2. Search Result
Search Result
Results for "

antiarrhythmic activity

" in MedChemExpress (MCE) Product Catalog:

46

Inhibitors & Agonists

9

Natural
Products

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-124883
    R-(–)-Flecainide

    		Others Cardiovascular Disease
    R-(–)-Flecainide is an orally active antiarrhythmic agent, which inhibits ventricular ectopic activity .
    R-(–)-Flecainide
  • HY-B1656
    Fomocaine

    P 652

    		 Others Cardiovascular Disease Neurological Disease
    Fomocaine (P 652) is an orally active local agent that can suppress or relieve pain. Fomocaine shows antiarrhythmic activity .
    Fomocaine
  • HY-122364
    Bucumolol hydrochloride

    		Adrenergic Receptor Cardiovascular Disease
    Bucumolol hydrochloride is a β-adrenergic receptor antagonist that can slow heart rate (negative chronotropic effect) and reduce cardiac contractility (negative inotropic effect). Bucumolol hydrochloride has antiarrhythmic and local anesthetic activity and can be used in the study of cardiovascular diseases .
    Bucumolol hydrochloride
  • HY-117471
    Antiarrhythmic agent-3

    		Others Neurological Disease
    Antiarrhythmic agent-3 is an antiarrhythmic drug with the activity of enhancing antiarrhythmic efficacy and improving inhibition index. The antiarrhythmic effect of antiarrhythmic agent-3 is related to its hydrophobicity (log P). The central nervous system toxicity of antiarrhythmic agent-3 is related to the combined effect of its hydrophobicity and acid constant (pKa) .
    Antiarrhythmic agent-3
  • HY-122423
    Desethylamiodarone

    N-Deethylamiodarone; LB 33020

    		 Apoptosis Drug Metabolite Cardiovascular Disease Cancer
    Desethylamiodarone (N-Deethylamiodarone) is the major metabolite of antiarrhythmic compound Amiodarone (HY-14187). Desethylamiodarone has antiarrhythmic activity. Desethylamiodaron also induces cancer cell apoptosis .
    Desethylamiodarone
  • HY-101668
    Sulamserod

    RS-100302

    		 5-HT Receptor Cardiovascular Disease
    Sulamserod is a 5-HT4 receptor antagonist, with antiarrhythmic activities.
    Sulamserod
  • HY-19679
    Quinacainol

    PK 10139

    		 Others Cardiovascular Disease
    Quinacainol is a Class I antiarrhythmic drug with antiarrhythmic activity. Quinacainol improves arrhythmias by affecting the electrophysiological properties of the heart. Quinacainol is 5 to 10 times more effective for arrhythmia than Quinidine (HY-150123). Quinacainol can be used to study cardiac electrophysiology .
    Quinacainol
  • HY-19004
    711389-S hydrochloride

    		Others Cardiovascular Disease
    711389-S hydrochloride is an antiarrhythmic compound that demonstrates its antiarrhythmic activity by increasing the ventricular fibrillation threshold (VFT). 711389-S hydrochloride also has strong anti-fibrillation effects and safety, and can be used in the study of ventricular fibrillation and sudden cardiac death .
    711389-S hydrochloride
  • HY-19857
    Sulcardine sulfate

    		Calcium Channel Potassium Channel Sodium Channel Neurological Disease
    Sulcardine (sulfate) is a novel multi-ion channel blocker with activity against Na +, K + and Ca 2+ channels. Sulcardine has antiarrhythmic activity .
    Sulcardine sulfate
  • HY-18600B
    (E)-Azimilide

    (E)-NE-10064

    		 Potassium Channel Cardiovascular Disease
    (E)-Azimilide is an isomer of Azimilide (HY-18600), a class of antiarrhythmic compounds that inhibit I(Ks) and I(Kr) activity .
    (E)-Azimilide
  • HY-B1067B
    Antazoline phosphate

    Phenazoline phosphate

    		 Histamine Receptor Neurological Disease
    Antazoline phosphate is an H1 receptor antagonist that affects the activity of the central nervous system, has a potent antiarrhythmic effect .
    Antazoline phosphate
  • HY-B1067A
    Antazoline

    Phenazoline

    		 Histamine Receptor Neurological Disease
    Antazoline (Phenazoline) is an H1 receptor antagonist that affects the activity of the central nervous system, has a potent antiarrhythmic effect .
    Antazoline
  • HY-101205
    ICI 199441

    		Opioid Receptor Cardiovascular Disease
    ICI 199441 is a potent and selective κ-opioid receptor agonist. ICI 199441 can improve heart resistance to ischemia/reperfusion .
    ICI 199441
  • HY-116500A
    AH-1058

