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Results for "

alpha 2-adrenoceptor

" in MedChemExpress (MCE) Product Catalog:

By Targets:	5-HT Receptor (7) Adrenergic Receptor (71) Apoptosis (4) Autophagy (4) Dopamine Receptor (7) Endogenous Metabolite (3) Histamine Receptor (4) Histone Methyltransferase (5) Imidazoline Receptor (9) Isotope-Labeled Compounds (8) Monoamine Oxidase (3) Parasite (2)
By Research Areas:	Cancer (26) Cardiovascular Disease (28) Endocrinology (38) Inflammation/Immunology (5) Metabolic Disease (4) Neurological Disease (39)

Inhibitors & Agonists

Natural
Products

Isotope-Labeled Compounds

Targets Recommended: 5 alpha Reductase IFNAR α-synuclein PGC-1α

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-N1163

Tetrahydroalstonine	Adrenergic Receptor	Neurological Disease Endocrinology
Tetrahydroalstonine, a indole alkaloid isolated from the fruits of Rhazya stricta, is a selective **alpha 2-adrenoceptor** antagonist .

HY-103197

2-Methoxyidazoxan monohydrochloride RX821002 hydrochloride	Adrenergic Receptor	Neurological Disease
2-Methoxyidazoxan monohydrochloride (RX821002 hydrochloride) is a highly selective **alpha 2-adrenoceptor** antagonist with little or no imidazoline antagonist effect. RX 821002 has markedly higher affinity for (guinea-pig) alpha 2D-adrenoceptors (pK_d 9.7) than for (rabbit) alpha 2A-adrenoceptors (pK_d 8.2) .

HY-N3298

Meranzin	Adrenergic Receptor	Cardiovascular Disease Neurological Disease
Meranzin is an absorbed bioactive compound from the Traditional Chinese Medicine (TCM) Chaihu-Shugan-San (CSS). Meranzin, isolated from leaves of Murraya exotica L., regulates the shared alpha 2-adrenoceptor and involves the AMPA-ERK1/2–BDNF signaling pathway. Meranzin has the potential for the prevention of the comorbidity of atherosclerosis and depression .

HY-100490B

Rilmenidine phosphate	Imidazoline Receptor Adrenergic Receptor Apoptosis Autophagy	Cardiovascular Disease Cancer
Rilmenidine phosphate, an innovative antihypertensive agent, is an orally active, selective I1 imidazoline receptor agonist. Rilmenidine phosphate is an **alpha 2-adrenoceptor agonist. Rilmenidine phosphate induces autophagy**. Rilmenidine phosphate acts both centrally by reducing sympathetic overactivity and in the kidney by inhibiting the Na ⁺/H ⁺ antiport. Rilmenidine phosphate modulates proliferation and stimulates the proapoptotic protein Bax thus inducing the perturbation of the mitochondrial pathway and apoptosis in human leukemic K562 cells .

HY-106769

Fluparoxan GR50360	Adrenergic Receptor	Neurological Disease
Fluparoxan is an orally active, selective and competitive **alpha 2-adrenoceptor** antagonist. Fluparoxan is an anti-depressant agent .

HY-106769C

Fluparoxan hydrochloride GR50360 hydrochloride	Adrenergic Receptor	Neurological Disease
Fluparoxan hydrochloride is an orally active, selective and competitive **alpha 2-adrenoceptor** antagonist. Fluparoxan hydrochloride is an anti-depressant agent .

HY-103212

Azepexole dihydrochloride B-HT 933 dihydrochloride; Oxazoloazepin dihydrochloride	Adrenergic Receptor	Cardiovascular Disease Endocrinology
Azepexole (B-HT 933) dihydrochloride is a potent and selective **alpha 2-adrenoceptor agonist with pK_i*s of 8.3, 7.6, and 7.5 for α2A-, α2B- and α2C-adrenoceptor* subtypes, resepctively . Azepexole dihydrochloride causes concentration-dependent inhibition of peristaltic contractions (IC₅₀= 78.72 nM) .

