070A

Eritoran tetrasodium E5564	EBV Toll-like Receptor (TLR)	Infection Inflammation/Immunology
Eritoran tetrasodium (E5564) is a **Toll-like receptor 4 (TLR4**) antagonist. Eritoran tetrasodium protects mice against lethal influenza virus infection, such as Ebola virus (EBOV), Marburg virus (MARV). Eritoran tetrasodium decreases the level of granulocytosis, may alleviate the severity of the "cytokine storm". Eritoran tetrasodium inhibits pathogenesis of filovirus infection. Eritoran tetrasodium has anti-inflammatory activity .

HY-11109

Resatorvid Maximum Cited Publications 380 Publications Verification TAK-242; CLI-095	Toll-like Receptor (TLR) TNF Receptor Interleukin Related Autophagy	Inflammation/Immunology Cancer
Resatorvid (TAK-242) is a selective Toll-like receptor 4 (TLR4) inhibitor. Resatorvid inhibits NO, TNF-α and IL-6 production with IC_50s of 1.8 nM, 1.9 nM and 1.3 nM, respectively. Resatorvid downregulates expression of TLR4 downstream signaling molecules MyD88 and TRIF. Resatorvid inhibits autophagy and plays pivotal role in various inflammatory diseases .

HY-128598

MD2-TLR4-IN-1	Toll-like Receptor (TLR)	Inflammation/Immunology Cancer
MD2-TLR4-IN-1 (compound 22m) is an inhibitor of myeloid differentiation protein 2/toll-like receptor 4 (MD2-TLR4) complex, inhibiting lipopolysaccharides (LPS)-induced expression of tumor necrosis factor alpha (TNF-α) and interleukin-6 (IL-6) in macrophages with IC₅₀ values of 0.89 μM and 0.53 μM, respectively .

HY-N6612

D-Glucuronic acid 1 Publications Verification	Endogenous Metabolite Toll-like Receptor (TLR)	Metabolic Disease Inflammation/Immunology Cancer
D-Glucuronic acid is a major component of many anti-inflammatory proteoglycans, which can promote embryonic development and inhibit cell aggregation. After being metabolized into ethyl glucuronide (HY-113093), D-Glucuronic acid activates **Toll-like receptor 4** (TLR4), causing pain. D-Glucuronic acid and its derivative glucurono-lactone can serve as liver detoxifiers for human health prevention, and its derivatives also possess anti-tumor activity .

HY-N6612R

D-Glucuronic acid (Standard)	Endogenous Metabolite Toll-like Receptor (TLR)	Metabolic Disease Inflammation/Immunology Cancer
D-Glucuronic acid (Standard) is the analytical standard of D-Glucuronic acid. This product is intended for research and analytical applications. D-Glucuronic acid is a major component of many anti-inflammatory proteoglycans, which can promote embryonic development and inhibit cell aggregation. After being metabolized into ethyl glucuronide (HY-113093), D-Glucuronic acid activates Toll-like receptor 4 (TLR4), causing pain. D-Glucuronic acid and its derivative glucurono-lactone can serve as liver detoxifiers for human health prevention, and its derivatives also possess anti-tumor activity .

HY-123789

T5342126	Toll-like Receptor (TLR)	Inflammation/Immunology
T-5342126 is a toll-like receptor 4 (TLR4) antagonist. It reduces LPS-induced production of nitric oxide (NO) in RAW 264.7 cells (IC₅₀=27.8 μM), as well as decreases LPS-induced IL-8, TNF-α, and IL-6 production in isolated human whole blood (IC₅₀s=110.5, 315.6, and 318.4 μM, respectively). T-5342126 (82 mg/kg) reduces ethanol intake and the abundance of ionized calcium-binding adapter molecule 1 (Iba1), a marker of microglial activation, in the central nucleus of the amygdala in ethanol-dependent mice.