    		Others Cardiovascular Disease
    AH-1058 is a newly synthesized antiarrhythmic agent that exhibits significant antiarrhythmic activity by delaying premature ventricular complexes and ventricular fibrillation in experimental arrhythmia models. AH-1058 effectively inhibits both ventricular tachycardia and ventricular fibrillation in the reperfusion-induced arrhythmia model in rats. AH-1058 demonstrates potent calcium channel-blocking effects, suppressing L-type Ca2+ currents in isolated cardiomyocytes.
    AH-1058
  • HY-124031
    Lobetyolinin

    		Others Cardiovascular Disease
    Lobetyolinin shows anti-arrhythmic activity . Lobetyolinin is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
    Lobetyolinin
  • HY-14834A
    Budiodarone tartrate

    ATI-2042 tartrate

    		 Potassium Channel Sodium Channel Calcium Channel Cardiovascular Disease
    Budiodarone (ATI-2042) tartrate is a chemical analogue of Amiodarone (HY-14187) with balanced, multiple cardiac ion channel (potassium, sodium and calcium channels) inhibiting activity. Budiodarone tartrate is an antiarrhythmic agent .
    Budiodarone tartrate
  • HY-126704
    Tedisamil

    KC-8857

    		 Potassium Channel Cardiovascular Disease
    Tedisamil (KC-8857) is an antiarrhythmic compound with important biological activities. Tedisamil exhibits a significant slowing effect on heart rate, which is achieved by inhibiting the transient outward potassium current (I(to)) in the atrium. Tedisamil inhibits multiple potassium currents, including IK, K(ATP), and PKA-activated chloride channels, thereby prolonging the cardiac action potential and QT interval, and increasing cardiac reentry. Tedisamil has antiarrhythmic effects on ventricular arrhythmias and atrial flutter in animal models .
    Tedisamil
  • HY-B0432B
    (S)-Propafenone
    1 Publications Verification

    (S)-SA-79

    		 Sodium Channel Cardiovascular Disease
    (S)-Propafenone ((S)-SA-79) is the S-enantiomer of Propafenone. (S)-Propafenone ((S)-SA-79) exerts beta-blocking action and the sodium channel-dependent antiarrhythmic class 1 activity .
    (S)-Propafenone
  • HY-130335
    Encainide

    MJ9067

    		 Sodium Channel Cardiovascular Disease
    Encainide (MJ9067) is an antiarrhythmic agent with class IC activity. Encainide blocks voltage-dependent potassium channels. Encainide has the potential for life-threatening ventricular arrhythmias, symptomatic ventricular arrhythmias and supraventricular arrhythmias research .
    Encainide
  • HY-12531
    Encainide hydrochloride

    MJ9067 hydrochloride

    		 Sodium Channel Cardiovascular Disease
    Encainide (MJ9067) hydrochloride is an antiarrhythmic agent with class IC activity. Encainide hydrochloride blocks voltage-dependent potassium channels. Encainide hydrochloride has the potential for life-threatening ventricular arrhythmias, symptomatic ventricular arrhythmias and supraventricular arrhythmias research .
    Encainide hydrochloride
  • HY-B1067AR
    Antazoline (Standard)

    		Histamine Receptor Neurological Disease
    Antazoline (Standard) is the analytical standard of Antazoline. This product is intended for research and analytical applications. Antazoline (Phenazoline) is an H1 receptor antagonist that affects the activity of the central nervous system, has a potent antiarrhythmic effect .
    Antazoline (Standard)
  • HY-B0997
    Hydroquinidine

    Dihydroquinidine; (+)-Hydroquinidine; Hydroconquinine

    		 Others Cardiovascular Disease Cancer
    Hydroquinidine (Dihydroquinidine) is a potent ion channel blocker, which exhibits strong anti-cancer activity on colon, pancreatic, and hepatocellular cancer cells. Hydroquinidine prolongs the QT interval and has antiarrhythmic efficacy .
    Hydroquinidine
  • HY-N2080
    Songorine

    		GABA Receptor Cancer
    Songorine is a diterpenoid alkaloid isolated from the genus Aconitum. Songorine is a GABAA receptor antagonist in rat brain and has anti cancer, antiarrhythmic and anti-inflammatory activities. Songorine has the potential for the treatment of Epithelial ovarian cancer (EOC) .
    Songorine
  • HY-N2255
    Crebanine
    1 Publications Verification