HY-103212A

Azepexole hydrochloride B-HT 933 hydrochloride; Oxazoloazepin hydrochloride	Adrenergic Receptor	Cardiovascular Disease
Azepexole hydrochloride (B-HT 933 dihydrochloride; Oxazoloazepin dihydrochloride) is a selective agonist for α 2-adrenoceptor, with pK_i of 8.3, 7.6, and 7.5 for α2A-, α2B- and α2C-adrenoceptor subtypes, resepctively. Azepexole dihydrochloride causes concentration-dependent inhibition of peristaltic contractions with IC₅₀ of 78.72 nM. Azepexole hydrochloride exhibits antitussive and analgesic efficacy .

HY-100490

Rilmenidine	Imidazoline Receptor Adrenergic Receptor Apoptosis Autophagy	Cardiovascular Disease Cancer
Rilmenidine, an innovative antihypertensive agent, is an orally active, selective I1 imidazoline receptor agonist. Rilmenidine is an **alpha 2-adrenoceptor agonist. Rilmenidine induces autophagy**. Rilmenidine acts both centrally by reducing sympathetic overactivity and in the kidney by inhibiting the Na ⁺/H ⁺ antiport. Rilmenidine modulates proliferation and stimulates the proapoptotic protein Bax thus inducing the perturbation of the mitochondrial pathway and apoptosis in human leukemic K562 cells .

HY-N3298R

Meranzin (Standard)	Adrenergic Receptor	Cardiovascular Disease Neurological Disease
Meranzin (Standard) is the analytical standard of Meranzin. This product is intended for research and analytical applications. Meranzin is an absorbed bioactive compound from the Traditional Chinese Medicine (TCM) Chaihu-Shugan-San (CSS). Meranzin, isolated from leaves of Murraya exotica L., regulates the shared alpha 2-adrenoceptor and involves the AMPA-ERK1/2–BDNF signaling pathway. Meranzin has the potential for the prevention of the comorbidity of atherosclerosis and depression .

HY-100490A

Rilmenidine hemifumarate	Imidazoline Receptor Adrenergic Receptor Apoptosis Autophagy	Cardiovascular Disease Cancer
Rilmenidine hemifumarate, an innovative antihypertensive agent, is an orally active, selective I1 imidazoline receptor agonist. Rilmenidine hemifumarate is an **alpha 2-adrenoceptor** agonist. Rilmenidine hemifumarate induces autophagy. Rilmenidine hemifumarate acts both centrally by reducing sympathetic overactivity and in the kidney by inhibiting the Na ⁺/H ⁺ antiport. Rilmenidine hemifumarate modulates proliferation and stimulates the proapoptotic protein Bax thus inducing the perturbation of the mitochondrial pathway and apoptosis in human leukemic K562 cells .

HY-100490S

Rilmenidine-d4	Isotope-Labeled Compounds Imidazoline Receptor Adrenergic Receptor Apoptosis Autophagy	Cardiovascular Disease Cancer
Rilmenidine-d₄ is the deuterium labeled Rilmenidine. Rilmenidine, an innovative antihypertensive agent, is an orally active, selective I1 imidazoline receptor agonist. Rilmenidine is an alpha 2-adrenoceptor agonist. Rilmenidine induces autophagy. Rilmenidine acts both centrally by reducing sympathetic overactivity and in the kidney by inhibiting the Na+/H+ antiport. Rilmenidine modulates proliferation and stimulates the proapoptotic protein Bax thus inducing the perturbation of the mitochondrial pathway and apoptosis in human leukemic K562 cells[1][2][3].

HY-106769A

(3aR,9aR)-Fluparoxan hydrochloride (3aR,9aR)-GR50360 hydrochloride	Others	Neurological Disease
(3aR,9aR)-Fluparoxan ((3aR,9aR)-GR50360) hydrochloride is a compound that can be used to synthesize and prevent and improve neurodevelopmental disorders .

HY-U00165

Midaglizole hydrochloride (±)-DG5128; DG5128	Adrenergic Receptor	Metabolic Disease Endocrinology
Midaglizole hydrochloride (DG5128) is a preferential *α2-adrenoceptor* antagonist. Midaglizole hydrochloride (DG5128) exhibits 7.4 times higher affinity (pK_i=6.28) toward α2-adrenoceptor than α1-adrenoceptor.

HY-106874B

rel-Delequamine rel-RS-15385-197	Others	Neurological Disease
rel-Delequamine (rel-RS-15385-197) is an orally active, brain-penetrant, potent and selective *M₂-adrenoceptor* antagonist and *α₂-adrenoceptor* antagonist. rel-Delequamine has a pK_i of 9.45 for α₂-adrenoceptors in the rat cortex. rel-Delequamine augments K ⁺-evoked release of noradrenaline with an EC₅₀ of 1 nM .

