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Ventricular arrhythmia

" in MedChemExpress (MCE) Product Catalog:

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8

Isotope-Labeled Compounds

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-130335
    Encainide

    MJ9067

    		 Others Cardiovascular Disease
    Encainide (MJ9067) is an antiarrhythmic agent with class IC activity. Encainide has the potential for life-threatening ventricular arrhythmias, symptomatic ventricular arrhythmias and supraventricular arrhythmias research .
    Encainide
  • HY-12533
    Disopyramide
    1 Publications Verification

    Dicorantil; SC-7031

    		 Sodium Channel Potassium Channel Cardiovascular Disease
    Disopyramide (Dicorantil) is a class IA antiarrhythmic agent with efficacy in ventricular and atrial arrhythmias. Disopyramide blocks the fast inward sodium current of cardiac muscle and prolongs the duration of cardiac action potentials. Disopyramide inhibits HERG encoded potassium channels. Disopyramide also exhibits complex protein binding, and has a potent negative inotropic action .
    Disopyramide
  • HY-12533A
    Disopyramide phosphate
    1 Publications Verification

    Dicorantil phosphate; SC-7031 phosphate

    		 Potassium Channel Sodium Channel Cardiovascular Disease
    Disopyramide phosphate is a class IA antiarrhythmic agent with efficacy in ventricular and atrial arrhythmias. Disopyramide phosphate blocks the fast inward sodium current of cardiac muscle and prolongs the duration of cardiac action potentials. Disopyramide phosphate inhibits HERG encoded potassium channels. Disopyramide phosphate also exhibits complex protein binding, and has a potent negative inotropic action .
    Disopyramide phosphate
  • HY-12531
    Encainide hydrochloride

    MJ9067 hydrochloride

    		 Others Cardiovascular Disease
    Encainide (MJ9067) hydrochloride is an antiarrhythmic agent with class IC activity. Encainide has the potential for life-threatening ventricular arrhythmias, symptomatic ventricular arrhythmias and supraventricular arrhythmias research .
    Encainide hydrochloride
  • HY-123646
    RS 2135

    		Others Cardiovascular Disease
    RS 2135 is an antiarrhythmic compound that can suppress ischemia-induced ventricular arrhythmias .
    RS 2135
  • HY-W181626
    Tiprenolol

    DU 21445

    		 5-HT Receptor Cardiovascular Disease
    Tiprenolol is a β-adrenoceptor blocker. Tiprenolol can abolish the ventricular arrhythmias produced by adrenaline in dogs respired with halothane .
    Tiprenolol
  • HY-101361
    Lidocaine methiodide

    Methyllidocaine iodide

    		 Others Neurological Disease
    Lidocaine methiodide (Methyllidocaine iodide) is a potent antiarrythmic agent. Lidocaine methiodide can be used for the research of ventricular arrhythmias produced by coronary occlusion .
    Lidocaine methiodide
  • HY-111013
    VK-II-86

    		Others Cardiovascular Disease
    VK-II-86 is a Carvedilol (HY-B0006) analogue lacking antagonist activity at β-adrenoceptors, in hypokalaemia. VK-II-86 prevents hypokalaemia-induced ventricular arrhythmia through multi-channel effects. VK-II-86 prevents all hypokalaemia-induced changes in ion channel activity and oxidative stress .
    VK-II-86
  • HY-106207
    Celivarone

    SSR149744C

    		 Others Cardiovascular Disease
    Celivarone (SSR149744C) is a orally active noniodinated benzofuran derivative with antiarrhythmic properties. Celivarone has the potential for atrial fibrillation and in ventricular arrhythmias research .
    Celivarone
  • HY-12533B
    Disopyramide hydrochloride

