2. Immunology/Inflammation Apoptosis Autophagy
  3. Toll-like Receptor (TLR) TNF Receptor Interleukin Related Autophagy
  4. Resatorvid

Resatorvid  (Synonyms: TAK-242; CLI-095)

Cat. No.: HY-11109 Purity: 99.10%
COA Handling Instructions

Molarity Calculator

Resatorvid (TAK-242) est un inhibiteur sélectif du Toll-like récepteur 4 (TLR4). Resatorvid inhibe la production de NO, TNF-R et IL-6 avec IC50s de 1,8 nM, 1,9 nM et 1,3 nM, respectivement. Resatorvid régule à la baisse l'expression des molécules de signalisation en aval TLR4 MyD88 et TRIF. Résatorvid inhibe l'autophagie et joue un rôle central dans diverses maladies inflammatoires.

Resatorvid (TAK-242) ist ein selektiver Inhibitor des Toll-like receptor 4 (TLR4). Resatorvid hemmt die NO, TNF-R und IL-6-Produktion mit IC50s von 1,8 nM, 1,9 nM bzw. 1,3 nM. Resatorvid regelt die Expression der TLR4 Downstream-Signalmoleküle MyD88 und TRIF herunter. Resatorvid hemmt die Autophagie und spielt eine zentrale Rolle bei verschiedenen entzündlichen .

Resatorvid (TAK-242) is a selective Toll-like receptor 4 (TLR4) inhibitor. Resatorvid inhibits NO, TNF-α and IL-6 production with IC50s of 1.8 nM, 1.9 nM and 1.3 nM, respectively. Resatorvid downregulates expression of TLR4 downstream signaling molecules MyD88 and TRIF. Resatorvid inhibits autophagy and plays pivotal role in various inflammatory diseases.

For research use only. We do not sell to patients.

Resatorvid Chemical Structure

Resatorvid Chemical Structure

CAS No. : 243984-11-4

Size Price Stock Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 USD 145 In-stock
Solution
10 mM * 1 mL in DMSO USD 145 In-stock
Solid
1 mg USD 53 In-stock
5 mg USD 132 In-stock
10 mg USD 204 In-stock
50 mg USD 640 In-stock
100 mg USD 1024 In-stock
200 mg   Get quote  
500 mg   Get quote  

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

Customer Review

Based on 426 publication(s) in Google Scholar

Other Forms of Resatorvid:

Resatorvid Related Antibodies

Top Publications Citing Use of Products

376 Publications Citing Use of MCE Resatorvid

WB
IHC
IF
Proliferation Assay

    Resatorvid purchased from MedChemExpress. Usage Cited in: Metabolites. 2022, 12(11), 1132

    Resatorvid (TAK-242; 0.1, 1, 10, 50 µM; 24 h) inhibits the proliferation of B16 cells and A375 cells in a dose-dependent manner.

    Resatorvid purchased from MedChemExpress. Usage Cited in: Anesthesiology. 2019 Feb;130(2):292-308.   [Abstract]

    Detection of PCNA by immunohistochemistry with the treatment of 2DG, MET and COM.

    Resatorvid purchased from MedChemExpress. Usage Cited in: Anesthesiology. 2019 Feb;130(2):292-308.   [Abstract]

    Detection of the expression of key glucose metabolism enzymes via western blotting with the treatment of 2DG, MET and COM.

    Resatorvid purchased from MedChemExpress. Usage Cited in: Anesthesiology. 2019 Feb;130(2):292-308.   [Abstract]

    Detection of PCNA by western blotting with the treatment of 2DG, MET and COM.

    Resatorvid purchased from MedChemExpress. Usage Cited in: Anesthesiology. 2019 Feb;130(2):292-308.   [Abstract]

    The detection of activated signaling molecules of the ERK pathway via western blotting with the treatment of 2DG, MET and COM.

    Resatorvid purchased from MedChemExpress. Usage Cited in: Anesthesiology. 2019 Feb;130(2):292-308.   [Abstract]

    Detection of activated signaling molecules in the mTOR pathway via western blotting with the treatment of 2DG, MET and COM.