    		 Akt Apoptosis Cardiovascular Disease Inflammation/Immunology Cancer
    Crebanine, an alkaloid from Stephania venosa, induces G1 arrest and apoptosis in human cancer cells. Crebanine exhibits anti-inflammatory activity via suppressing MAPKs and Akt signaling. Crebanine also possesses antiarrhythmic effect .
    Crebanine
  • HY-136995
    AFD-21 maleate

    		Others Cardiovascular Disease
    AFD-21 maleate is a drug with antiarrhythmic activity. AFD-21 maleate inhibits sodium channels by binding to sodium channels in an inactive state, with both use-dependent and voltage-dependent effects. The unbinding rate of AFD-21 maleate is similar to that of Class I antiarrhythmic drugs with moderate kinetics. AFD-21 maleate can cause a slight prolongation of the action potential duration and significantly reduce the maximum rise rate of the action potential at certain concentrations. AFD-21 maleate also showed use-dependent blocking effects as stimulation frequency increased .
    AFD-21 maleate
  • HY-149101
    Riboxin

    IDP

    		 Others Cardiovascular Disease Inflammation/Immunology
    Riboxin (IDP), an orally active purine derivative-hypoxanthine rlboside, has antihypoxic and antihyperthermic activity. Riboxin also has an antiarrhythmic action in cats, rabbits, and mice with cardiac rhythm disorders induced by Ouabain. Riboxin protects animals against the noxious effects of γ-irradiation .
    Riboxin
  • HY-N1483A
    Guanfu base A hydrochloride

    		Potassium Channel Cardiovascular Disease
    Guanfu base A hydrochloride is an antiarrhythmic alkaloid with the ability to inhibit CYP2D6 enzyme activity. Guanfu base A hydrochloride can be used to inhibit arrhythmia-related diseases. Guanfu base A hydrochloride exhibits inhibitory effects on CYP2D6 in different species of organisms, including humans, monkeys, and dogs. The biological activity of Guanfu base A hydrochloride makes it have potential clinical application value .
    Guanfu base A hydrochloride
  • HY-115014
    Cibenzoline succinate

    Cifenline succinate; Ro 22-7796 succinate

    		 Potassium Channel Cardiovascular Disease Metabolic Disease
    Cibenzoline succinate (Cifenline succinate) is the succinate form of Cibenzoline (HY-106577). Cibenzoline succinate is an inhibitor for ATP-sensitive potassium (KATP) channel by affecting the pore-forming Kir6.2 subunit with IC50 of 22.2 µM. Cibenzoline succinate affects insulin secretion and exhibits antiarrhythmic and antidiabetic activities .
    Cibenzoline succinate
  • HY-144801A
    DDO-02005

    		Potassium Channel Cardiovascular Disease
    DDO-02005 is a potent Kv1.5 potassium channel inhibitor with an IC50 value of 0.72 μM. DDO-02005 has good anti-atrial fibrillation (AF) effect in CaCl2-ACh AF rats model and effective anti-arrhythmic activity caused by aconitine .
    DDO-02005
  • HY-40294
    Indazole

    		Monoamine Oxidase GSK-3 LRRK2 Cardiovascular Disease Neurological Disease Cancer
    Indazole, also called isoindazole, a heterocyclic aromatic organic compound. Its derivatives display a broad variety of biological activities including anti-inflammatory, antibacterial, anti-HIV, antiarrhythmic, antifungal and antitumour properties. Indazole and its derivatives can be used for research of cancer, neurological disorders, cardiovascular diseases, gastrointestinal diseases .
    Indazole
  • HY-A0082
    Diphenidol hydrochloride

    Difenidol hydrochloride

    		 mAChR Sodium Channel Neurological Disease
    Diphenidol hydrochloride (Difenidol hydrochloride) is a non-selective muscarinic M1-M4 receptor antagonist, has anti-arrhythmic activity. Diphenidol hydrochloride is also a potent non-specific blocker of voltage-gated ion channels (Na +, K +, and Ca 2+) in neuronal cells. Diphenidol hydrochloride can be used in the study of antivertigo and antinausea .
    Diphenidol hydrochloride
  • HY-144801
    DDO-02005 free base

    		Potassium Channel Cardiovascular Disease
    DDO-02005 (free base) is a potent Kv1.5 potassium channel inhibitor with an IC50 value of 0.72 μM. DDO-02005 (free base) has good anti-atrial fibrillation (AF) effect in CaCl2-ACh AF rats model and effective anti-arrhythmic activity caused by aconitine .
    DDO-02005 free base
  • HY-A0270
    Diphenidol

    		mAChR Sodium Channel Neurological Disease
    Diphenidol is a non-selective muscarinic M1-M4 receptor antagonist, has anti-arrhythmic activity. Diphenidol is also a potent non-specific blocker of voltage-gated ion channels (Na +, K +, and Ca 2+) in neuronal cells. Diphenidol can be used in the study of antivertigo and antinausea .
    Diphenidol
  • HY-14924
    Inakalant

