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PS121912 is a selective vitaminDreceptor (VDR)-coregulator inhibitor. PS121912 has acceptable metabolic stability in vivo. PS121912 can be used for the research of cancer .
Calcitriol Impurities D is the impurity of Calcitriol, Calcitriol is the hormonally active form of vitaminD, Calcitriol is the active metabolite of vitaminD3 that activates the vitaminDreceptor (VDR).
Calcitriol Impurities A is the impurity of Calcitriol, Calcitriol is the hormonally active form of vitaminD, Calcitriol is the active metabolite of vitaminD3 that activates the vitaminDreceptor (VDR).
Impurity C of Calcitriol, Calcitriol(1,25-Dihydroxyvitamin D3; Rocaltrol ) is the hormonally active form of vitaminD, Calcitriol is the active metabolite of vitaminD3 that activates the vitaminDreceptor (VDR).
Impurity B of Calcitriol, Calcitriol(1,25-Dihydroxyvitamin D3; Rocaltrol ) is the hormonally active form of vitaminD, Calcitriol is the active metabolite of vitaminD3 that activates the vitaminDreceptor (VDR).
trans-Doxercalciferol is an isomer of Doxercalciferol. Doxercalciferol is a VitaminD2 analog, acts as an activator of VitaminDreceptor, and prevent renal disease .
Paricalcitol, a vitaminD analogue, is a vitaminDreceptor agonist, used for the prevention and treatment of secondary hyperparathyroidism (excessive secretion of parathyroid hormone) associated with chronic renal failure.
Calcitriol (Standard) is the analytical standard of Calcitriol. This product is intended for research and analytical applications. Calcitriol is the most active metabolite of vitaminD and also a vitaminDreceptor (VDR) agonist.
Calcitriol-d3 is the deuterium labeled Calcitriol[1]. Calcitriol is the most active metabolite of vitaminD and also a vitaminDreceptor (VDR) agonist[2][3][4][5].
Doxercalciferol (Standard) is the analytical standard of Doxercalciferol. This product is intended for research and analytical applications. Doxercalciferol is a VitaminD2 analog, acts as an activator of VitaminDreceptor, and prevent renal disease.
Paricalcitol (Standard) is the analytical standard of Paricalcitol. This product is intended for research and analytical applications. Paricalcitol, a vitaminD analogue, is a vitaminDreceptor agonist, used for the prevention and treatment of secondary hyperparathyroidism (excessive secretion of parathyroid hormone) associated with chronic renal failure.
Maxacalcitol-d66 is the deuterated form of Maxacalcitol (22-Oxacalcitriol), which is a non-calcemic vitaminD3 analog and VDR ligand of VDR-like receptors.
25-Hydroxytachysterol3 is the metabolite of VitaminD3 (HY-15398). 25-Hydroxytachysterol3 inhibits the proliferation of epidermal keratinocytes and dermal fibroblasts, stimulates the expression of differentiation- and antioxidant-related genes in keratinocytes. 25-Hydroxytachysterol3 activates vitaminDreceptor (VDR) and aryl hydrocarbon receptor (AhR), liver X receptor α/β (LXR α/β) and peroxisome proliferator-activated receptor γ (PPARγ), stimulates the expression of CYP24A1 .
Calcipotriol (Standard) is the analytical standard of Calcipotriol. This product is intended for research and analytical applications. Calcipotriol is a synthetic VitD3 analogue with a high affinity for the vitaminDreceptor.
Calcipotriol (monohydrate) (Standard) is the analytical standard of Calcipotriol (monohydrate). This product is intended for research and analytical applications. Calcipotriol monohydrate is a synthetic VitD3 analogue with a high affinity for the vitaminDreceptor.
(1S)-Calcitriol (1α,25-Dihydroxy-3-epi-vitamin-D3) is a natural metabolite of 1α,25-dihydroxyvitamin D3(1α,25(OH)2D3). (1S)-Calcitriol exhibits potent vitaminDreceptor (VDR)-mediated actions such as inhibition of keratinocyte growth or suppression of parathyroid hormone secretion .
Inecalcitol (TX 522), a unique vitaminD3 analog, is an orally active vitaminDreceptor (VDR) agonist with a Kd of 0.53 nM. Inecalcitol can induce cell apoptosis and has potent anticancer activities . Inecalcitol is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
Secalciferol ((24R)-24,25-Dihydroxyvitamin D3) is the major active metabolite of VitaminD. Secalciferol activates vitaminDreceptor (VDR) with an EC50 value of 150 nM. Secalciferol is involved in a wide range of biological functions such as calcium homeostasis, cellular differentiation and proliferation processes, as well as other functions related to the immune system, which is promising for research of rickets, osteomalacia, hypercalcemia and autoimmune disorders .
ZK159222, a 25-carboxylic ester analogue of 1α,25-(OH)2D3, is a potent 1α,25-(OH)2D3 receptor (VDR) antagonist. The mechanism of ZK159222 antagonistic action is mediated by a lack of ligand-induced vitaminDreceptor interaction with coactivators. ZK159222 has a partial agonistic character .