    Resatorvid purchased from MedChemExpress. Usage Cited in: Anesthesiology. 2019 Feb;130(2):292-308.   [Abstract]

    The detection of cell cycle-related proteins by western blotting with the treatment of 2DG, MET and COM.

    Resatorvid purchased from MedChemExpress. Usage Cited in: Chem Biol Interact. 2019 Feb 1;299:179-185.  [Abstract]

    Western blot analysis of TLR4 and MyD88 showing effect of TLR4 inhibitor (CLI-095) on PQ-induced inflammation in BV2 microglia. The blots are representative of three independent experiments. The bar diagrams which reflect mean fold change in the expression levels of TLR4 and MyD88 with respect to the control.

    Resatorvid purchased from MedChemExpress. Usage Cited in: FASEB J. 2019 Mar;33(3):3451-3464.  [Abstract]

    Western blot analyses of TLR4 and MAP4K4, and moesin phosphorylation in HRMECs with the different treatments of TAK-242 or LPS.

    Resatorvid purchased from MedChemExpress. Usage Cited in: FASEB J. 2019 Mar;33(3):3451-3464.  [Abstract]

    Western blot analyses of TLR4 and MAP4K4 in the retina of PN 17 OIR mice with or without TAK-242 treatment.

    Resatorvid purchased from MedChemExpress. Usage Cited in: Front Physiol. 2019 Mar 1;10:165.  [Abstract]

    Effect of EP and TAK-242 treatment on CD68 protein expressions in aortic sinus of CUMS ApoE-/- mice. Over a 16-week period treatment, entire aorta from the aortic root to the iliac bifurcation is harvested, and then frozen-sections of aortic sinus are performed for immunofluorescent staining of CD68. Representative images of CD68 expression in aortic sinus.

    Resatorvid purchased from MedChemExpress. Usage Cited in: EBioMedicine. 2018 Nov;37:78-90.  [Abstract]

    TAK-242 alters NF-κB downstream targets in PSAP overexpressing SNB19 and GSC-21 cells as measured by western blotting.

    Resatorvid purchased from MedChemExpress. Usage Cited in: J Neuroinflammation. 2018 Sep 4;15(1):252.  [Abstract]

    The phosphorylation of NF-κB p65 evoked by Mrp14 is decreased after TAK-242 treatment.

    Resatorvid purchased from MedChemExpress. Usage Cited in: Front Immunol. 2018 Jul 23;9:1667.  [Abstract]

    The inhibitory effect of TAK-242 on the TLR4 mRNA and protein expression is detected by RT-qPCR and Western Blot in NR8383 cells.

    Resatorvid purchased from MedChemExpress. Usage Cited in: Carbohyd Polym. 2018 Mar 1;183:207-218.  [Abstract]

    TAK-242 significantly reduces the protein expression of p-JNK, p-ERK, p-p38, p-Akt and LC3-II.

    Resatorvid purchased from MedChemExpress. Usage Cited in: Transplantation. 2018 Sep;102(9):1505-1513.  [Abstract]

    Whole-islet lysates are prepared from islets with (TAK) or without (CTRL) early TLR4 blockade immediately after isolation (0 hours) and at 6- and 24-hours postisolation. Lysates are immunoblotted for ERK1/2, P38, SAPK, and P65, and analyzed for relative activation (phospho:total) normalized to β-actin.

    Resatorvid purchased from MedChemExpress. Usage Cited in: Cancer Sci. 2018 Aug;109(8):2391-2400.  [Abstract]

    A549 cells pretreated with or without 5 μM TAK-242 and/or 10 μM PP1 (Src inhibitor) for 1 h are treated with 50 ng/mL Resistin for 15 min. Total protein is isolated and expression of phosphorylated (p-)Src, Src, p-EGFR, and EGFR is detected by Western blot

    Resatorvid purchased from MedChemExpress. Usage Cited in: Int Immunopharmacol. 2018 Aug;61:266-276.  [Abstract]

    The protein expressions of TLR4 and NF-κB p65 are measured by western blot.