HY-D1056C2

Lipopolysaccharides, from S. enterica serotype minnesota LPS, from Salmonella enterica (Serotype minnesota)	Toll-like Receptor (TLR)	Inflammation/Immunology
Lipopolysaccharides (LPS) are specific endotoxins and one of the major components of the cell wall of Gram-negative bacteria. Lipopolysaccharides consist of three parts: lipid A, core oligosaccharide, and O-specific polysaccharide. Lipopolysaccharides are powerful immune stimulants that can activate the host immune system, particularly by binding to Toll-like receptor 4 (TLR4) on the surface of immune cells, triggering an inflammatory response. The LPS of most Salmonella serotypes has a complex O-antigen (OAg) structure, with the number of OAg units in the core polysaccharide varying between 16 and over 100 repeats. Mutations in OAg-regulating factors that alter the OAg structure can change the interaction between Salmonella and epithelial cells. Strains with long OAg have increased SPI1-T3SS effector protein translocation and invasion. Strains completely lacking OAg exhibit increased invasiveness and higher adhesiveness. This product is derived from Salmonella enterica serotype Minnesota. Lipopolysaccharides, from S. enterica serotype minnesota, can be used to study host immune system activation and its role in inflammation and immune regulation .

Cat. No.	Product Name	Type

HY-144002

RIBI-529 RC-529	Drug Delivery
RIBI-529 (RC-529), a lipid A mimetic (aminoalkyl glucosaminide 4-phosphate), is a adjuvant with a similar efficacy to MPL (Corixa). RIBI-529 signals through Toll-like receptor 4 to stimulate the innate immune system .

HY-D1056C2

Lipopolysaccharides, from S. enterica serotype minnesota LPS, from Salmonella enterica (Serotype minnesota)	Carbohydrates
Lipopolysaccharides (LPS) are specific endotoxins and one of the major components of the cell wall of Gram-negative bacteria. Lipopolysaccharides consist of three parts: lipid A, core oligosaccharide, and O-specific polysaccharide. Lipopolysaccharides are powerful immune stimulants that can activate the host immune system, particularly by binding to Toll-like receptor 4 (TLR4) on the surface of immune cells, triggering an inflammatory response. The LPS of most Salmonella serotypes has a complex O-antigen (OAg) structure, with the number of OAg units in the core polysaccharide varying between 16 and over 100 repeats. Mutations in OAg-regulating factors that alter the OAg structure can change the interaction between Salmonella and epithelial cells. Strains with long OAg have increased SPI1-T3SS effector protein translocation and invasion. Strains completely lacking OAg exhibit increased invasiveness and higher adhesiveness. This product is derived from Salmonella enterica serotype Minnesota. Lipopolysaccharides, from S. enterica serotype minnesota, can be used to study host immune system activation and its role in inflammation and immune regulation .

Lipopolysaccharides, from S. enterica serotype minnesota

LPS, from Salmonella enterica (Serotype minnesota)

Carbohydrates

Lipopolysaccharides (LPS) are specific endotoxins and one of the major components of the cell wall of Gram-negative bacteria. Lipopolysaccharides consist of three parts: lipid A, core oligosaccharide, and O-specific polysaccharide. Lipopolysaccharides are powerful immune stimulants that can activate the host immune system, particularly by binding to Toll-like receptor 4 (TLR4) on the surface of immune cells, triggering an inflammatory response. The LPS of most Salmonella serotypes has a complex O-antigen (OAg) structure, with the number of OAg units in the core polysaccharide varying between 16 and over 100 repeats. Mutations in OAg-regulating factors that alter the OAg structure can change the interaction between Salmonella and epithelial cells. Strains with long OAg have increased SPI1-T3SS effector protein translocation and invasion. Strains completely lacking OAg exhibit increased invasiveness and higher adhesiveness. This product is derived from Salmonella enterica serotype Minnesota. Lipopolysaccharides, from S. enterica serotype minnesota, can be used to study host immune system activation and its role in inflammation and immune regulation .

Cat. No.	Product Name	Target	Research Area

HY-P10208A

RKH acetate	Toll-like Receptor (TLR)	Infection Inflammation/Immunology
RKH acetate exerts protective effects against sepsis-induced death and organ damage. RKH acetate can directly bind to **Toll-like receptor** 4 (TLR4) and block TLR4 signal transduction in immune cells .