Elocalcitol (BXL-628) is a selective, orally active vitaminDreceptor (VDR) agonist. Elocalcitol shows anti-inflammatory activity. Elocalcitol inhibits growth of prostate cancer cells .
TEI-9648, a VitaminD3 Lactone analogue, is a potent and specific vitaminDreceptor (VDR) antagonist. TEI-9648 inhibits VDR/VDRE-mediated genomic actions of 1α,25(OH)2D3. TEI-9648 also inhibits HL-60 cell differentiation induced by of 1α,25(OH)2D3. TEI-9648 has the potential for bone metabolism research .
MeTC7 is a Vitamin-Dreceptor (VDR) antagonist. MeTC7 has potent VDR inhibition activity with an IC50 value of 2.9 μM. MeTC7 shows good antitumor effects .
TEI-9647, a VitaminD3 Lactone analogue, is a potent and specific vitaminDreceptor (VDR) antagonist. TEI-9647 inhibits VDR/VDRE-mediated genomic actions of 1α,25(OH)2D3. TEI-9647 inhibits bone resorption and HL-60 cell differentiation induced by of 1α,25(OH)2D3. TEI-9647 has the potential for suppressing the excessive bone resorption and osteoclast formation in Paget's disease .
Lunacalcipol (CTA-018), as a vitaminD analogue, has a dual role in the pathogenesis of Chronic Kidney Disease (CKD), as an agonist of vitaminDreceptor and an antagonist of cytochrome P450 enzyme 24-hydroxylase. Lunacalcipol binds to VDR and regulates transcriptional activity of VDR by influencing ligand binding affinity, ligand-dependent coactivator recruitment or inhibitory factor dissociation, efficiency of ligand entry into target cells, tissue specificity and different metabolism of ligand. Lunacalcipol can be used in the study of CKD, especially Secondary Hyperparathyroidism (sHPT) .
VDR agonist 2 (compound 16i) is a VDR(vitaminDreceptor) agonist that can effectively inhibit TGF-β1-induced activation of hepatic stellate cells (HSC). VDR agonist 2 has significant anti-hepatic fibrosis effects both in vitro and in vivo .
VDR agonist 1 (compound 28) is a nonsteroidal VitaminDreceptor (VDR) agonist, with an IC50 of 690 nM in MCF-7 cells. VDR agonist 1 arrests the cell cycle through the up-regulation of p21 and p27, promotes apoptosis by increasing the expression of BAX and decrease the expression of Bcl-2 .
LG190178 is a non-steroidal vitaminDreceptor (VDR) ligand that can induce the formation of heterodimer complexes between VDR and retinoid X receptor (RXR), stabilizing the agonistic conformation of the VDR ligand-binding domain and promoting its interaction with co-activators. LG190178 has functions in regulating calcium homeostasis, bone mineralization, as well as cell proliferation, differentiation, and apoptosis, making it useful for research in psoriasis, osteoporosis, and cancer .
Flucythrinate is a synthetic pyrethroid with endocrine suppressive properties. Flucythrinate showed good binding affinity to the vitaminD nuclear receptor (VDR) with a score of -11.0 kcal/mol. Flucythrinate has been proposed as a multi-target ligand that may interact with several proteins associated with breast cancer. The screening method for Flucythrinate showed good accuracy in binding site prediction and affinity estimation .
11-cis-Retinoic Acid-d5 is the deuterium labeled Retinoic acid. Retinoic acid is a metabolite of vitamin A that plays important roles in cell growth, differentiation, and organogenesis. Retinoic acid is a natural agonist of RAR nuclear receptors, with IC50s of 14 nM for RARα/β/γ. Retinoic acid bind to PPARβ/δ with Kd of 17 nM. Retinoic acid acts as an inhibitor of transcription factor Nrf2 through activation of retinoic acid receptor alpha[1][2].
Retinoic acid-d5 is the the deuterium labeled Retinoic acid (HY-14649). Retinoic acid is a metabolite of vitamin A that plays important roles in cell growth, differentiation, and organogenesis. Retinoic acid is a natural agonist of RAR nuclear receptors, with IC50s of 14 nM for RARα/β/γ. Retinoic acid bind to PPARβ/δ with Kd of 17 nM. Retinoic acid acts as an inhibitor of transcription factor Nrf2 through activation of retinoic acid receptor alpha .
Retinoic acid-d6 is the deuterium labeled Retinoic acid[1]. Retinoic acid is a metabolite of vitamin A that plays important roles in cell growth, differentiation, and organogenesis. Retinoic acid is a natural agonist of RAR nuclear receptors, with IC50s of 14 nM for RARα/β/γ. Retinoic acid bind to PPARβ/δ with Kd of 17 nM. Retinoic acid acts as an inhibitor of transcription factor Nrf2 through activation of retinoic acid receptor alpha[2][3][4][5][6][7].