HY-B0409A

Clonidine hydrochloride 5 Publications Verification	Adrenergic Receptor	Cardiovascular Disease Endocrinology Cancer
Clonidine hydrochloride is an agonist of *α2-adrenoceptor* and potent antihypertensive agent.

HY-155879

(±)-N-Methylcoclaurine	Adrenergic Receptor	Others
(±)-N-Methylcoclaurine is a selective α2-adrenoceptor antagonist .

HY-101683

Deriglidole SL 86-0715	Adrenergic Receptor	Metabolic Disease Endocrinology
Deriglidole is a peripheral *adrenoceptor* antagonist with a high affinity for α₂-adrenoceptors.

HY-12380A

Atipamezole 5+ Cited Publications MPV 1248	Adrenergic Receptor	Neurological Disease Endocrinology
Atipamezole (MPV 1248) is a potent α₂-adrenoceptor antagonist with a K_i of 1.6 nM .

HY-12380

Atipamezole hydrochloride 5+ Cited Publications MPV-1248 hydrochloride	Adrenergic Receptor	Neurological Disease Endocrinology
Atipamezole (MPV-1248) hydrochloride is a potent α₂-adrenoceptor antagonist with a K_i of 1.6 nM .

HY-12710

Rauwolscine α-Yohimbine; Corynanthidine; Isoyohimbine	Adrenergic Receptor	Cancer
Rauwolscine is a selective *α2-adrenoceptor* antagonist that inhibits tumor growth and induces apoptosis .

HY-17034

Medetomidine	Adrenergic Receptor	Neurological Disease Endocrinology
Medetomidine is an orally active *α2-adrenoceptor* agonist (K_i: 1.08 nM). Medetomidine has sedative and analgesic effects. Medetomidine can cause peripheral vasoconstriction through the activation of α2 adrenoceptors on blood vessels .

HY-17034B

Medetomidine hydrochloride MPV785	Adrenergic Receptor	Neurological Disease Endocrinology
Medetomidine hydrochloride is an orally active *α2-adrenoceptor* agonist (K_i: 1.08 nM). Medetomidine hydrochloride has sedative and analgesic effects. Medetomidine hydrochloride can cause peripheral vasoconstriction through the activation of α2 adrenoceptors on blood vessels .

HY-136935

Alloyohimbine	Adrenergic Receptor	Endocrinology
Alloyohimbine, an alkaloid, is a selective *α2-adrenoceptor* antagonist with K_Dα1, K_Dα2 of 0.28 μM and 0.006 μM, respectively .

HY-W263279

(E)-Guanabenz (E)-Wy-8678	Adrenergic Receptor	Cardiovascular Disease Neurological Disease
(E)-Guanabenz ((E)-Wy-8678) is an orally active central *α2-adrenoceptor* agonist. (E)-Guanabenz has antihypertensive activity, acts via stimulating central α2-adrenoceptors, and reducing net sympathetic outflow into the periphery. (E)-Guanabenz also directly binds to and inhibits GADD34, and has neuroprotective activity. (E)-Guanabenz can be used for researching hypertension and Parkinson disease .

HY-B0409AR

Clonidine hydrochloride (Standard)	Adrenergic Receptor	Cardiovascular Disease Endocrinology Cancer
Clonidine (hydrochloride) (Standard) is the analytical standard of Clonidine (hydrochloride). This product is intended for research and analytical applications. Clonidine hydrochloride is an agonist of α2-adrenoceptor and potent antihypertensive agent.

HY-U00206

D2343	Adrenergic Receptor	Endocrinology
D2343 is a *β2-adrenoceptor* agonist and also is an α1- adrenoceptor inhibitor.

HY-103203

ST91	Adrenergic Receptor	Neurological Disease
ST91 is a **α₂-adrenoceptor (α₂AR)** agonist. ST91 activates both α_2AAR and non-α_2AAR subtypes to produce spinal antinociception .

HY-B0409S

Clonidine-d4	Adrenergic Receptor	Cardiovascular Disease Endocrinology Cancer
Clonidine-d₄ is the deuterium labeled Clonidine. Clonidine hydrochloride is an agonist of α2-adrenoceptor and potent antihypertensive agent[1][2][3][4][5].