    Dicorantil hydrochloride; SC-7031 hydrochloride

    		 Sodium Channel Potassium Channel Cardiovascular Disease
    Disopyramide hydrochloride is a class IA antiarrhythmic agent with efficacy in ventricular and atrial arrhythmias. Disopyramide hydrochloride blocks the fast inward sodium current of cardiac muscle and prolongs the duration of cardiac action potentials. Disopyramide hydrochloride inhibits HERG encoded potassium channels. Disopyramide hydrochloride also exhibits complex protein binding, and has a potent negative inotropic action .
    Disopyramide hydrochloride
  • HY-12533R
    Disopyramide (Standard)

    		Sodium Channel Potassium Channel Cardiovascular Disease
    Disopyramide (Standard) is the analytical standard of Disopyramide. This product is intended for research and analytical applications. Disopyramide (Dicorantil) is a class IA antiarrhythmic agent with efficacy in ventricular and atrial arrhythmias. Disopyramide blocks the fast inward sodium current of cardiac muscle and prolongs the duration of cardiac action potentials. Disopyramide inhibits HERG encoded potassium channels. Disopyramide also exhibits complex protein binding, and has a potent negative inotropic action .
    Disopyramide (Standard)
  • HY-14188
    Amiodarone hydrochloride
    5+ Cited Publications

    		 Potassium Channel Autophagy Cardiovascular Disease Cancer
    Amiodarone hydrochloride, a benzofuran-based Class III antiarrhythmic agent, inhibits WT outwardIhERG tails with an IC50 of ∼45 nM . Amiodarone hydrochloride induces cell proliferation and myofibroblast differentiation via ERK1/2 and p38 MAPK signaling in fibroblasts . Amiodarone hydrochloride can be used in the research of both supraventricular and ventricular arrhythmias .
    Amiodarone hydrochloride
  • HY-B1238
    Pronethalol
    1 Publications Verification

    (±)-Pronethalo

    		 Adrenergic Receptor Cardiovascular Disease Neurological Disease
    Pronethalol ((±)-Pronethalo) is a non-selective β-adrenergic antagonist. Pronethalol is a potent inhibitor of Sox2 expression. Pronethalol protects against and to reverse Digitalis-induced ventricular arrhythmias and limits the cerebral arteriovenous malformation (AVMs) .
    Pronethalol
  • HY-B1238A
    Pronethalol hydrochloride

    (±)-Pronethalo hydrochloride

    		 Adrenergic Receptor Cardiovascular Disease Neurological Disease
    Pronethalol ((±)-Pronethalo) is a non-selective β-adrenergic antagonist. Pronethalol is a potent inhibitor of Sox2 expression. Pronethalol protects against and to reverse Digitalis-induced ventricular arrhythmias, and limits the cerebral arteriovenous malformation (AVMs) .
    Pronethalol hydrochloride
  • HY-121312
    Flutonidine

    ST-600

    		 Adrenergic Receptor Cardiovascular Disease
    Flutonidine (ST-600) is a Clonidine (HY-12721) analogue that shows antihypertensive and sympatholytic effects. The initial hypertension produced by Flutonidine is due to stimulation of the peripheral α1, α2 adrenoceptors and the subsequent fall in blood pressure is due to the stimulation of central α2 adrenoceptors. Flutonidine reduces the arrhythmogenic and lethal effects of ouabain. Flutonidine is promising for research of ventricular arrhythmias caused by cardiac glycosides .
    Flutonidine
  • HY-116500A
    AH-1058

    		Others Cardiovascular Disease
    AH-1058 is a newly synthesized antiarrhythmic agent that exhibits significant antiarrhythmic activity by delaying premature ventricular complexes and ventricular fibrillation in experimental arrhythmia models. AH-1058 effectively inhibits both ventricular tachycardia and ventricular fibrillation in the reperfusion-induced arrhythmia model in rats. AH-1058 demonstrates potent calcium channel-blocking effects, suppressing L-type Ca2+ currents in isolated cardiomyocytes.
    AH-1058
  • HY-B0432AS2
    Propafenone D5 hydrochloride