ZG-126 is an agonist for vitaminDreceptor (VDR) and an inhibitor for histone deacetylase (HDAC) (IC50=0.63-67.6 μM). ZG-126 exhibits cytotoxicity in cancer cells MDA-MB-231 and 4T1. ZG-126 exhibits antitumor and anti-metastatic efficacy against melanoma and triple-negative breast cancer (TNBC) in mouse models. ZG-126 also exhibits anti-inflammatory activity, through the reduction of macrophage infiltration and immunosuppressive M2-polarization .
Secalciferol ((24R)-24,25-Dihydroxyvitamin D3) is the major active metabolite of VitaminD. Secalciferol activates vitaminDreceptor (VDR) with an EC50 value of 150 nM. Secalciferol is involved in a wide range of biological functions such as calcium homeostasis, cellular differentiation and proliferation processes, as well as other functions related to the immune system, which is promising for research of rickets, osteomalacia, hypercalcemia and autoimmune disorders .
Calcitriol (Standard) is the analytical standard of Calcitriol. This product is intended for research and analytical applications. Calcitriol is the most active metabolite of vitaminD and also a vitaminDreceptor (VDR) agonist.
Vitamin D receptor (VDR) acts as a nuclear receptor for calcitriol, the active form of vitamin D3, triggering cellular effects. After vitamin D3 binding, VDR translocates to the nucleus and forms a heterodimer with the retinoid X receptor (RXR). Vitamin D Receptor/VDR Protein, Human (sf9, His) is the recombinant human-derived Vitamin D Receptor/VDR protein, expressed by Sf9 insect cells , with C-His labeled tag. The total length of Vitamin D Receptor/VDR Protein, Human (sf9, His) is 427 a.a., with molecular weight of ~50 kDa.
Vitamin D receptor (VDR) protein is the nuclear receptor of calcitriol, which translocates to the nucleus after binding vitamin D3, thereby coordinating cellular activities.VDR forms a heterodimer with RXR, binds to DNA response elements, and initiates the transcription of vitamin D3-responsive genes.Vitamin D Receptor/VDR Protein, Mouse (sf9, His) is the recombinant mouse-derived Vitamin D Receptor/VDR protein, expressed by Sf9 insect cells , with C-His labeled tag.
Maxacalcitol-d66 is the deuterated form of Maxacalcitol (22-Oxacalcitriol), which is a non-calcemic vitaminD3 analog and VDR ligand of VDR-like receptors.
Retinoic acid-d5 is the the deuterium labeled Retinoic acid (HY-14649). Retinoic acid is a metabolite of vitamin A that plays important roles in cell growth, differentiation, and organogenesis. Retinoic acid is a natural agonist of RAR nuclear receptors, with IC50s of 14 nM for RARα/β/γ. Retinoic acid bind to PPARβ/δ with Kd of 17 nM. Retinoic acid acts as an inhibitor of transcription factor Nrf2 through activation of retinoic acid receptor alpha .
Calcitriol-d3 is the deuterium labeled Calcitriol[1]. Calcitriol is the most active metabolite of vitaminD and also a vitaminDreceptor (VDR) agonist[2][3][4][5].
11-cis-Retinoic Acid-d5 is the deuterium labeled Retinoic acid. Retinoic acid is a metabolite of vitamin A that plays important roles in cell growth, differentiation, and organogenesis. Retinoic acid is a natural agonist of RAR nuclear receptors, with IC50s of 14 nM for RARα/β/γ. Retinoic acid bind to PPARβ/δ with Kd of 17 nM. Retinoic acid acts as an inhibitor of transcription factor Nrf2 through activation of retinoic acid receptor alpha[1][2].
Retinoic acid-d6 is the deuterium labeled Retinoic acid[1]. Retinoic acid is a metabolite of vitamin A that plays important roles in cell growth, differentiation, and organogenesis. Retinoic acid is a natural agonist of RAR nuclear receptors, with IC50s of 14 nM for RARα/β/γ. Retinoic acid bind to PPARβ/δ with Kd of 17 nM. Retinoic acid acts as an inhibitor of transcription factor Nrf2 through activation of retinoic acid receptor alpha[2][3][4][5][6][7].
Vitamin D3 receptor; 125 dihydroxyVitamin D3 receptor; 1 antibody 1,25-@dihydroxyVitamin D3 receptor; 125 dihydroxyVitamin D3 receptor; 25-dihydroxyVitamin D3 receptor; NR1I1; Nuclear receptor subfamily 1 group I member 1; VDR; VDR_HUMAN; Vitamin D (1,25- dihydroxyVitamin D3) receptor; Vitamin D hormone receptor; Vitamin D receptor; Vitamin D3 receptor,
IHC-P, IHC-F, ICC/IF
Human, Rat
Vitamin D Receptor Antibody is an unconjugated, approximately 47 kDa, rabbit-derived, anti-Vitamin D Receptor polyclonal antibody. Vitamin D Receptor Antibody can be used for: IHC-P, IHC-F, ICC, IF expriments in human, rat, and predicted: mouse, chicken, pig, cow, horse, rabbit background without labeling.
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