HY-17034BS1

Medetomidine-13C,d3 hydrochloride MPV785-¹³C,d₃	Isotope-Labeled Compounds Adrenergic Receptor	Endocrinology
Medetomidine-13C,d3 (hydrochloride) is a deuterated labeled Medetomidine (hydrochloride) . Medetomidine hydrochloride is an orally active *α2-adrenoceptor* agonist (K_i: 1.08 nM). Medetomidine hydrochloride has sedative and analgesic effects. Medetomidine hydrochloride can cause peripheral vasoconstriction through the activation of α2 adrenoceptors on blood vessels .

HY-A0008

Talipexole dihydrochloride B-HT 920 dihydrochloride	Adrenergic Receptor Dopamine Receptor 5-HT Receptor	Neurological Disease Endocrinology
Talipexole dihydrochloride (B-HT 920 dihydrochloride) is a dopamine D2 receptor agonist, α2-adrenoceptor agonist and 5-HT3 receptor antagonist, which displays antiParkinsonian activity.

HY-B0354A

Urapidil hydrochloride	5-HT Receptor Adrenergic Receptor	Cardiovascular Disease Endocrinology
Urapidil hydrochloride is an orally active *α1-adrenoceptor* antagonist and 5-HT_1A receptor agonist with a pIC₅₀ of 6.13 and 4.38 against α1- and α2-adrenoceptor, respectively. Urapidil hydrochloride shows antihypertensive effect .

HY-17034A

Dexmedetomidine hydrochloride Maximum Cited Publications 10 Publications Verification (+)-Medetomidine hydrochloride; (S)-Medetomidine hydrochloride	Adrenergic Receptor	Neurological Disease Endocrinology Cancer
Dexmedetomidine hydrochloride ((+)-Medetomidine hydrochloride) is a potent, selective and orally active agonist of *α2-adrenoceptor, with a K_i* of 1.08 nM. Dexmedetomidine hydrochloride shows 1620-fold selectivity against α1-adrenoceptor. Dexmedetomidine hydrochloride exhibits anxiolysis, sedation, and modest analgesia effects .

HY-12719

Dexmedetomidine Maximum Cited Publications 10 Publications Verification (+)-Medetomidine; (S)-Medetomidine	Adrenergic Receptor	Neurological Disease Cancer
Dexmedetomidine ((+)-Medetomidine) is a potent, selective and orally active agonist of *α2-adrenoceptor, with a K_i* of 1.08 nM. Dexmedetomidine shows 1620-fold selectivity against α1-adrenoceptor. Dexmedetomidine exhibits anxiolysis, sedation, and modest analgesia effects .

HY-101061

2-MPMDQ	Adrenergic Receptor	Cardiovascular Disease
2-MPMDQ is a potent and selective *α1-adrenoceptor* (K_i=0.37 nM) antagonist over α2-adrenoceptor (K_i=1740 nM). 2-MPMDQ is potent anti-hypertensive agent and has the potential for hypertension research .

HY-B1416A

Efaroxan hydrochloride	Adrenergic Receptor Imidazoline Receptor	Cardiovascular Disease Metabolic Disease
Efaroxan hydrochloride is a potent, selective and orally active *α2-adrenoceptor* antagonist, with antidiabetic activity. Efaroxan hydrochloride is a selective I1-Imidazoline receptor antagonist. Efaroxan hydrochloride can be used for the research of cardiovascular disease .

HY-148529

Midaglizole (±)-DG5128 free base; DG5128 free base	Adrenergic Receptor	Metabolic Disease
Midaglizole ((±)-DG5128 free base, DG5128 free base) is a potent *α2-adrenoceptor* antagonist. Midaglizole is a hypoglycemic agent. Midaglizole increases blood pressure and reduces blood glucose levels in vivo .

HY-100850

Piperoxan hydrochloride Benodaine hydrochloride	Adrenergic Receptor	Inflammation/Immunology Endocrinology
Piperoxan (Benodaine) hydrochloride is an α₂ adrenoceptor antagonist. Piperoxan hydrochloride is the first-generation antihistamine.

HY-106874

Delequamine RS-15385-197	Adrenergic Receptor	Neurological Disease
Delequamine (RS-15385-197) is an orally active and selective α2-adrenergic receptor antagonist with a pK_i of 9.5 for α2-adrenoceptors in rat cortex. Delequamine shows >1000 fold selectivity against 5-HT1A receptors and α1-adrenoceptors. Delequamine can be used for the study of erectile dysfunction .

HY-106874A

Delequamine hydrochloride RS-15385-197 hydrochloride	Adrenergic Receptor	Neurological Disease
Delequamine (RS-15385-197) hydrochloride is an orally active and selective α2-adrenergic receptor antagonist with a pK_i of 9.5 for α2-adrenoceptors in rat cortex. Delequamine hydrochloride shows >1000 fold selectivity against 5-HT1A receptors and α1-adrenoceptors. Delequamine hydrochloride can be used for the study of erectile dysfunction .

HY-B0354AR

Urapidil hydrochloride (Standard)	5-HT Receptor Adrenergic Receptor	Cardiovascular Disease Endocrinology
Urapidil (hydrochloride) (Standard) is the analytical standard of Urapidil (hydrochloride). This product is intended for research and analytical applications. Urapidil hydrochloride is an orally active *α1-adrenoceptor* antagonist and 5-HT_1A receptor agonist with a pIC₅₀ of 6.13 and 4.38 against α1- and α2-adrenoceptor, respectively. Urapidil hydrochloride shows antihypertensive effect .

HY-101338

RS-79948-197	Adrenergic Receptor	Neurological Disease
RS-79948-197 is a non-imidazoline *α2-adrenoceptor* antagonist. RS-79948-197 shows K_d values of 0.42 nM, 0.18 nM, 0.19 nM, 0.60 nM, 0.46 nM, and 0.77 nM for rat α2A, rat α2B, rat α2C, human α2A, human α2B, and human α2C, respectively .

HY-12724

Guanabenz	Adrenergic Receptor Parasite	Cardiovascular Disease
Guanabenz is an orally active *α-2-adrenoceptor* agonist. Guanabenz has antihypertensive effect and antiparasitic activity. Guanabenz interferes ER stress-signalling and has protective effects in cardiac myocytes. Guanabenz also is used for the research of high blood pressure .

HY-12724A

Guanabenz hydrochloride 2 Publications Verification	Parasite Adrenergic Receptor	Cardiovascular Disease
Guanabenz hydrochloride is an orally active *α-2-adrenoceptor* agonist. Guanabenz hydrochloride has antihypertensive effect and antiparasitic activity. Guanabenz hydrochloride interferes ER stress-signalling and has protective effects in cardiac myocytes. Guanabenz hydrochloride also is used for the research of high blood pressure .

HY-12719R

Dexmedetomidine (Standard)	Adrenergic Receptor	Neurological Disease Cancer
Dexmedetomidine (Standard) is the analytical standard of Dexmedetomidine. This product is intended for research and analytical applications. Dexmedetomidine ((+)-Medetomidine) is a potent, selective and orally active agonist of *α2-adrenoceptor, with a K_i* of 1.08 nM. Dexmedetomidine shows 1620-fold selectivity against α1-adrenoceptor. Dexmedetomidine exhibits anxiolysis, sedation, and modest analgesia effects .

HY-B0528A

Octopamine hydrochloride 1 Publications Verification (±)-p-Octopamine hydrochloride	Adrenergic Receptor Endogenous Metabolite	Neurological Disease Endocrinology
Octopamine ((±)-p-Octopamine) hydrochloride, a biogenic monoamine structurally related to noradrenaline, acts as a neurohormone, a neuromodulator and a neurotransmitter in invertebrates. Octopamine hydrochloride can stimulate alpha2-adrenoceptors (ARs) in Chinese hamster ovary cells transfected with human alpha2-ARs. Octopamine hydrochloride increased glycogenolysis, glycolysis, oxygen uptake, gluconeogenesis and the portal perfusion pressure .

HY-17034AR

Dexmedetomidine hydrochloride (Standard) (+)-Medetomidine hydrochloride (Standard); (S)-Medetomidine hydrochloride (Standard)	Adrenergic Receptor	Neurological Disease Endocrinology Cancer
Dexmedetomidine (hydrochloride) (Standard) is the analytical standard of Dexmedetomidine (hydrochloride). This product is intended for research and analytical applications. Dexmedetomidine hydrochloride ((+)-Medetomidine hydrochloride) is a potent, selective and orally active agonist of *α2-adrenoceptor, with a K_i* of 1.08 nM. Dexmedetomidine hydrochloride shows 1620-fold selectivity against α1-adrenoceptor. Dexmedetomidine hydrochloride exhibits anxiolysis, sedation, and modest analgesia effects .