    		Sodium Channel Cardiovascular Disease
    Propafenone-d5 (hydrochloride) is the deuterium labeled Propafenone hydrochloride. Propafenone (SA-79) hydrochloride is a class of anti-arrhythmic medication, which treats illnesses associated with rapid heart beats such as atrial and ventricular arrhythmias[1].
    Propafenone D5 hydrochloride
  • HY-B0432AS4
    Propafenone-(phenyl-d5) (hydrochloride)

    		Sodium Channel Cardiovascular Disease
    Propafenone-(phenyl-dd5) (hydrochloride) is the deuterium labeled Propafenone hydrochloride[1]. Propafenone hydrochloride is a class of anti-arrhythmic medication, which treats illnesses associated with rapid heart beats such as atrial and ventricular arrhythmias[2].
    Propafenone-(phenyl-d5) (hydrochloride)
  • HY-B0432AS3
    Propafenone-d5 (hydrochloride)(Ethyl)

    		Sodium Channel Cardiovascular Disease
    Propafenone-d5 Ethyl (hydrochloride) is the deuterium labeled Propafenone hydrochloride. Propafenone (SA-79）hydrochloride is a class of anti-arrhythmic medication, which treats illnesses associated with rapid heart beats such as atrial and ventricular arrhythmias[1].
    Propafenone-d5 (hydrochloride)(Ethyl)
  • HY-B0432A
    Propafenone hydrochloride
    1 Publications Verification

    SA-79 hydrochloride

    		 Sodium Channel Cardiovascular Disease
    Propafenone (hydrochloride) (SA-79 (hydrochloride)) is a class of anti-arrhythmic medication, which treats illnesses associated with rapid heart beats such as atrial and ventricular arrhythmias.
    Propafenone hydrochloride
  • HY-119850
    Aladorian

    ARM036

    		 Others Cardiovascular Disease
    Aladorian (ARM036) is a benzothiazepine derivative, with anti-arrhythmia effect. Aladorian is used for the research of heart failure and catecholaminergic polymorphic ventricular tachycardia .
    Aladorian
  • HY-119850A
    Aladorian sodium

    ARM036 sodium

    		 Others Cardiovascular Disease
    Aladorian (ARM036) sodium is a benzothiazepine derivative, with anti-arrhythmia effect. Aladorian sodium is used for the research of heart failure and catecholaminergic polymorphic ventricular tachycardia .
    Aladorian sodium
  • HY-15208A
    Clamikalant

    HMR 1098 free base

    		 Others Others
    Clamikalant (HMR 1098 free base) is a compound used to suppress cardiac arrhythmias. It prevents the reduction of the refractory period during ventricular fibrillation in dogs and also shows antiarrhythmic effects in a rabbit heart model.
    Clamikalant
  • HY-112075
    Lidoflazine

    		Potassium Channel Calcium Channel Cardiovascular Disease
    Lidoflazine is a high affinity blocker of the HERG (human ether-a-go-go-related gene) K + channel. Lidoflazine is an antianginal calcium channel blocker that carries a significant risk of QT interval prolongation and ventricular arrhythmia .
    Lidoflazine
  • HY-105454
    Recainam

    Wy-42362

    		 Others Cardiovascular Disease
    Recainam (Wy-42362) is an orally active anti-arrhythmic agent with Class I electrophysiological properties. Recainam suppresses complex ventricular arrhythmias. Racainam exhibits a good pharmacokinetic character in Sprague Dawley rats .
    Recainam
  • HY-105454A
    Recainam hydrochloride

    Wy-42362 hydrochloride

    		 Others Cardiovascular Disease
    Recainam (Wy-42362) hydrochloride is an orally active anti-arrhythmic agent with Class I electrophysiological properties. Recainam suppresses complex ventricular arrhythmias. Racainam hydrochloride exhibits a good pharmacokinetic character in Sprague Dawley rats .
    Recainam hydrochloride
  • HY-B0432AR
    Propafenone hydrochloride (Standard)