    Resatorvid purchased from MedChemExpress. Usage Cited in: Front Pharmacol. 2018 Jan 30;9:28.  [Abstract]

    Effects of TAK-242 on the protein expressions of TLR4, MyD88, TRAF6, p-NF-κB p65, and total NF-κB p65 induced by Aβ1-42 in hBMECs by Western blotting analysis. The bands of TLR4, MyD88, TRAF6, p-NF-κB p65, total NF-κB p65, and β-actin. β-actin is used as a loading control.

    Resatorvid purchased from MedChemExpress. Usage Cited in: Sci Rep. 2018 Jan 24;8(1):1535.  [Abstract]

    Effect of TAK242 on MAPKs phosphorylation in HUVECs treated with 9t18:1 and 11t18:1. HUVECs are treated with TAK242 (0.5, 1, 1.5 μM) for 30 min and then cultured with 9t18:1 for 24 h.

    Resatorvid purchased from MedChemExpress. Usage Cited in: Cell Immunol. 2018 Jun;328:86-92.  [Abstract]

    Washed platelets are dealt with LPS (10 ug/mL, 30 min), LPS (10 ug/mL, 30 min) and TAK242 (132 nM, 30 min) or vehicle. PKC, AKT and p38 are detected by western blotting.

    Resatorvid purchased from MedChemExpress. Usage Cited in: Cancer Prev Res (Phila). 2018 May;11(5):265-278.  [Abstract]

    There is a remarkable reduction in average levels of p21waf1 expression in the Prevention tumors compared to controls.

    Resatorvid purchased from MedChemExpress. Usage Cited in: J Mol Neurosci. 2018 Dec;66(4):535-546.  [Abstract]

    In SC, p-NF-κB production is inhibited by TRAM1 siRNA or TAK242.

    Resatorvid purchased from MedChemExpress. Usage Cited in: J Mol Neurosci. 2018 Dec;66(4):535-546.  [Abstract]

    The increasing of TRAM1 is reversed by TAK242.

    Resatorvid purchased from MedChemExpress. Usage Cited in: J Mol Neurosci. 2018 Dec;66(4):535-546.  [Abstract]

    In DRG, p-NF-κB production is inhibited by TRAM1 siRNA or TAK242.

    Resatorvid purchased from MedChemExpress. Usage Cited in: Neurosci Lett. 2018 Nov 1;686:33-40.   [Abstract]

    Images show the expression of MCPIP1 after the treatment of of PBS and LPS (with TAK-242, C29, FPS-ZM1).

    Resatorvid purchased from MedChemExpress. Usage Cited in: Neurosci Lett. 2018 Nov 1;686:33-40.   [Abstract]

    Western Blot analyses show the protein expression of MCPIP1 after the treatment of PBS and LPS (with TAK-242, C29, FPS-ZM1).

    Resatorvid purchased from MedChemExpress. Usage Cited in: Oxid Med Cell Longev. 2018 May 16;2018:6296802.  [Abstract]

    HK-2 cells are treated with TLR4 inhibitor (TAK242, 5 μM) for 2 h prior to HG (30 mM) treatment for 2 h and with NF-κB blocker (Parthenolide, 10 μM) and HG (30 mM) for 2 h, and the samples are collected for Western blot analysis.

    Resatorvid purchased from MedChemExpress. Usage Cited in: Cell Physiol Biochem. 2018;47(4):1497-1508.  [Abstract]

    TAK-242 inhibits coronary microembolization (CME)-induced TLR4 upregulation and NLRP3 inflammasome activation.

    Resatorvid purchased from MedChemExpress. Usage Cited in: Chin Med J (Engl). 2017 Apr 20;130(8):906-913.  [Abstract]

    The levels of TLR4, IL-1β mRNA, and protein in TAK242 group are much lower than those in IgANTAK242 group.

    Resatorvid purchased from MedChemExpress. Usage Cited in: Front Immunol. 2017 Dec 13;8:1808.  [Abstract]

    The protein expression levels of Tgm2 in the 8-week Sj-infected mouse liver with TAK242 treatment are significantly reduced compared to those of the non-treated control.

    Resatorvid purchased from MedChemExpress. Usage Cited in: Life Sci. 2017 Feb 1;170:25-32.  [Abstract]

    Inhibition of TLR4 signaling attenuates PQ-induced NF-B activation and cytokine production. A549 cells are pre-treated 1 M TAK-242, followed by treatment with 300 M PQ for 24 h. The levels of (A) p-IB, (B) nuclear NF-B and (C) TLR4 are examined by Western blot analysis. (D) The relative mRNA expressions of TNF-, IL-1and IL-6 are measured by real-time PCR.

    Resatorvid purchased from MedChemExpress. Usage Cited in: Sci Rep. 2017 Mar 8;7:43834.  [Abstract]

    Compared with the expression in the DM + MCAO group, the expression of Bcl-2, Bax, cleaved caspase-3, TNF-α, IL-1β and TLR4 proteins is greatly reduced in the DM + MCAO + TAK242 group.

    Resatorvid purchased from MedChemExpress. Usage Cited in: PLoS One. 2017 May 24;12(5):e0178147.  [Abstract]

    (A) Titration of TAK-242 concentration. RPTC cells are cultured for 12 h in low glucose or high glucose medium with or without TAK-242. (B) MyD88 upregulation is also inhibited by TAK-242 under high glucose conditions by Western blotting.

    Resatorvid purchased from MedChemExpress. Usage Cited in: Mol Med Rep. 2017 Sep;16(3):3111-3116.  [Abstract]

    TLR4 inhibitor TAK 242 suppresses the TLR4/IRAK/NF ΚB signaling pathway in PASMCs. Western blot analysis is performed to detect the levels of p IRAK, IRAK, p IKK, IKK, p IκB, IκB and NF κB p65, and the representative blot results are shown.

    Resatorvid purchased from MedChemExpress. Usage Cited in: Graefes Arch Clin Exp Ophthalmol. 2017 Nov;255(11):2199-2210.  [Abstract]

    The effect of TAK-242 on the expression levels of TRAF6 and NLRP3 in retinal ganglion cells (RGCs) under high glucose are detected by Western blotting.

    Resatorvid purchased from MedChemExpress. Usage Cited in: Graefes Arch Clin Exp Ophthalmol. 2017 Nov;255(11):2199-2210.  [Abstract]

    The effect of TAK-242 on the expression levels of NF-κB and MyD88 in retinal ganglion cells (RGCs) under high glucose are detected by Western blotting.

    Resatorvid purchased from MedChemExpress. Usage Cited in: Oncotarget. 2017 May 9;8(19):31802-31814.  [Abstract]

    Activation of the β-catenin signaling pathway by Fn (F01) can be inhibited by both the TLR4 inhibitor (TAK-242) and PAK1 inhibitor (IPA-3).

    Resatorvid purchased from MedChemExpress. Usage Cited in: Cell Physiol Biochem. 2017;41(4):1675-1683.  [Abstract]

    NF-κB p65 (nuclei) protein expression detected by western blot.

    Resatorvid purchased from MedChemExpress. Usage Cited in: Cell Physiol Biochem. 2017;41(4):1675-1683.  [Abstract]

    Cleaved caspase-3 protein expression detected by western blot.

    Resatorvid purchased from MedChemExpress. Usage Cited in: Cell Physiol Biochem. 2017;41(4):1675-1683.  [Abstract]

    p-IκBα protein expression detected by western blot.

    Resatorvid purchased from MedChemExpress. Usage Cited in: Cell Physiol Biochem. 2017;41(4):1675-1683.  [Abstract]

    TLR4 protein expression detected by western blot.

    Resatorvid purchased from MedChemExpress. Usage Cited in: Cell Physiol Biochem. 2017;41(4):1675-1683.  [Abstract]

    MyD88 protein expression detected by western blot.

    Resatorvid purchased from MedChemExpress. Usage Cited in: J Neurochem. 2016 May;137(4):576-88.  [Abstract]

    TAK-242 markedly inhibits the up-regulation of IRAK-M and the down-regulation of p-IRAK-1 in rHMGB1-pretreated rats underwent MCAO. WB analysis of IRAK-M and p-IRAK-1 in rat ipsilateral hemispheres.

    Resatorvid purchased from MedChemExpress. Usage Cited in: Sci Rep. 2016 Aug 4;6:30957.  [Abstract]

    SEA promotes the senescence of LX-2 cells through activation of TLR4 signaling. Western blot analysis for P-p53 or TLR4 in LX-2 cells treated with SEA or TLR4 inhibitor TAK-242 (1 nM).

    Resatorvid purchased from MedChemExpress. Usage Cited in: Sci Rep. 2016 Jun 9;6:27866.  [Abstract]

    Examination of TLR4 expression level in each group. The protein and mRNA levels of TLR4 are down-regulated by pretreatment with TAK-242.

    Resatorvid purchased from MedChemExpress. Usage Cited in: Photochem Photobiol. 2016 Nov;92(6):816-825.  [Abstract]

    Western blot analysis reveals that Resatorvid-based inhibition of TLR4 is able to block UV-induced phosphorylation of MAP kinases (p38 and JNK) and Akt.

    Resatorvid purchased from MedChemExpress. Usage Cited in: Oncol Lett. 2016 Aug;12(2):1034-1040.  [Abstract]

    Involvement of TLR4 signaling pathway in HIF-1α silencing affects inflammatory and apoptosis under hypoxic conditions. In total, 30 mg total lysate is harvested with radioimmunoprecipitation assay buffer to detect TLR4, HIF-1α, caspase-3, MyD88, p-ASK1 and p-p38 protein expression by western blot analysis in human hepatocellular carcinoma HepG2 cells. The expression of TLR4, HIF-1α, MyD88, p-ASK1 NS and p-p38 in shHIF-1α transfected cells is significantly higher compared with the parental cells.

    Resatorvid purchased from MedChemExpress. Usage Cited in: Am J Physiol Gastrointest Liver Physiol. 2016 Dec 1;311(6):G1091-G1104.  [Abstract]

    Effects of TAK 242 and Catalpol on the expression of TLR-4 and activation of Src, PI3K, FAK, and Cathepsin B induced by LPS in HUVECs. Representative Western blots of TLR-4, p-Src, Src, p-PI3K, PI3K, p-FAK, FAK, activated cathepsin B, and cathepsin B proenzyme in different groups.

    Resatorvid purchased from MedChemExpress. Usage Cited in: PLoS One. 2015 Nov 10;10(11):e0142456.  [Abstract]

    Renal protein expression of E-cadherin (an epithelial marker), and Fibronectin and a-SMA (mesenchymal markers) are assayed in rats treated with Aldo-salt or with Aldo-salt plus TAK-242. TAK-242 reverses the Aldo-salt-induced renal epithelial-mesenchymal transition.

    View All Toll-like Receptor (TLR) Isoform Specific Products:

    View All Isoforms
    TLR3 TLR8 TLR9 TLR2 TLR4 TLR7 TLR1 TLR6

    View All TNF Receptor Isoform Specific Products:

    View All Isoforms
    TNFRSF1A/CD120a TNFRSF5/CD40 TNFRSF6/Fas/CD95 TNFRSF8/CD30 TNFRSF9/4-1BB/CD137 TNFRSF16/NGF Receptor/CD271 TNFRSF18/GITR/CD357

    View All Interleukin Related Isoform Specific Products:

    View All Isoforms
    IL-1 IL-2 IL-3 IL-4 IL-5 IL-6 IL-8 IL-10 IL-12 IL-13 IL-15 IL-17 IL-23 IL-7 IL-33 IL-22

    • Biological Activity

    • Purity & Documentation

    • References

    • Customer Review

    Description

    Resatorvid (TAK-242) is a selective Toll-like receptor 4 (TLR4) inhibitor. Resatorvid inhibits NO, TNF-α and IL-6 production with IC50s of 1.8 nM, 1.9 nM and 1.3 nM, respectively. Resatorvid downregulates expression of TLR4 downstream signaling molecules MyD88 and TRIF. Resatorvid inhibits autophagy and plays pivotal role in various inflammatory diseases[1][2].