HY-161836

α2AR agonist 1	Adrenergic Receptor	Cardiovascular Disease
α2AR agonist 1 (compound S6a), a new morpholine-containing pyrimidinone, acts as an agonist of *α2-adrenoceptor*. α2AR agonist 1 induces a concentration-dependent relaxation on aortic ring pre-contracted with Phenylephrine (HY-B0769; pEC₅₀=6.81). α2AR agonist 1 increases NOx and NO levels in HUVECs .

HY-17034AS

Dexmedetomidine-13C,d3 hydrochloride (+)-Medetomidine-¹³C,d₃ hydrochloride; (S)-Medetomidine-¹³C,d₃ hydrochloride	Isotope-Labeled Compounds Adrenergic Receptor	Neurological Disease Endocrinology Cancer
Dexmedetomidine- ¹³C,d₃ (hydrochloride) is the ¹³C- and deuterium labeled Dexmedetomidine (hydrochloride). Dexmedetomidine hydrochloride ((+)-Medetomidine hydrochloride) is a potent, selective and orally active agonist of α2-adrenoceptor, with a Ki of 1.08 nM. Dexmedetomidine hydrochloride shows 1620-fold selectivity against α1-adrenoceptor. Dexmedetomidine hydrochloride exhibits anxiolysis, sedation, and modest analgesia effects[1][2][3].

HY-14561A

Idazoxan hydrochloride RX 781094 hydrochloride	Adrenergic Receptor Imidazoline Receptor	Neurological Disease Endocrinology
Idazoxan hydrochloride (RX 781094 hydrochloride) is an *α₂-adrenoceptor* antagonist and is also a imidazoline receptors (IRs) antagonist competitively antagonized the centrally induced hypotensive effect of imidazoline-like agents (IMs). Idazoxan hydrochloride also improves motor symptoms in Parkinson’s disease, L-DOPA-induced dyskinesias, and experimental Parkinsonism .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N1163

Tetrahydroalstonine	Apocynaceae Alkaloids Source classification Plants Indole Alkaloids Catharanthus roseus (L.) G. Don	Adrenergic Receptor
Tetrahydroalstonine, a indole alkaloid isolated from the fruits of Rhazya stricta, is a selective **alpha 2-adrenoceptor** antagonist .

HY-N3298

Meranzin	Cardiovascular Disease other families Classification of Application Fields Neurological Disease Source classification Coumarins Phenylpropanoids Plants Disease Research Fields	Adrenergic Receptor
Meranzin is an absorbed bioactive compound from the Traditional Chinese Medicine (TCM) Chaihu-Shugan-San (CSS). Meranzin, isolated from leaves of Murraya exotica L., regulates the shared alpha 2-adrenoceptor and involves the AMPA-ERK1/2–BDNF signaling pathway. Meranzin has the potential for the prevention of the comorbidity of atherosclerosis and depression .

HY-12710

Rauwolscine α-Yohimbine; Corynanthidine; Isoyohimbine	Apocynaceae Rauvolfia tetraphylla Linn. Alkaloids Structural Classification Source classification Plants Indole Alkaloids	Adrenergic Receptor
Rauwolscine is a selective *α2-adrenoceptor* antagonist that inhibits tumor growth and induces apoptosis .

HY-B0528A

Octopamine hydrochloride 1 Publications Verification (±)-p-Octopamine hydrochloride	Structural Classification Monophenols Neurological Disease Classification of Application Fields Source classification Phenols Endogenous metabolite Disease Research Fields Endocrinology	Adrenergic Receptor Endogenous Metabolite
Octopamine ((±)-p-Octopamine) hydrochloride, a biogenic monoamine structurally related to noradrenaline, acts as a neurohormone, a neuromodulator and a neurotransmitter in invertebrates. Octopamine hydrochloride can stimulate alpha2-adrenoceptors (ARs) in Chinese hamster ovary cells transfected with human alpha2-ARs. Octopamine hydrochloride increased glycogenolysis, glycolysis, oxygen uptake, gluconeogenesis and the portal perfusion pressure .

HY-N3298R

Meranzin (Standard)	Structural Classification other families Source classification Coumarins Phenylpropanoids Plants	Adrenergic Receptor
Meranzin (Standard) is the analytical standard of Meranzin. This product is intended for research and analytical applications. Meranzin is an absorbed bioactive compound from the Traditional Chinese Medicine (TCM) Chaihu-Shugan-San (CSS). Meranzin, isolated from leaves of Murraya exotica L., regulates the shared alpha 2-adrenoceptor and involves the AMPA-ERK1/2–BDNF signaling pathway. Meranzin has the potential for the prevention of the comorbidity of atherosclerosis and depression .

HY-136935

Alloyohimbine	Apocynaceae Alkaloids Structural Classification Source classification Alstonia scholaris (L.) R. Br. Plants Indole Alkaloids	Adrenergic Receptor
Alloyohimbine, an alkaloid, is a selective *α2-adrenoceptor* antagonist with K_Dα1, K_Dα2 of 0.28 μM and 0.006 μM, respectively .

HY-B0528AR

Octopamine hydrochloride (Standard)	Structural Classification Monophenols Source classification Phenols Endogenous metabolite	Adrenergic Receptor Endogenous Metabolite
Octopamine (hydrochloride) (Standard) is the analytical standard of Octopamine (hydrochloride). This product is intended for research and analytical applications. Octopamine ((±)-p-Octopamine) hydrochloride, a biogenic monoamine structurally related to noradrenaline, acts as a neurohormone, a neuromodulator and a neurotransmitter in invertebrates. Octopamine hydrochloride can stimulate alpha2-adrenoceptors (ARs) in Chinese hamster ovary cells transfected with human alpha2-ARs. Octopamine hydrochloride increased glycogenolysis, glycolysis, oxygen uptake, gluconeogenesis and the portal perfusion pressure .

HY-101392R

Harmane (Standard)	Structural Classification Alkaloids other families Source classification Plants	Imidazoline Receptor Monoamine Oxidase Adrenergic Receptor
Harmane (Standard) is the analytical standard of Harmane. This product is intended for research and analytical applications. Harmane, a β-Carboline alkaloid (BCA), is a potent neurotoxin that causes severe action tremors and psychiatric manifestations. Harmane shows 1000-fold selectivity for I1-Imidazoline receptor (IC₅₀=30 nM) over *α2-adrenoceptor* (IC₅₀=18 μM). Harmane is also a potent and selective inhibitor of monoamine oxidase (MAO) (IC₅₀s=0.5 and 5 μM for human MAO A/B, respectively). Harmane exhibits comutagenic effect .

Cat. No.	Product Name	Chemical Structure

HY-B0528AS

Octopamine-d4 hydrochloride

Octopamine-d₄ (hydrochloride) is the deuterium labeled Octopamine hydrochloride. Octopamine ((±)-p-Octopamine) hydrochloride, a biogenic monoamine structurally related to noradrenaline, acts as a neurohormone, a neuromodulator and a neurotransmitter in invertebrates. Octopamine hydrochloride can stimulate alpha2-adrenoceptors (ARs) in Chinese hamster ovary cells transfected with human alpha2-ARs. Octopamine hydrochloride increased glycogenolysis, glycolysis, oxygen uptake, gluconeogenesis and the portal perfusion pressure[1][2][3].

HY-101392S

Harmane-d1

Harmane-d is the deuterium labeled Harmane. Harmane, a β-Carboline alkaloid (BCA), is a potent neurotoxin that causes severe action tremors and psychiatric manifestations. Harmane shows 1000-fold selectivity for I1-Imidazoline receptor (IC50=30 nM) over α2-adrenoceptor (IC50=18 μM). Harmane is also a potent and selective inhibitor of monoamine oxidase (MAO) (IC50s=0.5 and 5 μM for human MAO A/B, respectively)[1][2][3][4].

HY-100490S

Rilmenidine-d4

Rilmenidine-d₄ is the deuterium labeled Rilmenidine. Rilmenidine, an innovative antihypertensive agent, is an orally active, selective I1 imidazoline receptor agonist. Rilmenidine is an alpha 2-adrenoceptor agonist. Rilmenidine induces autophagy. Rilmenidine acts both centrally by reducing sympathetic overactivity and in the kidney by inhibiting the Na+/H+ antiport. Rilmenidine modulates proliferation and stimulates the proapoptotic protein Bax thus inducing the perturbation of the mitochondrial pathway and apoptosis in human leukemic K562 cells[1][2][3].

HY-B0409S

Clonidine-d4
Clonidine-d₄ is the deuterium labeled Clonidine. Clonidine hydrochloride is an agonist of α2-adrenoceptor and potent antihypertensive agent[1][2][3][4][5].

HY-17034BS1

Medetomidine-13C,d3 hydrochloride
Medetomidine-13C,d3 (hydrochloride) is a deuterated labeled Medetomidine (hydrochloride) . Medetomidine hydrochloride is an orally active *α2-adrenoceptor* agonist (K_i: 1.08 nM). Medetomidine hydrochloride has sedative and analgesic effects. Medetomidine hydrochloride can cause peripheral vasoconstriction through the activation of α2 adrenoceptors on blood vessels .

HY-17034AS

Dexmedetomidine-13C,d3 hydrochloride

Dexmedetomidine- ¹³C,d₃ (hydrochloride) is the ¹³C- and deuterium labeled Dexmedetomidine (hydrochloride). Dexmedetomidine hydrochloride ((+)-Medetomidine hydrochloride) is a potent, selective and orally active agonist of α2-adrenoceptor, with a Ki of 1.08 nM. Dexmedetomidine hydrochloride shows 1620-fold selectivity against α1-adrenoceptor. Dexmedetomidine hydrochloride exhibits anxiolysis, sedation, and modest analgesia effects[1][2][3].

HY-B0352S2

Mirtazapine-d4
Mirtazapine-d₄ is deuterium labeled Mirtazapine. Mirtazapine (Org3770) is a potent and orally active noradrenergic and specific serotonergic antidepressant (NaSSA) agent. Mirtazapine is also a 5-HT2, 5-HT3, histamine H1 receptor and α2-adrenoceptor antagonist with pKi values of 8.05, 8.1, 9.3 and 6.95, respectively[1][2].

HY-B0352S3

Mirtazapine-d4 hydrochloride
Mirtazapine-d₄ hydrochloride is deuterated labeled Mirtazapine (HY-B0352). Mirtazapine (Org3770) is a potent and orally active noradrenergic and specific serotonergic antidepressant (NaSSA) agent. Mirtazapine is also a 5-HT₂, 5-HT₃, histamine H1 receptor and *α2-adrenoceptor* antagonist with pK_i values of 8.05, 8.1, 9.3 and 6.95, respectively .

HY-101392S1

Harmane-d2

Harmane-d₂ is the deuterium labeled Harmane. Harmane, a β-Carboline alkaloid (BCA), is a potent neurotoxin that causes severe action tremors and psychiatric manifestations. Harmane shows 1000-fold selectivity for I1-Imidazoline receptor (IC50=30 nM) over α2-adrenoceptor (IC50=18 μM). Harmane is also a potent and selective inhibitor of monoamine oxidase (MAO) (IC50s=0.5 and 5 μM for human MAO A/B, respectively)[1][2][3][4].

HY-15746S1

(rac)-Dobutamine-d6 hydrochloride

(rac)-Dobutamine-d₆ (hydrochloride) is a labelled racemic Dobutamine hydrochloride. Dobutamine hydrochloride is a synthetic catecholamine that acts on α1-AR, β1-AR, β2-AR (α-1, β-1 andβ-2 adrenoceptors). Dobutamine hydrochloride is a selective β1-AR agonist, relatively weak activity at α1-AR and β2-AR. Dobutamine hydrochloride can increase cardiac output and correct hypoperfusion[1][2][3][4].

HY-15746S

(rac)-Dobutamine-d4 hydrochloride

(rac)-Dobutamine-d₄ (hydrochloride) is a labelled racemic Dobutamine hydrochloride. Dobutamine hydrochloride is a synthetic catecholamine that acts on α1-AR, β1-AR, β2-AR (α-1, β-1 andβ-2 adrenoceptors). Dobutamine hydrochloride is a selective β1-AR agonist, relatively weak activity at α1-AR and β2-AR. Dobutamine hydrochloride can increase cardiac output and correct hypoperfusion[1][2][3][4].

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