    		Sodium Channel Cardiovascular Disease
    Propafenone (hydrochloride) (Standard) is the analytical standard of Propafenone (hydrochloride). This product is intended for research and analytical applications. Propafenone (hydrochloride) (SA-79 (hydrochloride)) is a class of anti-arrhythmic medication, which treats illnesses associated with rapid heart beats such as atrial and ventricular arrhythmias.
    Propafenone hydrochloride (Standard)
  • HY-B0185AS
    Lidocaine-d10 hydrochloride

    		Sodium Channel MEK ERK NF-κB Apoptosis Cardiovascular Disease Cancer
    Lidocaine-d10 (hydrochloride) is the deuterium labeled Lidocaine hydrochloride. Lidocaine hydrochloride (Lignocaine hydrochloride) inhibits sodium channels involving complex voltage and using dependence[1]. Lidocaine hydrochloride decreases growth, migration and invasion of gastric carcinoma cells via up-regulating miR-145 expression and further inactivation of MEK/ERK and NF-κB signaling pathways. Lidocaine hydrochloride, an amide derivative, has the potential for the research of the ventricular arrhythmia[2].
    Lidocaine-d10 hydrochloride
  • HY-14188S
    Amiodarone-d4 hydrochloride

    		Potassium Channel Autophagy Cardiovascular Disease Cancer
    Amiodarone-d4 (hydrochloride) is the deuterium labeled Amiodarone hydrochloride. Amiodarone hydrochloride, a benzofuran-based Class III antiarrhythmic agent, inhibits WT outwardIhERG tails with an IC50 of ∼45 nM[1]. Amiodarone hydrochloride induces cell proliferation and myofibroblast differentiation via ERK1/2 and p38 MAPK signaling in fibroblasts[2]. Amiodarone hydrochloride can be used in the research of both supraventricular and ventricular arrhythmias[1].
    Amiodarone-d4 hydrochloride
  • HY-B0185S1
    Lidocaine-d10

    		Sodium Channel MEK ERK NF-κB Apoptosis Cardiovascular Disease Cancer
    Lidocaine-d10 is the deuterium labeled Lidocaine. Lidocaine (Lignocaine) inhibits sodium channels involving complex voltage and using dependence[1]. Lidocaine decreases growth, migration and invasion of gastric carcinoma cells via up-regulating miR-145 expression and further inactivation of MEK/ERK and NF-κB signaling pathways. Lidocaine is an amide derivative and has potential for the research of ventricular arrhythmia[2].
    Lidocaine-d10
  • HY-B0185S
    Lidocaine-d10 N-Oxide

    		Sodium Channel MEK ERK NF-κB Apoptosis Cardiovascular Disease Cancer
    N-Oxide Lidocaine-d10 is the deuterium labeled Lidocaine. Lidocaine (Lignocaine) inhibits sodium channels involving complex voltage and using dependence[1]. Lidocaine decreases growth, migration and invasion of gastric carcinoma cells via up-regulating miR-145 expression and further inactivation of MEK/ERK and NF-κB signaling pathways. Lidocaine is an amide derivative and has potential for the research of ventricular arrhythmia[2].
    Lidocaine-d10 N-Oxide
  • HY-14304A
    Zinterol hydrochloride
    1 Publications Verification

    MJ 9184 hydrochloride

    		 Adrenergic Receptor Cardiovascular Disease
    Zinterol hydrochloride (MJ 9184 hydrochloride) is a potent and selective β2-adrenoceptor agonist . Zinterol hydrochloride increases ICa in a concentration-dependent manner with an EC50 of 2.2 nM . Zinterol hydrochloride induces ventricular arrhythmias in conscious heart failure rabbits .
    Zinterol hydrochloride
  • HY-118317
    Zacopride

    		Others Cardiovascular Disease
    Zacopride is a selective agonist with the activity of enhancing the inward rectifier potassium current (IK1) in rabbit hearts. Zacopride also exhibits significant antiarrhythmic effects, inhibiting ventricular arrhythmias by increasing IK1 without affecting atrial arrhythmias. Zacopride can hyperpolarize the resting membrane potential and shorten the action potential duration (APD) in a concentration-dependent manner. Zacopride significantly reduced the incidence of compound-induced early afterdepolarizations (EADs) at 1 μmol/L .
    Zacopride
  • HY-A0154
    Deslanoside

    Deacetyllanatoside C; Desacetyllanatoside C

    		 Na+/K+ ATPase Drug Metabolite Cardiovascular Disease
    Deslanoside (Desacetyllanatoside C) is a rapidly acting cardiac glycoside used to treat congestive heart failure and supraventricular arrhythmias due to reentry mechanisms, and to control ventricular rate in the treatment of chronic atrial fibrillation. Deslanoside inhibits the Na-K-ATPase membrane pump, resulting in an increase in intracellular sodium and calcium concentrations .
    Deslanoside
  • HY-B0185
    Lidocaine
    10+ Cited Publications

    Lignocaine

    		 Sodium Channel MEK ERK NF-κB Apoptosis Cardiovascular Disease Cancer
    Lidocaine (Lignocaine) inhibits sodium channels involving complex voltage and using dependence . Lidocaine decreases growth, migration and invasion of gastric carcinoma cells via up-regulating miR-145 expression and further inactivation of MEK/ERK and NF-κB signaling pathways. Lidocaine is an amide derivative and has potential for the research of ventricular arrhythmia .
    Lidocaine
  • HY-16952
    Bepridil

    (±)-Bepridil; Org 5730

    		 Calcium Channel Sodium Channel SARS-CoV Infection Cardiovascular Disease
    Bepridil ((±)-Bepridil) is a calcium channel blocking agent used as antiarrhythmic agent. Bepridil inhibits both calcium and sodium currents, has research potential in certain ischemia-induced ventricular arrhythmias. Bepridil also has strong inhibition of SARS-CoV-2 from entry and replication inside Vero E6 and A549 cells .
    Bepridil
  • HY-B0185B
    Lidocaine hydrochloride hydrate
    10+ Cited Publications

    Lignocaine hydrochloride hydrate

    		 Sodium Channel MEK ERK NF-κB Apoptosis Cardiovascular Disease Cancer
    Lidocaine (Lignocaine) hydrochloride hydrate inhibits sodium channels involving complex voltage and using dependence. Lidocaine hydrochloride hydrate decreases growth, migration and invasion of gastric carcinoma cells via up-regulating miR-145 expression and further inactivation of MEK/ERK and NF-κB signaling pathways. Lidocaine hydrochloride hydrate is an amide derivative and has potential for the research of ventricular arrhythmia .
    Lidocaine hydrochloride hydrate
  • HY-100952
    Nifenalol hydrochloride

    		Adrenergic Receptor Cardiovascular Disease
    Nifenalol hydrochloride is a β-adrenergic receptor antagonist. Nifenalol hydrochloride induces the Early Afterdepolarization (EAD) effect. EAD is a phenomenon in cardiac electrophysiology that usually occurs during an action potential in ventricular muscle cells and can lead to arrhythmia. The EAD effect of Nifenalol hydrochloride can be blocked by Tetrodotoxin. Nifenalol hydrochloride is used in the study of conditions such as irregular heartbeat or high blood pressure .
    Nifenalol hydrochloride
  • HY-N2333
    Resiniferatoxin
    1 Publications Verification

    (+)-Resiniferatoxin

    		 TRP Channel Cardiovascular Disease
    Resiniferatoxin ((+)-Resiniferatoxin), is a selective agonist of transient receptor potential vanilloid 1 (TRPV1) receptor agonist. Resiniferatoxin can be isolated from the Euphorbia resinifera plant. Resiniferatoxin eliminates TRPV1+ primary sensory afferents and blunt cardiac sympathetic afferent reflex for a relatively long period .
    Resiniferatoxin
  • HY-108998
    Bisaramil hydrochloride

    		Others Cardiovascular Disease
    Bisaramil hydrochloride is an antiarrhythmic compound with activity in inhibiting free radical generation. Bisaramil hydrochloride directly blocks sodium currents and exhibits enhanced sodium channel blocking ability. Bisaramil hydrochloride inhibits isoproterenol-induced slow calcium action potentials in cardiomyocytes. Bisaramil hydrochloride reduces heart rate and prolongs the PR, QRS, and QT intervals in the electrocardiogram, showing blocking effects on sodium and potassium channels. Bisaramil hydrochloride reduces cardiac conduction velocity, increases the threshold current for capture and atrial fibrillation, and prolongs the effective refractory period. Bisaramil hydrochloride reduces ventricular arrhythmias and eliminates mortality caused by ventricular fibrillation in ischemic rat hearts .
    Bisaramil hydrochloride
  • HY-B0185A
    Lidocaine hydrochloride
    10+ Cited Publications

    Lignocaine hydrochloride

    		 Sodium Channel MEK ERK NF-κB Apoptosis Cardiovascular Disease Cancer
    Lidocaine hydrochloride (Lignocaine hydrochloride) inhibits sodium channels involving complex voltage and using dependence . Lidocaine hydrochloride decreases growth, migration and invasion of gastric carcinoma cells via up-regulating miR-145 expression and further inactivation of MEK/ERK and NF-κB signaling pathways. Lidocaine hydrochloride is an amide derivative and a agent to treat ventricular arrhythmia and an effective tumor-inhibitor .
    Lidocaine hydrochloride
  • HY-117135
    HNS-32

    		Others Cardiovascular Disease
    HNS-32 is a compound with antiarrhythmic and vasodilatory effects in canine hearts, showing superior protective effects against ischemic and reperfusion arrhythmias compared to an equivalent dose of Mexiletine hydrochloride (HY-A0093). Furthermore, HNS-32 exhibits significant negative chronotropic effects on mammalian ventricular myocardium, indicating its potential application value in the study of acute coronary syndrome .
    HNS-32
  • HY-A0154R
    Deslanoside (Standard)

    		Na+/K+ ATPase Drug Metabolite Cardiovascular Disease
    Deslanoside (Standard) is the analytical standard of Deslanoside. This product is intended for research and analytical applications. Deslanoside (Desacetyllanatoside C) is a rapidly acting cardiac glycoside used to treat congestive heart failure and supraventricular arrhythmias due to reentry mechanisms, and to control ventricular rate in the treatment of chronic atrial fibrillation. Deslanoside inhibits the Na-K-ATPase membrane pump, resulting in an increase in intracellular sodium and calcium concentrations .
    Deslanoside (Standard)
  • HY-14188R
    Amiodarone hydrochloride (Standard)

    		Potassium Channel Autophagy Cardiovascular Disease Cancer
    Amiodarone (hydrochloride) (Standard) is the analytical standard of Amiodarone (hydrochloride). This product is intended for research and analytical applications. Amiodarone hydrochloride, a benzofuran-based Class III antiarrhythmic agent, inhibits WT outwardIhERG tails with an IC50 of ∼45 nM . Amiodarone hydrochloride induces cell proliferation and myofibroblast differentiation via ERK1/2 and p38 MAPK signaling in fibroblasts . Amiodarone hydrochloride can be used in the research of both supraventricular and ventricular arrhythmias .
    Amiodarone hydrochloride (Standard)
  • HY-123196
    CVT-2759