    IC50 & Target[1][2]

    TLR4

     

    TNF-R

    1.9 nM (IC50)

    IL-6

    1.3 nM (IC50)

    In Vitro

    Resatorvid suppresses the production of NO, TNF-α, and IL-6 from LPS-stimulated human peripheral blood mononuclear cells (PBMCs) at IC50 values from 11 to 33 nM[1].
    Resatorvid (1-100 nM; 4 hours) inhibits mRNA expression of IL-6 and TNF-α induced by LPS and IFN-γ in RAW264.7 cells[1].
    Resatorvid (1-100 nM; 15 minutes; PBMCs cells) markedly inhibits the LPS-induced phosphorylation of extracellular signal-regulated kinase 1/2 (Erk1/2), p38, and JNK/SAPK as well as degradation of IκBβ at a concentration of 100 nM[1].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Resatorvid Related Antibodies

    RT-PCR[1]

    Cell Line: RAW264.7 cells
    Concentration: 1 nM, 10 nM, 100 nM
    Incubation Time: 4 hours
    Result: TNF-α and IL-6 mRNA expression levels were clearly suppressed at concentrations of 10 to 100 nM.

    Western Blot Analysis[1]

    Cell Line: PBMCs cells
    Concentration: 1 nM, 10 nM, 100 nM
    Incubation Time: 15 minutes
    Result: The phosphorylation of mitogen-activated protein kinases induced by LPS was also inhibited in a concentration-dependent manner.
    In Vivo

    Resatorvid (TAK-242; 3 mg/kg; intraperitoneal injection; for 2 days; male C57BL/6 mice) pretreatment markedly and significantly reverses the LPS-induced body weight loss, TA muscle loss, and muscle strength loss. TAK-242 reverses the LPS-induced shrinkage of muscle fibres and increases the interstitial space. TAK-242 blocks systemic catabolic cytokine release and skeletal muscle proteolysis in LPS-administered mice[3].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Animal Model: Male C57BL/6 mice (8-12 weeks of age) treated with lipopolysaccharide (LPS)[3]
    Dosage: 3 mg/kg
    Administration: Intraperitoneal injection; for 2 days
    Result: Pretreatment of mice reduced or reversed all the detrimental effects of LPS.
    Clinical Trial
    Molecular Weight

    361.82

    Formula

    C15H17ClFNO4S
    CAS No.
    Appearance

    Solid

    Color

    Off-white to yellow

    SMILES

    O=S([C@H]1C(C(OCC)=O)=CCCC1)(NC2=CC=C(C=C2Cl)F)=O
    Shipping

    Room temperature in continental US; may vary elsewhere.
    Storage
    Powder -20°C 3 years
    4°C 2 years
    In solvent -80°C 6 months
    -20°C 1 month
    Solvent & Solubility
    In Vitro: 

    DMSO : 100 mg/mL (276.38 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

    Ethanol : 20 mg/mL (55.28 mM; Need ultrasonic and warming)

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 2.7638 mL 13.8190 mL 27.6381 mL
    5 mM 0.5528 mL 2.7638 mL 5.5276 mL
    View the Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

    • Molarity Calculator

    • Dilution Calculator

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

    Mass
    =
    Concentration
    ×
    Volume
    ×
    Molecular Weight *

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    This equation is commonly abbreviated as: C1V1 = C2V2

    Concentration (start)

    C1

    ×
    Volume (start)

    V1

    =
    Concentration (final)

    C2

    ×
    Volume (final)

    V2

    In Vivo:

    Select the appropriate dissolution method based on your experimental animal and administration route.

    For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
    To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
    The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

    • Protocol 1

      Add each solvent one by one:  5% DMSO    40% PEG300    5% Tween-80    50% Saline

      Solubility: 5.5 mg/mL (15.20 mM); Suspended solution; Need ultrasonic

    • Protocol 2

      Add each solvent one by one:  5% DMSO    95% (20% SBE-β-CD in Saline)

      Solubility: 5.5 mg/mL (15.20 mM); Suspended solution; Need ultrasonic

    In Vivo Dissolution Calculator
    Please enter the basic information of animal experiments:

    Dosage

    mg/kg

    Animal weight
    (per animal)

    g

    Dosing volume
    (per animal)

    μL

    Number of animals

    Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
    Please enter your animal formula composition:
    %
    DMSO +
    % 
    +
    %
    Tween-80 +
    %
    Saline
    Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
    The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
    Calculation results:
    Working solution concentration: mg/mL
    Method for preparing stock solution: mg drug dissolved in μL  DMSO (Stock solution concentration: mg/mL).
    The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).
    Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.
     If the continuous dosing period exceeds half a month, please choose this protocol carefully.
    Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
    Purity & Documentation

    Purity: 99.95% ee.: 98.00%

    COA (257 KB) HNMR (179 KB) RP-HPLC (334 KB) NP-HPLC (288 KB)

    Handling Instructions (2659 KB)
    References

    Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

    Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
    Ethanol / DMSO 1 mM 2.7638 mL 13.8190 mL 27.6381 mL 69.0951 mL
    5 mM 0.5528 mL 2.7638 mL 5.5276 mL 13.8190 mL
    10 mM 0.2764 mL 1.3819 mL 2.7638 mL 6.9095 mL
    15 mM 0.1843 mL 0.9213 mL 1.8425 mL 4.6063 mL
    20 mM 0.1382 mL 0.6910 mL 1.3819 mL 3.4548 mL
    25 mM 0.1106 mL 0.5528 mL 1.1055 mL 2.7638 mL
    30 mM 0.0921 mL 0.4606 mL 0.9213 mL 2.3032 mL
    40 mM 0.0691 mL 0.3455 mL 0.6910 mL 1.7274 mL
    50 mM 0.0553 mL 0.2764 mL 0.5528 mL 1.3819 mL
    DMSO 60 mM 0.0461 mL 0.2303 mL 0.4606 mL 1.1516 mL
    80 mM 0.0345 mL 0.1727 mL 0.3455 mL 0.8637 mL
    100 mM 0.0276 mL 0.1382 mL 0.2764 mL 0.6910 mL
    • No file chosen (Maximum size is: 1024 Kb)
    • If you have published this work, please enter the PubMed ID.
    • Your name will appear on the site.

    Resatorvid Related Classifications

    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    Resatorvid243984-11-4TAK-242 CLI-095TAK242TAK 242CLI095CLI 095CLI-095Toll-like Receptor (TLR)TNF ReceptorInterleukin RelatedAutophagyTumor Necrosis Factor ReceptorTNFRILNOTNF-RIL-6MyD88TRIFinflammatorydiseasesInhibitorinhibitorinhibit

    Your Recently Viewed Products:

    Inquiry Online

    Your information is safe with us. * Required Fields.

    Product Name

    		  

    Salutation

    Applicant Name *

    		 

    Email Address *

    Phone Number *

    		 

    Organization Name *

    Department *

    		 

    Requested quantity *

    Country or Region *

    		      

    Remarks

    Bulk Inquiry

    Inquiry Information

    Product Name:
    Resatorvid
    Cat. No.:
    HY-11109
    Quantity:
    MCE Japan Authorized Agent:

    Customer Review

    Thank You for Your Feedback!

    Request for HNMR Report

    Please fill out this form to request the QC report. We will send it to your Email address shortly.

    Your information is safe with us. * Required Fields.

    Product Name

    		  

    Lot #

    Applicant Name *

    		 

    Email Address *

    Phone Number

    		 

    Department *

    Organization Name *

    		 

    Country or Region *

    Remarks

    Request for HNMR Report

    We have received your request and will respond to you as soon as possible.