    		Potassium Channel Cardiovascular Disease
    Inakalant is an atrial specific potassium channel blocker with antiarrhythmic activity. Inakalant works by selectively blocking potassium channels in heart cells, thereby prolongs the action potential duration (APD) of cardiomyocytes and increases the effective refractory period of the atria and ventricles, which helps to terminate and prevent the occurrence of arrhythmias such as atrial fibrillation (AF). Inakalant can be used in the study of arrhythmia and cardiac electrophysiology .
    Inakalant
  • HY-N3289A
    (E)-Methyl 3,4,5-trimethoxycinnamate

    		Others Inflammation/Immunology
    (E)-Methyl 3,4,5-trimethoxycinnamate is a bioactive natural phenylpropanoid. (E)-Methyl 3,4,5-trimethoxycinnamate suppresses inflammation in RAW264.7 macrophages and blocks macrophage-adipocyte interaction. (E)-Methyl 3,4,5-trimethoxycinnamate also has antiarrhythmic effect, leads to suppression of triggered activities in rabbit myocytes .
    (E)-Methyl 3,4,5-trimethoxycinnamate
  • HY-N0596
    Panaxadiol

    20(R)-Panaxadiol

    		 PD-1/PD-L1 HIF/HIF Prolyl-Hydroxylase STAT Cancer
    Panaxadiol (20(R)-Panaxadiol) is an orally active HIF-1α/STAT3 inhibitor. Panaxadiol can suppress HIF-1α and STAT3 then lead to downregulation of programmed cell death-ligand 1 (PD-L1) expression. Panaxadiol shows anticancer, cardioprotective, anti-arrhythmic, and antioxidative activities .
    Panaxadiol
  • HY-107708
    threo-Ifenprodil hemitartrate

    		iGluR Sigma Receptor Potassium Channel Neurological Disease
    threo Ifenprodil hemitartrate is a σ receptor agonist, with Kis of 59.1 and 2 nM for σ1 and σ2 receptors, respectively. threo Ifenprodil hemitartrate is also a NR2B subunit-selective NMDA receptor antagonist (IC50=0.22 μM). threo Ifenprodil hemitartrate is a hERG potassium channel inhibitor, with an IC 50 of 88 nM, showing antiarrhythmic activity .
    threo-Ifenprodil hemitartrate
  • HY-N7491A
    Ent-(+)-Verticilide

    		Calcium Channel Cancer
    ent-(+)-verticilide is a potent and selective inhibitor of cardiac ryanodine receptor (RyR2) calcium release channels with antiarrhythmic activity. ent-(+)-verticilide inhibits RyR2-mediated diastolic Ca 2+?leak and exhibits higher potency and a distinct mechanism of action compared with theDantrolene and Tetracaine.?ent-(+)-verticilide is a useful tool to investigate the therapeutic potential of targeting RyR2 hyperactivity in heart and brain pathologies .
    Ent-(+)-Verticilide
  • HY-106577
    Cibenzoline

    Cifenline; Ro 22-7796

    		 Potassium Channel Cardiovascular Disease Metabolic Disease
    Cibenzoline is a class Ia antiarrhythmic active molecule with low anticholinergic activity. Cibenzoline is a KATP channel inhibitor, acting through the pore forming subunit Kir6.2, with an IC50 of 22.2 μM. Cibenzoline inhibits IKr and IKs currents with IC50 values of 8.8 μM and 12.3 μM, respectively. Cibenzoline is used in the study of cardiac diseases. In addition, Cibenzoline can induce hypoglycemia .
    Cibenzoline
  • HY-A0082R
    Diphenidol hydrochloride (Standard)

    		mAChR Sodium Channel Neurological Disease
    Diphenidol (hydrochloride) (Standard) is the analytical standard of Diphenidol (hydrochloride). This product is intended for research and analytical applications. Diphenidol hydrochloride (Difenidol hydrochloride) is a non-selective muscarinic M1-M4 receptor antagonist, has anti-arrhythmic activity. Diphenidol hydrochloride is also a potent non-specific blocker of voltage-gated ion channels (Na+, K+, and Ca2+) in neuronal cells. Diphenidol hydrochloride can be used in the study of antivertigo and antinausea [4] .
    Diphenidol hydrochloride (Standard)
  • HY-118317
    Zacopride