Benzyl alcohol Benzenemethanol	Structural Classification Natural Products Microorganisms Classification of Application Fields Source classification Inflammation/Immunology Disease Research Fields	Cytochrome P450 Toll-like Receptor (TLR)
Benzyl alcohol is an aromatic alcohol, a colorless liquid with a mild aromatic odor. Benzyl alcohol is an inhibitor of P450 enzyme. Benzyl alcohol mediated **Toll-Like Receptor 4** to reduce the inflammatory response of liver injury in mice .

6'-Sialyllactose	Structural Classification Polysaccharides Endogenous metabolite Saccharides	Toll-like Receptor (TLR)
6'-Sialyllactose is a sialylated human milk oligosaccharide that can promote the proliferation of bifidobacteria and shaping the gut microbiota. 6'-Sialyllactose also inhibits **toll-like receptor 4** signaling and protects against the development of necrotizing enterocolitis .

D-Glucuronic acid 1 Publications Verification	Structural Classification Human Gut Microbiota Metabolites Classification of Application Fields Ketones, Aldehydes, Acids Source classification Endogenous metabolite Inflammation/Immunology Disease Research Fields	Endogenous Metabolite Toll-like Receptor (TLR)
D-Glucuronic acid is a major component of many anti-inflammatory proteoglycans, which can promote embryonic development and inhibit cell aggregation. After being metabolized into ethyl glucuronide (HY-113093), D-Glucuronic acid activates **Toll-like receptor 4** (TLR4), causing pain. D-Glucuronic acid and its derivative glucurono-lactone can serve as liver detoxifiers for human health prevention, and its derivatives also possess anti-tumor activity .

Benzyl alcohol (Standard) Benzenemethanol (Standard)	Structural Classification Natural Products Microorganisms Classification of Application Fields Source classification Other Diseases Disease Research Fields	Toll-like Receptor (TLR) Cytochrome P450
Benzyl alcohol (Standard) is the analytical standard of Benzyl alcohol. This product is intended for research and analytical applications. Benzyl alcohol is an aromatic alcohol, a colorless liquid with a mild aromatic odor. Benzyl alcohol is an inhibitor of P450 enzyme. Benzyl alcohol mediated **Toll-Like Receptor 4** to reduce the inflammatory response of liver injury in mice .

D-Glucuronic acid (Standard)	Structural Classification Human Gut Microbiota Metabolites Ketones, Aldehydes, Acids Source classification Endogenous metabolite	Endogenous Metabolite Toll-like Receptor (TLR)
D-Glucuronic acid (Standard) is the analytical standard of D-Glucuronic acid. This product is intended for research and analytical applications. D-Glucuronic acid is a major component of many anti-inflammatory proteoglycans, which can promote embryonic development and inhibit cell aggregation. After being metabolized into ethyl glucuronide (HY-113093), D-Glucuronic acid activates Toll-like receptor 4 (TLR4), causing pain. D-Glucuronic acid and its derivative glucurono-lactone can serve as liver detoxifiers for human health prevention, and its derivatives also possess anti-tumor activity .

Cat. No.	Compare	Product Name	Species	Source

HY-P73586

	TLR4 Protein, Human (sf9, His) 1 Publications Verification CD284; hToll; TLR-4; Toll like receptor 4 protein; Toll	Human	Sf9 insect cells
	TLR4 is a transmembrane receptor that recognizes PAMPs and DAMPs and cooperates with LY96 for LPS detection. TLR4 activates MYD88-dependent and independent signaling pathways and participates in TIRAP, TRAF6 and CD14-mediated endocytosis. TLR4 Protein, Human (sf9, His) is the recombinant human-derived TLR4 protein, expressed by Sf9 insect cells , with C-His labeled tag. The total length of TLR4 Protein, Human (sf9, His) is 608 a.a., with molecular weight of ~68 kDa.

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HY-P80918

	Toll-Like Receptor 4 Antibody TLR4; Toll-like receptor 4; hToll; CD antigen CD284	WB, FC	Human
	Toll-Like Receptor 4 Antibody is a non-conjugated and Rabbit origined polyclonal antibody about 96 kDa, targeting to Toll-Like Receptor 4. It can be used for WB,FC assays with tag free, in the background of Human.