    		Adenosine Receptor Cardiovascular Disease
    CVT-2759 is a potent inhibitor of A1-ADOR, with the IC50 values of 0.18 μM and 9.5 μM to reduce the binding of [3H]CPX in the absence and presence of 1 mM GTP. CVT-2759 plays an important role in slowing AV nodal conduction and thereby ventricular rate without causing AV block, bradycardia, atrial arrhythmias, or vasodilation .
    CVT-2759
  • HY-B0185AS1
    Lidocaine-d6 hydrochloride

    Lignocaine-d6 hydrochloride

    		 Sodium Channel MEK ERK NF-κB Apoptosis Cardiovascular Disease Cancer
    Lidocaine-d6 (hydrochloride) is deuterium labeled Lidocaine (hydrochloride). Lidocaine hydrochloride (Lignocaine hydrochloride) inhibits sodium channels involving complex voltage and using dependence[1]. Lidocaine hydrochloride decreases growth, migration and invasion of gastric carcinoma cells via up-regulating miR-145 expression and further inactivation of MEK/ERK and NF-κB signaling pathways. Lidocaine hydrochloride is an amide derivative and a agent to treat ventricular arrhythmia and an effective tumor-inhibitor[2].
    Lidocaine-d6 hydrochloride
  • HY-B0185R
    Lidocaine (Standard)
    10+ Cited Publications

    Lignocaine (Standard)

    		 Sodium Channel MEK ERK NF-κB Apoptosis Cardiovascular Disease Cancer
    Lidocaine (Standard) is the analytical standard of Lidocaine. This product is intended for research and analytical applications. Lidocaine (Lignocaine) inhibits sodium channels involving complex voltage and using dependence . Lidocaine decreases growth, migration and invasion of gastric carcinoma cells via up-regulating miR-145 expression and further inactivation of MEK/ERK and NF-κB signaling pathways. Lidocaine is an amide derivative and has potential for the research of ventricular arrhythmia .
    Lidocaine (Standard)
  • HY-B0185BR
    Lidocaine hydrochloride hydrate (Standard)

    		Sodium Channel MEK ERK NF-κB Apoptosis Cardiovascular Disease Cancer
    Lidocaine (hydrochloride hydrate) (Standard) is the analytical standard of Lidocaine (hydrochloride hydrate). This product is intended for research and analytical applications. Lidocaine (Lignocaine) hydrochloride hydrate inhibits sodium channels involving complex voltage and using dependence. Lidocaine hydrochloride hydrate decreases growth, migration and invasion of gastric carcinoma cells via up-regulating miR-145 expression and further inactivation of MEK/ERK and NF-κB signaling pathways. Lidocaine hydrochloride hydrate is an amide derivative and has potential for the research of ventricular arrhythmia .
    Lidocaine hydrochloride hydrate (Standard)
  • HY-126704
    Tedisamil

    KC-8857

    		 Others Cardiovascular Disease
    Tedisamil (KC-8857) is an antiarrhythmic compound with important biological activities. Tedisamil exhibits a significant slowing effect on heart rate, which is achieved by inhibiting the transient outward potassium current (I(to)) in the atrium. Tedisamil inhibits multiple potassium currents, including IK, K(ATP), and PKA-activated chloride channels, thereby prolonging the cardiac action potential and QT interval, and increasing cardiac reentry. Tedisamil has antiarrhythmic effects on ventricular arrhythmias and atrial flutter in animal models .
    Tedisamil
  • HY-B0185G
    Lidocaine

    Lignocaine

    		 Apoptosis Sodium Channel MEK ERK NF-κB Cancer
    Lidocaine (GMP) is Lidocaine (HY-B0185) produced by using GMP guidelines. GMP small molecules work appropriately as an auxiliary reagent for cell therapy manufacture. Lidocaine inhibits sodium channels involving complex voltage and using dependence . Lidocaine decreases growth, migration and invasion of gastric carcinoma cells via up-regulating miR-145 expression and further inactivation of MEK/ERK and NF-κB signaling pathways. Lidocaine is an amide derivative and has potential for the research of ventricular arrhythmia .
    Lidocaine

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