    		Endogenous Metabolite Cardiovascular Disease
    Zacopride is a selective agonist with the activity of enhancing the inward rectifier potassium current (IK1) in rabbit hearts. Zacopride also exhibits significant antiarrhythmic effects, inhibiting ventricular arrhythmias by increasing IK1 without affecting atrial arrhythmias. Zacopride can hyperpolarize the resting membrane potential and shorten the action potential duration (APD) in a concentration-dependent manner. Zacopride significantly reduced the incidence of compound-induced early afterdepolarizations (EADs) at 1 μmol/L .
    Zacopride
  • HY-117181
    UK-1745

    		Phosphodiesterase (PDE) Adrenergic Receptor Cardiovascular Disease
    UK-1745 is a cardiotonic agent with vasodilating and antiarrhythmic properties. It increases intracellular levels of cyclic adenosine monophosphate (cAMP) in cardiomyocytes by inhibiting phosphodiesterase III, thereby enhancing myocardial contractility. Additionally, UK-1745 exhibits β-adrenergic receptor blocking activity, which helps reduce the oxygen consumption of the heart and prevent calcium overload. These characteristics make UK-1745 a promising candidate for research in congestive heart failure .
    UK-1745
  • HY-N0596R
    Panaxadiol (Standard)

    		PD-1/PD-L1 HIF/HIF Prolyl-Hydroxylase STAT Cancer
    Panaxadiol (Standard) is the analytical standard of Panaxadiol. This product is intended for research and analytical applications. Panaxadiol (20(R)-Panaxadiol) is an orally active HIF-1α/STAT3 inhibitor. Panaxadiol can suppress HIF-1α and STAT3 then lead to downregulation of programmed cell death-ligand 1 (PD-L1) expression. Panaxadiol shows anticancer, cardioprotective, anti-arrhythmic, and antioxidative activities .
    Panaxadiol (Standard)
  • HY-106577R
    Cibenzoline (Standard)

    		Potassium Channel Cardiovascular Disease Metabolic Disease
    Cibenzoline (Standard) is the analytical standard of Cibenzoline. This product is intended for research and analytical applications. Cibenzoline is a class Ia antiarrhythmic active molecule with low anticholinergic activity. Cibenzoline is a KATP channel inhibitor, acting through the pore forming subunit Kir6.2, with an IC50 of 22.2 μM. Cibenzoline inhibits IKr and IKs currents with IC50 values of 8.8 μM and 12.3 μM, respectively. Cibenzoline is used in the study of cardiac diseases. In addition, Cibenzoline can induce hypoglycemia .
    Cibenzoline (Standard)
  • HY-103160A
    EHNA hydrochloride
    3 Publications Verification

    		 Adenosine Deaminase Phosphodiesterase (PDE) Influenza Virus Infection Cardiovascular Disease Neurological Disease Cancer
    EHNA hydrochloride is a potent and selective dual inhibitor of cyclic nucleotide phosphodiesterase 2 (PDE2)(IC50=4 μM) and adenosine deaminase (ADA). EHNA hydrochloride exerts a concentration inhibition of the cGMP-stimulated PDE II (cGs-PDE)(IC50:0.8 μM (human), 2 μM (porcine myocardium)), but has smaller inhibitory effect on the unstimulated PDE2 activity. EHNA hydrochloride play roles in mediating diverse pharmacological responses, including antiviral, antitumour and antiarrhythmic effects .
    EHNA hydrochloride
  • HY-108998
    Bisaramil hydrochloride

    		Others Cardiovascular Disease
    Bisaramil hydrochloride is an antiarrhythmic compound with activity in inhibiting free radical generation. Bisaramil hydrochloride directly blocks sodium currents and exhibits enhanced sodium channel blocking ability. Bisaramil hydrochloride inhibits isoproterenol-induced slow calcium action potentials in cardiomyocytes. Bisaramil hydrochloride reduces heart rate and prolongs the PR, QRS, and QT intervals in the electrocardiogram, showing blocking effects on sodium and potassium channels. Bisaramil hydrochloride reduces cardiac conduction velocity, increases the threshold current for capture and atrial fibrillation, and prolongs the effective refractory period. Bisaramil hydrochloride reduces ventricular arrhythmias and eliminates mortality caused by ventricular fibrillation in ischemic rat hearts .
    Bisaramil hydrochloride

Inquiry Online

Your information is safe with us. * Required Fields.

Salutation

  

Country or Region *

Applicant Name *

 

Organization Name *

Department *

     

Email Address *

 

Product Name *

Cat. No.

  

Requested quantity *

Phone Number *

     

Remarks

Inquiry Online

Inquiry Information

Product Name:
Cat. No.:
Quantity:
MCE Japan Authorized Agent: